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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Mutagenesis and DNA Methylation in Aging
edited by Steven S. Smith
submission deadline 31 May 2026 | Viewed by 174 | Submission Open
Keywords: genome structure evolution; epigenetics; aging; tumorigenesis; endogenous mutagenisis; endogenous decay of methylation patterns
(This special issue belongs to the Section Molecular Cancer Biology)
Insulin Resistance, Diabetes, and Cancer: An Overview of the Pathogenetic Mechanisms submission deadline 31 May 2026 | Viewed by 173 | Submission Open
Keywords: insulin resistance; type 2 diabetes; hyperinsulinemia; IGF-1 signaling; tumor microenvironment; metabolic inflammation; adipokines; antidiabetic drugs; cancer metabolism; phytocompounds; bioactive molecules; hormone regulation; intracellular signalling pathways
(This special issue belongs to the Section Cancer Pathophysiology)
Infectious Agents and Oesophageal Cancer (2nd Edition)
edited by and Mohammed Rabiei
submission deadline 31 May 2026 | Viewed by 161 | Submission Open
Keywords: oesophageal cancer; human papillomavirus; infection; Barrett’ s oesophagus; cancer; oesophageal adenocarcinoma; oesophageal squamous cell carcinoma
(This special issue belongs to the Section Infectious Agents and Cancer)
Head and Neck Cancer: MRI and PET/CT Diagnosis and Surgical Treatment submission deadline 31 May 2026 | Viewed by 155 | Submission Open
Keywords: head and neck cancer; MRI; PET/CT; diagnostic imaging; surgical treatment; tumor staging; image-guided surgery; multidisciplinary approach; oncologic outcomes
(This special issue belongs to the Section Cancer Therapy)
Single-Cell and Spatial Data Analytics in Cancers
edited by and Qi Liu
submission deadline 31 May 2026 | Viewed by 150 | Submission Open
Keywords: single-cell and spatial omics; tumor heterogeneity; tumor progression; tumor microenvironment; cancer immunotherapy
(This special issue belongs to the Section Cancer Informatics and Big Data)
Image-Guided Radiotherapy in Head and Neck Cancer
edited by Petar Suton
submission deadline 31 May 2026 | Viewed by 145 | Submission Open
Keywords: image-guided radiotherapy (IGRT); head and neck cancer; radiation therapy; cone-beam CT (CBCT); adaptive radiotherapy
(This special issue belongs to the Section Cancer Therapy)
Clinical Imaging and Immunotherapy in Cancer Research
edited by
submission deadline 31 May 2026 | Viewed by 137 | Submission Open
Keywords: immunotherapy; immune checkpoint inhibitors; molecular imaging; tumor microenvironment; artificial intelligence (AI); radiomics
(This special issue belongs to the Section Clinical Research of Cancer)
Targeted Therapy in Gastrointestinal Cancer (2nd Edition)
edited by and
submission deadline 31 May 2026 | Viewed by 136 | Submission Open
Keywords: gastrointestinal cancer; tumor microenvironment; gut microbiome; molecular mechanism; cancer treatment; prognostic and predictive biomarker; therapeutic target; cancer prognosis; targeted therapy; targeted drug development
(This special issue belongs to the Section Cancer Therapy)
Role of Cytokines in Cancer (2nd Edition) submission deadline 31 May 2026 | Viewed by 131 | Submission Open
Keywords: inflammation; tumor microenvironment; cytokines
(This special issue belongs to the Section Tumor Microenvironment)
Reducing the Risk of Hepatitis B-Associated Chronic Liver Disease and Hepatocellular Carcinoma
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 126 | Submission Open
Keywords: HBsAg loss; prolonged nucleoside therapy; autoimmune diseases; gut dysbiosis; hepatitis delta coinfection; HIV coinfection; functional cure; immunomodulation; HBV integration; immune-mediated CLD; combination therapies
(This special issue belongs to the Section Clinical Research of Cancer)
Tumor Microenvironment in Ovarian Cancer Progression, Dissemination, Recurrence: Biology and Therapeutic Opportunities submission deadline 31 May 2026 | Viewed by 119 | Submission Open
Keywords: transperitoneal carcinomatosis; malignant ascites; chemoresistance; metabolic adaptations; regulation of immune response; tumor– stroma interaction; tumor– peritoneal interaction
(This special issue belongs to the Section Tumor Microenvironment)
Three-Dimensional In Vitro Modeling for the Study of Epithelial Cancers
edited by and George Wai Cheong Yip
submission deadline 31 May 2026 | Viewed by 117 | Submission Open
Keywords: 3D cancer model; 3D cancer stem cell culture; 3D tumor invasion model; cancer-on-a-chip; cancer spheroids; carcinogenesis organoid model; bioprinted cancer tissue; microfluidic platform for cancer; scaffold-based cancer model
(This special issue belongs to the Section Methods and Technologies Development)
The Pathogenesis and Treatment of Diffuse Midline Glioma submission deadline 31 May 2026 | Viewed by 93 | Submission Open
Keywords: pediatric brain tumors; diffuse midline glioma; high-grade glioma; H3K27M mutant glioma; liquid biopsy; diffuse intrinsic pontine glioma
(This special issue belongs to the Section Cancer Therapy)
The Advances in Proton Therapy in Head-and-Neck Cancers
edited by and Edward Christopher Dee
submission deadline 31 May 2026 | Viewed by 93 | Submission Open
Keywords: proton therapy; head-and-neck cancer; clinical outcomes; toxicity reduction; multinational studies; reirradiation; skull base tumors; salivary gland cancers; prospective and retrospective cohorts
(This special issue belongs to the Section Cancer Therapy)
Cellular Senescence, Aging and the Tumor Microenvironment in Cancer
edited by Jabed Iqbal and Jeremy Wee Kiat Ng
submission deadline 31 May 2026 | Viewed by 85 | Submission Open
Keywords: aging; senescence; immunosenescence; SASP; tumor microenvironment; immunotherapy
(This special issue belongs to the Section Tumor Microenvironment)
Noncoding RNA and Molecular Mechanisms of Metastasis in Gastrointestinal Cancers
edited by
submission deadline 31 May 2026 | Viewed by 80 | Submission Open
Keywords: noncoding RNA; gastrointestinal cancers; metastasis; molecular mechanisms; microRNA; long noncoding RNA; circular RNA; cancer biology; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Cancer Biology)
Innovative Approaches of Multimodal Imaging of Cancer Characteristics in Nuclear Medicine submission deadline 31 May 2026 | Viewed by 79 | Submission Open
Keywords: multimodal imaging; molecular imaging; PET; SPECT; MRI; CT; ultrasound; optical imaging; cancer
(This special issue belongs to the Section Methods and Technologies Development)
Innovations in Colorectal Cancer
edited by Sandy Hwang Fang
submission deadline 31 May 2026 | Viewed by 70 | Submission Open
Keywords: colon cancer; rectal cancer; innovation; clinical trials; total neoadjuvant therapy; medical oncology; radiation oncology
Advances in Primary and Secondary Bone and Soft Tissue Tumors
edited by
submission deadline 31 May 2026 | Viewed by 69 | Submission Open
Keywords: primary bone tumors; soft tissue sarcomas; metastatic bone disease; molecular diagnostics including liquid biopsy; surgical management including reconstruction; immunotherapy; tumor microenvironment; biomarkers and prognostic factors; cancer surveillance; translational oncology
The Evolving Role of CDK4/6 Inhibitors in Early and Recurrent Breast Cancer: Clinical and Translational Findings and Work in Progress
edited by Hans-Christian Kolberg
submission deadline 31 May 2026 | Viewed by 64 | Submission Open
Keywords: CDK4/6 inhibitors; breast cancer; treatment resistance; combination therapy; biomarkers
Clinical Treatment and Translational Advances in Myelodysplastic Syndromes and Acute Myeloid Leukemia submission deadline 31 May 2026 | Viewed by 64 | Submission Open
Keywords: myeloid neoplasms; myelodysplastic neoplasms; acute myeloid leukemia; leukemogenesis; target therapy
Role of Protein and Metabolite in Cancers
edited by
submission deadline 31 May 2026 | Viewed by 62 | Submission Open
Keywords: cancer progression; cancer cells; proteins; metabolites; signaling pathway; metabolic dysregulations
(This special issue belongs to the Section Tumor Microenvironment)
Multimodality Imaging for More Precise Radiotherapy (2nd Edition)
edited by Stefano Arcangeli, and
submission deadline 31 May 2026 | Viewed by 61 | Submission Open
Keywords: multimodality imaging; radiotherapy; stereotactic radiotherapy
(This special issue belongs to the Section Cancer Therapy)
Evolving Role of Surgery in Thoracic Oncology
edited by Inderpal S. Sarkaria and Shamus Carr
submission deadline 31 May 2026 | Viewed by 61 | Submission Open
Keywords: non-small cell lung cancer; esophageal cancer; thymic epithelial tumors; BAP1 malignant mesothelioma; robotic surgery; immunotherapy; cellular therapies; molecular imaging
Multiple Myeloma: From Molecular Insights to Clinical Treatments
edited by Mikala Gabor
submission deadline 31 May 2026 | Viewed by 61 | Submission Open
Keywords: multiple myeloma; novel therapy; bispecific; CelMod; CAR-T; CAR-NK; ADC; CD38; BCMA; GPRC5D; FcRH5; transplantation
Epigenetic Alterations in Human Tumors
edited by Mihalis I. Panayiotidis and
submission deadline 31 May 2026 | Viewed by 60 | Submission Open
Keywords: cancer; DNA methylation; post-translational histone modifications; miRNAs; genome reorganization; multi-omics; experimental/translational therapeutics
(This special issue belongs to the Section Molecular Cancer Biology)
Neuroimaging Biomarkers of Cancer Therapy-Related CNS Complications
edited by Jasmina Boban
submission deadline 31 May 2026 | Viewed by 59 | Submission Open
Keywords: neuroimaging; multimodal imaging; chemotherapy; immunotherapy; chemotherapy-related cognitive dysfunction; drug- related side effects and adverse reactions
Breast Cancer and Hormone-Related Therapy: 2nd Edition
edited by
submission deadline 31 May 2026 | Viewed by 57 | Submission Open
Keywords: breast cancer; estrogen receptor; hormone activated transcription factors; hormonal therapy; molecular mechanisms
(This special issue belongs to the Section Cancer Therapy)
Gynecological Cancers: Molecular Insights to Precision Therapy
edited by Gian Franco Zannoni and
submission deadline 31 May 2026 | Viewed by 57 | Submission Open
Keywords: gynecological cancers; precision medicine; molecular biomarkers; targeted therapy; tumor microenvironment; immunotherapy; translational oncology
Toxicities of Antineoplastic Therapies
edited by Ysabella Van Sebille, and
submission deadline 31 May 2026 | Viewed by 52 | Submission Open
Keywords: antineoplastic therpay; cancer treatment-related toxicities; cancer treatment adverse events; chemotherapy toxicity; targeted therapy toxicities; immunotherapy toxicity; hormonal therapy toxicity; radiation-induced toxicity; cellular and gene therapy toxicity; supportive cancer care; survivorship; patient-reported outcomes; toxicity management
(This special issue belongs to the Section Cancer Therapy)
Adjuvant Therapy and The Cytotoxic Effects in Colorectal Cancers
edited by William H. Gmeiner
submission deadline 31 May 2026 | Viewed by 52 | Submission Open
Keywords: colorectal cancer; adjuvant chemotherapy; targeted therapy; immunotherapy; metastatic colorectal cancer; drug resistance; combination therapy; cytotoxic effects
(This special issue belongs to the Section Cancer Therapy)
T-Cell Lymphoma: From Diagnosis to Treatment
edited by Lubomir Sokol and Yumeng Zhang
submission deadline 31 May 2026 | Viewed by 51 | Submission Open
Keywords: cutaneous T-cell lymphomas (CTCLs); peripheral T-cell lymphomas (PTCLs); Sezary syndrome (SS); mycosis fungoides (MF); genetic; epigenetic; therapeutic strategies
Flow Cytometry in Acute Leukemia: From Diagnosis to Disease Monitoring submission deadline 31 May 2026 | Viewed by 51 | Submission Open
Keywords: acute leukemia; ALL; AML; flow cytometry; NGF; leukemia stem cells (LSCs; minimal residual disease (MRD)
(This special issue belongs to the Section Methods and Technologies Development)
Machine Learning and Artificial Intelligence in Leukemia
edited by Garrett M. Dancik and
submission deadline 31 May 2026 | Viewed by 47 | Submission Open
Keywords: cancer genomics; genomic sequencing; biomarkers; predictive modeling; machine learning; artificial intelligence; leukemia; computer vision; natural language processing
(This special issue belongs to the Section Methods and Technologies Development)
Chemoradiotherapy for Non-Small Cell Lung Cancer
edited by Carlo Greco
submission deadline 31 May 2026 | Viewed by 45 | Submission Open
Keywords: NSCLC; concurrent chemoradiotherapy; immunotherapy consolidation; adaptive radiotherapy; functional imaging; radiomics; biomarkers; re-irradiation; toxicity mitigation; AI decision support
(This special issue belongs to the Section Cancer Therapy)
Updates on Progress in Stem-Cell Transplantation in Cancer Patients
edited by Nidhi Jyotsana
submission deadline 31 May 2026 | Viewed by 43 | Submission Open
Keywords: hematopoietic stem cell transplantation (HSCT); acute myeloid leukemia (AML); leukemic stem cells; optimize transplant protocols
(This special issue belongs to the Section Transplant Oncology)
The Intelligent Scalpel: AI and the Future of Cancer Surgery
edited by Abdallah S. Attia and Kristen E. Limbach
submission deadline 31 May 2026 | Viewed by 42 | Submission Open
Keywords: artificial intelligence; surgical oncology; radiomics; pathomics; robotic surgery; large language models; multimodal learning; explainable AI; precision surgery; ethical AI
(This special issue belongs to the Section Methods and Technologies Development)
What’s Behind the Scenes? New Insights in Endometrial Cancer Management and Risk Stratification (2nd Edition)
edited by
submission deadline 31 May 2026 | Viewed by 37 | Submission Open
Keywords: endometrial cancer; molecular classification; surgical staging; surgery; target therapy; gynecologic oncology; precision medicine; immunohistochemistry
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
The Role of Medical Imaging in Gynecological Cancer
edited by Emma R. Allanson and Ming Yin Lin
submission deadline 1 Jun 2026 | 6 articles | Viewed by 15599 | Submission Open
Keywords: cervical cancer; endometrial cancer; ovarian cancer; staging; ultrasound; MRI; PET-CT; radiotherapy; image-guided brachytherapy
(This special issue belongs to the Section Methods and Technologies Development)
Drug Repurposing and Reformulation for Cancer Treatment: 2nd Edition submission deadline 1 Jun 2026 | 2 articles | Viewed by 14743 | Submission Open
Keywords: drug repurposing; cancer; drug resistance; metastasis; drug delivery; liposomes; nanoparticles; bioavailability; drug targeting; reformulation
(This special issue belongs to the Section Cancer Drug Development)
New Developments in Breast Cancer Surgery, Risk, and Related Quality of Life
edited by Vesna Bjelic-Radisic, and Constanze Elfgen
submission deadline 1 Jun 2026 | 3 articles | Viewed by 6096 | Submission Open
Keywords: oncoplastic breast surgery; breast reconstruction; quality of life
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Proton Therapy of Cancer Treatment
edited by Minglei Kang, Benjamin Durkee and Kuo Men
submission deadline 1 Jun 2026 | 3 articles | Viewed by 4947 | Submission Open
Keywords: proton therapy; FLASH radiotherapy; upright; pediatric cancer; head and neck cancer; affordable proton solutions; adaptive radiation therapy; treatment planning optimization; proton system commissioning
(This special issue belongs to the Section Cancer Therapy)
Looking for New Biochemical Mechanisms in Cancer: The New Dawn in the Omics Sciences
edited by , Marco Bocchetti and
submission deadline 1 Jun 2026 | 1 articles | Viewed by 2776 | Submission Open
Keywords: multi-omics; machine learning; sequencing; signal transduction; molecular mechanisms; circulating biomarker; cancer
(This special issue belongs to the Section Molecular Cancer Biology)
Stereotactic Radiosurgery for Malignant Brain Tumors
edited by Stylianos Pikis, Jason P. Sheehan, and Georgios Mantziaris
submission deadline 1 Jun 2026 | Viewed by 396 | Submission Open
Keywords: radiosurgery; brain metastases; low-grade gliomas; high-grade gliomas; glioblastoma; malignant meningiomas
(This special issue belongs to the Section Clinical Research of Cancer)
Novel Developments in Invasive Lobular Breast Cancer: Diagnosis, Prognosis and Therapy (2nd Edition) submission deadline 1 Jun 2026 | Viewed by 210 | Submission Open
Keywords: invasive lobular carcinoma; imaging; diagnosis; pathology; tumor microenvironment; treatment; metastasis
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Gastrointestinal Tumors: Prevention, Screening and Predictive Analytics
edited by Mohamed I. Elsaid, and Vinod Rustgi
submission deadline 1 Jun 2026 | Viewed by 70 | Submission Open
Keywords: gastrointestinal and hepatobiliary cancers; prevention and screening; chemoprevention; risk stratification; biomarkers and liquid biopsy (ctDNA); imaging and radiomics; predictive analytics and machine learning; causal inference; population-based studies; implementation science and health equity
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Neurofibromatosis in Children, Adolescents, and Young Adults
edited by , and Russell Taylor Sundby
submission deadline 1 Jun 2026 | Viewed by 51 | Submission Open
Keywords: neurofibromatosis; schwannomatosis; natural history; clinical trials; targeted therapy; outcomes; psychosocial; biomarkers; pediatric
Advances in the Immunotherapy of Metastatic Cancer
edited by
submission deadline 5 Jun 2026 | Viewed by 98 | Submission Open
Keywords: metastatic cancer; immunotherapy; immune checkpoint inhibitors; CAR-T cells; tumor microenvironment; immune-related adverse events; biomarkers; combination therapy; resistance mechanisms
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
New Insights in Thymic Tumors
edited by Till Ploenes
submission deadline 5 Jun 2026 | Viewed by 95 | Submission Open
Keywords: thymic tumors; thymic carcinoma; thymomas; new daignostic and therapeutic approaches; myasthenia gravis
Research on New Drugs and Drug Targets in Melanoma: 2nd Edition submission deadline 5 Jun 2026 | Viewed by 50 | Submission Open
Keywords: melanoma; new drugs; drug targets; mechanism of action; substances with anti-melanoma potential
(This special issue belongs to the Section Cancer Drug Development)
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