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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Oral Cancer: The Latest Advances in Clinical and Basic Research (Second Edition)

edited by

Kenji Yamagata

and Fumihiko Uchida

submission deadline 31 Jan 2026 | 4 articles | Viewed by 3973 | Submission Open

Keywords: oral cancer; clinical research; basic research; surgery; radiotherapy; chemotherapy; molecular biology; immune checkpoint inhibitor

(This special issue belongs to the Section Clinical Research of Cancer)

Prediction of Melanoma

edited by

Irene Stefanaki

submission deadline 31 Jan 2026 | 3 articles | Viewed by 3830 | Submission Open

Keywords: melanoma; melanoma genetics; biomarkers; predictive tools; risk prediction; risk factors; artificial intelligence

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Clinical Studies and Outcomes in Urologic Cancer

edited by Nikolaos Pyrgidis

submission deadline 31 Jan 2026 | 3 articles | Viewed by 3549 | Submission Open

Keywords: urologic cancer; clinical outcomes; prostate cancer; urothelial cancer; kidney cancer; survival analysis; treatment response; quality of life; novel therapies; oncology

(This special issue belongs to the Section Clinical Research of Cancer)

Recent Advances in Nanomedicine-Based Cancer Immunotherapy

edited by Navin Kumar Verma,

Rajeev Parameswaran

and

Manash Paul

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2840 | Submission Open

Keywords: cancer nano-therapy; nano-enabled therapeutic; immune checkpoint inhibitors; tumor immunosuppression; adoptive cell therapy; CAR T-cell therapy; tumor-infiltrating lymphocyte therapy; monoclonal antibody therapy for cancer; cancer vaccines; immune system modulators

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Minimally Invasive Approaches in Urological Oncology: Current Trends and Innovations

edited by

Alchiede Simonato

and

Nicola Pavan

submission deadline 31 Jan 2026 | 3 articles | Viewed by 2634 | Submission Open

Keywords: minimally invasive; robotic; laparoscopic; uro-oncology; prostate cancer; bladder cancer; kidney cancer; testicular cancers; quality of life; penile cancer

(This special issue belongs to the Section Clinical Research of Cancer)

Computational Research in Cancer Neuroscience

edited by Shaolei Teng

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2630 | Submission Open

Keywords: machine learning; large language models; protein structure modeling; omics data analysis; neural– cancer communication; tumor microenvironments; personalized medicine; targeted therapies; cancer neuroscience

(This special issue belongs to the Section Methods and Technologies Development)

Advances and Future Developments in Liver Transplantation for Cancers: 2nd Edition

edited by

Nicolas Golse

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2006 | Submission Open

Keywords: machine perfusion; marginal graft; split liver; immunotherapy; auxiliary liver transplantation; digital twin; modeling; organoid

(This special issue belongs to the Section Transplant Oncology)

Novel Perspectives in Hepato-Biliary and Pancreatic Cancer

edited by Tudor Mocan and Emil-Ioan Moiș

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1949 | Submission Open

Keywords: HCC; cholangiocarcinoma; surgery; biliary drainage; pancreatic cancer; combination therapies

(This special issue belongs to the Section Cancer Therapy)

Post-Neoadjuvant Strategies in Breast Cancer (2nd Edition)

edited by

Edwin Bölke

, Tanja Fehm and

Stefanie Corradini

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1949 | Submission Open

Keywords: chemotherapy; prospective trials; clinical investigation; breast tumor; local recurrence; overall survival

(This special issue belongs to the Section Cancer Therapy)

Cancers Hijack Immune Surveillance and Tumor Microenvironment Leading to Immune Evasion

edited by

Yona Keisari

, Viktor Umansky and

Rostyslav Bilyy

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1782 | Submission Open

Keywords: anti-tumor immunity; cancer immunotherapy; immune evasion; immune response modulation; immunosuppression; immune surveillance; manipulating IR components function and migration; metabolic modulation of the TME; metabolic reprogramming; tumor-associated immune cells; tumor microenvironment (TME)

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Head and Neck Cancer: Survivorship Challenges and Therapeutic Approaches

edited by

Lucía Ortiz-Comino

, Avraham Eisbruch and

Ángela González-Santos

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1718 | Submission Open

Keywords: head and neck cancer; supportive care; survivorship care; physiotherapy; quality of life; lifestyle interventions

(This special issue belongs to the Section Cancer Therapy)

Radiosensitivity and Radiotoxicity in Cancer

edited by

Alexandros Georgakilas

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1429 | Submission Open

Keywords: radiation therapy; clinical outcome; radiosensitivity; radiotoxicity; biomarkers; bioinformatics; systems biology

(This special issue belongs to the Section Methods and Technologies Development)

Advanced Glycation End-Products and Its Receptors in Cancer Progression

edited by Bhaumik B. Patel

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1339 | Submission Open

Keywords: advanced glycation end products; toxic advanced glycation end products; receptor for advanced glycation end products (RAGEs); glycosaminoglycans; cancer; cancer stem cells (CSCs); tumor immune microenvironment (TME)

(This special issue belongs to the Section Tumor Microenvironment)

Advanced Strategies in the Care of Hepatocellular Carcinoma Patients (2nd Edition)

edited by

Matteo Donadon

and

Guido Torzilli

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1326 | Submission Open

Keywords: hepatocellular carcinoma; hepatic resection; hepatectomy; liver resection; liver surgery; parenchymal-sparing liver surgery; intraoperative ultrasound; liver-specific magnetic resonance imaging; trans-arterial therapy; liver function; FibroScan

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Clinical Trials and Outcomes for Non-Small Cell Lung Cancer

edited by Ana Rodrigues and

António Araújo

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1321 | Submission Open

Keywords: non-small cell lung cancer; oncogenic alterations; clinical trial; systemic therapy; targeted therapy; immunotherapy; radiotherapy; real-world data; surgery; drug development

(This special issue belongs to the Section Clinical Research of Cancer)

Nutrition in Survivors with Advanced Cancer: The Role of Appetite, Muscle Wasting, Obesity, and Altered Body Composition

edited by Egidio Del Fabbro

submission deadline 31 Jan 2026 | 1 articles | Viewed by 831 | Submission Open

Keywords: advanced cancer; nutrition; wasting; body composition; multimodal

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Updates on Imaging of Common Urogenital Neoplasms 2nd Edition

edited by Athina C Tsili

submission deadline 31 Jan 2026 | 1 articles | Viewed by 654 | Submission Open

Keywords: urogenital neoplasms; renal cell carcinoma; prostatic neoplasms; urinary bladder neoplasms; testicular neoplasms; uterine neoplasms; ovarian neoplasms; ultrasonography; computed tomography; magnetic resonance imaging

(This special issue belongs to the Section Methods and Technologies Development)

Novel Approaches in the Management of Gynecological Cancers

edited by

Mikel Gorostidi

Martina Aida Angeles

and

Ignacio Zapardiel

submission deadline 31 Jan 2026 | 1 articles | Viewed by 632 | Submission Open

Keywords: gynecological cancer; ovarian cancer; endometrial cancer; cervical cancer; vulvar cancer; surgical management; clinical management

(This special issue belongs to the Section Cancer Therapy)

Emerging Technologies in Thoracic Surgery

edited by Filippo Lococo and

Carolina Sassorossi

submission deadline 31 Jan 2026 | 1 articles | Viewed by 540 | Submission Open

Keywords: lung cancer; molecular biology; liquid biopsy; immunotherapy; precision surgery; minimally invasive surgery; new technologies; artificial intelligence

(This special issue belongs to the Section Methods and Technologies Development)

New Insights in Nanomedicine and Targeted Drugs for Breast Cancer

edited by

Maria Gazouli

, Gennaro Sanità, Alessandro Venuta and Rosarita Nasso

submission deadline 31 Jan 2026 | Viewed by 433 | Submission Open

Keywords: breast cancer; nanoparticles; active targeting; BC; nanomedicine

(This special issue belongs to the Section Cancer Drug Development)

The Cancer Stem Cells and the Quiescence

edited by

Bhopal Mohapatra

submission deadline 31 Jan 2026 | Viewed by 384 | Submission Open

Keywords: cancer stem cells; new markers; organoid cultures; cancer cell dormancy and quiescence; metastasis; animal models; metabolism; drug resistance

(This special issue belongs to the Section Molecular Cancer Biology)

Lymph Node Involvement in Cervical Cancer: From Single Isolated Tumor Cell to Macrometastasis

edited by

Vincent Balaya

Marcin Sniadecki

and Thomas Gaillard

submission deadline 31 Jan 2026 | Viewed by 339 | Submission Open

Keywords: cervical cancer; lymph nodes; metastasis; isolated Tumor Cells; sentinel lymph node; non-sentinel lymph node; tumor-draining lymph nodes; microenvironment; one-step nucleic acid amplification; imaging

(This special issue belongs to the Section Tumor Microenvironment)

Recent Advances in Pancreatic Surgery for Pancreatic Ductal Adenocarcinoma (2nd Edition)

edited by Shuji Isaji

submission deadline 31 Jan 2026 | Viewed by 235 | Submission Open

Keywords: neoadjuvant therapy; adjuvant therapy; resectability; conversion surgery; surgical technique; laparoscopic surgery; robotic surgery

(This special issue belongs to the Section Cancer Therapy)

Surgery for Lung Cancer: Robot-Assisted Versus Video-Assisted Thoracoscopic Surgery and Open Thoracotomy

edited by

Mariusz Chabowski

submission deadline 31 Jan 2026 | Viewed by 209 | Submission Open

Keywords: laparoscopic thoracic surgery; open thoracotomy; robotic thoracic surgery (RTS); lung cancer; surgical treatment; minimally invasive intervention

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in the Molecular Biology of Urologic Cancers: Integrative Insights from Pathogenesis to Clinical Applications

edited by

Whi-An Kwon

submission deadline 31 Jan 2026 | Viewed by 187 | Submission Open

Keywords: urologic cancers; molecular biology; pathogenesis; precision medicine; biomarkers; multi-omics; targeted therapies; immunotherapy; translational research; clinical applications

(This special issue belongs to the Section Molecular Cancer Biology)

Prostate-Specific Membrane Antigen (PSMA)-Targeted Radionuclide Therapy in Cancer

edited by

Ning Zhou

and

Sashi Debnath

submission deadline 31 Jan 2026 | Viewed by 174 | Submission Open

Keywords: PSMA-TRNT; radioligand therapy; radionuclide therapy; theranostics; prostate-specific membrane antigen (PSMA); PSMA targeted; PSMA ligands; prostate cancer (PCa); metastatic castration-resistant prostate cancer (mCRPC)

(This special issue belongs to the Section Methods and Technologies Development)

Diagnosis and Biomarkers for Hematologic Malignancies

edited by

Luis Colomo

and

Francesco Lanza

submission deadline 31 Jan 2026 | Viewed by 162 | Submission Open

Keywords: hematologic malignancies; diagnosis; biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

The Biology of Hepatocellular Carcinoma: Implications for Genomic and Immune Therapies (2nd Edition)

edited by

Naoshi Nishida

submission deadline 31 Jan 2026 | Viewed by 159 | Submission Open

Keywords: hepatocellular carcinoma; diagnosis; treatment; molecular targeted agent; immune checkpoint inhibitor; artificial intelligence

(This special issue belongs to the Section Molecular Cancer Biology)

Breast Cancer and Stem Cells

edited by Leandro Marcelo Martinez

submission deadline 31 Jan 2026 | Viewed by 142 | Submission Open

Keywords: breast cancer; cancer stem cells; tumor microenvironment; metastasis; therapeutic strategies; in vitro models

(This special issue belongs to the Section Molecular Cancer Biology)

Curative Therapies for Non-Small and Small Cell Lung Cancers

edited by John Michael Varlotto

submission deadline 31 Jan 2026 | Viewed by 137 | Submission Open

Keywords: radiotherapy; surgery; early stage NSCLC; oligometastases; immunotherapy; small-cell lung cancer

(This special issue belongs to the Section Cancer Therapy)

Transformative Drug Innovations Reshaping Myeloma Treatment

edited by Despina Fotiou

submission deadline 31 Jan 2026 | Viewed by 125 | Submission Open

Keywords: multiple myeloma; cellular therapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Laryngeal Cancer: Diagnostic Workup, Treatment, and Complications

edited by Francesco Mattioli,

Alfredo Lo Manto

and Edoardo Serafini

submission deadline 31 Jan 2026 | Viewed by 123 | Submission Open

Keywords: laryngeal cancers; diagnosis; laryngeal surgery; transoral laser microsurgery; transoral robotic surgery

(This special issue belongs to the Section Clinical Research of Cancer)

Conversion Surgery for Initially Unresectable, Locally Advanced, Metastatic or Recurrent Gastrointestinal Cancers

edited by

Takashi Murakami

submission deadline 31 Jan 2026 | Viewed by 115 | Submission Open

Keywords: conversion surgery; locally advanced disease; metastatic disease; chemotherapy; radiotherapy; immunotherapy; heptobiliary-pancreatic cancers; gastrointestinal tract cancers

(This special issue belongs to the Section Clinical Research of Cancer)

Immune Profiling in Gastrointestinal Cancers: Implications for Precision Immunotherapy

edited by

Paulina Mertowska

submission deadline 31 Jan 2026 | Viewed by 113 | Submission Open

Keywords: gastrointestinal cancer; immune profiling; immunocompetent cells; personalized immunotherapy; biomarkers; precision medicine; tumor microenvironment; tumor-infiltrating lymphocytes; immune checkpoint inhibitors; microbiota– immunity interactions; single-cell analysis; spatial transcriptomics

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Neoadjuvant Therapy for Urologic Cancer

edited by Marlon Perera and David Chen

submission deadline 31 Jan 2026 | Viewed by 111 | Submission Open

Keywords: urologic oncology; neoadjuvant therapy; treatment; improved survival

(This special issue belongs to the Section Cancer Therapy)

Personalized Cancer Therapy: Strategies for Overcoming On-Target and Bypass Resistance

edited by

Valentina Foglizzo

submission deadline 31 Jan 2026 | Viewed by 75 | Submission Open

Keywords: resistance mechanisms; biomarker; oncogene dependency; target therapy; personalized therapy

(This special issue belongs to the Section Molecular Cancer Biology)

Therapy for HER2 Breast Cancer

edited by

Junji Tsurutani

and Sandra M. Swain

submission deadline 1 Feb 2026 | Viewed by 128 | Submission Open

Keywords: antibody– drug conjugate; trastuzumab; pertuzumab; tyrosine kinase inhibitor; trastuzumab deruxtecan

(This special issue belongs to the Section Cancer Therapy)

Cancer Immunotherapy in Clinical and Translational Research

edited by Sofia Genta

submission deadline 10 Feb 2026 | 7 articles | Viewed by 27029 | Submission Open

Keywords: cancer immunotherapy; clinical research; immune checkpoint inhibitor; cancer vaccines; biomarker; translational research

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

New Insights into Prostate Cancer Radiotherapy

edited by

Grace Lu-Yao

submission deadline 10 Feb 2026 | 6 articles | Viewed by 13924 | Submission Open

Keywords: prostate cancer; radiotherapy; radiation therapy

(This special issue belongs to the Section Cancer Therapy)

New Insights into Cancer Radiotherapy

edited by

Michael L. F. Lerch

submission deadline 10 Feb 2026 | 2 articles | Viewed by 2251 | Submission Open

Keywords: radiotherapy; X-rays; gamma rays; external beam radiation therapy; brachytherapy; palliative care; intensity-modulated radiotherapy (IMRT); stereotactic body radiotherapy (SBRT); proton therapy

(This special issue belongs to the Section Cancer Therapy)

Recent Developments in the Field of Radiotherapy Treatment for Lung Cancer

edited by Ioannis C. Maroulis

submission deadline 10 Feb 2026 | 1 articles | Viewed by 1568 | Submission Open

Keywords: lung cancer; radiotherapy; non-small-cell lung cancer (NSCLC)

(This special issue belongs to the Section Cancer Therapy)

Transforming Liver Cancer Care: From Molecular Understanding to Novel Therapeutic Strategies

edited by

Chencheng Xie

submission deadline 10 Feb 2026 | 1 articles | Viewed by 464 | Submission Open

Keywords: liver cancer; molecular research; biomarkers; targeted therapy; translational research

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Surgical Treatment of Gynecological Cancers

edited by

Denis Querleu

, Joanna P. Kacperczyk-Bartnik and

Aleksandra Strojna

submission deadline 14 Feb 2026 | 2 articles | Viewed by 2558 | Submission Open

Keywords: gynecological oncology; image-guided surgery; lymphadenectomy; minimally invasive surgery; ovarian cancer surgery; patient outcomes; perioperative care; precision surgery; radical hysterectomy; robotic-assisted surgery; surgical oncology

(This special issue belongs to the Section Cancer Therapy)

Metronomic Chemotherapy in Female Cancers

edited by

Luca Roncati

submission deadline 14 Feb 2026 | 1 articles | Viewed by 1719 | Submission Open

Keywords: metronomic chemotherapy; female cancers; anti-tumor mechanisms; clinical trials and outcomes; combination therapies

(This special issue belongs to the Section Cancer Therapy)

New and Emerging Strategies for Targeting Genomic Instability and Overcoming Drug Resistance in Lung Cancer

edited by Kelsie L. Thu

submission deadline 15 Feb 2026 | 5 articles | Viewed by 16309 | Submission Open

Keywords: lung cancer; genomic instability; drug resistance; treatment strategy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

New Strategies in Diagnosis and Treatments for Brain Tumors: 2nd Edition

edited by Sven Rainer Kantelhardt

submission deadline 15 Feb 2026 | 4 articles | Viewed by 15694 | Submission Open

Keywords: glioma; brain tumor; molecular guided therapy; personal medicine; radiomics; digital analysis; artificial intelligence; intraoperative imaging; surgical resection

(This special issue belongs to the Section Cancer Therapy)

Advances in Esophageal Cancer

edited by Sacheen Kumar

submission deadline 15 Feb 2026 | 4 articles | Viewed by 6818 | Submission Open

Keywords: esophageal adenocarcinoma; esophageal squamous cell carcinoma; long-term survival; biomarkers; disease surveillance; treatment response

(This special issue belongs to the Section Cancer Therapy)

Neoadjuvant Therapy in Hepatopancreatobiliary Malignancies: Current Trends and Future Directions

edited by

Daniela Cornelia Lazăr

submission deadline 15 Feb 2026 | 1 articles | Viewed by 2375 | Submission Open

Keywords: neoadjuvant therapy; hepatopancreatobiliary malignancies; hepatocellular carcinoma; pancreatic cancer; cholangiocarcinoma; chemotherapy; radiotherapy; immunotherapy; targeted therapies; personalized treatment

(This special issue belongs to the Section Cancer Therapy)

Oligometastases Hypothesis to Advancing New Perspectives on Cancer: Oligo-Reurrence

edited by

Yuzuru Niibe

Dai Sonoda

and