Harnessing DNA Amplification for Biosensing: From Molecular Mechanisms to Diagnostic Platforms
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 102
Special Issue Editors
Interests: study of DNA repair and replication mechanisms in model systems with the aim of deepening knowledge of DNA metabolism and the effects of damage caused by carcinogenic agents; design of isothermal amplification systems based on the use of replicative enzymes with the aim of creating devices for the rapid diagnosis (point-of-care, POC) of infections caused by microorganisms
Interests: biochemical analysis of DNA repair and replication proteins to investigate DNA metabolism and the cellular effects of damage induced by carcinogenic agents; development of isothermal nucleic-acid-amplification systems based on replicative enzymes to create rapid diagnostic devices for point-of-care (POC) detection of microbial infections
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Special Issue Information
Dear Colleagues,
Infectious diseases represent a major threat to human health, with significant social and economic consequences. Current diagnostic methods often require several days to provide definitive results. Consequently, patients are treated empirically with broad-spectrum antibiotics, contributing to the emergence of antimicrobial resistance (AMR) and increasing the risk of opportunistic infections.
Nucleic acids have emerged as biomarkers for pathogen detection through DNA/RNA amplification technologies, such as PCR, which enable specific amplification of target sequences. Unfortunately, they require specialized equipment and personnel.
To address these limitations, several isothermal nucleic-acid-amplification methods have been developed. These techniques enable amplification at a constant temperature, reducing the need for sophisticated instrumentation.
We are pleased to invite you to contribute to this Special Issue dedicated to recent advances in molecular diagnostic technologies, with particular emphasis on innovative isothermal amplification strategies and other emerging rapid, sensitive and cost-effective approaches, to improve more effective surveillance of infectious diseases.
In this Special Issue, original research articles and reviews are welcome. Research areas may include the following:
- Isothermal amplification technologies
- Molecular diagnostics for infectious diseases
- Point-of-care diagnostic platforms
- Rapid pathogen detection methods
- Biochemical studies of DNA replication proteins in isothermal amplification
We look forward to receiving your contributions.
Dr. Mariarosaria De Falco
Dr. Mariarita De Felice
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- infectious diseases
- isothermal DNA/RNA amplification
- molecular biology–based diagnostic technologies
- point-of-care (POC) diagnostics
- rapid pathogen detection
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