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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Evolving Landscape of Squamous Cell Carcinoma of the Anal Canal: State of the Art, Current Challenges and Future Perspectives

edited by

Alessandra Boccaccino

and Francesco Vasuri

submission deadline 15 Dec 2026 | 1 articles | Viewed by 958 | Submission Open

Keywords: squamous cell anal carcinoma; anal cancer; HIV; HPV

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Multilevel Molecular Regulation in Cancer: From Epigenetics to Signaling Pathways and Therapeutic Targets

edited by

Sudhir Rai

and

Seema Kumari

submission deadline 15 Dec 2026 | Viewed by 86 | Submission Open

Keywords: cancer metastasis; epigenetics; oncogenic signals; therapy; TME

(This special issue belongs to the Section Molecular Cancer Biology)

Histopathology and Pathogenesis of Skin Cancer

edited by

Carlos Torres-Cabala

and

Alessio Giubellino

submission deadline 20 Dec 2026 | 6 articles | Viewed by 12897 | Submission Open

Keywords: skin; tumor; cancer; histopathology; pathogenesis; molecular; immunohistochemistry; pathway; pathology

(This special issue belongs to the Section Cancer Pathophysiology)

The State of the Art in Cardio-Oncology

edited by

Fabio Maria Turazza

submission deadline 20 Dec 2026 | 5 articles | Viewed by 3401 | Submission Open

Keywords: cardio-oncology; cardiotoxicity; cancer therapeutics; reverse cardio-oncology; precision cardio-oncology; genetics in cardio-oncology

Integrating Neoadjuvant Immunotherapy and Surgery for NSCLC: From Biomarkers to Optimized Resection Tactics

edited by Piergiorgio Solli and

Giovanni Leuzzi

submission deadline 20 Dec 2026 | 3 articles | Viewed by 2520 | Submission Open

Keywords: neoadjuvant immunotherapy; NSCLC; precision surgery; pathological response (pCR/MPR); ctDNA; sublobar resection; fibrosis; multidisciplinary team

(This special issue belongs to the Section Cancer Therapy)

Advances in T-Cell Redirecting Therapy in Plasma Cell Neoplasms

edited by Henry Chi Hang Fung and Asya Varshavsky

submission deadline 20 Dec 2026 | 1 articles | Viewed by 2269 | Submission Open

Keywords: multiple myeloma; CAR-T; T-cell engager; novel targets; sequencing

(This special issue belongs to the Section Cancer Therapy)

Hematological Malignancies: From Translational Discoveries to Clinical Trends

edited by

Arati Sharma

and Charyguly Annageldiyev

submission deadline 20 Dec 2026 | 1 articles | Viewed by 2204 | Submission Open

Keywords: hematological malignancies; leukemia; lymphoma; myeloma; translational research; preclinical studies; clinical outcomes; molecular biomarkers; targeted therapy; precision medicine

(This special issue belongs to the Section Cancer Therapy)

Cancer Genetics and Epigenetics: Their Roles and Clinical Implications (2nd Edition)

edited by

Armita Bahrami

and

Ying Qing

submission deadline 20 Dec 2026 | 2 articles | Viewed by 1935 | Submission Open

Keywords: cancer genetics; cancer epigenetics; carcinogenesis; cancer prognosis; cancer therapeutics; genetic mutations; DNA methylation; histone modifications; RNA methylation

(This special issue belongs to the Section Molecular Cancer Biology)

Retroviruses and Cancer Development: Molecular Mechanisms and Therapeutic Prospects

edited by Donna D'Agostino and

Vincenzo Ciminale

submission deadline 20 Dec 2026 | 2 articles | Viewed by 1534 | Submission Open

Keywords: retroviruses; cancer; ERV; antivirals; persistent infection

(This special issue belongs to the Section Infectious Agents and Cancer)

Current Progress in the Clinical Management and Basic Science of Head and Neck Cancer: 2nd Edition

edited by

Takumi Kumai

submission deadline 20 Dec 2026 | 1 articles | Viewed by 1181 | Submission Open

Keywords: head and neck cancer; immunotherapy; chemoradiotherapy; surgery; molecular biology; oncogenesis; cancer immunology

Genetic Predisposition to Hematological Malignancies

edited by

Danika Di Giacomo

submission deadline 20 Dec 2026 | 1 articles | Viewed by 927 | Submission Open

Keywords: leukemia predisposition; germline variants; inherited syndromes; myelodysplastic syndrome (MDS); acute myeloid leukemia (AML); precision medicine

(This special issue belongs to the Section Molecular Cancer Biology)

Stereotactic Radiosurgery for Malignant Brain Tumors

edited by Stylianos Pikis, Jason P. Sheehan,

Yuki Shinya

and Georgios Mantziaris

submission deadline 20 Dec 2026 | Viewed by 886 | Submission Open

Keywords: radiosurgery; brain metastases; low-grade gliomas; high-grade gliomas; glioblastoma; malignant meningiomas

(This special issue belongs to the Section Clinical Research in Cancer)

Recent Advances in the Fertility-Sparing Treatment of Gynecological Cancers

edited by

Giorgia Mangili

and

Raffaella Cioffi

submission deadline 20 Dec 2026 | Viewed by 407 | Submission Open

Keywords: fertility-sparing treatment; gynecologic oncology; fertility preservation; oncofertility; conservative surgery; recurrence risk; pregnancy outcomes; biomarkers in fertility preservation; assisted reproductive technology; long-term follow-up

(This special issue belongs to the Section Cancer Therapy)

Multi-Omics Data Integration and Bioinformatics Tools in Oncology

edited by

Tongjun Gu

and

Wei Zhang

submission deadline 20 Dec 2026 | Viewed by 313 | Submission Open

Keywords: cancer multi-omics integration; biomarker discovery; precision oncology; machine learning in cancer research; cancer bioinformatics; systems biology; functional genomics; translational oncology

(This special issue belongs to the Section Cancer Informatics and Big Data)

Innovations and Challenges in Clinical Trials and Translational Research in Hematologic Malignancies and Solid Tumors

edited by

Abdurraouf Mokhtar Mahmoud

and Clara Deambrogi

submission deadline 20 Dec 2026 | Viewed by 255 | Submission Open

Keywords: clinical trials; hematologic malignancies; solid tumors; translational research; precision medicine; biomarker-driven therapy; real-world evidence; investigator-initiated studies

Computational Analysis of Cancer Clonal Evolution: Signatures, Determinants and Dynamics

edited by

Qiyuan Li

submission deadline 23 Dec 2026 | Viewed by 455 | Submission Open

Keywords: clonal evolution in cancers; computational analysis; genetic determinants; epigenetic reprogramming; DNA methylation signatures; mutational signatures; tumor–immune microenvironment; cancer driver genes; somatic mutations; germline variants; multi-omics integration

(This special issue belongs to the Section Cancer Informatics and Big Data)

Recent Advances in Gynecologic Oncology: Encompassing Oncopathology, Surgical Innovations, and Modern Therapeutic Approaches

edited by Małgorzata Walentowicz-Sadlecka

submission deadline 24 Dec 2026 | Viewed by 280 | Submission Open

Keywords: oncology; oncopathology; surgical innovations; modern therapies; molecular diagnostics; ovarian cancer; endometrial cancer; cervical cancer; precision medicine; tumor microenvironment

(This special issue belongs to the Section Cancer Therapy)

Cancer-Associated Fibroblasts and Translational Biomarkers in Tumor Progression, Metastasis and Therapy Response

edited by

Bonan Chen

submission deadline 25 Dec 2026 | 2 articles | Viewed by 1958 | Submission Open

Keywords: cancer-associated fibroblasts; CAF; tumor microenvironment

(This special issue belongs to the Section Tumor Microenvironment)

Cancer Cell Death and Immune Response

edited by Seema Singh and

Amod Sharma

submission deadline 25 Dec 2026 | 1 articles | Viewed by 1873 | Submission Open

Keywords: immunogenic cell death; tumor immunity; epigenetics; apoptosis; tumor microenvironment; biomarkers

(This special issue belongs to the Section Molecular Cancer Biology)

Toxicities of Antineoplastic Therapies

edited by Ysabella Van Sebille,

Hannah Wardill

and

Connor Williams

submission deadline 25 Dec 2026 | Viewed by 434 | Submission Open

Keywords: antineoplastic therpay; cancer treatment-related toxicities; cancer treatment adverse events; chemotherapy toxicity; targeted therapy toxicities; immunotherapy toxicity; hormonal therapy toxicity; radiation-induced toxicity; cellular and gene therapy toxicity; supportive cancer care; survivorship; patient-reported outcomes; toxicity management

(This special issue belongs to the Section Cancer Therapy)

Tumor–Microbiota Crosstalk: Immune Modulation and Resistance to Cancer Therapies

edited by

Massimiliano Berretta

submission deadline 25 Dec 2026 | Viewed by 415 | Submission Open

Keywords: tumor–microbiota; immune modulation; cancer therapies

(This special issue belongs to the Section Infectious Agents and Cancer)

Surgery for Thoracic Cancer

edited by Andrea Billé and Akshay Patel

submission deadline 25 Dec 2026 | Viewed by 360 | Submission Open

Keywords: thoracic surgery; lung cancer; mesothelioma; thymic malignancies; minimally invasive surgery; robotic-assisted thoracic surgery; multimodal therapy; immunotherapy; perioperative management; surgical outcomes

(This special issue belongs to the Section Cancer Therapy)

Epitranscriptomics and the Tumor Microenvironment

edited by

Reza Izadpanah

submission deadline 25 Dec 2026 | Viewed by 279 | Submission Open

Keywords: epitranscriptomics; tumor microenvironment; immune

(This special issue belongs to the Section Tumor Microenvironment)

Minimally Invasive Methods for MRD Monitoring and Diagnosis in Multiple Myeloma

edited by

Joaquín Martínez-López

submission deadline 25 Dec 2026 | Viewed by 216 | Submission Open

Keywords: liquid biopsy; circulating tumor DNA; ctDNA; cfDNA; multiple myeloma; minimal residual disease; disease monitoring; precision medicine

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

AI-Driven Oncology: Advancing Cancer Detection, Diagnosis, and Personalized Treatment

edited by

Mohamed Shehata

and

Fatma M. Talaat

submission deadline 30 Dec 2026 | 10 articles | Viewed by 14047 | Submission Open

Keywords: cancer detection and diagnosis; AI in oncology; explainable AI (XAI); precision oncology; medical imaging; prognostic biomarkers; clinical decision support systems

(This special issue belongs to the Section Methods and Technologies Development)

Multidisciplinary Approaches in Oral Cancer: Pathology, Imaging, and Patient-Centered Outcomes

edited by

André Luiz Sena Guimarães

submission deadline 30 Dec 2026 | 2 articles | Viewed by 1039 | Submission Open

Keywords: oral cancer; oral squamous cell carcinoma; pathology; imaging; supportive care; quality of life; patient-reported outcomes; radiotherapy-related complications; survivorship

Castration- and Therapy-Resistant Prostate Cancer: Biomarkers, Therapeutic Targets, and Emerging Approaches

edited by

Pia Giovannelli

submission deadline 30 Dec 2026 | 1 articles | Viewed by 748 | Submission Open

Keywords: castration-resistant prostate cancer; therapy-resistant prostate cancer; androgen receptor signaling; EGFR-related signaling; biomarkers; drug resistance; signal transduction pathways; translational research; targeted therapy

(This special issue belongs to the Section Molecular Cancer Biology)

Multimodality Imaging for More Precise Radiotherapy (2nd Edition)

edited by Stefano Arcangeli,

Denis Panizza

and

Valeria Faccenda

submission deadline 30 Dec 2026 | 2 articles | Viewed by 628 | Submission Open

Keywords: multimodality imaging; radiotherapy; stereotactic radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Personalizing Genitourinary Cancer Care

edited by

Soum D. Lokeshwar

submission deadline 30 Dec 2026 | 1 articles | Viewed by 625 | Submission Open

Keywords: prostate cancer; bladder cancer; kidney cancer; testicular cancer; cancer diagnostics; translational research; perioperative optimization

(This special issue belongs to the Section Clinical Research in Cancer)

Surgical Oncology: Innovations in Precision, Multimodal, and Technology-Driven Cancer Care

edited by Fabio Pacelli and Giorgio D’Annibale

submission deadline 30 Dec 2026 | 1 articles | Viewed by 624 | Submission Open

Keywords: surgical oncology; complex cancer surgery; precision surgery; peritoneal surface malignancies; retroperitoneal tumors; cytoreductive surgery; HIPEC; minimally invasive surgery; robotic surgery; multimodal treatment

Innovation and Optimization of Radiation or Drug Therapy for Gynecological Cancers

edited by

Hong Zhu

and

Yangying Zhou

submission deadline 30 Dec 2026 | 1 articles | Viewed by 587 | Submission Open

Keywords: cervical cancer; endometrial cancer; ovarian cancer; radiation therapy; immunotherapy; targeted therapy; comprehensive treatment; cost-effectiveness

(This special issue belongs to the Section Cancer Therapy)

Immunotherapy with Checkpoint Inhibitors for Non-Small-Cell Lung Cancer (2nd Edition)

edited by

Alessandro Inno

and

Diego Signorelli

submission deadline 30 Dec 2026 | Viewed by 381 | Submission Open

Keywords: immune-checkpoint inhibitors; non-small cell lung cancer; neoadjuvant therapy; adjuvant therapy; primary resistance; acquired; resistance; biomarkers; immune-related adverse events

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

KRAS-Driven Lung Cancer: Heterogeneity, Microenvironment, and Therapeutic Innovation

edited by

Haitang Yang

submission deadline 30 Dec 2026 | Viewed by 266 | Submission Open

Keywords: KRAS mutation; targeted therapy; immunotherapy; tumor microenvironment; heterogeneity

Advances in Surgical Strategies for Gynecologic Malignancies

edited by Krzysztof Nowosielski, Paweł Grzegorz Knapp and Joanna P. Kacperczyk-Bartnik

submission deadline 30 Dec 2026 | Viewed by 235 | Submission Open

Keywords: gynecological cancer; cytoreductive surgeries; peritoneal surface malignancy; surgical techniques; prehabilitation; sexuality; perioperative cancer management; minimal invasive surgery; robotic surgery

Gastrointestinal Cancer Surgery

edited by Florian Primavesi and

Daniel Neureiter

submission deadline 31 Dec 2026 | 6 articles | Viewed by 17903 | Submission Open

Keywords: gastrointestinal cancer surgery; precision surgery; personalized medicine; robotics; pathology; colorectal cancer; stomach cancer; pancreatic cancer; hepatocellular cancer; biliary tract cancer

(This special issue belongs to the Section Cancer Therapy)

Feature Papers in the Section “Cancer Therapy” in 2025-2026

edited by

Abdullah Esmail

, Qiang Wang and

Hiroyuki Takei

submission deadline 31 Dec 2026 | 10 articles | Viewed by 14779 | Submission Open

Keywords: chemotherapy; immunotherapy for cancer; oncology; systemic treatment and targeted therapy.

(This special issue belongs to the Section Cancer Therapy)

Neuroendocrine Neoplasms: Pathogenesis, Diagnostics, and Therapy

edited by

Beata Jabłońska

submission deadline 31 Dec 2026 | 4 articles | Viewed by 14097 | Submission Open

Keywords: neuroendocrine neoplasms; pathogenesis; diagnostics; therapy

(This special issue belongs to the Section Cancer Therapy)

Feature Paper in Section ‘Cancer Epidemiology and Prevention’ in 2025-2026

edited by Roger Anderson and

Paweł Koczkodaj

submission deadline 31 Dec 2026 | 6 articles | Viewed by 13975 | Submission Open

Keywords: cancer prevention; cancer epidemiology; health policy; public health; global health; health education; health promotion

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Recent Advances in Hematological Malignancies in Children

edited by

Radosław Chaber

submission deadline 31 Dec 2026 | 4 articles | Viewed by 13724 | Submission Open

Keywords: acute lymphoblastic leukemia; acute myeloid leukemia; hematological malignancies in children; diagnostic and therapeutic methods; supportive care strategies

(This special issue belongs to the Section Pediatric Oncology)

Viral Oncogenes and Their Role in Cancer Pathogenesis

edited by

Ronen Borenstein

and Yosef Sabo

submission deadline 31 Dec 2026 | 4 articles | Viewed by 12031 | Submission Open

Keywords: viral oncogenes; cancer pathogenesis; cellular regulation; tumorigenesis mechanisms; antiviral and anticancer strategies

(This special issue belongs to the Section Infectious Agents and Cancer)

Rehabilitation Opportunities in Cancer Survivorship

edited by

Marie Carmen Valenza

and Alejandro Heredia-Ciuro

submission deadline 31 Dec 2026 | 3 articles | Viewed by 10322 | Submission Open

Keywords: cancer; rehabilitation; sequelae; disability; impairment

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Immune Biomarkers in Solid Tumors: From Peripheral Blood Parameters to Tissue-Based Indicators for Prognosis and Therapy Response

edited by

Ioannis P. Trontzas

and

Konstantinos Syrigos

submission deadline 31 Dec 2026 | 4 articles | Viewed by 9366 | Submission Open

Keywords: immune biomarkers; solid tumors; peripheral blood immune parameters; circulating immune cells; cytokines; tissue-based biomarkers; immune checkpoint molecules; prognostic biomarkers; predictive biomarkers; tumor microenvironment; immunotherapy response; translational oncology

(This special issue belongs to the Section Cancer Biomarkers)

Challenges and New Developments in the Diagnosis and Treatment of Sarcoma

edited by

Xiaolan Feng

submission deadline 31 Dec 2026 | 4 articles | Viewed by 9345 | Submission Open

Keywords: bone and soft tissue sarcoma; prognostic and predictive biomarker; transcriptomic/genomic profiling; immunotherapy; targeted treatment

(This special issue belongs to the Section Cancer Therapy)

Advances in Radiology for the Detection, Diagnosis, and Management of Breast Cancer

edited by Takouhie Catherine Maldjian and Mary M. Salvatore

submission deadline 31 Dec 2026 | 6 articles | Viewed by 8406 | Submission Open

Keywords: breast cancer; radiology; breast imaging; mammography; MRI; ultrasound; AI; radiomics; diagnosis; treatment response; image-guided biopsy

(This special issue belongs to the Section Methods and Technologies Development)

Classification, Risk Assessment and Clinical Management of Malignant Thyroid Nodules: 2nd Edition

edited by Claudio Spinelli and Marco Ghionzoli

submission deadline 31 Dec 2026 | 4 articles | Viewed by 8160 | Submission Open

Keywords: thyroid nodule; thyroid cancer; guidelines; surgery

(This special issue belongs to the Section Clinical Research in Cancer)

Recent Advances in Epidemiology of Childhood Cancer

edited by Rafael Peris-Bonet,

Rebeca Ramis

and Adela Cañete

submission deadline 31 Dec 2026 | 7 articles | Viewed by 7624 | Submission Open

Keywords: childhood cancer epidemiology; childhood cancer registries; environmental causes of childhood cancer; genetic epidemiology; molecular epidemiology; survival of children with cancer; quality of life; social determinants and inequalities; information technologies and statistical innovations

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in Targeted Therapies in Cancer (2nd Edition)

edited by

Bulent Ozpolat

submission deadline 31 Dec 2026 | 3 articles | Viewed by 7056 | Submission Open

Keywords: targeted therapy; cancer, antibody therapy; small molecule inhibitor; RNAi therapy; cell-based therapy

(This special issue belongs to the Section Cancer Therapy)

Molecular Pathology and Human Cancers

edited by

Stefano Marletta

, Alessandro Russo and Giuliana Pavone

submission deadline 31 Dec 2026 | 3 articles | Viewed by 6727 | Submission Open

Keywords: molecular pathology; cancer pathogenesis; targeted therapy; personalized medicine; cancer signaling

(This special issue belongs to the Section Cancer Pathophysiology)

Focus on Focal Therapy for Prostate Cancer

edited by Abhinav Sidana and Samuel Tremblay

submission deadline 31 Dec 2026 | 3 articles | Viewed by 6321 | Submission Open

Keywords: focal therapy; prostate cancer treatment; image-guided therapy; oncological outcomes; functional outcome; patient selection; surveillance

(This special issue belongs to the Section Cancer Therapy)

Contemporary Management for Gallbladder Cancer: From Diagnosis to Treatment (2nd Edition)

edited by Hiromichi Ito

submission deadline 31 Dec 2026 | 2 articles | Viewed by 6103 | Submission Open

Keywords: gallbladder cancer; radical cholecystectomy; adjuvant chemotherapy; neoadjuvant therapy; incidental gallbladder cancer; multidisciplinary management; preoperative staging

(This special issue belongs to the Section Cancer Therapy)

Displaying special issue 451-500 on page 10 of 21.

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