Pathogenesis, Diagnosis, and Treatment of Diabetic Kidney Disease
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 1 May 2026 | Viewed by 29
Special Issue Editor
Interests: advanced glycation end-products (AGEs); atherosclerosis; chronic kidney disease (CKD); diabetes; diabetic complications; diabetic kidney disease (DKD); renin angiotensin system
Special Issue Information
Dear Colleagues,
The pathogenesis of diabetic kidney disease (DKD) represents a Gordian knot-like cascade that extends far beyond simple glucose toxicity, making the seemingly logical solution of "eating less sugar" woefully inadequate for addressing this complex condition. While hyperglycemia serves as the initial trigger, DKD develops through intricate interconnected mechanisms that involve metabolic disruption, epigenetic memory, hemodynamic alterations, inflammatory cascades, and fibrotic processes that cannot be resolved through dietary sugar restriction alone.
The sobering truth is that despite our best therapeutic advances, DKD remains a formidable challenge that requires comprehensive management beyond glucose control. The global burden continues to escalate, with projections indicating nearly one billion deaths from diabetic nephropathy by 2050 if current trends persist.
Current therapeutic approaches must address multiple pathways simultaneously. This includes SGLT2 inhibitors for hemodynamic benefits, mineralocorticoid receptor antagonists for anti-inflammatory effects, and emerging therapies targeting fibrotic pathways. The combination of lifestyle modifications, multi-target pharmacotherapy, and early intervention offers the best hope for preventing progression to end-stage kidney disease.
This issue of Biomolecules will aim to focus on the following:
- The pathogenesis of DKD, including atypical onset.
- Highlighting the emergence of novel biomarkers for the early and specific detection of DKD.
- Research that suggests new or standardized treatment methods for diabetes.
Understanding these intricate mechanisms is essential for developing next-generation therapies that can truly halt or reverse this devastating complication of diabetes. We would like to invite you to submit your original research or well-balanced review articles to this important Special Issue.
We look forward to receiving your contributions.
Dr. Carlos Rosado
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- diabetic kidney disease
- pathogenesis
- novel biomarkers
- metabolic memory
- SGLT2 inhibitors
- fibrotic pathways
- epigenetic modification
- multi-target pharmacotherapy
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