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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Robotic Surgery in Colorectal Cancer
edited by James Chi Yong Ngu
submission deadline 31 Dec 2025 | 3 articles | Viewed by 8591 | Submission Open
Keywords: robotic surgery; colorectal cancer; minimally invasive surgery; therapeutic endoscopy; laparoscopy
(This special issue belongs to the Section Clinical Research of Cancer)
Technological Development for Advances in Cancer Research and Precision Oncology
edited by , and Fenglong Ma
submission deadline 31 Dec 2025 | 4 articles | Viewed by 7960 | Submission Open
Keywords: bioengineering; bioinformatics; biosensor; extracellular vesicles; genome editing; machine learning; molecular profiling; nanoparticles; organoids; robotics
(This special issue belongs to the Section Molecular Cancer Biology)
Ovarian Cancer Biomarkers, Diagnostic, and Therapeutic Technologies 2nd Edition
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 7872 | Submission Open
Keywords: diagnostic; prognostic; theranostic; therapy; metastasis; biomarker; regression; chemoresistance; invasion
(This special issue belongs to the Section Cancer Biomarkers)
Feature Papers in Section "Tumor Microenvironment"
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 7608 | Submission Open
Keywords: tumor microenvironment; cancer progression; interactions; therapeutic targeting; immune response
(This special issue belongs to the Section Tumor Microenvironment)
Advances in Spine Oncology: Research and Clinical Studies
edited by Oluwaseun O. Akinduro
submission deadline 31 Dec 2025 | 6 articles | Viewed by 7514 | Submission Open
Keywords: metastatic spine cancer; targeted therapy; stereotactic body radiotherapy; proton radiotherapy; chordoma; chondrosarcoma; spondylectomy
(This special issue belongs to the Section Clinical Research of Cancer)
Physiotherapy in Advanced Cancer and Palliative Care
edited by Nele Adriaenssens
submission deadline 31 Dec 2025 | 3 articles | Viewed by 7492 | Submission Open
Keywords: advanced cancer; palliative care; palliative needs; physiotherapy; physical therapy modalities; quality of life; physical autonomy
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Long-Term Cancer Survivors: Rehabilitation and Quality of Life submission deadline 31 Dec 2025 | 7 articles | Viewed by 7310 | Submission Open
Keywords: long term; cancer survivors; quality of life; rehabilitation; physical activity; cognition; non-pharmacological therapies
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Medical Complications and Supportive Care in Patients with Cancer (2nd Edition) submission deadline 31 Dec 2025 | 7 articles | Viewed by 7260 | Submission Open
Keywords: cancer; oncological emergencies; immune-related adverse events; immunotherapy; supportive care; palliative care; infectious diseases; thromboembolic disease; treatment; toxicities; CAR-T cell therapy
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Ovarian Cancer Stem Cells and Tumor Microenvironment
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 6984 | Submission Open
Keywords: cancer stem cells; stem-like cells; tumor initiation; chemotherapy resistance; tumor relapse; tumor microenvironment; tumor immunology; stromal cells; cancer-associated fibroblasts
(This special issue belongs to the Section Tumor Microenvironment)
Overcoming Chemoresistance in Cancer: Identifying Biomarkers and Novel Targets submission deadline 31 Dec 2025 | 3 articles | Viewed by 6968 | Submission Open
Keywords: cancer treatment; chemoresistance; tumor microenvironment; cancer signaling pathways; targeted therapy; personalized anti-cancer therapies; biomarker; anti-cancer drug response prediction
(This special issue belongs to the Section Cancer Biomarkers)
Advancements in Preclinical Models for Solid Cancers
edited by and Paula Dobosz
submission deadline 31 Dec 2025 | 4 articles | Viewed by 6769 | Submission Open
Keywords: solid cancers; preclinical cancer models; in vitro cancer models; in vivo cancer models; translational cancer research; strengths and limitations of preclinical cancer models
(This special issue belongs to the Section Clinical Research of Cancer)
Advancements in Head and Neck Cancer Surgery submission deadline 31 Dec 2025 | 4 articles | Viewed by 6695 | Submission Open
Keywords: minimal invasive; transoral; robotic; reconstructive; 3D printing; targeting therapies; imaging
(This special issue belongs to the Section Clinical Research of Cancer)
Immunotherapy in Non-Small Cell Lung Cancers
edited by Marco Russano
submission deadline 31 Dec 2025 | 3 articles | Viewed by 6223 | Submission Open
Keywords: non-small cell lung cancer; immune checkpoint inhibitors; PD-1/PD-L1 blockade; immunotherapy; biomarkers
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Advances in Surgical Treatment of Urinary Tumors
edited by Pierre I. Karakiewicz and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5793 | Submission Open
Keywords: bladder cancer; prostate cancer; kidney cancer; quality of life; urologic oncology
(This special issue belongs to the Section Cancer Therapy)
Celebrating the 2024 Nobel Prize in Chemistry: Advancements in Artificial Intelligence and Machine Learning for Cancer Therapeutics submission deadline 31 Dec 2025 | 2 articles | Viewed by 5709 | Submission Open
Keywords: AI in cancer therapeutics; machine learning for drug discovery; protein structure prediction; personalized cancer treatment; clinical AI applications
(This special issue belongs to the Section Cancer Therapy)
Advances in Radiation Therapy for Head and Neck Cancer submission deadline 31 Dec 2025 | 4 articles | Viewed by 5615 | Submission Open
Keywords: adaptive radiotherapy  ; hyper- and hypo-fractionated radiotherapy  ; artificial intelligence in radiotherapy for head and neck cancer  ; quality assurance and set-up errors associated with IMRT; VMAT; IGRT; and SGRT techniques  ; protons and heavy ions for radiotherapy  ; re-irradiation  ; nanoparticles plus radiotherapy  ; hyperthermia plus radiotherapy  ; radiotherapy plus immunotherapy  ; the de-escalation of radiation therapy
(This special issue belongs to the Section Cancer Therapy)
The Advance of Biomarker-Driven Targeted Therapies in Cancer
edited by , Qiushi Wang and Ann Bode
submission deadline 31 Dec 2025 | 4 articles | Viewed by 5387 | Submission Open
Keywords: biomarkers; targeted therapies; precision medicine; cancer treatment; molecular profiling; personalized medicine; genomic alterations; therapeutic interventions; tumor microenvironment; immune therapy
(This special issue belongs to the Section Cancer Therapy)
Application of Artificial Intelligence-Based Approaches in Cancer Diagnosis, Treatment and Prognosis
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5385 | Submission Open
Keywords: cancer genomics; artificial intelligence; machine learning; deep learning; tumor microenvironment; graph-based convolutional neural network; computational cancer biology
(This special issue belongs to the Section Methods and Technologies Development)
Recent Advances in Non-muscle Invasive Bladder Cancer
edited by Paul L. Crispen
submission deadline 31 Dec 2025 | 3 articles | Viewed by 5321 | Submission Open
Keywords: non-muscle invasive bladder cancer; adjuvant therapy; surveillance; BCG refractory; intravesical therapy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Unravelling Cancer Mechanism and Developing Novel Therapeutics: An Urgent Need to Treat Cancer (2nd Edition) submission deadline 31 Dec 2025 | 4 articles | Viewed by 5258 | Submission Open
Keywords: cancer; anticancer therapy; combination therapy; natural compound; nanotherapy; exosome therapy; targeted therapy; immunotherapy; chemokines; cytokines; antibodies; drug resistance
(This special issue belongs to the Section Cancer Therapy)
Artificial Intelligence-Assisted Radiomics in Cancer
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5257 | Submission Open
Keywords: radiomics; learning tools; data normalization; segmentation; artificial intelligence; quantitative imaging; multi-dimensional feature analysis; statistical models; precision medicine
(This special issue belongs to the Section Methods and Technologies Development)
Enhancing Cancer Treatments through Fluorescence-Guided Surgery
edited by Ibrahim Khot and Yazan Sulaiman Khaled
submission deadline 31 Dec 2025 | 3 articles | Viewed by 5157 | Submission Open
Keywords: fluorescence-guided resection; fluorescent imaging; cancer surgery; tumour targeting; intraoperative staging; oncological fluorescence; precision medicine
(This special issue belongs to the Section Methods and Technologies Development)
Clear Cell Renal Cell Carcinoma 2024–2025 submission deadline 31 Dec 2025 | 2 articles | Viewed by 4797 | Submission Open
Keywords: clear cell renal cell carcinoma; pathology; diagnosis; hypoxia; intratumor heterogeneity; immune checkpoint blockage antiangiogenic therapy
(This special issue belongs to the Section Cancer Pathophysiology)
Radiomics in Cancer
edited by Isabelle M. Germano
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4777 | Submission Open
Keywords: radiomic; medical imaging; personalized treatment; diagnosis; staging; management; targeted treatment; patient outcome; clinical practice; cancer therapies; patient care
(This special issue belongs to the Section Cancer Therapy)
Surgical Treatment of Hepatocellular Carcinoma
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4575 | Submission Open
Keywords: surgical techniques; surgical indications; surgical outcomes; clinical trials; liver transplantation; adjuvant therapy; basic research
(This special issue belongs to the Section Clinical Research of Cancer)
Innovative Biomarkers and Imaging Techniques for the Early Detection and Risk Stratification of Urological Tumours
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4526 | Submission Open
Keywords: urological tumours; novel biomarkers; advanced imaging techniques; early detection; risk stratification; molecular diagnostics; multimodal data integration; personalized treatment
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
The Development and Application of Imaging Biomarkers in Cancer
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4441 | Submission Open
Keywords: imaging biomarkers; oncology; cancer imaging; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
Perspectives on the Efficacy and Biomarkers of Immunotherapy and Targeted Therapy for Patients with Colorectal Cancer submission deadline 31 Dec 2025 | 2 articles | Viewed by 4364 | Submission Open
Keywords: colorectal cancer; precision medicine; targeted therapeutics; immunotherapy; KRAS; BRAF; HER2; biomarkers
(This special issue belongs to the Section Cancer Therapy)
Natural Compounds in Cancers: 2nd Edition submission deadline 31 Dec 2025 | 1 articles | Viewed by 4319 | Submission Open
Keywords: nutrition; bioactive molecules; inflammation; natural extracts; nutraceuticals; immunotherapy; chemotherapy
(This special issue belongs to the Section Molecular Cancer Biology)
Hereditary and Familial Colorectal Cancer
edited by Bryson W. Katona and Peter P. Stanich
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4224 | Submission Open
Keywords: hereditary colorectal cancer; familial colorectal cancer; genetic predisposition; polyposis; Lynch syndrome; familial adenomatous polyposis (FAP); MUTYH-associated polyposis (MAP); genetic testing
(This special issue belongs to the Section Cancer Pathophysiology)
Advances in the Use of PET/CT and MRI in Prostate Cancer
edited by Carmelo Caldarella
submission deadline 31 Dec 2025 | 3 articles | Viewed by 4222 | Submission Open
Keywords: PET/CT; MRI; prostate cancer; radiomic; receptor-targeted radiopharmaceuticals
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Pancreatic Ductal Adenocarcinoma Diagnosis and Treatment 2nd Edition
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4195 | Submission Open
Keywords: pancreatic cancer; pancreatic ductal adenocarcinoma; genetic changes; genomics; surgical resection; radiotherapy; radiochemotherapy; chemotherapy; targeted therapy; immunotherapy; resectable tumor; borderline resectable tumor; metastatic disease; nutritional treatment; quality of life
(This special issue belongs to the Section Cancer Therapy)
Molecular Mechanisms in Bone and Soft Tissue Sarcomas
edited by and Zachary D.C. Burke
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4152 | Submission Open
Keywords: sarcoma; bone sarcoma; soft tissue sarcoma; osteosarcoma; molecular level; translation
(This special issue belongs to the Section Molecular Cancer Biology)
Precision Oncology for Rare Skin Cancers
edited by Gino K. In and Aparna Nallagangula
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4071 | Submission Open
Keywords: rare skin cancers; melanoma; cutaneous squamous cell carcinoma; basal cell carcinoma; Merkel cell carcinoma; sebaceous carcinoma; adnexal/sweat gland carcinoma; dermatofibrosarcoma protuberans; extramammary Paget’ s disease; cutaneous sarcomas
(This special issue belongs to the Section Molecular Cancer Biology)
Feature Papers in Section “Cancer Informatics and Big Data”
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3829 | Submission Open
Keywords: artificial intelligence; deep learning; next-generation sequencing; precision medicine and clinical decision-making; single-cell data analytics
(This special issue belongs to the Section Cancer Informatics and Big Data)
Advances in Breast and Gynecologic Cancer Pathology: Molecular Insights and Therapeutic Implications
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 3805 | Submission Open
Keywords: breast cancer; gynecologic malignancies; diagnostic pathology; molecular biomarkers; histopathology; cytopathology; prognostic markers; targeted therapy
(This special issue belongs to the Section Cancer Pathophysiology)
New Perspectives in the Management of Central Nervous System (CNS) Tumors
edited by , Francesco Bruno and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3606 | Submission Open
Keywords: gliomas; brain metastases; leptomeningeal metastases; liquid biopsy; neuroradiological tools; brain surgery; targeted therapy; immunotherapy; clinical trials; molecular factors
(This special issue belongs to the Section Cancer Therapy)
New Insights on Management of Acute Lymphoblastic Leukemia in the Contemporary Era
edited by Talha Badar
submission deadline 31 Dec 2025 | 1 articles | Viewed by 3582 | Submission Open
Keywords: B-cell ALL; T-cell ALL; MRD in ALL; Ph+ve ALL; CAR T-cells; NGS-MRD; menin inhibitors; blinatumomab; inotuzumab; ponatinib; BCR-ABL1; TKI
(This special issue belongs to the Section Cancer Therapy)
Sequence Variants in Breast/Ovarian Cancer Susceptibility Genes: From Risk Assessment to Clinical Management in Carrier Individuals and Their Blood Relatives
edited by Arcangela De Nicolo and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3488 | Submission Open
Keywords: breast/ovarian cancer susceptibility genes; risk assessment and clinical management of carrier individuals and their blood relatives; risk models; variant classification; multifactorial approaches
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Diagnostics and Prognostics in the Management of Intrathoracic Malignancies
edited by Akshay Jatin Patel and Marcus Taylor
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3271 | Submission Open
Keywords: intrathoracic malignancies; diagnostics; prognostics; molecular biomarkers; radiomics; artificial intelligence; immunobiological parameters; personalized therapy
(This special issue belongs to the Section Methods and Technologies Development)
AI-Based Applications in Cancers
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 3256 | Submission Open
Keywords: AI; machine learning; deep learning; Bayesian networks; causal learning; LLM; cancer
(This special issue belongs to the Section Cancer Informatics and Big Data)
Radiosurgery for Brain Tumors
edited by Anna Petoukhova
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3151 | Submission Open
Keywords: radiosurgery with photons and protons; stereotactic radiosurgery (SRS); brain tumors; gliomas; meningioma; pituitary adenoma; magnetic resonance imaging (MRI); magnetic resonance linac (MRL)
(This special issue belongs to the Section Cancer Therapy)
Pancreatic Cancer: Clinical Standards, Unmet Needs and Future Directions submission deadline 31 Dec 2025 | 2 articles | Viewed by 3101 | Submission Open
Keywords: standard clinical management; surgery; neoadjuvant and/or adjuvant treatment; cancer immunotherapy; targeted therapy; detection and elimination of MRD
(This special issue belongs to the Section Clinical Research of Cancer)
Novel Treatments for Ocular and Periocular Cancers
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 2873 | Submission Open
Keywords: ocular cancer; intraocular tumor; retinoblastoma; uveal melanoma
(This special issue belongs to the Section Cancer Therapy)
Feature Review for Cancer Therapy: 2nd Edition submission deadline 31 Dec 2025 | 2 articles | Viewed by 2797 | Submission Open
Keywords: cancer therapy; chemotherapy; targeted therapy; cancer co-treatment; biomarkers; natural compounds; drug-repurposing; nanomaterials
(This special issue belongs to the Section Cancer Therapy)
Chemotherapy and Immunotherapy of Lung Cancer
edited by and Klaus Hackner
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2768 | Submission Open
Keywords: immune checkpoint inhibitors; immunotherapy; lung cancer; programmed-death ligand; chemoimmunotherapy; non-small-cell lung cancer; small-cell lung cancer
(This special issue belongs to the Section Cancer Therapy)
Cancer Mechanosensing
edited by Meenal Datta and Xin Tang
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2717 | Submission Open
Keywords: cancer mechanosensing; mechanotransduction; mechanical cues; mechanosensitive ion channels; focal adhesions; cytoskeletal elements; tumor microenvironments; fluid shear stress; stiffness; cell compression; tumor progression; metastasis; drug resistance; immune response; biophysical tools
(This special issue belongs to the Section Cancer Pathophysiology)
Advances in Cancer Data and Statistics: 2nd Edition
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2533 | Submission Open
Keywords: cancer registries; cancer incidence; cancer survival; population-based studies; cancer risk factors
(This special issue belongs to the Section Cancer Informatics and Big Data)
Endometrial Cancer—from Diagnosis to Management
edited by Mingxin Shi and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2465 | Submission Open
Keywords: endometrial cancer; prognosis; diagnosis; novel biomarker; immunotherapy; targeted therapy; prevention
(This special issue belongs to the Section Cancer Therapy)
Palliative Care and Pain Management in Cancer
edited by María Fernández-Gonzáles and Moira O'Connor
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2453 | Submission Open
Keywords: pain; quality of life; palliative care; non-pharmacological; pharmacological; cancer; metastasis; advanced cancer
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
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