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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pathology of Renal Tumors
edited by and Anna Caliò
submission deadline 30 Nov 2026 | 1 articles | Viewed by 1574 | Submission Open
Keywords: renal cell tumors; diagnosis; prognosis; metabolomics; genomics; molecular; immunohistochemistry; histopathology
(This special issue belongs to the Section Cancer Pathophysiology)
Contemporary Head and Neck Oncology: Progress, Clinical Dilemmas, and Future Directions submission deadline 30 Nov 2026 | 3 articles | Viewed by 1570 | Submission Open
Keywords: head and neck oncology; clinical dilemmas; future directions; diagnosis; biological characterization; treatment strategies; recurrent/metastatic settings
(This special issue belongs to the Section Cancer Therapy)
Burkitt Lymphoma: From Pathogenesis to Current Treatments: 2nd Edition
edited by Lorenzo Leoncini and
submission deadline 30 Nov 2026 | 2 articles | Viewed by 1553 | Submission Open
Keywords: Burkitt lymphoma; high-grade B-cell lymphoma; EBV; NGS; whole-exome sequencing; RNAseq; methylation analysis; tumor microenvironment; immunotherapy; chemotherapy
In Vitro and In Vivo Pharmacology for Glioma Drug Discovery submission deadline 30 Nov 2026 | 1 articles | Viewed by 1388 | Submission Open
Keywords: pre-clinical modern in vitro /in vivo glioma models; complementary glioma therapy; immunotherapy in glioma; inhibition of glioma recurrence
(This special issue belongs to the Section Cancer Drug Development)
Adjuvant Therapy and the Cytotoxic Effects in Colorectal Cancers
edited by William H. Gmeiner
submission deadline 30 Nov 2026 | 1 articles | Viewed by 1319 | Submission Open
Keywords: colorectal cancer; adjuvant chemotherapy; targeted therapy; immunotherapy; metastatic colorectal cancer; drug resistance; combination therapy; cytotoxic effects
(This special issue belongs to the Section Cancer Therapy)
Thermal Analysis and Proteomic Approaches for Biofluid Proteome Profiling in Cancer Diagnostics
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 1318 | Submission Open
Keywords: thermal analysis; proteomics; thermal liquid biopsy; differential scanning calorimetry; mass spectrometry; serum proteome; clinical diagnostics; cancer diagnostics; biospecimen
(This special issue belongs to the Section Methods and Technologies Development)
Tumor Microenvironment Biomarkers: Bridging Immunology and Metastasis submission deadline 30 Nov 2026 | 1 articles | Viewed by 1286 | Submission Open
Keywords: tumor microenvironment; molecular biomarkers; cancer progression; immunomodution; therapeutic targets
(This special issue belongs to the Section Cancer Biomarkers)
New Clinical Insights into Gastrointestinal Cancers
edited by Dai Shida
submission deadline 30 Nov 2026 | 2 articles | Viewed by 1271 | Submission Open
(This special issue belongs to the Section Clinical Research in Cancer)
Targeted Therapy in Glioblastoma and Glioma
edited by Ben A. Strickland
submission deadline 30 Nov 2026 | 1 articles | Viewed by 976 | Submission Open
Keywords: glioblastoma; neuro-oncology; immunotherapy; tumor microenvironment; macrophage checkpoint; complement system; sphingolipid metabolism; drug resistance; MGMT methylation; combination therapy
(This special issue belongs to the Section Molecular Cancer Biology)
Pharmacology, Microbiology and Immunology in Cancers
edited by Mihail Virgil Boldeanu
submission deadline 30 Nov 2026 | 1 articles | Viewed by 911 | Submission Open
Keywords: cancer pharmacology; tumor immunology; cancer microbiome; immunotherapy; targeted therapy; tumor microenvironment; drug resistance; host–microbiota interactions; translational oncology; personalized cancer therapy
Diet, Microbiome, and Immune Regulation in Early-Onset and Obesity-Associated Gastrointestinal Cancers: Mechanisms, Biomarkers, and Therapeutic Targets
edited by Saratchandra Khumukcham and
submission deadline 30 Nov 2026 | Viewed by 851 | Submission Open
Keywords: colorectal cancer; gastrointestinal cancer; obesity-associated cancer; diet-induced obesity; aging; intestinal epithelium; tumor microenvironment; Wnt signaling; cancer immunology; organoid models
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Precision Diagnostics and Personalized Therapeutics for Prostate Cancer
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 850 | Submission Open
Keywords: diagnostics; personalized therapeutics; prostate cancer
Signaling Pathways and Molecular Crosstalk in the Tumor Microenvironment submission deadline 30 Nov 2026 | 2 articles | Viewed by 846 | Submission Open
Keywords: tumor microenvironment (TME); signal transduction pathways; intercellular communication; cancer progression and metastasis; therapeutic targets and drug resistance
(This special issue belongs to the Section Tumor Microenvironment)
The Prevalence and Incidence of Different Cancers: Risk Factors, Predictions and Modelling Cancer Rates
edited by Aleksandra Izabela Czerw
submission deadline 30 Nov 2026 | 1 articles | Viewed by 797 | Submission Open
Keywords: cancer epidemiology; prevalence modelling; incidence modelling; epidemic modelling; risk factors
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Recent Advances and Emerging Directions in Lung Cancer Radiotherapy
edited by Arturo Navarro-Martín
submission deadline 30 Nov 2026 | 1 articles | Viewed by 649 | Submission Open
Keywords: lung cancer; hypofractionated radiotherapy; lattice; flash therapy; protons
(This special issue belongs to the Section Cancer Therapy)
Imaging in Breast Cancer: Advancing Screening, Diagnosis, and Therapy
edited by Almir Galvão Vieira Bitencourt and Soraia Damião
submission deadline 30 Nov 2026 | 1 articles | Viewed by 614 | Submission Open
Keywords: breast neoplasms/diagnostic imaging; mammography; contrast media; magnetic resonance imaging; ultrasound; PET-CT; early detection of cancer; neoadjuvant therapy; artificial intelligence; precision medicine
Advances in High-Grade Serous Ovarian Cancer: New Perspectives Promising Hope for Eradicating a Devastating Disease
edited by
submission deadline 30 Nov 2026 | Viewed by 534 | Submission Open
Keywords: high-grade serous ovarian cancer; risk factors; prevention; early detection; symptoms; screening; standard of care; platinum resistant ovarian cancer; novel therapeutic approaches; drug repositioning; artificial intelligence; life expectancy, quality of life, and prognosis
Tumor Heterogeneity in Breast Cancer—the “Omics” Revolution submission deadline 30 Nov 2026 | Viewed by 466 | Submission Open
Keywords: breast cancer; tumor heterogeneity; tumor microenvironment; transcriptional regulation; single-cell RNA-seq; spatial transcriptomics; genomics; epigenomics; proteomics; metabolomics
(This special issue belongs to the Section Molecular Cancer Biology)
Role of Cytokines in Cancer (2nd Edition) submission deadline 30 Nov 2026 | Viewed by 449 | Submission Open
Keywords: inflammation; tumor microenvironment; cytokines
(This special issue belongs to the Section Tumor Microenvironment)
After Cancer Remission: Tracking Minimal Residual Disease and Relapse submission deadline 30 Nov 2026 | Viewed by 417 | Submission Open
Keywords: minimal residual disease (MRD); cancer relapse; liquid biopsy; circulating tumor DNA (ctDNA); biomarkers; molecular monitoring; post-remission surveillance; translational oncology; multi-omics; personalized cancer care; precision medicine
New Approaches to Surgical Treatment and Care for Urological Cancer
edited by and Bente Thoft Jensen
submission deadline 30 Nov 2026 | Viewed by 378 | Submission Open
Keywords: bladder cancer; prostate cancer; kidney cancer; penile cancer; patient perspective; patient education; enhanced recovery after surgery (ERAS) protocols; prehabilitation rehabilitation; sexual health
(This special issue belongs to the Section Clinical Research in Cancer)
HMGA Oncoproteins in Cancer submission deadline 30 Nov 2026 | Viewed by 355 | Submission Open
Keywords: HMGA1; HMGA2; chromatin architecture; oncogenic signaling; tumor progression; biomarkers; therapeutic targeting
(This special issue belongs to the Section Molecular Cancer Biology)
Acute Myeloid Leukemia: Novel Therapeutic Agents and Clinical Trials
edited by Wieslaw W. Jedrzejczak
submission deadline 30 Nov 2026 | Viewed by 353 | Submission Open
Keywords: acute leukemia; targeted therapy; antibody–drug conjugates
(This special issue belongs to the Section Clinical Research in Cancer)
Intraoperative Radiotherapy in Cancer Treatment
edited by
submission deadline 30 Nov 2026 | Viewed by 352 | Submission Open
Keywords: intraoperative radiation therapy; image-guided IORT; IOERT; kV-IORT; HDR-IORT; FLASH
(This special issue belongs to the Section Cancer Therapy)
Cellular Senescence in Cancer: Therapeutic Induction, Microenvironmental Crosstalk and Clinical Implications submission deadline 30 Nov 2026 | Viewed by 350 | Submission Open
Keywords: therapy-induced senescence (TIS); TIS resistance; senescence-associated secretory phenotype (SASP); senescence-associated heterochromatin foci (SAHF); immune escape; immune response; immune surveillance; cancer-associated fibroblasts; tumor microenvironment; senolytic therapy; senomorphics; senomodulation; extracellular vesicles; chromatin; imprinting and epigenetic reprogramming; biomarkers
(This special issue belongs to the Section Molecular Cancer Biology)
Epigenetic Alterations in Human Tumors
edited by Michail Panagiotidis and
submission deadline 30 Nov 2026 | Viewed by 346 | Submission Open
Keywords: cancer; DNA methylation; post-translational histone modifications; miRNAs; genome reorganization; multi-omics; experimental/translational therapeutics
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Minimally Invasive Surgery in Gastrointestinal Cancers
edited by and Fabio Rondelli
submission deadline 30 Nov 2026 | Viewed by 336 | Submission Open
Keywords: laparoscopic surgery; robotic surgery; gastrointestinal cancer; colorectal surgery; hepatobiliary surgery; pancreatic surgery; oesophagogastric surgery; peritoneal surface malignancies
(This special issue belongs to the Section Cancer Therapy)
Biomarkers in Liquid Biopsy: Circulating Tumor DNA (ctDNA), Circulating Tumor Cells (CTCs) and Exosomes
edited by George Zarkavelis
submission deadline 30 Nov 2026 | Viewed by 321 | Submission Open
Keywords: liquid biopsy; circulating tumor DNA; circulating tumor cells; early cancer detection; assessment of minimal residual disease (MRD); monitoring treatment response; identifying resistance to therapy
(This special issue belongs to the Section Methods and Technologies Development)
Novel Approaches to Management of Therapy and Prevention of Pancreatic Cancer
edited by and Vasiliki Liaki
submission deadline 30 Nov 2026 | Viewed by 312 | Submission Open
Keywords: pancreatic ductal adenocarcinoma (PDAC); targeted therapy; preclinical models; cancer mutiomics; early detection; prevention; precision medicine; biomarkers; drug resistance
(This special issue belongs to the Section Cancer Therapy)
Metabolic Reprogramming and Neuroendocrine Regulation in Cancer: From Pathophysiology to Therapeutic Targets submission deadline 30 Nov 2026 | Viewed by 310 | Submission Open
Keywords: ageing and cancer; breast cancer metabolism; cancer metabolism; inflammation; insulin resistance; metabolic reprogramming; neuroendocrine signaling; obesity and cancer; precision oncology; tumor microenvironment
(This special issue belongs to the Section Cancer Pathophysiology)
Multiple Myeloma: From Molecular Insights to Clinical Treatment
edited by Mikala Gabor
submission deadline 30 Nov 2026 | Viewed by 308 | Submission Open
Keywords: multiple myeloma; novel therapy; bispecific; CelMod; CAR-T; CAR-NK; ADC; CD38; BCMA; GPRC5D; FcRH5; transplantation
Advances in Adoptive Cell Therapy for Cancer
edited by Andrew Furness
submission deadline 30 Nov 2026 | Viewed by 299 | Submission Open
Keywords: CAR-T cells; adoptive cell therapy; tumor microenvironment; immunotherapy; translational oncology
Mechanism of Action of Novel Anticancer Drugs in Cancer Treatment
edited by
submission deadline 30 Nov 2026 | Viewed by 291 | Submission Open
Keywords: targeted therapy; immunotherapy; tumor-agostic approval; therapy resistence; mechaninsm of action; kinase inhibitor; immune checkpoint inhibitor
(This special issue belongs to the Section Cancer Drug Development)
Radiation Therapy for Sarcomas
edited by Peter Chung and Elizabeth H. Baldini
submission deadline 30 Nov 2026 | Viewed by 287 | Submission Open
Keywords: radiation therapy; dose-fractionation; functional outcomes; combination approaches; histology-specific outcomes; toxicity; site-specific
(This special issue belongs to the Section Cancer Therapy)
Mammographic Density in Prevention and Early Detection of Breast Cancer
edited by
submission deadline 30 Nov 2026 | Viewed by 287 | Submission Open
Keywords: mammographic density; breast cancer; risk; prevention; early detection; mammogram; breast cancer screening
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Clinical Studies in Gastrointestinal Malignancies: 2nd Edition submission deadline 30 Nov 2026 | Viewed by 270 | Submission Open
Keywords: gastrointestinal cancers; clinical studies; multimodal treatment; study design; outcomes
(This special issue belongs to the Section Clinical Research in Cancer)
Applications of Imaging in Lung Cancer
edited by
submission deadline 30 Nov 2026 | Viewed by 270 | Submission Open
Keywords: lung cancer; chest X-ray; computed tomography; magnetic resonance imaging; tumor staging; treatment response; radiomics; artificial intelligence
(This special issue belongs to the Section Methods and Technologies Development)
Advancements in the Science of Endocrine Surgical Oncology
edited by Alessandra L. Moore
submission deadline 30 Nov 2026 | Viewed by 268 | Submission Open
Keywords: endocrine oncology; endocrine surgery; endocrine; cancer; biology; surgery; oncology; science; surgical science
(This special issue belongs to the Section Clinical Research in Cancer)
The Use of Artificial Intelligence in Cancer Research, Diagnosis, and Care
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 265 | Submission Open
Keywords: artificial intelligence; oncology; cancer diagnosis; prognostic modeling; clinical validation; digital twins
External Environmental Factors Inducing Cancer-Related Mutations submission deadline 30 Nov 2026 | Viewed by 257 | Submission Open
Keywords: molecular epidemiology; cancer; environmental exposure; cancer-related mutations; cancer molecular pathways; risk assessment
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Update in Pathology of Gynaecologic Cancer
edited by
submission deadline 30 Nov 2026 | Viewed by 256 | Submission Open
Keywords: gynaecological; cancer; pathology; diagnosis
(This special issue belongs to the Section Cancer Pathophysiology)
Optimizing Cancer Healthcare with Clinical Decision Support submission deadline 30 Nov 2026 | Viewed by 256 | Submission Open
Keywords: cancer clinical decision support; AI in oncology; human-centered AI; trust, safety and explainability; health informatics; decision analytics; patient safety; digital oncology
Hippo/YAP Signaling Pathways in Cancers
edited by
submission deadline 30 Nov 2026 | Viewed by 248 | Submission Open
Keywords: Hippo signaling pathway; YAP/TAZ; tumorigenesis; tumor microenvironment; targeted therapy
(This special issue belongs to the Section Molecular Cancer Biology)
Health Equity and Clinical Outcomes in Hepatocellular Carcinoma
edited by and Catherine Mezzacappa
submission deadline 30 Nov 2026 | Viewed by 233 | Submission Open
Keywords: hepatocellular carcinoma; health equity; material deprivation; social determinants of health; clinical outcomes; access to care; cancer staging; liver cancer disparities
(This special issue belongs to the Section Clinical Research in Cancer)
Redefining Breast Cancer Surgery: Emerging Technologies and De-Escalation Strategies
edited by Marco Pellicciaro
submission deadline 30 Nov 2026 | Viewed by 221 | Submission Open
Keywords: breast cancer surgery; surgical innovation; indocyanine green; fluorescence imaging; tumor localization; sentinel lymph node; axillary surgery; de-escalation; precision surgery
(This special issue belongs to the Section Clinical Research in Cancer)
Research Progress of Targeted Therapy for Acute Myeloid Leukemia
edited by Maher Abdul-Hay
submission deadline 30 Nov 2026 | Viewed by 219 | Submission Open
Keywords: acute myeloid leukemia; targeted therapy; chimeric antigen receptor T-cell therapy; menin inhibitors; FLT3; IDH1; IDH2; NPM1; molecular; therapeutic targets
(This special issue belongs to the Section Cancer Therapy)
New Insights in Urologic Oncology: Immune and Tumor Antigen Targeting Approaches
edited by Justin H. Hwang, Alex Tsai and Ali Arafa
submission deadline 30 Nov 2026 | 1 articles | Viewed by 201 | Submission Open
Keywords: urologic cancer; immune therapies; tumor antigens; tumor microenvironment; targeted therapies; therapeutic resistance; tumor heterogeneity
Surgical Management of Sarcomas
edited by Maniram Ragbir
submission deadline 30 Nov 2026 | Viewed by 200 | Submission Open
Keywords: sarcoma; MDT; surgical management; microsurgery; reconstruction
(This special issue belongs to the Section Cancer Therapy)
Novel Developments Regarding Pathological Complete Response in Breast Cancer Patients
edited by , Dimitris Goutas and
submission deadline 30 Nov 2026 | Viewed by 199 | Submission Open
Keywords: neoadjuvant chemotherapy; adjuvant therapy; pathologic complete response; HER2-positive; triple-negative; tumor microenvironment
(This special issue belongs to the Section Cancer Pathophysiology)
Hepatocellular Carcinoma Ablation: Technology, Biology, and Immunologic Synergy
edited by
submission deadline 30 Nov 2026 | Viewed by 199 | Submission Open
Keywords: hepatocellular carcinoma; ablation therapy; radiofrequency ablation; microwave ablation; irreversible electroporation; tumor microenvironment; immunogenic cell death; immunotherapy; combination therapy; biomarkers; locoregional therapy; liver cancer
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