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Cancers
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Sarcoma Management in Orthopaedic Oncology
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Sarcoma Management in Orthopaedic Oncology

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: 20 June 2026 | Viewed by 3225

Special Issue Editors

Prof. Dr. Vasileios Kontogeorgakos

E-Mail Website
Guest Editor
Department of Orthopaedic Surgery, “Attikon” University General Hospital, National and Kapodistrian University of Athens, 1 Rimini Street, 12461 Athens, Greece
Interests: orthopaedic surgical oncology; bone and soft tissue sarcoma; paediatric sarcomas; microsurgery; musculoskeletal oncology
Prof. Dr. Jendrik Hardes

E-Mail Website
Guest Editor
Department of Orthopedic Oncology, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany
Interests: orthopaedic surgery; sarcoma surgery; musculoskeletal oncology; soft tissue sarcoma

Special Issue Information

Dear Colleagues,

Cancer is a leading cause of morbidity and mortality worldwide. Significant efforts to improve disease diagnosis and treatment are currently underway, with the aim of improving patients’ health, quality of life, and survival. Previously, sarcomas, representing a minority of cancer diagnoses in children and adults, received less attention from the medical community. However, over the last two decades, there has been a clear and impressive increase in knowledge on sarcoma biology, histology, adjuvant therapies, and surgical procedures. As a result, health care quality and patients’ survival and daily living activities have been greatly improved. This is the result of the combined work of researchers in basic science and in clinical settings.

Our aim in launching this Special Issue is to provide an overview of the current landscape of treatment and diagnosis in sarcoma in both children and adults and to provide directions for future investigations.

Prof. Dr. Vasileios Kontogeorgakos
Prof. Dr. Jendrik Hardes
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • orthopaedic surgical oncology
  • sarcoma
  • orthopaedic surgery
  • bone and soft tissue sarcoma
  • diagnose
  • neoadjuvant therapy
  • targeted therapy
  • immunotherapy

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Published Papers (3 papers)

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Research

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13 pages, 2448 KB  
Article
Pelvic Floor Functionality and Outcomes in Oncologic Patients Treated with Pelvic Bone Resection
by Edoardo Ipponi, Pier Luigi Ipponi, Fabrizia Gentili, Elena Bechini, Vittoria Bettarini, Paolo Domenico Parchi and Lorenzo Andreani
Cancers 2025, 17(16), 2629; https://doi.org/10.3390/cancers17162629 - 12 Aug 2025
Viewed by 889
Abstract
Background: Pelvic resections represent some of the most challenging procedures in orthopedic oncology, often necessitating the sacrifice of large bone segments and, subsequently, the loss of nearby soft tissues. Our study aims to evaluate the impact of surgical resections of pelvic bone tumors [...] Read more.
Background: Pelvic resections represent some of the most challenging procedures in orthopedic oncology, often necessitating the sacrifice of large bone segments and, subsequently, the loss of nearby soft tissues. Our study aims to evaluate the impact of surgical resections of pelvic bone tumors on the performance of the pelvic floor and digestive, urinary, and genital systems. Methods: We evaluated all malignant or locally aggressive pelvic bone tumors treated with bone resection in our institution between January 2017 and January 2024. The reconstructive approaches were recorded. Pre- and post-operative MRI and CT scans were used to evaluate the grade of pelvic prolapse. The prolapse of the pelvic floor was assessed with the M-line, the H-line, and the anorectal angle. Hydronephrosis was also evaluated. Urinary and fecal incontinence were evaluated with the Pelvic Floor Impact Questionnaire (PFIQ7). Results: Thirty cases were included in our study. Nine cases were treated with custom-made prostheses, five had ice-cone prostheses, two massive allografts, and one composite allograft-prosthesis. The others had no bone reconstruction. Meshes were used to reconstruct the pelvic floor in 9 cases. Patients with discontinuity of the pelvic ring had a significantly higher grade of pelvic prolapse (M-line) and worse PFIQ7 scores. Conclusions: The resection of pelvic bone tumors represents one of the main challenges in orthopedic oncology. While planning surgical demolition and performing the subsequent reconstruction, surgeons should also consider the impact of the surgical treatment on the pelvic floor and surrounding organs. Intra-operative reconstructions and post-operative rehabilitation are advisable. Full article
(This article belongs to the Special Issue Sarcoma Management in Orthopaedic Oncology)
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Review

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17 pages, 3694 KB  
Review
Beyond the Signal: Imaging Insights and Diagnostic Relevance of Bone Oedema in Bone Tumours and Tumour-like Lesions
by Neel R. Raja, Hasaam Uldin, Ali Shah, Shashank Chapala and Rajesh Botchu
Cancers 2025, 17(13), 2074; https://doi.org/10.3390/cancers17132074 - 20 Jun 2025
Cited by 1 | Viewed by 1146
Abstract
Bone oedema is a non-specific imaging finding associated with a wide range of pathologies, including trauma, infection, inflammation, and neoplasms [...] Full article
(This article belongs to the Special Issue Sarcoma Management in Orthopaedic Oncology)
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Other

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15 pages, 794 KB  
Systematic Review
Rehabilitation Protocols and Functional Outcomes in Oncological Patients Treated with Modular Megaprosthesis: A Systematic Review
by Filip Fryderyk Brzeszczyński, Michał Karpiński, Marcel Aleksander Brzeszczyński, Oktawiusz Bończak and David F. Hamilton
Cancers 2025, 17(18), 2951; https://doi.org/10.3390/cancers17182951 - 9 Sep 2025
Viewed by 743
Abstract
Background/Objectives: Bone reconstruction using megaprostheses is increasingly performed following bone tumour resections, including sarcomas, to enhance patient outcomes and quality of life. However, this is a complex patient group, and there is little consensus as to postoperative rehabilitation and associated outcomes. Methods: A [...] Read more.
Background/Objectives: Bone reconstruction using megaprostheses is increasingly performed following bone tumour resections, including sarcomas, to enhance patient outcomes and quality of life. However, this is a complex patient group, and there is little consensus as to postoperative rehabilitation and associated outcomes. Methods: A systematic search was conducted in MEDLINE and EMBASE databases according to the Implementing Prisma in Exercise, Rehabilitation, Sport medicine and SporTs science (PERSiST) guidelines. Studies describing rehabilitation protocols and functional outcomes following bone tumour resection and modular oncologic megaprosthesis reconstruction were included. All papers were individually assessed for methodological quality using the Joanna Briggs Institute (JBI) critical appraisal tool. Results: The search generated 105 records, 28 underwent full-text review, and 13 studies were included. Available data reflect 371 patients with a mean age of 49.17 (S.D. 21.40) years and a mean postoperative follow-up of 41.88 (S.D. 32.88) months. Surgical indications were documented as sarcomas in 9 studies, and tumour metastasis to the bone in 10 studies. Rehabilitation protocols were reported in 5 studies following proximal humerus resection with a mean dislocation rate of 14.5% (S.D. 5.26). All protocols advised brace immobilisation for a period ranging between 10 days and 6 months. Superior Constant-Murley shoulder score was reported in patients with early active isometric exercises at 6 weeks. Six studies reported proximal femur prosthesis rehabilitation and functional outcomes, with a mean dislocation rate of 10% (S.D. 9.82). Enhanced outcomes were reported in studies employing early mobilisation. Two studies assessed distal femur prosthesis; both studies reported similar protocols with full weight bearing 3 weeks following surgery. The methodological quality of the studies varied, but was overall modest, with 10/13 studies meeting at least 50% of JBI reporting criteria. Conclusions: The existing literature on rehabilitation and outcomes in orthopaedic oncology patients following arthroplasty with megaprosthesis is limited, with rehabilitative protocols variably described. However, it seems that early active mobilisation does not increase the risk of joint dislocations or infections. Full article
(This article belongs to the Special Issue Sarcoma Management in Orthopaedic Oncology)
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