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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Pathology in Cancer: From Diagnosis to Precision Medicine

edited by

Georgia Levidou

submission deadline 28 Sep 2026 | Viewed by 549 | Submission Open

Keywords: cancer biomarkers; precision medicine; histopathology; clinical pathology; diagnosis; prognostic/predictive biomarker

(This special issue belongs to the Section Cancer Pathophysiology)

Advances and Challenges in the Diagnosis and Treatment of Urological Malignancies (2nd Edition)

edited by

Bartosz Małkiewicz

Jakub Dobruch

and

Łukasz Nowak

submission deadline 30 Sep 2026 | 10 articles | Viewed by 22641 | Submission Open

Keywords: prostate cancer; bladder cancer; upper urinary tract tumors; kidney cancer; testicular tumors; molecular markers; lymph node metastasis; diagnosis; radical treatment; systemic treatment

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advances in Soft Tissue and Bone Sarcoma (2nd Edition)

edited by

Catrin Sian Rutland

submission deadline 30 Sep 2026 | 14 articles | Viewed by 19691 | Submission Open

Keywords: bone sarcoma; soft tissue sarcoma; prognosis; diagnosis; detection; molecular biomarkers; histopathology; treatment

(This special issue belongs to the Section Cancer Therapy)

Immunotherapy for Skin Cancers

edited by

Reinhard Dummer

and Lara Valeska Maul-Duwendag

submission deadline 30 Sep 2026 | 4 articles | Viewed by 12927 | Submission Open

Keywords: melanoma; non-melanoma skin cancer; merkel cell carcinoma; kaposi sarcoma; cutaneous angi-osarcoma; immune checkpoint; immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Health Economic and Policy Issues Regarding Cancer

edited by

Aviad Tur-Sinai

submission deadline 30 Sep 2026 | 5 articles | Viewed by 9785 | Submission Open

Keywords: cancer economics; health policy; cost-effectiveness; financial toxicity; healthcare disparities; value-based oncology

Neurosurgery Research on Brain Tumors: A Focus on Gliomas and Other Intra-Axial Brain Tumors

edited by

Andrea Di Cristofori

, Carlo Giussani, Cesare Zoia and Daniele Bongetta

submission deadline 30 Sep 2026 | 2 articles | Viewed by 8202 | Submission Open

Keywords: neurosurgery; glioma; neuropsychology; neurophysiological monitoring; intraoperative imaging (including iMRI and iOUS); neuroanatomy; outcome; prognosis and quality of life; MRI (including fMRI, MR spectroscopy, perfusion and DTI tractography); radiogenomics; multimodal treatments; druggable targets; artificial intelligence and deep learning

(This special issue belongs to the Section Clinical Research in Cancer)

Cellular and Molecular Mechanisms of Malignant Nervous System Cancers

edited by

April Weissmiller

submission deadline 30 Sep 2026 | 7 articles | Viewed by 7994 | Submission Open

Keywords: medulloblastoma; pediatric glioma; neuroblastoma; diagnosis and prognostic markers; IDH, TERT, and EGFR mutations; DNA methylation; treatment approaches and strategies (chemotherapy, radiation therapy, immunotherapy, and targeted therapy); resistance mechanisms; tumor microenvironment; molecular characteristics of tumor heterogeneity

(This special issue belongs to the Section Molecular Cancer Biology)

The EGFR-Tyrosine Kinase Inhibitors (EGFR-TKIs) and Immune Checkpoint Inhibitors (ICIs) for Non-Small Cell Lung Cancer

edited by

Greta Alì

and

Maria Giovanna Mastromarino

submission deadline 30 Sep 2026 | 3 articles | Viewed by 7619 | Submission Open

Keywords: non-small cell lung cancer; target therapy; EGFR-tyrosine kinase inhibitors; immunotherapy; immune checkpoint inhibitors; molecular analysis; surgery; precision medicine

(This special issue belongs to the Section Cancer Therapy)

Current Issues, Innovations, and Emerging Therapies in Thoracic Surgical Oncology

edited by Inderpal S. Sarkaria and Shamus Carr

submission deadline 30 Sep 2026 | 5 articles | Viewed by 7500 | Submission Open

Keywords: non-small cell lung cancer; esophageal cancer; thymic epithelial tumors; BAP1 malignant mesothelioma; robotic surgery; immunotherapy; cellular therapies; molecular imaging

Biomarkers for Therapy Response in Gastrointestinal Malignancies: Predicting Outcomes and Personalizing Care

edited by

Devalingam Mahalingam

submission deadline 30 Sep 2026 | 5 articles | Viewed by 7016 | Submission Open

Keywords: immunotherapy; biomarkers; resistance mechanisms; predictive markers; clinical trials; translational research

(This special issue belongs to the Section Cancer Biomarkers)

Fertility Preservation and Hormonal Health in Oncology

edited by

Amelia Barcellini

and

Chiara Cassani

submission deadline 30 Sep 2026 | 4 articles | Viewed by 6941 | Submission Open

Keywords: oncofertility; fertility preservation; hormonal health; cancer survivorship; reproductive oncology

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Novel Perspectives in Hepato-Biliary and Pancreatic Cancer

edited by Tudor Mocan and Emil-Ioan Moiș

submission deadline 30 Sep 2026 | 4 articles | Viewed by 6828 | Submission Open

Keywords: HCC; cholangiocarcinoma; surgery; biliary drainage; pancreatic cancer; combination therapies

(This special issue belongs to the Section Cancer Therapy)

Multiple Myeloma: Diagnosis and Therapy

edited by

Yvonne A. Efebera

and

Nidhi Sharma

submission deadline 30 Sep 2026 | 3 articles | Viewed by 6601 | Submission Open

Keywords: multiple myeloma; plasma cell disorders; relapsed and refractory multiple myeloma; blood and marrow transplant

(This special issue belongs to the Section Cancer Therapy)

Proteomic and Oncogenic Biomarkers in Gastrointestinal Cancer

edited by

Marta Lukaszewicz-Zajac

and

Adrianna Romanowicz

submission deadline 30 Sep 2026 | 4 articles | Viewed by 6493 | Submission Open

Keywords: tumor biomarkers; early detection; tumor progression; carcinogenesis; inflammatory mediators; gastrointestinal cancer; prognostic biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

Contemporary Lung Cancer Nodal Staging and Evolving Therapeutic Paradigms

edited by

Takahiro Nakajima

and

George A. Eapen

submission deadline 30 Sep 2026 | 8 articles | Viewed by 6292 | Submission Open

Keywords: ninth TNM classification; nodal staging; endoscopic/endobronchial ultrasound; neoadjuvant/adjuvant therapy; biomarker testing

(This special issue belongs to the Section Cancer Therapy)

Exercise Interventions for People Living with Cancer: Advances in Knowledge and Implementation

edited by

Lara Edbrooke

and Chris Swain

submission deadline 30 Sep 2026 | 3 articles | Viewed by 6065 | Submission Open

Keywords: cancer; survivorship; exercise; physical activity; implementation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

State-of-the-Art Research on Multiple Myeloma Progression: 2nd Edition

edited by

Shebli Atrash

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5685 | Submission Open

Keywords: multiple myeloma; novel targets; novel therapies; molecular therapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Clinical Applications of Precision Diagnosis for Thyroid Cancers and Its Clinical Use for Treatments Choice

edited by

Maria Trovato

, Silvia Martina Ferrari and

Fausto Famà

submission deadline 30 Sep 2026 | 2 articles | Viewed by 5523 | Submission Open

Keywords: thyroid cancer; precision diagnosis; clinical management; molecular tests; molecular therapeutic targets; thyroid cancer epidemiology; artificial intelligence; health inequalities

(This special issue belongs to the Section Clinical Research in Cancer)

The Cellular Ecosystem of Cancer: New Insights into Cell Biology

edited by Xiaochao Tan and

Guan-Yu Xiao

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5421 | Submission Open

Keywords: cell organelle; ER; mitochondria; lysosome; Golgi; secretion; tumor microenvironment

(This special issue belongs to the Section Molecular Cancer Biology)

The Development of Effective Therapy Targeting the Microenvironment of Cancer (2nd Edition)

edited by

Moriaki Kusakabe

and

Kanae Taruno

submission deadline 30 Sep 2026 | 3 articles | Viewed by 5387 | Submission Open

Keywords: cancer; tumor microenvironment; cancer therapy; cancer cell; animal level

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Brain Tumors

edited by

David S. Baskin

submission deadline 30 Sep 2026 | 2 articles | Viewed by 4772 | Submission Open

Keywords: diagnosis; biomarker; treatment; brain tumors

(This special issue belongs to the Section Clinical Research in Cancer)

Cancer Survivors: Late Effects of Cancer Therapy

edited by

Gaurav Kumar

submission deadline 30 Sep 2026 | 3 articles | Viewed by 4497 | Submission Open

Keywords: late effects; cancer survivorship; treatment toxicity; long-term outcomes

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Robotic and Thoracoscopic Surgery for Thoracic Oncology

edited by

Elisa Meacci

submission deadline 30 Sep 2026 | 1 articles | Viewed by 3881 | Submission Open

Keywords: robotic-assisted thoracic surgery; video-assisted thoracoscopic surgery (VATS); lung cancer surgery; esophageal cancer; thymic tumors; minimally invasive surgery; pleural tumors; chest wall tumors; mediastinal surgery; thoracic oncology

(This special issue belongs to the Section Clinical Research in Cancer)

Management of Orbital Tumors

edited by

Peerooz Saeed

submission deadline 30 Sep 2026 | 1 articles | Viewed by 3650 | Submission Open

Keywords: orbital tumor; diagnostic; multidisciplinary approaches; personalized treatment; imaging techniques

(This special issue belongs to the Section Clinical Research in Cancer)

Multimodal Artificial Intelligence/Machine Learning Applications in Malignant Tumors: Diagnosis, Prognosis, and Management

edited by

Sam Payabvash

and Stefan Haider

submission deadline 30 Sep 2026 | 1 articles | Viewed by 3519 | Submission Open

Keywords: machine learning; radiomics; cancer imaging; malignancy; survival

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Radiotherapy for Head and Neck Squamous Cell Carcinoma (2nd Edition)

edited by

Cesare Guida

and Ida D'Onofrio

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3336 | Submission Open

Keywords: head and neck squamous cell carcinoma; radiotherapy; biomarker; chemoradiotherapy; head and neck cancers

(This special issue belongs to the Section Cancer Therapy)

Cancer and Melatonin: Updates on Current Findings

edited by

Rita Rezzani

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3229 | Submission Open

Keywords: cancer; melatonin; oxidative stress; inflammation; antioxidant defense

Novel Advancements in Prostate Cancer Surgery: Indications and Techniques

edited by Valerio Santarelli and

Alessandro Sciarra

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3105 | Submission Open

Keywords: radical prostatectomy; prostate cancer; technology; minimally invasive surgery

(This special issue belongs to the Section Cancer Therapy)

Clinical Trials and Translational Research in Multiple Myeloma

edited by Laszlo Varoczy

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3046 | Submission Open

Keywords: multiple myeloma; disease evolution; translational research; personalizing therapy; clinical trial

(This special issue belongs to the Section Clinical Research in Cancer)

Chromatin-Remodeling Factors in Cancer Cells

edited by

Sudhakar Jha

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2942 | Submission Open

Keywords: chromatin remodeling; transcription factors; epigenetic therapy; cancer epigenomics; SWI/SNF complex; CRISPR functional screens; single-cell epigenomics; gene regulation in cancer; therapy resistance; targeted cancer therapies

(This special issue belongs to the Section Cancer Pathophysiology)

Hematologic Malignancies: Clinical Features and Prognostic Indicators

edited by Danijela Leković

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2771 | Submission Open

Keywords: leukemia; myelodysplastic syndrome; myeloproliferative neoplasms; lymphoma; multiple myeloma; diagnosis; prognosis; molecular markers; infections; survival; machine learning

(This special issue belongs to the Section Clinical Research in Cancer)

miRNAs in Targeted Cancer Therapy

edited by Mustafa Özen

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2758 | Submission Open

Keywords: miRNA; micro-RNA; targeted therapy; cancer treatment; solid tumors; hematological malignancies; non-coding RNAs; epigenetic regulation; cancer therapeutics; gene therapy

(This special issue belongs to the Section Cancer Therapy)

Advances in PET/CT Imaging in Cancer Management

edited by Jasna M. Mihailovic and Mihaela Raluca Mititelu

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2601 | Submission Open

Keywords: PET/CT imaging; oncology; staging; restaging; treatment monitoring; recurrence detection

(This special issue belongs to the Section Methods and Technologies Development)

Targeting RNA to Improve Cancer Precision Medicine

edited by

Gabriella Misso

, Anna Grimaldi and Chiara Tammaro

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2541 | Submission Open

Keywords: cancer; RNA therapy; RNA delivery; RNA; miRNA; mRNA; siRNA; oligonucleotides; aptamers; precision medicine

(This special issue belongs to the Section Cancer Therapy)

Advances in Cancer Targeted Therapy

edited by Ponniah Selvakumar

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2290 | Submission Open

Keywords: targeted therapy; cancer treatment; molecular targets; signaling pathways; angiogenesis inhibition; artificial intelligence (AI); single-cell technologies; informatics; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

A New Era in the Treatment of Early-Stage Non-Small Cell Lung Cancer (2nd Edition)

edited by

Tsutani Yasuhiro

submission deadline 30 Sep 2026 | 4 articles | Viewed by 2169 | Submission Open

Keywords: minimally invasive surgery; video-assisted thoracic surgery; robotic-assisted thoracic surgery; sublobar resection; segmentectomy; neoadjuvant therapy; adjuvant therapy; immunotherapy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Senescence and Cell Plasticity in Cancer Development

edited by

Eva María Verdugo-Sivianes

and Elena Aguado-Domínguez

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2112 | Submission Open

Keywords: cellular senescence; cell plasticity; stem cells; SASP; therapy resistance; tumor microenvironment; cancer development

(This special issue belongs to the Section Molecular Cancer Biology)

Cell Cycle Dysregulation in Cancers

edited by Radoslav Janostiak

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2033 | Submission Open

Keywords: cell cycle regulation; proliferation-quiescence decision; post translational regulation; quiescence maintenance; senescence escape; environmental stress adaptation; minimal residual disease; cell cycle checkpoints

(This special issue belongs to the Section Molecular Cancer Biology)

Stress, Epigenetic Regulation, and DNA Damage: Insights into Cancer Development and Therapeutic Challenges

edited by Yanying Huo

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1785 | Submission Open

Keywords: ROS; oxidative stress; metabolic stress; DNA damage repair; genomic instability; cancer

(This special issue belongs to the Section Cancer Pathophysiology)

Gut Microbiota and Inflammation in Colorectal Tumor Development and Progression

edited by

Giovanni Monteleone

and Irene Marafini

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1745 | Submission Open

Keywords: gut microbiota; colorectal cancer; inflammation; tumor microenvironment; mucosal immunity; microbial metabolites; immune–microbiota interactions; inflammatory bowel disease; cancer progression

Clinical and Surgical Outcomes in the Management of Extremity Soft Tissue Sarcomas (2nd Edition)

edited by

Matthew T. Houdek

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1742 | Submission Open

Keywords: soft tissue sarcoma; outcome; limb salvage; radiotherapy; surgery

(This special issue belongs to the Section Cancer Therapy)

Imaging and Liquid Biopsy Biomarkers for Cancer Diagnosis and Treatment (2nd Edition)

edited by

Mark Jesus M. Magbanua

and

Wen Li

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1733 | Submission Open

Keywords: cancer imaging; liquid biopsy; cancer diagnosis; treatment response; prognosis; metastasis; circulating tumor cells; disseminated tumor cells; circulating tumor DNA; circulating tumor RNA

(This special issue belongs to the Section Methods and Technologies Development)

Lung Cancer—Molecular Insights and Targeted Therapies (Third Edition)

edited by

Sonia Molina-Pinelo

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1714 | Submission Open

Keywords: lung cancer; non-small-cell lung cancer; small-cell lung cancer; biomarkers; oncogene-drive tumors; molecular mechanisms; targeted therapies; immunotherapy; precision medicine; preclinical models

(This special issue belongs to the Section Molecular Cancer Biology)

Artificial Intelligence (AI), Robotics, and Cancer Surgery

edited by Zaid M. Abdelsattar

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1713 | Submission Open

Keywords: cancer surgery; artificial intelligence; robotics surgery; surgical outcome; decision-making

(This special issue belongs to the Section Methods and Technologies Development)

Cancer Immunotherapy-Related Adverse Events and Therapy-Related Accelerated Aging

edited by

Grace Lu-Yao

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1663 | Submission Open

Keywords: immune-related adverse events (irAEs); accelerated aging; immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Biomarkers in the Management of Gynecological Cancer

edited by Ferenc Bánhidy,

Keszthelyi Márton

and Balázs Lintner

submission deadline 30 Sep 2026 | 3 articles | Viewed by 1656 | Submission Open

Keywords: gynecologic cancer; biomarkers; cervical cancer; endometrial cancer; ovarian cancer; vulvar cancer; diagnostic biomarkers; prognostic biomarkers; predictive biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

Decoding and Remodeling the Suppressive Tumor Immune Microenvironment in Head and Neck Cancer

edited by Andrew G. Sikora and Jennifer L. Anderson

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1586 | Submission Open

Keywords: tumor immune microenvironment (TIME); cancer-mediated immunosuppression; myeloid cells; regulatory T cells; cytokines; anti-tumor immunity; immune modulation

(This special issue belongs to the Section Tumor Microenvironment)

Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy, and Beyond in Peritoneal Disease: Advancing Clinical Care and Therapeutics

edited by

Benjamin D. Powers

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1470 | Submission Open

Keywords: peritoneal surface malignancies; peritoneal carcinomatosis; colorectal cancer; appendiceal cancer; pseudomyxoma peritonei; ovarian cancer; mesothelioma; gastric cancer; small bowel cancer; cytoreductive surgery; HIPEC; PIPAC; photodynamic therapy; chemotherapy; chemoresistance; novel therapies; rare diseases

(This special issue belongs to the Section Cancer Therapy)

Breast Cancer Microenvironment: Molecular Mechanisms and Therapeutic Targeting

edited by Yi Fang

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1432 | Submission Open

Keywords: breast cancer; tumor microenvironment; biomarkers; therapeutic targeting; tumor-stromal interactions; precision oncology

(This special issue belongs to the Section Tumor Microenvironment)

The Molecular Mechanisms of DNA Replication and Repair

edited by Taru Muranen

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1288 | Submission Open

Keywords: DNA replication; DNA repair; double helix; drug resistance

(This special issue belongs to the Section Molecular Cancer Biology)

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