Epilepsy Among Children and Adolescents

Dear Colleagues,

Epilepsy affects over 18 million children and adolescents worldwide, making it one of the most prevalent neurological disorders in pediatrics, with recent Global Burden of Disease data reporting 8.24 million cases of idiopathic epilepsy and 9.91 million secondary cases as of 2021.

The recent literature has produced transformative advances in the field: precision medicine via trio-based whole-exome sequencing identifying SLC2A1 variants linked to developmental epileptic encephalopathies (DEEs); next-generation antiseizure medications; neurostimulation methods such as responsive vagus nerve and deep brain stimulation; hundreds of novel epilepsy genes (e.g., SCN3A) boosting DEE diagnostic yields beyond 40%; and AI-driven tools achieving 93-97.5% accuracy in EEG interictal discharge detection, rs-fMRI lesion identification, and focal cortical dysplasia spotting up to 94%—all revolutionizing seizure prediction and personalized prognostication.

This landmark Special Issue offers a comprehensive, multidisciplinary exploration of pediatric epilepsy—from precision diagnostics and innovative therapies to comorbidities like neurodevelopmental delays and lifelong cognitive outcomes—empowering clinicians, researchers, and families to transform care paradigms.

We invite contributions of original research articles, rigorous systematic reviews and meta-analyses, pivotal clinical trials, illuminating case series, and innovative translational studies exploring disease mechanisms, cutting-edge interventions, real-world evidence, and patient-centered approaches in childhood epilepsy. High-impact submissions will drive global advancements and reach our influential readership of pediatric neurologists, epileptologists, neuroscientists, and policy-makers.

Dr. Emanuele Bartolini
Guest Editor

Manuscript Submission Information

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