Inflammasome and Inflammasome Inhibitors
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates".
Deadline for manuscript submissions: 8 January 2027 | Viewed by 122
Special Issue Editor
Interests: the mechanism of inflammasome activation and its regulation; the mechanism of gasdermin-mediated pyroptosis and its regulation; chemical compound screening and structure-based drug design for inflammasome/pyroptosis inhibitors or activators
Special Issue Information
Dear Colleagues,
Inflammasomes are cytosolic multiprotein signaling platforms that detect cellular stress and microbial components, driving caspase-1 activation, IL-1β and IL-18 maturation, and gasdermin D-mediated pyroptosis. They lie at the crossroads of innate immunity, metabolism, and tissue homeostasis, and dysregulated activity contributes to infectious, metabolic, neurodegenerative, autoinflammatory, and oncologic diseases. Inhibitors and modulators that affect sensing, oligomerization, ASC speck formation, caspase-1 activity, or gasdermin pore formation hold promise for treating inflammatory and infectious diseases while balancing host defense. This area sits at the frontier of structural biology, pharmacology, and clinical science, with the potential to transform diagnostics and therapeutics through precise, context-dependent inflammasome modulation.
This Special Issue aims to highlight the latest advances in the mechanistic understanding of inflammasome assembly and signaling, the discovery and characterization of inhibitors and modulators, and the translational potential of targeting inflammasomes for diagnostics and therapy. By integrating fundamental biology with preclinical and clinical perspectives, the issue aims to spur cross-disciplinary insights and accelerate therapeutic development.
Topics of interest include, but are not limited to:
- Molecular architecture and activation mechanisms of canonical and non-canonical inflammasomes;
- Regulatory checkpoints, post-translational modifications, and signaling cross-talk;
- Endogenous and pharmacological modulators, including inflammasome inhibitors and activators;
- Genetic and epigenetic regulation of inflammasome pathways;
- Methodologies: assays, imaging, and omics approaches to study inflammasomes.
We look forward to receiving your contributions.
Dr. Zhonghua Liu
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- inflammasomes
- pyroptosis
- innate immunity
- inflammasome modulators
- inhibitors
- inflammatory diseases
- drug discovery
- translational research
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
