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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Radiotherapy of Gastrointestinal Cancers

edited by

Sunil Krishnan

submission deadline 15 Jun 2026 | Viewed by 134 | Submission Open

Keywords: gastrointestinal cancer; radiotherapy; IMRT; SBRT; MR-guided; proton therapy; adaptive radiotherapy; treatment planning; radiomics; artificial intelligence; combination therapy; immunotherapy; toxicity management; quality of life; personalized medicine

(This special issue belongs to the Section Methods and Technologies Development)

Surgical Strategies in the Era of Perioperative Immunotherapy for Thoracic Cancer

edited by Tomoyuki Hishida

submission deadline 15 Jun 2026 | Viewed by 83 | Submission Open

Keywords: lung cancer; perioperative treatment; immunotherapy; innmue checkpoint inhibitors; surgery

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Perioperative Management and Anesthetic Strategies for Improving Cancer Prognosis

edited by

Juan P. Cata

Lucillia Bezu

and

Nicolas Villablanca Uribe

submission deadline 15 Jun 2026 | Viewed by 58 | Submission Open

Keywords: perioperative care; anesthesia; cancer; oncological outcomes

Thoracic Cancer Surgery: From Classic to Robotic Approaches

edited by Sai Yendamuri and

Kenneth Patrick Seastedt

submission deadline 15 Jun 2026 | Viewed by 23 | Submission Open

Keywords: thoracic surgery; robotic surgery; image-guided technologies; minimally invasive surgery

(This special issue belongs to the Section Cancer Therapy)

Current Progress in Radiotherapy and Particle Therapy of Cancer

edited by

Carla Hajj

submission deadline 16 Jun 2026 | Viewed by 193 | Submission Open

Keywords: radiotherapy; particle therapy; proton therapy; heavy ion therapy; radiobiological; carbon ion therapy

(This special issue belongs to the Section Cancer Therapy)

Novel Insights into Cancer-Related Cognitive Impairment

edited by Danielle Tometich

submission deadline 20 Jun 2026 | 3 articles | Viewed by 6700 | Submission Open

Keywords: cognitive impairment; cognitive dysfunction; cancer survivorship; quality of life; neuropsychological assessment; cognitive rehabilitation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Histopathology and Pathogenesis of Skin Cancer

edited by

Carlos Torres-Cabala

and

Alessio Giubellino

submission deadline 20 Jun 2026 | 3 articles | Viewed by 3717 | Submission Open

Keywords: skin; tumor; cancer; histopathology; pathogenesis; molecular; immunohistochemistry; pathway; pathology

(This special issue belongs to the Section Cancer Pathophysiology)

Sarcoma Management in Orthopaedic Oncology

edited by

Vasileios Kontogeorgakos

and Jendrik Hardes

submission deadline 20 Jun 2026 | 3 articles | Viewed by 3391 | Submission Open

Keywords: orthopaedic surgical oncology; sarcoma; orthopaedic surgery; bone and soft tissue sarcoma; diagnose; neoadjuvant therapy; targeted therapy; immunotherapy

(This special issue belongs to the Section Methods and Technologies Development)

The Advance of Clinical Therapy and Prognosis in Gastrointestinal Cancer

edited by Liliana Streba and Michael Schenker

submission deadline 20 Jun 2026 | 1 articles | Viewed by 2359 | Submission Open

Keywords: gastrointestinal cancer; tumorigenesis; microbiome; early detection; molecular mechanisms; personalized medicine; novel therapeutics; translational research; clinical application; diagnostic innovations

(This special issue belongs to the Section Clinical Research of Cancer)

p53 Family in Cancer: How Close Are We to the Clinic? (2nd Edition)

edited by

Lucília Saraiva

and

Marco M. Candeias

submission deadline 20 Jun 2026 | 1 articles | Viewed by 753 | Submission Open

Keywords: p53; p63; p73; proteins; protein-coding and non-coding genes; genetics; drug discovery; cancer; targeted anticancer therapy

(This special issue belongs to the Section Cancer Therapy)

Advances in Pleural and Peritoneal Mesothelioma

edited by

Rossella Bruno

submission deadline 20 Jun 2026 | 1 articles | Viewed by 468 | Submission Open

Keywords: pleural mesothelioma; peritoneal mesothelioma; differential diagnosis; biomarkers; next-generation sequencing; gene expression

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in the Ubiquitin–Proteasome System (UPS) in Cancer Biology

edited by

Tarek A. Abbas

submission deadline 20 Jun 2026 | Viewed by 172 | Submission Open

Keywords: ubiquitin– proteasome system (UPS); cancer biology; E3 ubiquitin ligases; deubiquitinating enzymes (DUBs); protein degradation; proteasome inhibitors; ubiquitination signaling; genome stability and DNA repair; PROTACs and molecular glues; targeted cancer therapeutics

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Squamous Cell Carcinoma: From Pathogenesis to Treatment

edited by Carolin Götz

submission deadline 20 Jun 2026 | Viewed by 136 | Submission Open

Keywords: squamous cell carcinoma (SCC); oncological surgery; carcinogenesis; tumor microenvironment; HPV; immunotherapy; molecular targets; precision oncology; biomarkers; head and neck cancer; translational oncology

(This special issue belongs to the Section Cancer Pathophysiology)

Genetic Predisposition to Hematological Malignancies

edited by

Danika Di Giacomo

submission deadline 20 Jun 2026 | Viewed by 71 | Submission Open

Keywords: leukemia predisposition; germline variants; inherited syndromes; myelodysplastic syndrome (MDS); acute myeloid leukemia (AML); precision medicine

(This special issue belongs to the Section Molecular Cancer Biology)

The Next Cutting-Edge Technologies in Abdominal Solid Tumor Treatment

edited by Jerome Canady, Saravana R.K. Murthy, Aviram Nissan and

Michael Keidar

submission deadline 20 Jun 2026 | Viewed by 61 | Submission Open

Keywords: multi-visceral surgical resection for complex advanced gastrointestinal tumors; cytoreductive surgery; colon and gynecological cancers; pancreatic cancer; cold atmospheric plasma (CAP); robotic AI CAP surgical delivery systems; targeted immunotherapies; irreversible electroporation; HIPEC (hyperthermic intraperitoneal chemotherapy); PIPAC (pressurized intraperitoneal aerosol chemotherapy)

(This special issue belongs to the Section Methods and Technologies Development)

Decoding and Remodeling the Suppressive Tumor Immune Microenvironment in Head and Neck Cancer

edited by Andrew G. Sikora and Jennifer L. Anderson

submission deadline 20 Jun 2026 | Viewed by 38 | Submission Open

Keywords: tumor immune microenvironment (TIME); cancer-mediated immunosuppression; myeloid cells; regulatory T cells; cytokines; anti-tumor immunity; immune modulation

(This special issue belongs to the Section Tumor Microenvironment)

Novel Strategies in the Prevention/Treatment of Colorectal Cancer: 2nd Edition

edited by

William H. Gmeiner

submission deadline 20 Jun 2026 | Viewed by 22 | Submission Open

Keywords: colorectal cancer; chemotherapy; chemoprevention; targeted therapy; kinase inhibitor; immunotherapy

Angiogenesis and Anti-Angiogenic Therapies in Cancer

edited by

Girolamo Ranieri

and Giovanni Mastrandrea

submission deadline 24 Jun 2026 | Viewed by 121 | Submission Open

Keywords: angiogenesis; anti-angiogenic therapies; cancer; tumor vasculature; therapeutic strategies

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Soft Tissue and Bone Sarcoma (2nd Edition)

edited by

Catrin Sian Rutland

submission deadline 25 Jun 2026 | 3 articles | Viewed by 3094 | Submission Open

Keywords: bone sarcoma; soft tissue sarcoma; prognosis; diagnosis; detection; molecular biomarkers; histopathology; treatment

(This special issue belongs to the Section Cancer Therapy)

Digital Pathology in Precision Oncology: Emerging Tools for Diagnosis and Treatment Guidance

edited by Daniela Hartmann and

Maximilian Deussing

submission deadline 25 Jun 2026 | Viewed by 190 | Submission Open

Keywords: dermatology ; digital pathology ; ex vivo confocal microscopy ; artificial intelligence ; machine learning ; virtual biopsy ; teledermatology ; histopathological images; image analysis algorithms

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Clinical and Translational Research in Head and Neck Cancer—2nd Edition

edited by Young J. Kim

submission deadline 25 Jun 2026 | Viewed by 90 | Submission Open

Keywords: head and neck cancer; immunotherapy; translation; combinatorial clinical trials; oncologic therapeutics

(This special issue belongs to the Section Clinical Research of Cancer)

Surgery for Thoracic Cancer

edited by Andrea Billé and Louisa Patel

submission deadline 25 Jun 2026 | Viewed by 90 | Submission Open

Keywords: thoracic surgery; lung cancer; mesothelioma; thymic malignancies; minimally invasive surgery; robotic-assisted thoracic surgery; multimodal therapy; immunotherapy; perioperative management; surgical outcomes

(This special issue belongs to the Section Cancer Therapy)

Immune Deficiency-Associated Lymphoma

edited by

Régis Thierry Costello

submission deadline 25 Jun 2026 | Viewed by 36 | Submission Open

Keywords: lymphoma; immune; HIV infection

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advances in the Diagnosis, Stratification, and Targeted Treatment of Myeloproliferative Neoplasms

edited by

Bojana Beleslin Čokić

submission deadline 25 Jun 2026 | Viewed by 26 | Submission Open

Keywords: myeloproliferative neoplasms; molecular diagnostics; targeted therapy; mutational profiling; biomarkers; disease progression; therapy resistance; translational research; personalized medicine

Epigenetic and Metabolic Alterations in the Tumor Microenvironment: 2nd Edition

edited by

Ciro Isidoro

and

Danny N. Dhanasekaran

submission deadline 26 Jun 2026 | 1 articles | Viewed by 2562 | Submission Open

Keywords: tumor microenvironment; hypoxia; inflammation; cytokines; epigenetics; metabolic cross-talk; cancer stroma cells; epigenetic alterations; cancer cell dormancy; cancer cell proliferation; cancer cell migration; cancer cell stemness

(This special issue belongs to the Section Tumor Microenvironment)

New Strategies for Molecular Targeted Therapy in Multiple Myeloma

edited by Daniele Caracciolo

submission deadline 26 Jun 2026 | 1 articles | Viewed by 1118 | Submission Open

Keywords: multiple myeloma; molecular target; drug target; signaling pathway; immunotherapeutic strategy; drug resistance

(This special issue belongs to the Section Cancer Therapy)

Clinical Epidemiology and Risk Prediction for Gastrointestinal Cancers

edited by

Holli Loomans-Kropp

submission deadline 30 Jun 2026 | 11 articles | Viewed by 37694 | Submission Open

Keywords: gastrointestinal cancers; genetic risk; polygenic risk scores; exposome; lifestyle risk factors; biomarkers; chemoprevention

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

New Perspectives in the Management of Breast Cancer

edited by

Sonia Santander Ballestín

and

María José Luesma

submission deadline 30 Jun 2026 | 12 articles | Viewed by 30208 | Submission Open

Keywords: breast cancer; treatment; nutrition; physical exercise; psychosocial impact

(This special issue belongs to the Section Cancer Therapy)

Hematologic Malignancies and Related Disorders: Challenges from Diagnosis to Treatment

edited by

Ioanna Sakellari

and

Eleni Gavriilaki

submission deadline 30 Jun 2026 | 9 articles | Viewed by 25574 | Submission Open

Keywords: hematopoietic cell transplantation; cell therapy; acute myeloid leukemia; graft-versus-host disease; hematologic malignancies; thrombosis; complement; lymphoma; myeloma; COVID-19

(This special issue belongs to the Section Cancer Therapy)

New Challenges for Gastric Cancer—Gut Microbiota, Post-eradication and Chemotherapy

edited by Kazunari Murakami and

Kazuhiro Mizukami

submission deadline 30 Jun 2026 | 7 articles | Viewed by 24874 | Submission Open

Keywords: gastric cancer; microbiota; Helicobacter pylori; after Helicobacter pylori eradication therapy; chemotherapy; immune checkpoint inhibitor

(This special issue belongs to the Section Cancer Therapy)

Advances in Clinical Trials: Outcome, Innovations, Challenges, and Ethical Practice in Cancer Research 2025–2026

edited by

Naoto T. Ueno

and David R. Gandara

submission deadline 30 Jun 2026 | 5 articles | Viewed by 23686 | Submission Open

Keywords: phase I; phase II; phase III; phase IV; clinical trials; features; design; implementation; outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in the Prevention and Treatment of Liver Cancer

edited by Ewa Janczewska

submission deadline 30 Jun 2026 | 8 articles | Viewed by 23456 | Submission Open

Keywords: new screening techniques; enhanced imaging; biomarker tests; radiofrequency ablation; transarterial chemoembolization

(This special issue belongs to the Section Cancer Therapy)

Advances in Bacteria and Cancer

edited by

Alain P. Gobert

submission deadline 30 Jun 2026 | 5 articles | Viewed by 18794 | Submission Open

Keywords: pathogenic bacteria; microbiota; tumor-associated bacteria; probiotics; oncogenesis; metastasis; chemotherapy; cancerous cells; tumor microenvironment; cell signaling

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Epidermal Growth Factor Receptor-Driven Non-Small-Cell Lung Cancer: Diagnostic Technologies and Therapeutic Strategies

edited by

Fang Wei

submission deadline 30 Jun 2026 | 4 articles | Viewed by 16713 | Submission Open

Keywords: EGFR-targeted therapy; non-small-cell lung cancer diagnosis; diagnostic technologies and devices; biological discoveries in NSCLC; AI-assisted diagnosis in oncology; clinical practice in NSCLC detection; therapeutic– diagnostic integration; early-stage lung cancer monitoring; advanced NSCLC diagnostic approaches; precision medicine in lung cancer

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Gynecologic Oncology: Clinical and Translational Research

edited by

Gennaro Daniele

, Pasquale Lombardi and Gaia Giannone

submission deadline 30 Jun 2026 | 7 articles | Viewed by 15010 | Submission Open

Keywords: gynecological cancer; ovarian cancer; translational research; effectiveness; toxicity; immunotherapy; PARP inhibitors

(This special issue belongs to the Section Cancer Therapy)

New Insights into Thyroid Cancer Surgery

edited by

Maurizio Iacobone

and Francesca Torresan

submission deadline 30 Jun 2026 | 6 articles | Viewed by 14762 | Submission Open

Keywords: total thyroidectomy; differentiated thyroid cancer; lymph node dissection; parathyroid autofluorescence; medullary thyroid carcinoma; recurrent laryngeal nerve neuromonitoring

(This special issue belongs to the Section Cancer Therapy)

Role of Cancer Biomarkers for Diagnosis, Prognosis and Targeted Therapy in Gastrointestinal Cancers

edited by

Ali Zaidi

submission deadline 30 Jun 2026 | 8 articles | Viewed by 12575 | Submission Open

Keywords: liquid biopsy; esophageal cancer; gastric cancer; colorectal cancer; pancreatic cancer; hepatocellular cancer; appendiceal cancer; cancer biomarker; DNA sequencing; transcriptomics; proteomics; immunohistochemistry

(This special issue belongs to the Section Cancer Biomarkers)

Advances in Spine Oncology: Research and Clinical Studies

edited by Oluwaseun O. Akinduro

submission deadline 30 Jun 2026 | 8 articles | Viewed by 12350 | Submission Open

Keywords: metastatic spine cancer; targeted therapy; stereotactic body radiotherapy; proton radiotherapy; chordoma; chondrosarcoma; spondylectomy

(This special issue belongs to the Section Clinical Research of Cancer)

Updates on Urologic Oncology: From Diagnosis to Localized and Systemic Therapy Options (2nd Edition)

edited by

Giuseppe Palermo

submission deadline 30 Jun 2026 | 5 articles | Viewed by 11399 | Submission Open

Keywords: bladder cancer; prostate cancer; renal cancer; urologic cancer treatment; urologic cancer diagnosis; urologic cancer innovation; urologic neoplasm therapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Gastrointestinal Cancer Surgery

edited by Florian Primavesi and

Daniel Neureiter

submission deadline 30 Jun 2026 | 6 articles | Viewed by 10604 | Submission Open

Keywords: gastrointestinal cancer surgery; precision surgery; personalized medicine; robotics; pathology; colorectal cancer; stomach cancer; pancreatic cancer; hepatocellular cancer; biliary tract cancer

(This special issue belongs to the Section Cancer Therapy)

Clinical Diagnosis, Treatment, and Prognosis of Uveal Melanoma

edited by Josep Maria Caminal Mitjana

submission deadline 30 Jun 2026 | 5 articles | Viewed by 10458 | Submission Open

Keywords: uveal melanoma; choroidal melanoma; gene expression profiling; immunotherapy; metastasis; radiotherapy; liquid biopsy; circulating tumor cells; brachytherapy; next-generation sequencing; proton therapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Application of Artificial Intelligence-Based Approaches in Cancer Diagnosis, Treatment and Prognosis

edited by

Wei Wu

submission deadline 30 Jun 2026 | 6 articles | Viewed by 10025 | Submission Open

Keywords: cancer genomics; artificial intelligence; machine learning; deep learning; tumor microenvironment; graph-based convolutional neural network; computational cancer biology

(This special issue belongs to the Section Methods and Technologies Development)

News and How Much to Improve in Management of Soft Tissue Sarcomas

edited by Vicente Artigas-Raventós and

José Manuel Asencio

submission deadline 30 Jun 2026 | 5 articles | Viewed by 10015 | Submission Open

Keywords: soft tissue sarcomas; prevalent types; multidisciplinary board; reference centers; news diagnosis methods and treatments; implication of IA and 3D in sarcomas; implication of minimally aggressive surgical techniques

(This special issue belongs to the Section Cancer Therapy)

The Progress of Pancreatectomy for Pancreatic Cancer Treatment

edited by

Reinhold Függer

and

Matthias Biebl

submission deadline 30 Jun 2026 | 5 articles | Viewed by 9885 | Submission Open

Keywords: pancreatic ductal adenocarcinoma (PDAC); pancreatectomy timing in multimodal regimen; minimally invasive pancreatectomy for PDAC; pancreatectomy and resectability; extended pancreatectomy; vascular resection and reconstruction; outcome research— pancreatectomy for cancer in unselected patient cohorts; interaction of postoperative complications and preoperative or adjuvant therapy; postoperative pancreatic fistula

(This special issue belongs to the Section Clinical Research of Cancer)

Human Papillomavirus (HPV) and Related Cancer

edited by

Beata Biesaga

submission deadline 30 Jun 2026 | 4 articles | Viewed by 9842 | Submission Open

Keywords: HPV; carcinogenesis; methods of virus identification diagnostics; prognostification

(This special issue belongs to the Section Infectious Agents and Cancer)

The Role of Neutrophils in Tumor Progression and Metastasis

edited by

Rakesh K. Singh

and Leah M. Cook

submission deadline 30 Jun 2026 | 5 articles | Viewed by 9122 | Submission Open

Keywords: neutrophils; innate immunity; tumor; microenvironment; metastasis; targeted therapeutics

(This special issue belongs to the Section Cancer Metastasis)

Perspectives on the Efficacy and Biomarkers of Immunotherapy and Targeted Therapy for Patients with Colorectal Cancer

edited by

Ibrahim Halil Sahin

submission deadline 30 Jun 2026 | 2 articles | Viewed by 7939 | Submission Open

Keywords: colorectal cancer; precision medicine; targeted therapeutics; immunotherapy; KRAS; BRAF; HER2; biomarkers

(This special issue belongs to the Section Cancer Therapy)

Epigenetic Regulation in Hematologic Malignancies

edited by Travis S. Johnson

submission deadline 30 Jun 2026 | 3 articles | Viewed by 7858 | Submission Open

Keywords: epigenetic regulation; hematologic malignancies; DNA methylation; non-coding RNA; therapeutic targeting

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Abdominal Surgical Oncology and Intraperitoneal Therapies

edited by

Juan Jose Segura-Sampedro

and

Constantino Fondevila

submission deadline 30 Jun 2026 | 5 articles | Viewed by 7751 | Submission Open

Keywords: abdominal oncologic surgery; minimally invasive techniques; laparoscopy; robotics; fluorescence; artificial intelligence; augmented vision; peritoneal carcinomatosis; intraperitoneal chemotherapy; liquid biopsy

(This special issue belongs to the Section Cancer Therapy)

Hereditary and Familial Colorectal Cancer

edited by Bryson W. Katona and Peter P. Stanich

submission deadline 30 Jun 2026 | 4 articles | Viewed by 7140 | Submission Open

Keywords: hereditary colorectal cancer; familial colorectal cancer; genetic predisposition; polyposis; Lynch syndrome; familial adenomatous polyposis (FAP); MUTYH-associated polyposis (MAP); genetic testing

(This special issue belongs to the Section Cancer Pathophysiology)

Displaying special issue 701-750 on page 15 of 25.

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