Protein Structure–Function and Proteomics in Health and Environment
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Bioinformatics and Systems Biology".
Deadline for manuscript submissions: 20 January 2027 | Viewed by 128
Special Issue Editors
Interests: protein/enzyme structure-function-stability; enzyme biotechnology; protein bioinformatics; biotechniques; protein chemical modification; extremophilic enzymes
Special Issues, Collections and Topics in MDPI journals
Interests: molecular biomarkers; proteomics; metabolomics; mass spectrometry; neurobiology
Special Issue Information
Dear Colleagues,
Proteins are central molecular determinants of cellular function, and their structure, stability, and dynamics govern biological outcomes in health and disease. Advances in proteomics, bioinformatics, and structural biology enable integrative analysis of protein structure–function relationships across physiological, pathological, stress-related contexts and the environment.
This Special Issue focuses on mechanistic insights into how protein/enzyme structure–function relationships are shaped by genetic variation, post-translational modifications, and environmental factors, and how these influences affect biological performance and disease mechanisms. We welcome studies examining the structural, biochemical, and proteomic consequences of mutations, altered stability, misfolding, aberrant interactions, dysregulated proteostasis, and changes in catalytic or regulatory mechanisms, particularly where environmental or physicochemical stressors such as oxidative conditions, chemical exposures, redox imbalance, pH, temperature, or metal ions modulate protein behaviour.
Topics of interest include structure–function prediction, mass spectrometry-based proteomics, protein interaction networks, enzyme mechanisms, redox-active proteins, protein aggregation and proteostasis, environmentally influenced modulation of catalytic activity, and molecular mechanisms underlying disorders where structural integrity and environmental context intersect. By integrating structural, proteomic, biochemical, biophysical, and computational/AI methodologies, this Special Issue aims to advance understanding of how intrinsic molecular properties and external influences converge to define protein function in biological systems and environments.
Dr. Khawar Sohail Siddiqui
Dr. Tharusha Jayasena
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- proteins
- proteomics
- mass spectrometry
- enzymes
- health and disease
- environment
- bioinformatics
- computational
- evolution
- artificial intelligence, ai
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