Molecular Mechanisms Regulating Cardiomyocyte Proliferation and Cell Cycle Re-Entry

Dear Colleagues,

Biomolecules invites submissions for a Special Issue dedicated to the molecular, cellular and translational mechanisms regulating cardiomyocyte proliferation and cell cycle re-entry. The goal is to showcase recent advances in understanding how cardiac muscle cells re-enter the cell cycle and contribute to heart regeneration, ultimately aiming to develop novel therapeutic strategies for cardiovascular disease. Cardiovascular disease remains the leading cause of morbidity and mortality globally, with myocardial infarction and heart failure posing significant public health challenges. A key obstacle in cardiac repair is the limited regenerative capacity of the adult mammalian heart. Unlike lower vertebrates and neonatal mammals, adult cardiomyocytes quickly exit the cell cycle after birth and become terminally differentiated, leading to permanent loss of functional myocardium after injury. Therefore, understanding the molecular mechanisms behind cardiomyocyte cell-cycle arrest and reactivation has become essential in regenerative medicine. This Special Issue seeks to provide a platform for researchers to present original research articles, reviews and perspectives that enhance our understanding of cardiomyocyte cell-cycle regulation and regenerative biology. Interdisciplinary studies linking molecular mechanisms with in vivo translational, preclinical and clinical applications are particularly encouraged. Submissions should explore both the fundamental and applied aspects of cardiomyocyte proliferation, focusing on opportunities and challenges in reactivating the cardiac cell cycle for therapeutic benefit. Innovative studies offering mechanistic insights, identifying new targets or proposing strategies for heart repair are welcome.

Dr. Jianyi Zhang
Dr. Yuji Nakada
Dr. Thanh Nguyen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.