Cancer Immunotherapy-Related Adverse Events and Therapy-Related Accelerated Aging
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 1
Special Issue Editor
Interests: cancer surveillance, screening, and treatment for prostate cancer; outcomes research and cancer epidemiology; host factors and immunotherapy outcomes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
As immunotherapy continues to revolutionize cancer treatment, understanding the risks and consequences associated with immune-related adverse events (irAEs) has become increasingly urgent. This Special Issue invites original research, reviews, and commentaries focused on the intersection of patient and tumor characteristics, patterns of irAE development, and emerging long-term complications—including accelerated aging—among individuals treated with immunotherapeutic agents.
We are particularly interested in studies that address the following:
- Host and tumor determinants of irAE risk, including immune profiles, genetic predisposition, comorbidities, and tumor microenvironmental factors;
- Timing and patterns of irAEs, including early vs. delayed onset, chronic toxicities, and their implications for treatment outcomes;
- Organ-specific and multisystemic complications, including severity grading, reversibility, and impact on survival or treatment discontinuation;
- Mechanisms and manifestations of accelerated aging in immunotherapy recipients, such as frailty, neurocognitive changes, or cardiovascular decline;
- Predictive biomarkers and clinical algorithms for risk stratification and the early detection of irAEs;
- Intervention strategies, both prophylactic and therapeutic, aimed at mitigating irAEs while preserving anti-tumor efficacy;
- Real-world data and survivorship outcomes that inform long-term monitoring and management frameworks.
Through this issue, we aim to deepen the collective understanding of irAE biology and improve patient-centered immunotherapy delivery. Submissions from multidisciplinary teams—including oncology, immunology, geriatrics, and survivorship research—are highly encouraged.
Prof. Dr. Grace Lu-Yao
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- immune-related adverse events (irAEs)
- accelerated aging
- immunotherapy
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