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Multimodal Artificial Intelligence/Machine Learning Applications in Malignant Tumors: Diagnosis, Prognosis, and Management

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Causes, Screening and Diagnosis".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 2792

Special Issue Editors


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Guest Editor
Department of Radioogy, Columbia University Medical Center, Alianza Building, 530 West 166th St, Radiology Research, 5th Floor, New York, NY 10032-3702, USA
Interests: artificial intelligence; medical imaging; cancer; cerebrovascular disease
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Guest Editor
Department of Otolaryngology, University Hospital, LMU Munich, 81377 Munich, Germany
Interests: machine learning; cancer imaging; radiomics; otorhinolaryngology; head and neck cancer

Special Issue Information

Dear Colleagues,

Artificial intelligence (AI) and machine learning (ML) models have shown promising results in the extraction of subtle imaging features that are beyond human perception from medical images, improving the detection of malignancies, risk stratification, and response assessments. The integration of multi-modal imaging data with clinical, molecular, and genomic information through AI/ML models further adds to the potential of precision oncology. However, the clinical translation of these technologies requires their rigorous validation, interpretability, and integration into complex healthcare workflows.

This Special Issue of Cancers highlights cutting-edge research on AI/ML applications across the continuum of cancer care, from automated detection and segmentation to outcome prediction and the optimization of therapy. We invite contributions addressing methodological advances, clinical implementation, multi-institutional validation, and ethical considerations, aiming to bridge the gap between technical innovation and real-world impact in oncologic imaging.

Dr. Sam Payabvash
Dr. Stefan Haider
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • machine learning
  • radiomics
  • cancer imaging
  • malignancy
  • survival

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Published Papers (1 paper)

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Review

21 pages, 1399 KB  
Review
Artificial Intelligence in Oncology: A 10-Year ClinicalTrials.gov-Based Analysis Across the Cancer Control Continuum
by Himanshi Verma, Shilpi Mistry, Krishna Vamsi Jayam, Pratibha Shrestha, Lauren Adkins, Muxuan Liang, Aline Fares, Ali Zarrinpar, Dejana Braithwaite and Shama D. Karanth
Cancers 2025, 17(21), 3537; https://doi.org/10.3390/cancers17213537 - 1 Nov 2025
Cited by 1 | Viewed by 2405
Abstract
Background/Objectives: Artificial Intelligence (AI) is rapidly advancing in medicine, facilitating personalized care by leveraging complex clinical data, imaging, and patient monitoring. This study characterizes current practices in AI use within oncology clinical trials by analyzing completed U.S. trials within the Cancer Control Continuum [...] Read more.
Background/Objectives: Artificial Intelligence (AI) is rapidly advancing in medicine, facilitating personalized care by leveraging complex clinical data, imaging, and patient monitoring. This study characterizes current practices in AI use within oncology clinical trials by analyzing completed U.S. trials within the Cancer Control Continuum (CCC), a framework that spans the stages of cancer etiology, prevention, detection, diagnosis, treatment, and survivorship. Methods: This cross-sectional study analyzed U.S.-based oncology trials registered on ClinicalTrials.gov between January 2015 and April 2025. Using AI-related MeSH terms, we identified trials addressing stages of the CCC. Results: Fifty completed oncology trials involving AI were identified; 66% were interventional and 34% observational. Machine Learning was the most common AI application, though specific algorithm details were often lacking. Other AI domains included Natural Language Processing, Computer Vision, and Integrated Systems. Most trials were single-center with limited participant enrollment. Few published results or reported outcomes, indicating notable reporting gaps. Conclusions: This analysis of ClinicalTrials.gov reveals a dynamic and innovative landscape of AI applications transforming oncology care, from cutting-edge Machine Learning models enhancing early cancer detection to intelligent chatbots supporting treatment adherence and personalized survivorship interventions. These trials highlight AI’s growing role in improving outcomes across the CCC in advancing personalized cancer care. Standardized reporting and enhanced data sharing will be important for facilitating the broader application of trial findings, accelerating the development and clinical integration of reliable AI tools to advance cancer care. Full article
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