Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Nutritional Immunity and Inflammation: Decoding Mechanisms for Therapeutic Advancement submission deadline 30 Sep 2026 | 1 articles | Viewed by 1088 | Submission Open
Keywords: nutritional deficiencies; antioxidants; minerals; vitamins; mucosal block; cross feeding; microbes; inflammation; tolerance
New Technologies and Translational Approach for an Early Diagnosis of Bipolar Spectrum and Hyperactive and Novelty Seeking Profiles
edited by , Serdar Dursun and
submission deadline 30 Sep 2026 | Viewed by 882 | Submission Open
Keywords: psychiatry; mental health; bipolar disorders; mood; biomarkers; new technology; BD
Spatial and Single-Cell Phosphoproteomics: Emerging Methods and Applications
edited by Cinzia Franchin
submission deadline 30 Sep 2026 | Viewed by 423 | Submission Open
Keywords: phosphoproteomics; single-cell phosphoproteomics; cell signalling; spatial phosphoproteomics; phosphopeptides
(This special issue belongs to the Section Molecular Biology)
Biomolecules and Material-Based Approaches in Biomedical Field—3rd Edition submission deadline 30 Sep 2026 | Viewed by 414 | Submission Open
Keywords: biomolecules roles in biological processes and pathologies; therapeutic molecules; biomarkers; biomolecules for disease diagnostics, and pharmaceutical development; cell signaling biomolecules; biomaterials for biomedical applications; self-assembled biomaterials; biofunctionalization of materials; new fabrication technologies (e.g., 3D printing); biosensors for disease diagnostics and/or prognosis; 3D scaffolds and hydrogels; 3D material-based tissue models; membrane bioreactors; bioartificial organs; materials for cell-/drug-delivery systems; in vitro material platforms for disease modeling/drug screening; materials for fabricating microfluidic systems
(This special issue belongs to the Section Molecular Medicine)
Role of Lipids in Cellular Metabolism and Communication
edited by
submission deadline 30 Sep 2026 | Viewed by 373 | Submission Open
Keywords: sphingolipids; phospholipids; eicosanoids; steroids; extracellular vesicles; cancer; diabetes; obesity; atherosclerosis
(This special issue belongs to the Section Lipids)
Molecular Circuits of Cell Fate Reprogramming and Plasticity
edited by
submission deadline 30 Sep 2026 | Viewed by 349 | Submission Open
Keywords: stem cell self-renewal and differentiation; pluripotency networks; cell fate reprogramming (dedifferentiation and trans-differentiation); cellular plasticity; transcriptional, post-transcriptional, and epigenetic regulation; chemical reprogramming; regenerative medicine; technologies for cell fate reprogramming; model organisms; disease models
(This special issue belongs to the Section Cellular Biochemistry)
Choline and Its Supplementation in Human Health and Disease
edited by and Enea Traini
submission deadline 30 Sep 2026 | Viewed by 342 | Submission Open
Keywords: choline; transporters; deficiencies; supplementations
(This special issue belongs to the Section Molecular Medicine)
Molecular Mechanisms and Novel Targets in Peripheral Neurotoxicity
edited by , and Federico Iseppon
submission deadline 30 Sep 2026 | Viewed by 341 | Submission Open
Keywords: peripheral neuropathies; peripheral neurotoxicity; ion channels; axonal damage; chemotherapy-induced peripheral neurotoxicity; pain; neuropathic pain
(This special issue belongs to the Section Molecular Biology)
Advances in Targeted At-211 Alpha Therapy
edited by Hsiaoju Sharon Lee and Yawen Li
submission deadline 30 Sep 2026 | Viewed by 339 | Submission Open
Keywords: Astatine-211; astatination; targeted alpha therapy; alpha radioimmunotherapy; radiotheranostics; radiopharmaceuticals
(This special issue belongs to the Section Chemical Biology)
Interleukin-11 Signalling in Cross-Tissue Diseases: Mechanisms, Pathophysiological Roles, and Therapeutic Targeting
edited by and Mark Sweeney
submission deadline 30 Sep 2026 | Viewed by 314 | Submission Open
Keywords: Interleukin-11; pathology; fibrosis; inflammation; therapeutics
(This special issue belongs to the Section Molecular Biomarkers)
Molecular Advances in Mechanism and Regulation of Lifespan and Aging: 2nd Edition
edited by Mark McCormick
submission deadline 30 Sep 2026 | Viewed by 298 | Submission Open
Keywords: aging; lifespan; healthspan
(This special issue belongs to the Section Biological Factors)
Microbial Metabolites as Key Mediators of Host Health submission deadline 30 Sep 2026 | Viewed by 264 | Submission Open
Keywords: microbiota; metabolites; short-chain fatty acids; amino acids; vitamins; secondary bile acids
(This special issue belongs to the Section Natural and Bio-derived Molecules)
The Impact of Blood Pressure on Neurological Outcomes
edited by Phillip J. Tully
submission deadline 30 Sep 2026 | Viewed by 232 | Submission Open
Keywords: neurological disorders; neurodegenerative disorders; brain imaging; dementia; hypertension; blood pressure; cerebral blood flow
(This special issue belongs to the Section Molecular Medicine)
Melatonin in Normal Physiology and Disease, 3rd Edition
edited by
submission deadline 30 Sep 2026 | Viewed by 227 | Submission Open
Keywords: circadian rhythms; immunity; skin; reproduction; aging; viral and bacterial infection; inflammation; mesenchymal stem cells; cancer; neurodegenerative diseases; osteoporosis
(This special issue belongs to the Section Molecular Biology)
Non-Natural Nucleotides: From Chemistry to Biochemistry to Cancer Pharmacology
edited by
submission deadline 30 Sep 2026 | Viewed by 227 | Submission Open
Keywords: nucleoside analogs; nucleic acid metabolism; DNA replication; mRNA vaccines; energy transfer; cell signaling; therapeutic agents
(This special issue belongs to the Section Chemical Biology)
Peroxisomes at the Crossroads of Cell Biology, Physiology, and Disease
edited by , Xin (Daniel) Gao and Maximiliano Presa
submission deadline 30 Sep 2026 | Viewed by 201 | Submission Open
Keywords: peroxisomes; basic research; mechanisms of disease; animal models; gene therapy; targeted therapies; clinical biomarkers
(This special issue belongs to the Section Enzymology)
Molecular Mechanisms and Functional Roles of Integral Membrane Proteins in Health and Disease
edited by
submission deadline 30 Sep 2026 | Viewed by 185 | Submission Open
Keywords: membrane proteins; molecular mechanisms; structural biology; post-translational modifications; protein interactions; biophysics
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
DNA Damage Response and Repair in Ovarian Cancer submission deadline 30 Sep 2026 | Viewed by 180 | Submission Open
Keywords: DNA damage response; DNA repair; ovarian cancer; PARP inhibitors
(This special issue belongs to the Section Cellular Biochemistry)
The Regulatory Mechanisms of Natural Bioactive Molecules on Metabolism and Immunity
edited by
submission deadline 10 Oct 2026 | 1 articles | Viewed by 2305 | Submission Open
Keywords: natural bioactive molecules; metabolic regulation; immune modulation; inflammation and immunity; immunometabolism
(This special issue belongs to the Section Biological Factors)
Cellular Signaling and Cardiovascular Diseases: From NF-κB to Golgi Dynamics
edited by
submission deadline 15 Oct 2026 | 1 articles | Viewed by 2522 | Submission Open
Keywords: cardiovascular diseases; NF-κB signaling; vascular cells; epigenetic regulation; vascular inflammation; intercellular crosstalk; Golgi dynamics
(This special issue belongs to the Section Cellular Biochemistry)
Advanced Analytical Techniques in Forensic and Clinical Biomarker Discovery submission deadline 15 Oct 2026 | Viewed by 283 | Submission Open
Keywords: post-mortem toxicology; clinical chemistry; forensic biomarkers; metabolomics; advanced detection techniques
(This special issue belongs to the Section Molecular Biomarkers)
Extracellular Vesicles as Signaling Hubs: From Lipid Biomarkers to Cellular Communication
edited by
submission deadline 15 Oct 2026 | Viewed by 257 | Submission Open
Keywords: extracellular vesicles; bioactive lipids; cellular communication; lipid rafts; signal transduction; pathophysiology
(This special issue belongs to the Section Cellular Biochemistry)
Metabolic Dysfunction and Mitochondrial Pathophysiology: From Mechanisms to Therapeutic Insights
edited by
submission deadline 15 Oct 2026 | Viewed by 204 | Submission Open
Keywords: mitochondrial dysfunction; mitochondrial respiration; mitophagy; Krebs cycle; oxidative stress
(This special issue belongs to the Section Molecular Medicine)
Alcohol-Related Nervous System Damage and Disease: From Mechanisms to Therapies submission deadline 16 Oct 2026 | 2 articles | Viewed by 2497 | Submission Open
Keywords: alcohol; brain; neurodegeneration; diagnostics; treatment; disease mechanisms; prevention; pathology; imaging; molecular and cellular studies; co-factor effects
(This special issue belongs to the Section Molecular Medicine)
Hyaluronic Acid and Proteoglycans: Basic and Biomedical Applications: 2nd Edition
edited by
submission deadline 20 Oct 2026 | 4 articles | Viewed by 6982 | Submission Open
Keywords: hyaluronic acid; proteoglycans; GAGs; extracellular matrix; hyaluronic acid and proteoglycans in disease; cancer; inflammation; angiogenesis; vascular homeostasis and damage; arthritis and arthrosis; glycobiology
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Recent Advances in the Role of Translation Machinery and Translational Control in the Cardiovascular System, 2nd Edition
edited by Peng Yao and
submission deadline 20 Oct 2026 | 1 articles | Viewed by 972 | Submission Open
Keywords: translational control; translation machinery; RNA-binding protein; non-coding RNA
(This special issue belongs to the Section Molecular Genetics)
Nutrition, Obesity and Metabolic Disorders: Molecular Bases, Biological Mechanisms, Related Diseases and Translational Research submission deadline 20 Oct 2026 | Viewed by 306 | Submission Open
Keywords: obesity; metabolic disorders; molecular bases; metabolomics; genomics; biological mechanisms; inflammation and oxidation; neuroimmunoendocrine modulation and aging; nutritional interventions; therapeutic strategies
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Novel Treatments of Stroke, 2nd Edition
edited by and Naseem Akhter
submission deadline 20 Oct 2026 | Viewed by 295 | Submission Open
Keywords: ischemic stroke; molecular mechanisms; neuroinflammation; signaling pathways; therapeutic approaches
(This special issue belongs to the Section Molecular Biology)
Molecular Regulation of Blood Biomarkers in Inflammation
edited by
submission deadline 20 Oct 2026 | Viewed by 258 | Submission Open
Keywords: inflammation; inflammatory diseases; blood; biomarker; molecular regulation
(This special issue belongs to the Section Molecular Biomarkers)
Molecular Mechanisms Regulating Cardiomyocyte Proliferation and Cell Cycle Re-Entry
edited by Jianyi Zhang, and Thanh Nguyen
submission deadline 20 Oct 2026 | Viewed by 207 | Submission Open
Keywords: cardiomyocyte proliferation; cardiomyocyte regeneration; cardiomyocyte dedifferentiation; cell-cycle; transcription factor; cardiac disease; epigenetic regulation; hiPSC-CMs; transcriptomics
(This special issue belongs to the Section Molecular Genetics)
Advances in Genetic and Epigenetic Gene Therapy for Diabetic Wound Healing
edited by
submission deadline 21 Oct 2026 | 1 articles | Viewed by 1396 | Submission Open
Keywords: chronic wounds; DFU; wound healing; diet; diabetes; obesity; nutrition; genomics; epigenetics; DNA methylation; histone modifications
(This special issue belongs to the Section Molecular Genetics)
The Function of Stromal Cells in Gastrointestinal (GI) Diseases
edited by Li Chang
submission deadline 23 Oct 2026 | Viewed by 236 | Submission Open
Keywords: gastrointestinal (GI) diseases; intestinal stromal cells; intestinal homeostasis; cytokine; extracellular matrix; tissue repair
(This special issue belongs to the Section Molecular Medicine)
Advances in Inflammatory Bowel Disease: From Molecular Mechanisms to Therapies
edited by Mariangela Allocca
submission deadline 24 Oct 2026 | 1 articles | Viewed by 1615 | Submission Open
Keywords: inflammatory bowel disease; Crohn's disease; ulcerative colitis; advanced therapies; treat-to-target; transmural healing; disease modification; personalized medicine
(This special issue belongs to the Section Molecular Medicine)
The Role of the Circadian Clock in Health and Disease
edited by Rajendram V. Rajnarayanan
submission deadline 24 Oct 2026 | 1 articles | Viewed by 993 | Submission Open
Keywords: circadian clock; chronobiology; clock genes; sleep; circadian misalignment; chronotherapy; metabolic disease; endocrine disruption; inflammation; neurodegeneration; biomarkers; multi-omics
(This special issue belongs to the Section Biological Factors)
Mechanism of Gene Modification Therapy for Cystic Fibrosis
edited by and Joerg Grosse-Onnebrink
submission deadline 28 Oct 2026 | Viewed by 221 | Submission Open
Keywords: cystic fibrosis; CFTR; gene modification therapy; mRNA therapy; gene editing; CRISPR/Cas; airway epithelium; ion transport; nanoparticle delivery; precision medicine
(This special issue belongs to the Section Molecular Genetics)
Mitochondrial Calcium Signaling in Cardiac Health and Disease
edited by Enrique Balderas
submission deadline 29 Oct 2026 | 1 articles | Viewed by 1973 | Submission Open
Keywords: mitochondrial Ca2+; OXPHOS; H+ gradient; ATP-synthesis; NAD(H) balance; Ca2+-overload; mitochondrial permeability; apoptosis; mtDNA; ROS production-clearance
(This special issue belongs to the Section Cellular Biochemistry)
Computational Pharmacology: Advances in Computational Modeling of Drug–Receptor Interactions and Pharmacokinetics
edited by and
submission deadline 30 Oct 2026 | 1 articles | Viewed by 1100 | Submission Open
Keywords: computational pharmacology; drug–receptor interactions; pharmacokinetics modeling; molecular dynamics simulations; molecular docking; QSAR analysis; ADME prediction; AI in drug design; machine learning for drug discovery; protein–ligand binding; bioactive peptide–protein interactions; drug–enzyme interactions; drug–nucleic acid interactions; protein–lipid interactions; peptoid-target interactions; therapeutic optimization; pharmacodynamic modeling
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Molecular Research on Sarcoma: From Pathogenesis to Molecular Targets
edited by
submission deadline 30 Oct 2026 | Viewed by 413 | Submission Open
Keywords: sarcoma; molecular pathogenesis; genetic alterations; biomarkers; molecular targets; signal transduction
Novel Molecular Targets for Beta Cell Regeneration and Diabetes Therapy
edited by
submission deadline 30 Oct 2026 | Viewed by 350 | Submission Open
Keywords: diabetes; pancreatic beta cells; regenerative therapy; molecular target
(This special issue belongs to the Section Molecular Medicine)
Serotonin Signaling in Cancer Development and Progression
edited by
submission deadline 30 Oct 2026 | Viewed by 222 | Submission Open
Keywords: serotonin; 5-HT; cancer; carcinogenesis; invasion; tumor microenvironment; serotonylation; mechanotransduction
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Molecular Mechanisms and Novel Therapeutic Approaches of Neurodegenerative Diseases
edited by
submission deadline 31 Oct 2026 | 7 articles | Viewed by 20417 | Submission Open
Keywords: neurodegenerative disease; therapeutic approaches; molecular mechanisms; RNA-based therapies; gene therapy; small-molecule inhibitors; immunotherapy
(This special issue belongs to the Section Biological Factors)
Molecular Advances in Drug Resistance and Novel Therapies for Cancer submission deadline 31 Oct 2026 | 6 articles | Viewed by 13724 | Submission Open
Keywords: cell signalling; cancer treatment; cancer metastasis; target validation; cancer and new molecules; cancer and cellular organelles
(This special issue belongs to the Section Biological Factors)
The Value of Natural Compounds as Therapeutic Agents: 3rd Edition submission deadline 31 Oct 2026 | 4 articles | Viewed by 5883 | Submission Open
Keywords: natural compound; acute and chronic conditions; cell proliferation; cell death; cell differentiation
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Updates on Molecular Mechanisms of Lysosomal Storage Disease submission deadline 31 Oct 2026 | 1 articles | Viewed by 4462 | Submission Open
Keywords: lysosomal storage disease (LSD); molecular mechanisms of LSD; genetic analyses; genotype–phenotype correlation in LSD; molecular biomarkers in LSD; gene therapy in LSD
(This special issue belongs to the Section Biological Factors)
The Immune Response to Severe Trauma
edited by and David N Naumann
submission deadline 31 Oct 2026 | 3 articles | Viewed by 3964 | Submission Open
Keywords: trauma-induced immune response; systemic inflammation; immune suppression; immune dysregulation; critical care
(This special issue belongs to the Section Molecular Medicine)
Pathophysiological Insights into Congenital Myasthenic Syndromes
edited by Xin-Ming Shen, Kinji Ohno and Duygu Selcen
submission deadline 31 Oct 2026 | 3 articles | Viewed by 3255 | Submission Open
Keywords: neuromuscular junction; neurotransmission; developmental biology; myasthenia; congenital myasthenic syndrome; human genetics; variant; mutation; animal model
(This special issue belongs to the Section Molecular Medicine)
Multifunctional Enzymes and Proteins: New Insights into Structure and Function submission deadline 31 Oct 2026 | Viewed by 2320 | Submission Open
Keywords: multifunctional enzymes; protein structure; protein function; catalytic activity; conformational dynamics; biochemistry; biophysics; drug discovery
(This special issue belongs to the Section Molecular Biology)
Obesity-Related Diseases: Molecular Basis and Therapeutic Approaches submission deadline 31 Oct 2026 | 1 articles | Viewed by 1919 | Submission Open
Keywords: obesity; causes; therapy; epigenetics; biomolecules
Prebiotics and Probiotics in Health and Disease: Precision Delivery and Microbiota-Informed Therapeutics submission deadline 31 Oct 2026 | 1 articles | Viewed by 1472 | Submission Open
Keywords: prebiotics; probiotics; postbiotics; drug delivery systems; nanocarriers; microbiota-targeted therapies; gut microbiota; precision biotics
(This special issue belongs to the Section Molecular Biology)
Recent Advances in the Enzymatic Synthesis of Bioactive Compounds—2nd Edition submission deadline 31 Oct 2026 | 1 articles | Viewed by 893 | Submission Open
Keywords: biocatalysis; biotransformation; enzyme-catalyzed reactions; whole-cell catalysis; green chemistry; enzymes; phenolic compounds; polyphenols; lipases; lipophilization; enzymatic synthesis; esterification; transesterification; green and sustainable chemistry approaches; lipid modification
(This special issue belongs to the Section Enzymology)
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