Sarcoma Management in Orthopaedic Oncology

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1152

Special Issue Editors


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Guest Editor
Department of Orthopaedic Surgery, “Attikon” University General Hospital, National and Kapodistrian University of Athens, 1 Rimini Street, 12461 Athens, Greece
Interests: orthopaedic surgical oncology; bone and soft tissue sarcoma; paediatric sarcomas; microsurgery; musculoskeletal oncology

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Guest Editor
Department of Orthopedic Oncology, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany
Interests: orthopaedic surgery; sarcoma surgery; musculoskeletal oncology; soft tissue sarcoma

Special Issue Information

Dear Colleagues,

Cancer is a leading cause of morbidity and mortality worldwide. Significant efforts to improve disease diagnosis and treatment are currently underway, with the aim of improving patients’ health, quality of life, and survival. Previously, sarcomas, representing a minority of cancer diagnoses in children and adults, received less attention from the medical community. However, over the last two decades, there has been a clear and impressive increase in knowledge on sarcoma biology, histology, adjuvant therapies, and surgical procedures. As a result, health care quality and patients’ survival and daily living activities have been greatly improved. This is the result of the combined work of researchers in basic science and in clinical settings.

Our aim in launching this Special Issue is to provide an overview of the current landscape of treatment and diagnosis in sarcoma in both children and adults and to provide directions for future investigations.

Prof. Dr. Vasileios Kontogeorgakos
Prof. Dr. Jendrik Hardes
Guest Editors

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Keywords

  • orthopaedic surgical oncology
  • sarcoma
  • orthopaedic surgery
  • bone and soft tissue sarcoma
  • diagnose
  • neoadjuvant therapy
  • targeted therapy
  • immunotherapy

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Published Papers (2 papers)

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Research

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13 pages, 2448 KB  
Article
Pelvic Floor Functionality and Outcomes in Oncologic Patients Treated with Pelvic Bone Resection
by Edoardo Ipponi, Pier Luigi Ipponi, Fabrizia Gentili, Elena Bechini, Vittoria Bettarini, Paolo Domenico Parchi and Lorenzo Andreani
Cancers 2025, 17(16), 2629; https://doi.org/10.3390/cancers17162629 - 12 Aug 2025
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Abstract
Background: Pelvic resections represent some of the most challenging procedures in orthopedic oncology, often necessitating the sacrifice of large bone segments and, subsequently, the loss of nearby soft tissues. Our study aims to evaluate the impact of surgical resections of pelvic bone tumors [...] Read more.
Background: Pelvic resections represent some of the most challenging procedures in orthopedic oncology, often necessitating the sacrifice of large bone segments and, subsequently, the loss of nearby soft tissues. Our study aims to evaluate the impact of surgical resections of pelvic bone tumors on the performance of the pelvic floor and digestive, urinary, and genital systems. Methods: We evaluated all malignant or locally aggressive pelvic bone tumors treated with bone resection in our institution between January 2017 and January 2024. The reconstructive approaches were recorded. Pre- and post-operative MRI and CT scans were used to evaluate the grade of pelvic prolapse. The prolapse of the pelvic floor was assessed with the M-line, the H-line, and the anorectal angle. Hydronephrosis was also evaluated. Urinary and fecal incontinence were evaluated with the Pelvic Floor Impact Questionnaire (PFIQ7). Results: Thirty cases were included in our study. Nine cases were treated with custom-made prostheses, five had ice-cone prostheses, two massive allografts, and one composite allograft-prosthesis. The others had no bone reconstruction. Meshes were used to reconstruct the pelvic floor in 9 cases. Patients with discontinuity of the pelvic ring had a significantly higher grade of pelvic prolapse (M-line) and worse PFIQ7 scores. Conclusions: The resection of pelvic bone tumors represents one of the main challenges in orthopedic oncology. While planning surgical demolition and performing the subsequent reconstruction, surgeons should also consider the impact of the surgical treatment on the pelvic floor and surrounding organs. Intra-operative reconstructions and post-operative rehabilitation are advisable. Full article
(This article belongs to the Special Issue Sarcoma Management in Orthopaedic Oncology)
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Review

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17 pages, 3694 KB  
Review
Beyond the Signal: Imaging Insights and Diagnostic Relevance of Bone Oedema in Bone Tumours and Tumour-like Lesions
by Neel R. Raja, Hasaam Uldin, Ali Shah, Shashank Chapala and Rajesh Botchu
Cancers 2025, 17(13), 2074; https://doi.org/10.3390/cancers17132074 - 20 Jun 2025
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Abstract
Bone oedema is a non-specific imaging finding associated with a wide range of pathologies, including trauma, infection, inflammation, and neoplasms [...] Full article
(This article belongs to the Special Issue Sarcoma Management in Orthopaedic Oncology)
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