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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Reducing the Risk of Hepatitis B-Associated Chronic Liver Disease and Hepatocellular Carcinoma

edited by

Mark A. Feitelson

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1739 | Submission Open

Keywords: HBsAg loss; prolonged nucleoside therapy; autoimmune diseases; gut dysbiosis; hepatitis delta coinfection; HIV coinfection; functional cure; immunomodulation; HBV integration; immune-mediated CLD; combination therapies

(This special issue belongs to the Section Clinical Research in Cancer)

New Clinical Insights into Gastrointestinal Cancers

edited by Dai Shida

submission deadline 30 Nov 2026 | 2 articles | Viewed by 1678 | Submission Open

(This special issue belongs to the Section Clinical Research in Cancer)

Burkitt Lymphoma: From Pathogenesis to Current Treatments: 2nd Edition

edited by Lorenzo Leoncini and

German K. Ott

submission deadline 30 Nov 2026 | 2 articles | Viewed by 1646 | Submission Open

Keywords: Burkitt lymphoma; high-grade B-cell lymphoma; EBV; NGS; whole-exome sequencing; RNAseq; methylation analysis; tumor microenvironment; immunotherapy; chemotherapy

Pathology of Renal Tumors

edited by

Guido Martignoni

and Anna Caliò

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1624 | Submission Open

Keywords: renal cell tumors; diagnosis; prognosis; metabolomics; genomics; molecular; immunohistochemistry; histopathology

(This special issue belongs to the Section Cancer Pathophysiology)

In Vitro and In Vivo Pharmacology for Glioma Drug Discovery

edited by

Anna Bielecka-Wajdman

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1437 | Submission Open

Keywords: pre-clinical modern in vitro /in vivo glioma models; complementary glioma therapy; immunotherapy in glioma; inhibition of glioma recurrence

(This special issue belongs to the Section Cancer Drug Development)

Thermal Analysis and Proteomic Approaches for Biofluid Proteome Profiling in Cancer Diagnostics

edited by

Nichola C. Garbett

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1367 | Submission Open

Keywords: thermal analysis; proteomics; thermal liquid biopsy; differential scanning calorimetry; mass spectrometry; serum proteome; clinical diagnostics; cancer diagnostics; biospecimen

(This special issue belongs to the Section Methods and Technologies Development)

Adjuvant Therapy and the Cytotoxic Effects in Colorectal Cancers

edited by William H. Gmeiner

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1345 | Submission Open

Keywords: colorectal cancer; adjuvant chemotherapy; targeted therapy; immunotherapy; metastatic colorectal cancer; drug resistance; combination therapy; cytotoxic effects

(This special issue belongs to the Section Cancer Therapy)

Tumor Microenvironment Biomarkers: Bridging Immunology and Metastasis

edited by

Abdel Kareem Azab

and

Tithi Bhattacharyya

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1338 | Submission Open

Keywords: tumor microenvironment; molecular biomarkers; cancer progression; immunomodution; therapeutic targets

(This special issue belongs to the Section Cancer Biomarkers)

Recent Advances and Emerging Directions in Lung Cancer Radiotherapy

edited by Arturo Navarro-Martín

submission deadline 30 Nov 2026 | 3 articles | Viewed by 1078 | Submission Open

Keywords: lung cancer; hypofractionated radiotherapy; lattice; flash therapy; protons

(This special issue belongs to the Section Cancer Therapy)

The Prevalence and Incidence of Different Cancers: Risk Factors, Predictions and Modelling Cancer Rates

edited by Aleksandra Izabela Czerw

submission deadline 30 Nov 2026 | 2 articles | Viewed by 1072 | Submission Open

Keywords: cancer epidemiology; prevalence modelling; incidence modelling; epidemic modelling; risk factors

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Targeted Therapy in Glioblastoma and Glioma

edited by Ben A. Strickland

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1060 | Submission Open

Keywords: glioblastoma; neuro-oncology; immunotherapy; tumor microenvironment; macrophage checkpoint; complement system; sphingolipid metabolism; drug resistance; MGMT methylation; combination therapy

(This special issue belongs to the Section Molecular Cancer Biology)

Pharmacology, Microbiology and Immunology in Cancers

edited by Mihail Virgil Boldeanu

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1012 | Submission Open

Keywords: cancer pharmacology; tumor immunology; cancer microbiome; immunotherapy; targeted therapy; tumor microenvironment; drug resistance; host–microbiota interactions; translational oncology; personalized cancer therapy

Signaling Pathways and Molecular Crosstalk in the Tumor Microenvironment

edited by

Masayoshi Yamaguchi

submission deadline 30 Nov 2026 | 2 articles | Viewed by 991 | Submission Open

Keywords: tumor microenvironment (TME); signal transduction pathways; intercellular communication; cancer progression and metastasis; therapeutic targets and drug resistance

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Precision Diagnostics and Personalized Therapeutics for Prostate Cancer

edited by

Takanobu Utsumi

submission deadline 30 Nov 2026 | 1 articles | Viewed by 891 | Submission Open

Keywords: diagnostics; personalized therapeutics; prostate cancer

Diet, Microbiome, and Immune Regulation in Early-Onset and Obesity-Associated Gastrointestinal Cancers: Mechanisms, Biomarkers, and Therapeutic Targets

edited by Saratchandra Khumukcham and

Maria Gazouli

submission deadline 30 Nov 2026 | Viewed by 869 | Submission Open

Keywords: colorectal cancer; gastrointestinal cancer; obesity-associated cancer; diet-induced obesity; aging; intestinal epithelium; tumor microenvironment; Wnt signaling; cancer immunology; organoid models

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Imaging in Breast Cancer: Advancing Screening, Diagnosis, and Therapy

edited by Almir Galvão Vieira Bitencourt and Soraia Damião

submission deadline 30 Nov 2026 | 1 articles | Viewed by 660 | Submission Open

Keywords: breast neoplasms/diagnostic imaging; mammography; contrast media; magnetic resonance imaging; ultrasound; PET-CT; early detection of cancer; neoadjuvant therapy; artificial intelligence; precision medicine

New Insights in Urologic Oncology: Immune and Tumor Antigen Targeting Approaches

edited by Justin H. Hwang, Alex Tsai and Ali Arafa

submission deadline 30 Nov 2026 | 1 articles | Viewed by 568 | Submission Open

Keywords: urologic cancer; immune therapies; tumor antigens; tumor microenvironment; targeted therapies; therapeutic resistance; tumor heterogeneity

Advances in High-Grade Serous Ovarian Cancer: New Perspectives Promising Hope for Eradicating a Devastating Disease

edited by

Carlos M. Telleria

submission deadline 30 Nov 2026 | Viewed by 544 | Submission Open

Keywords: high-grade serous ovarian cancer; risk factors; prevention; early detection; symptoms; screening; standard of care; platinum resistant ovarian cancer; novel therapeutic approaches; drug repositioning; artificial intelligence; life expectancy, quality of life, and prognosis

The Use of Artificial Intelligence in Cancer Research, Diagnosis, and Care

edited by

Daniele Giansanti

submission deadline 30 Nov 2026 | 1 articles | Viewed by 535 | Submission Open

Keywords: artificial intelligence; oncology; cancer diagnosis; prognostic modeling; clinical validation; digital twins

Onco-Nephrology: Managing Kidney Health in Cancer Patients

edited by Gerrit van den Berg

submission deadline 30 Nov 2026 | 1 articles | Viewed by 532 | Submission Open

Keywords: onconephrology; nephrotoxicity; acute kidney injury; chronic kidney disease; kidney health; nephrotoxin stewardship; cancer survival; personalized medicine; supportive care

Tumor Heterogeneity in Breast Cancer—the “Omics” Revolution

edited by

Angeliki Magklara

and

Spyros Foutadakis

submission deadline 30 Nov 2026 | Viewed by 470 | Submission Open

Keywords: breast cancer; tumor heterogeneity; tumor microenvironment; transcriptional regulation; single-cell RNA-seq; spatial transcriptomics; genomics; epigenomics; proteomics; metabolomics

(This special issue belongs to the Section Molecular Cancer Biology)

Role of Cytokines in Cancer (2nd Edition)

edited by

Venkataswarup Tiriveedhi

submission deadline 30 Nov 2026 | Viewed by 458 | Submission Open

Keywords: inflammation; tumor microenvironment; cytokines

(This special issue belongs to the Section Tumor Microenvironment)

Cellular Senescence in Cancer: Therapeutic Induction, Microenvironmental Crosstalk and Clinical Implications

edited by

Aria Baniahmad

and

Carlo Gaetano

submission deadline 30 Nov 2026 | Viewed by 398 | Submission Open

Keywords: therapy-induced senescence (TIS); TIS resistance; senescence-associated secretory phenotype (SASP); senescence-associated heterochromatin foci (SAHF); immune escape; immune response; immune surveillance; cancer-associated fibroblasts; tumor microenvironment; senolytic therapy; senomorphics; senomodulation; extracellular vesicles; chromatin; imprinting and epigenetic reprogramming; biomarkers

(This special issue belongs to the Section Molecular Cancer Biology)

New Approaches to Surgical Treatment and Care for Urological Cancer

edited by

Susanne Vahr Lauridsen

and Bente Thoft Jensen

submission deadline 30 Nov 2026 | Viewed by 390 | Submission Open

Keywords: bladder cancer; prostate cancer; kidney cancer; penile cancer; patient perspective; patient education; enhanced recovery after surgery (ERAS) protocols; prehabilitation rehabilitation; sexual health

(This special issue belongs to the Section Clinical Research in Cancer)

Intraoperative Radiotherapy in Cancer Treatment

edited by

Falk Roeder

submission deadline 30 Nov 2026 | Viewed by 363 | Submission Open

Keywords: intraoperative radiation therapy; image-guided IORT; IOERT; kV-IORT; HDR-IORT; FLASH

(This special issue belongs to the Section Cancer Therapy)

Acute Myeloid Leukemia: Novel Therapeutic Agents and Clinical Trials

edited by Wieslaw W. Jedrzejczak

submission deadline 30 Nov 2026 | Viewed by 361 | Submission Open

Keywords: acute leukemia; targeted therapy; antibody–drug conjugates

(This special issue belongs to the Section Clinical Research in Cancer)

HMGA Oncoproteins in Cancer

edited by

Monica Fedele

and

Sabrina Battista

submission deadline 30 Nov 2026 | Viewed by 358 | Submission Open

Keywords: HMGA1; HMGA2; chromatin architecture; oncogenic signaling; tumor progression; biomarkers; therapeutic targeting

(This special issue belongs to the Section Molecular Cancer Biology)

Epigenetic Alterations in Human Tumors

edited by Michail Panagiotidis and

Young Kyung Park

submission deadline 30 Nov 2026 | Viewed by 354 | Submission Open

Keywords: cancer; DNA methylation; post-translational histone modifications; miRNAs; genome reorganization; multi-omics; experimental/translational therapeutics

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Minimally Invasive Surgery in Gastrointestinal Cancers

edited by

Giovanni Domenico Tebala

and Fabio Rondelli

submission deadline 30 Nov 2026 | Viewed by 349 | Submission Open

Keywords: laparoscopic surgery; robotic surgery; gastrointestinal cancer; colorectal surgery; hepatobiliary surgery; pancreatic surgery; oesophagogastric surgery; peritoneal surface malignancies

(This special issue belongs to the Section Cancer Therapy)

Novel Approaches to Management of Therapy and Prevention of Pancreatic Cancer

edited by

Carmen Guerra

and Vasiliki Liaki

submission deadline 30 Nov 2026 | Viewed by 339 | Submission Open

Keywords: pancreatic ductal adenocarcinoma (PDAC); targeted therapy; preclinical models; cancer mutiomics; early detection; prevention; precision medicine; biomarkers; drug resistance

(This special issue belongs to the Section Cancer Therapy)

Biomarkers in Liquid Biopsy: Circulating Tumor DNA (ctDNA), Circulating Tumor Cells (CTCs) and Exosomes

edited by George Zarkavelis

submission deadline 30 Nov 2026 | Viewed by 333 | Submission Open

Keywords: liquid biopsy; circulating tumor DNA; circulating tumor cells; early cancer detection; assessment of minimal residual disease (MRD); monitoring treatment response; identifying resistance to therapy

(This special issue belongs to the Section Methods and Technologies Development)

Metabolic Reprogramming and Neuroendocrine Regulation in Cancer: From Pathophysiology to Therapeutic Targets

edited by

Dimiter B. Avtanski

submission deadline 30 Nov 2026 | Viewed by 322 | Submission Open

Keywords: ageing and cancer; breast cancer metabolism; cancer metabolism; inflammation; insulin resistance; metabolic reprogramming; neuroendocrine signaling; obesity and cancer; precision oncology; tumor microenvironment

(This special issue belongs to the Section Cancer Pathophysiology)

Multiple Myeloma: From Molecular Insights to Clinical Treatment

edited by Mikala Gabor

submission deadline 30 Nov 2026 | Viewed by 315 | Submission Open

Keywords: multiple myeloma; novel therapy; bispecific; CelMod; CAR-T; CAR-NK; ADC; CD38; BCMA; GPRC5D; FcRH5; transplantation

Radiation Therapy for Sarcomas

edited by Peter Chung and Elizabeth H. Baldini

submission deadline 30 Nov 2026 | Viewed by 306 | Submission Open

Keywords: radiation therapy; dose-fractionation; functional outcomes; combination approaches; histology-specific outcomes; toxicity; site-specific

(This special issue belongs to the Section Cancer Therapy)

Advances in Adoptive Cell Therapy for Cancer

edited by Andrew Furness

submission deadline 30 Nov 2026 | Viewed by 306 | Submission Open

Keywords: CAR-T cells; adoptive cell therapy; tumor microenvironment; immunotherapy; translational oncology

Mechanism of Action of Novel Anticancer Drugs in Cancer Treatment

edited by

Ruifang Liu

submission deadline 30 Nov 2026 | Viewed by 304 | Submission Open

Keywords: targeted therapy; immunotherapy; tumor-agostic approval; therapy resistence; mechaninsm of action; kinase inhibitor; immune checkpoint inhibitor

(This special issue belongs to the Section Cancer Drug Development)

Mammographic Density in Prevention and Early Detection of Breast Cancer

edited by

Wendy Ingman

submission deadline 30 Nov 2026 | Viewed by 295 | Submission Open

Keywords: mammographic density; breast cancer; risk; prevention; early detection; mammogram; breast cancer screening

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Clinical Studies in Gastrointestinal Malignancies: 2nd Edition

edited by

Ulrich Ronellenfitsch

submission deadline 30 Nov 2026 | Viewed by 284 | Submission Open

Keywords: gastrointestinal cancers; clinical studies; multimodal treatment; study design; outcomes

(This special issue belongs to the Section Clinical Research in Cancer)

Applications of Imaging in Lung Cancer

edited by

Chiara Romei

submission deadline 30 Nov 2026 | Viewed by 284 | Submission Open

Keywords: lung cancer; chest X-ray; computed tomography; magnetic resonance imaging; tumor staging; treatment response; radiomics; artificial intelligence

(This special issue belongs to the Section Methods and Technologies Development)

Advancements in the Science of Endocrine Surgical Oncology

edited by Alessandra L. Moore

submission deadline 30 Nov 2026 | Viewed by 282 | Submission Open

Keywords: endocrine oncology; endocrine surgery; endocrine; cancer; biology; surgery; oncology; science; surgical science

(This special issue belongs to the Section Clinical Research in Cancer)

Optimizing Cancer Healthcare with Clinical Decision Support

edited by

Avishek Choudhury

and

Safa Elkefi

submission deadline 30 Nov 2026 | Viewed by 268 | Submission Open

Keywords: cancer clinical decision support; AI in oncology; human-centered AI; trust, safety and explainability; health informatics; decision analytics; patient safety; digital oncology

Update in Pathology of Gynaecologic Cancer

edited by

Mona El-Bahrawy

submission deadline 30 Nov 2026 | Viewed by 264 | Submission Open

Keywords: gynaecological; cancer; pathology; diagnosis

(This special issue belongs to the Section Cancer Pathophysiology)

External Environmental Factors Inducing Cancer-Related Mutations

edited by

Evgeniya Ostroumova

submission deadline 30 Nov 2026 | Viewed by 263 | Submission Open

Keywords: molecular epidemiology; cancer; environmental exposure; cancer-related mutations; cancer molecular pathways; risk assessment

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Hippo/YAP Signaling Pathways in Cancers

edited by

Chunlin Ou

submission deadline 30 Nov 2026 | Viewed by 254 | Submission Open

Keywords: Hippo signaling pathway; YAP/TAZ; tumorigenesis; tumor microenvironment; targeted therapy

(This special issue belongs to the Section Molecular Cancer Biology)

Health Equity and Clinical Outcomes in Hepatocellular Carcinoma

edited by

Edoardo G. Giannini

and Catherine Mezzacappa

submission deadline 30 Nov 2026 | Viewed by 245 | Submission Open

Keywords: hepatocellular carcinoma; health equity; material deprivation; social determinants of health; clinical outcomes; access to care; cancer staging; liver cancer disparities

(This special issue belongs to the Section Clinical Research in Cancer)

Redefining Breast Cancer Surgery: Emerging Technologies and De-Escalation Strategies

edited by Marco Pellicciaro

submission deadline 30 Nov 2026 | Viewed by 231 | Submission Open

Keywords: breast cancer surgery; surgical innovation; indocyanine green; fluorescence imaging; tumor localization; sentinel lymph node; axillary surgery; de-escalation; precision surgery

(This special issue belongs to the Section Clinical Research in Cancer)

Research Progress of Targeted Therapy for Acute Myeloid Leukemia

edited by Maher Abdul-Hay

submission deadline 30 Nov 2026 | Viewed by 228 | Submission Open

Keywords: acute myeloid leukemia; targeted therapy; chimeric antigen receptor T-cell therapy; menin inhibitors; FLT3; IDH1; IDH2; NPM1; molecular; therapeutic targets

(This special issue belongs to the Section Cancer Therapy)

Surgical Management of Sarcomas

edited by Maniram Ragbir

submission deadline 30 Nov 2026 | Viewed by 214 | Submission Open

Keywords: sarcoma; MDT; surgical management; microsurgery; reconstruction

(This special issue belongs to the Section Cancer Therapy)

Novel Developments Regarding Pathological Complete Response in Breast Cancer Patients

edited by

Vasiliki Zolota

, Dimitris Goutas and

Nektarios Koufopoulos

submission deadline 30 Nov 2026 | Viewed by 210 | Submission Open

Keywords: neoadjuvant chemotherapy; adjuvant therapy; pathologic complete response; HER2-positive; triple-negative; tumor microenvironment

(This special issue belongs to the Section Cancer Pathophysiology)

Hepatocellular Carcinoma Ablation: Technology, Biology, and Immunologic Synergy

edited by

Robert C.G. Martin

submission deadline 30 Nov 2026 | Viewed by 207 | Submission Open

Keywords: hepatocellular carcinoma; ablation therapy; radiofrequency ablation; microwave ablation; irreversible electroporation; tumor microenvironment; immunogenic cell death; immunotherapy; combination therapy; biomarkers; locoregional therapy; liver cancer

Displaying special issue 351-400 on page 8 of 21.

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