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Innovation and Optimization of Radiation or Drug Therapy for Gynecological Cancers

A Special Issue of Cancers (ISSN 2072-6694) belonging to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 December 2026 | Viewed by 594

Editors


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Guest Editor
Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China
Interests: cervical cancer; radiation therapy; immunotherapy; comprehensive treatment; cost-effectiveness

E-Mail Website
Guest Editor
Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China
Interests: gynecological cancers

Special Issue Information

Dear Colleagues,

Gynecological tumors are one of the most common and difficult-to-treat types of cancer. Radiation therapy combined with other treatments plays a significant role in the treatment of gynecological tumors. As incidence and recurrence rates increase, more and more oncologists and clinical trial pioneers are paying attention to innovative treatment methods for gynecological tumors. However, with the emergence of numerous treatment methods, we must make comprehensive judgments on the optimal choice among these innovative treatment options. Therefore, new research strategies and evaluation methods are needed to better formulate future treatment plans for gynecological tumors.

The focus of this Special Issue lies in exploring the following research aspects of comprehensive treatment for gynecological tumors: (a) radiation therapy; (b) immunotherapy; (c) molecular targeted drugs; (d) clinical trials or real-world research analysis; (e) meta-analysis or cost-effectiveness analysis.

Prof. Dr. Hong Zhu
Dr. Yangying Zhou
Guest Editors

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Keywords

  • cervical cancer
  • endometrial cancer
  • ovarian cancer
  • radiation therapy
  • immunotherapy
  • targeted therapy
  • comprehensive treatment
  • cost-effectiveness

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Published Papers (1 paper)

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Research

24 pages, 407 KB  
Article
Impact of Post-Primary Treatment Hormone Replacement Therapy on Survival in Women with Cervical Cancer
by Hee Joong Lee and Banghyun Lee
Cancers 2026, 18(17), 2841; https://doi.org/10.3390/cancers18172841 - 2 Sep 2026
Viewed by 222
Abstract
Background/Objectives: The effects of hormone replacement therapy (HRT) after primary treatment on survival outcomes in women with cervical cancer (CC) remain unclear. This nationwide cohort study evaluated the association between post-primary treatment HRT and overall survival (OS) in women with CC. Methods [...] Read more.
Background/Objectives: The effects of hormone replacement therapy (HRT) after primary treatment on survival outcomes in women with cervical cancer (CC) remain unclear. This nationwide cohort study evaluated the association between post-primary treatment HRT and overall survival (OS) in women with CC. Methods: We identified 15,261 women aged ≤60 years with CC who received primary treatment using the Korean Health Insurance Review and Assessment Service database. HRT users were defined as women who received HRT prescriptions for ≥28 days within one year after completion of primary treatment. Stabilized inverse probability of treatment weighting (IPTW) was used to reduce baseline differences between HRT users and non-users, followed by multivariable Cox regression to further adjust for potential confounding. Landmark analyses were performed to address potential immortal time bias. Results: Among 15,261 women, 4118 (27.0%) received HRT. In IPTW-weighted analyses, HRT use was significantly associated with improved OS in both multivariable models (adjusted HR, 0.544; 95% CI, 0.502–0.590; p < 0.001 and adjusted HR, 0.653; 95% CI, 0.574–0.742; p < 0.001, respectively). This association was generally maintained in landmark analyses at 1, 3, and 5 years after diagnosis and remained significant across localized, regional, and distant disease in stage-stratified analyses. The association was most consistently observed among women with squamous cell carcinoma. Conclusions: Post-primary treatment HRT was associated with improved OS in women with CC. Further prospective studies are needed to clarify the clinical implications of this association. Full article
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