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Cancer and Melatonin: Updates on Current Findings

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: 30 September 2026 | Viewed by 1399

Special Issue Editor

Special Issue Information

Dear Colleagues,

Cancer is a disease that is continuously rising worldwide, thus constituting an important global health problem. Cancer patients are mainly treated with conventional protocols, including chemotherapy, radiotherapy, and surgery. However, these treatments are often associated with toxicity, incomplete tumor eradication, and various side effects. Due to these drawbacks, complementary and alternative therapies are attracting increasing interest in scientific research. Among these, melatonin emerged as a particularly promising strategy to enhance the efficacy of conventional anticancer therapies. Melatonin is an indoleamine secreted by the pineal gland and other organs. It is traditionally recognized for its role in regulating circadian rhythms and sleep; however, it has emerged as a multifunctional and pleiotropic molecule with antioxidant, anti-inflammatory, and immunomodulatory properties. To date, its antitumor activity is primarily preclinical and remains to be confirmed and amplified.

This Special Issue aims to provide a comprehensive overview of the current knowledge about the mechanism of action(s) of melatonin against cancer diseases and the impact of this complementary strategy. We welcome the submission of different article types to this collection, especially reviews and original research papers.

Prof. Dr. Rita Rezzani
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • melatonin
  • oxidative stress
  • inflammation
  • antioxidant defense

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Published Papers (1 paper)

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Review

15 pages, 957 KB  
Review
Glioblastoma and Melatonin’s Effects: A Narrative Review
by Gaia Favero, Francesca Sulas, Mauro Labanca, Francesco Scilla, Corrado Federico Punzi, Claudio Lonati and Rita Rezzani
Cancers 2026, 18(4), 703; https://doi.org/10.3390/cancers18040703 - 21 Feb 2026
Viewed by 1063
Abstract
Glioblastoma (GB) is an extremely aggressive, highly invasive brain tumor of astrocytic or oligodendrocyte glial origin. This tumor often infiltrates adjacent healthy brain tissue and can migrate significant distances from the primary tumor site. Given the poor overall survival of GB patients and [...] Read more.
Glioblastoma (GB) is an extremely aggressive, highly invasive brain tumor of astrocytic or oligodendrocyte glial origin. This tumor often infiltrates adjacent healthy brain tissue and can migrate significant distances from the primary tumor site. Given the poor overall survival of GB patients and the limited efficacy of current local and systemic treatments, new therapeutic strategies are needed to improve outcomes, reduce side effects, and enhance patients’ quality of life. In recent years, the potential chemotherapeutic effects of natural molecules have been investigated, either as primary agents or in combination with established chemotherapies in various types of cancer. Melatonin (MLT, N-acetyl-5-methoxytryptamine) is an endogenous indolamine primarily secreted by the pineal gland. MLT appears to discriminate between normal and tumoral cellular contexts and to modulate appropriate actions, thereby acting as a “smart killer” against cancer cells; however, further studies are needed to clarify this apparently paradoxical behavior. This review aims to summarize recent findings on the potential regulatory role of MLT in the modulation of key intracellular pathways in GB, underlining its potential role as a complementary adjuvant to conventional therapies. The clinical advantage of MLT in GB patients has not been demonstrated in randomized controlled trials; therefore, multicenter studies with well-defined objectives, appropriate dosage schedules, and clear patient classification are needed. Full article
(This article belongs to the Special Issue Cancer and Melatonin: Updates on Current Findings)
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