Biomarkers for Therapy Response in Gastrointestinal Malignancies: Predicting Outcomes and Personalizing Care
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Biomarkers".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 1
Special Issue Editor
Interests: drug development; hepatocellular cancer; pancreatic cancer; colorectal cancer; precision oncology; oncolytic viral therapy; apoptosis; autophagy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The management of gastrointestinal (GI) malignancies is undergoing a remarkable transformation driven by advances in targeted therapy, immunotherapy, and precision oncology. Yet, despite these therapeutic innovations, the ability to accurately predict treatment response in GI cancers remains limited. Unlike certain tumor types where validated biomarkers guide therapy selection, most GI malignancies lack robust, clinically actionable biomarkers to inform therapeutic decision-making across both targeted agents and immunotherapy platforms.
To address this critical gap, I am honored to serve as Guest Editor for a special edition titled “Biomarkers for Therapy Response in Gastrointestinal Malignancies: Predicting Outcomes and Personalizing Care”. This issue aims to showcase emerging science and translational research dedicated to identifying, validating, and clinically implementing predictive biomarkers that can optimize treatment selection, forecast resistance, and enhance patient outcomes in colorectal, gastric, hepatobiliary, pancreatic, and esophageal cancers.
We welcome original research, comprehensive reviews, and translational studies that
- Investigate molecular, genomic, proteomic, and immune-based biomarkers in GI cancers;
- Examine resistance mechanisms and their implications for biomarker development;
- Explore early-phase biomarker-driven trial designs in GI malignancies;
- Present real-world data on biomarker integration into clinical practice.
Through this issue, we seek to foster a deeper scientific dialog and accelerate progress toward personalized oncology care for patients with GI malignancies.
I warmly invite you to contribute your work to this focused edition and join us in advancing the field.
Dr. Devalingam Mahalingam
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- immunotherapy
- biomarkers
- resistance mechanisms
- predictive markers
- clinical trials
- translational research
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