Human ABC Transporters in Drug Disposition and Resistance: 50 Years of Progress and Future Perspectives
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 30
Special Issue Editor
Interests: ABC transporter; SNPs; drug resistance; disease; natural products
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In 1976, the first human ABC transporter, ABCB1 (P-glycoprotein/MDR1), was identified. Since then, a total of 49 human ABC transporter genes have been discovered, representing one of the largest and most diverse transporter families. ATP-binding cassette (ABC) transporters are critical for transporting various endogenous metabolites such as bile acids, sterols, lipids, and peptides, as well as exogenous molecules including antibiotics, toxins, and drugs. Their broad substrate specificity underlies essential physiological processes and also contributes to multidrug resistance in cancer and other diseases.
Following the success of the Human Genome Project, increasing attention has been paid to the impact of genetic variations, particularly single-nucleotide polymorphisms (SNPs), on the function of ABC transporters. These polymorphisms and their haplotypes have been shown to influence transporter activity, thereby affecting drug absorption, distribution, metabolism, and excretion, as well as therapeutic efficacy and disease susceptibility.
This Special Issue, entitled “Human ABC Transporters in Drug Disposition and Resistance: 50 Years of Progress and Future Perspectives”, aims to collect original research and reviews on the past achievements, current advances, and future directions in this field. The scope of this Special Issue includes structural and functional analyses, drug–transporter interactions, regulatory mechanisms, and pharmacogenetic studies of SNPs.
Dr. Hiroshi Nakagawa
Guest Editor
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Keywords
- ABC transporters
- drug disposition
- drug resistance
- pharmacokinetics
- pharmacodynamics
- pharmacogenetics
- single nucleotide polymorphisms (SNPs)
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