Histopathology and Pathogenesis of Skin Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 629

Special Issue Editors


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Guest Editor
The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Interests: cutaneous tumors; lymphomas; melanoma; pathology
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
Interests: dermatopathology; melanoma; receptor tyrosine kinase; MET; HGF; histopathology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cutaneous malignant neoplasms comprise a wide and varied group of tumors that often represent a challenge for both clinicians and researchers. The spectrum of tumors involving the skin encompasses indolent and very aggressive neoplasms arising from distinct lineages and with very different clinical presentations and therapeutic approaches.

This Special Issue will focus on the pathological features of tumors involving skin. Histopathological, immunohistochemical, and molecular aspects used in the diagnosis, prognosis, and prediction of these entities, along with research on the mechanisms of pathogenesis, will be covered. Original research and review topics on dermatopathology and basic, and translational research of cutaneous neoplasms (squamous, adnexal, melanocytic, hematolymphoid, mesenchymal, neural) will be included in a broad but also deep showcase of what is current and novel in cutaneous neoplasms.

We look forward to receiving your contributions.

Prof. Dr. Carlos Torres-Cabala
Dr. Alessio Giubellino
Guest Editors

Manuscript Submission Information

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Keywords

  • skin
  • tumor
  • cancer
  • histopathology
  • pathogenesis
  • molecular
  • immunohistochemistry
  • pathway
  • pathology

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Published Papers (1 paper)

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Review

16 pages, 3665 KiB  
Review
Squamous Cell Carcinoma and Its Rare Variant, Carcinoma Cuniculatum: Insights and Case Studies
by Klaudia Knecht-Gurwin, Aleksandra A. Stefaniak, Iwona Chlebicka, Lukasz Matusiak, Zdzisław Woźniak and Jacek C. Szepietowski
Cancers 2025, 17(7), 1217; https://doi.org/10.3390/cancers17071217 - 3 Apr 2025
Viewed by 388
Abstract
Background: Squamous cell carcinoma (SCC) presents a significant challenge in dermatological pathology, necessitating comprehensive insights for effective management. This review highlights SCC’s broad aspects and focuses particularly on carcinoma cuniculatum (CC), a rare variant that warrants special attention due to its unique diagnostic [...] Read more.
Background: Squamous cell carcinoma (SCC) presents a significant challenge in dermatological pathology, necessitating comprehensive insights for effective management. This review highlights SCC’s broad aspects and focuses particularly on carcinoma cuniculatum (CC), a rare variant that warrants special attention due to its unique diagnostic and therapeutic challenges. Methods:
We conducted a narrative review of current literature on SCC and CC, supplemented by illustrative clinical case presentations. The analysis emphasized epidemiology, pathogenesis, clinical presentation, diagnostic pitfalls, and treatment modalities. Results:
The key findings from our analysis indicate that CC, although locally aggressive, exhibits a lower metastatic potential and requires distinct management strategies, primarily surgical, due to its poor responsiveness to radiotherapy. Conclusions:
The review also includes illustrative clinical cases to highlight the diverse presentations and underscore the necessity for multidisciplinary approaches and heightened clinical vigilance in diagnosing and managing CC. By consolidating current knowledge and clinical experiences, this review aims to enhance awareness, facilitate early recognition, and optimize therapeutic strategies for SCC, particularly CC, thereby improving patient outcomes and prognosis. Full article
(This article belongs to the Special Issue Histopathology and Pathogenesis of Skin Cancer)
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