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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Human Reproductive Biology: Uncertainties and Controversies, 2nd Edition

edited by

Giuseppe Benagiano

, Paola Bianchi and

Marwan Habiba

submission deadline 31 Jan 2027 | Viewed by 121 | Submission Open

Keywords: molecular reproduction; endometriosis; endometrium; implantation; decidualization; placenta; cellular senescence; prostaglandin; inflammation; pregnancy; reproduction; implantation; decidualization; endometriosis; assisted reproductive technology; molecular reproductive biology; reproductive biology; reproductive immunology; reproductive medicine; reproductive endocrinology; molecular regulation of reproductive processes; embryo development; reproductive biology; gametogenesis and fertilization

(This special issue belongs to the Section Molecular Reproduction)

Environmental Contaminants and Health: Biological Effects, Molecular Mechanisms, and Protective Strategies

edited by

Massimo Venditti

and

Gabriella Chieffi Baccari

submission deadline 31 Jan 2027 | Viewed by 106 | Submission Open

Keywords: environmental contaminants; environmental exposure; health effects; cellular responses; oxidative stress; inflammation; epigenetics; non-coding RNAs; biomarkers; protective strategies

(This special issue belongs to the Section Biological Factors)

Advances in Stem Cell Models and Cardiac Disease Research

edited by

Amit Manhas

and Nazish Sayed

submission deadline 31 Jan 2027 | Viewed by 99 | Submission Open

Keywords: induced pluripotent stem cells (iPSCs); cardiomyocytes; cardiovascular disease modeling; cardiac organoids; heart-on-chip; drug discovery and cardiotoxicity; cardiac tissue engineering; new alternative methodologies (NAMs)

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms and Novel Treatments of Atherosclerosis

edited by

Vikrant Rai

submission deadline 10 Feb 2027 | 2 articles | Viewed by 995 | Submission Open

Keywords: atherosclerosis; plaque; plaque vulnerability; inflammation; immunomodulation; immune cells; multi-omics; imaging; management and therapeutics; targeted therapies

(This special issue belongs to the Section Lipids)

Purinergic Signalling in Disease and Inflammation

edited by Andréia Machado Cardoso

submission deadline 10 Feb 2027 | Viewed by 215 | Submission Open

Keywords: purinergic signalling; inflammation; ATP and adenosine; P1 receptors; P2 receptors; ectonucleotidases; chronic diseases; neurodegeneration; exercise physiology; translational research

(This special issue belongs to the Section Molecular Biology)

Novel Signaling Pathways in Cardiometabolic Diseases

edited by

Wei Liu

submission deadline 14 Feb 2027 | Viewed by 283 | Submission Open

Keywords: metabolic disorder; hypertension; stroke; cardiovascular disease; molecular mechanisms; hypertrophy; fibrosis; lipotoxiocity; mitochondrial function; inflammation

(This special issue belongs to the Section Biological Factors)

Perspectives on Cancer Drug Resistance

edited by Vinagolu K. Rajasekhar and

Zhen Chen

submission deadline 15 Feb 2027 | Viewed by 37 | Submission Open

Keywords: cancer drug resistance; targeted therapy resistance; immunotherapy resistance; EGFR-TKI resistance; tumor microenvironment; epigenetic regulation; ion channels in cancer; metabolic reprogramming; combination therapy

(This special issue belongs to the Section Molecular Medicine)

Exploring the Pathophysiology of Epilepsy: Metabolic Mechanisms and Therapeutic Potential

edited by

Halina Baran

and Christoph Baumgartner

submission deadline 28 Feb 2027 | 5 articles | Viewed by 5913 | Submission Open

Keywords: epilepsy; metabolic regulation; signaling pathways; kynurenic acid; seizure detection; antiseizure drugs; innovative therapies

(This special issue belongs to the Section Molecular Medicine)

Wound Repair and Regeneration: From Molecular and Cellular Mechanisms to New Approaches

edited by Elia Ranzato

submission deadline 28 Feb 2027 | 4 articles | Viewed by 4487 | Submission Open

Keywords: wound repair; tissue regeneration; molecular mechanisms; cellular mechanisms; chronic wounds; fibrosis/scarring; biomaterials; stem cells; translational therapies

(This special issue belongs to the Section Molecular Medicine)

Biomarkers and Therapeutic Approaches in Melanoma: New Omics-Strategies

edited by

Italia Falcone

Fabio Valenti

and

Stefano Giuliani

submission deadline 28 Feb 2027 | 2 articles | Viewed by 3810 | Submission Open

Keywords: melanoma; biomarkers; omics; precision oncology; drug resistance

(This special issue belongs to the Section Molecular Biomarkers)

Exercise Immunology: Molecular Mechanisms and Health Applications

edited by

Dorota Kostrzewa-Nowak

Robert Nowak

, Michał Sławiński and

Patrizia Proia

submission deadline 28 Feb 2027 | 3 articles | Viewed by 3565 | Submission Open

Keywords: post-effort immune response; lifestyle-associated molecular patterns; damage-associated molecular patterns; immune cell; cell signaling; cell death; growth factor; chemokines; cytokines; transcription factors

(This special issue belongs to the Section Molecular Biology)

Exploration of Drug Targets for Liver Fibrosis Based on Hepatic Stellate Cells and Extracellular Matrix Remodeling

edited by

Nadezda Apostolova

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1792 | Submission Open

Keywords: liver fibrosis; collagen; hepatic stellate cells; senescence; animal models; extracellular matrix; hepatitis; cytokines; biomarkers; MASH; MASLD; cirrhosis; hepatocellular carcinoma

(This special issue belongs to the Section Molecular Medicine)

Membrane Clusters in Health and Neurodegenerative Disease

edited by Tayuan Chang and Catherine C. Y. Chang

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1512 | Submission Open

Keywords: membrane cluster; membrane lipids; membrane proteins; caveolin; lipid rafts; phospholipid; cholesterol; sphingolipids; cholesteryl esters

Emerging Roles of Non-Coding RNAs in Gene Regulation and Disease

edited by

Laura Maria De Plano

and

Simona Taverna

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1431 | Submission Open

Keywords: non-coding RNAs; gene expression regulation; miRNA-based therapeutics; translational RNA research

(This special issue belongs to the Section Molecular Biology)

New Discoveries in the Field of Neuropharmacology: 2nd Edition

edited by

Beatrice Mihaela Radu

and Bogdan Amuzescu

submission deadline 28 Feb 2027 | 3 articles | Viewed by 1310 | Submission Open

Keywords: neurologic and psychiatric diseases pharmacology; in silico drug screening; in vitro pharmacology assays; animal models; neuropharmacogenomics; drug safety; blood brain barrier; electrophysiology; patch-clamp

(This special issue belongs to the Section Molecular Medicine)

Advancing Innovations in Biomedical Research for Translational Applications: 2nd Edition

edited by Jianjie Ma and

Yuchen Chen

submission deadline 28 Feb 2027 | 3 articles | Viewed by 1232 | Submission Open

Keywords: nanoparticle drug delivery; precision medicine; stem cell; proteomic and lipidomic profiling; novel therapeutic strategies; regenerative medicine; biologic drug development; IND submission

(This special issue belongs to the Section Molecular Medicine)

Ion Channels and Transporters in Immune Function and Inflammatory Disease

edited by Liang Hong and Lu Zhang

submission deadline 28 Feb 2027 | 1 articles | Viewed by 978 | Submission Open

Keywords: ion channel; immune regulation; electrophysiology; inflammation

(This special issue belongs to the Section Molecular Medicine)

Nutrition, Metabolism, and Obesity: Novel Strategies and Molecular Mechanisms—Future Perspectives, 2nd Edition

edited by Marion Korach-André

submission deadline 28 Feb 2027 | 1 articles | Viewed by 916 | Submission Open

Keywords: diet; nutrients; obesity; inflammation; fat; glucose intolerance; insulin resistance; fatty liver disease; metabolic syndrome

(This special issue belongs to the Section Molecular Medicine)

Natural Products Beyond Boundaries: Multidirectional Perspectives on Discovery, Bioactivity, Nanotechnology, and Industrial Applications

edited by

Przemysław Sitarek

and

Tomasz Kowalczyk

submission deadline 28 Feb 2027 | 1 articles | Viewed by 817 | Submission Open

Keywords: natural products; phytochemicals; nanotechnology; bioactivity; industrial applications

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Metabolic and Signaling Networks in Therapy Resistance

edited by

Jun He

and Lei Zhao

submission deadline 28 Feb 2027 | 1 articles | Viewed by 792 | Submission Open

Keywords: therapeutic resistance; metabolic reprogramming; systems biology; signaling networks

(This special issue belongs to the Section Molecular Medicine)

Detection of Cell-Associated Biomolecules

edited by

David R. Kaplan

submission deadline 28 Feb 2027 | 1 articles | Viewed by 771 | Submission Open

Keywords: cell-associated biomolecules; detection technologies; subcellular localization; quantification; biomolecular complexes; signaling pathways; flow cytometry; single-cell analysis; imaging techniques

(This special issue belongs to the Section Molecular Biomarkers)

Extracellular Matrix Components and Glycobiology in Cancer: From Mechanisms to Therapeutic Targeting

edited by

Achilleas Theocharis

submission deadline 28 Feb 2027 | 1 articles | Viewed by 770 | Submission Open

Keywords: extracellular matrix; glycobiology; glycoconjugates; proteoglycans; tumor microenvironment

(This special issue belongs to the Section Molecular Medicine)

Advances in Cellular and Molecular Mechanisms in Immuno-Oncology and Onco-Hematology: 2nd Edition

edited by

Paolo Fagone

submission deadline 28 Feb 2027 | 1 articles | Viewed by 755 | Submission Open

Keywords: cancer immunotherapy; inhibitory immune checkpoints; CAR T cells; tumor immune evasion; cancer target therapy

(This special issue belongs to the Section Cellular Biochemistry)

Tracking Aging and Stress: Omics-Based Insights into Physiology and Pathology

edited by

Dominika Drulis-Fajdasz

submission deadline 28 Feb 2027 | 1 articles | Viewed by 721 | Submission Open

Keywords: genetic proteomic; lipidomic metabolomic; aging senescence; neurodegeneration; cellular stress

(This special issue belongs to the Section Biological Factors)

Molecular Motors in Muscle: From Single Molecules to Tissue Function

edited by

Pasquale Bianco

submission deadline 28 Feb 2027 | 1 articles | Viewed by 568 | Submission Open

Keywords: molecular motors; muscle mechanics; motor protein energetics; cytoskeletal dynamics; single-molecule biophysics

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Molecular Basis and Translational Research in Metabolic Myopathies: A Themed Issue in Honor of Professor Corrado Angelini, 2nd Edition

edited by

Marija Meznaric

Daniela Tavian

and

Sara Missaglia

submission deadline 28 Feb 2027 | Viewed by 547 | Submission Open

Keywords: metabolic myopathies; lipid metabolism; glycogen metabolism; genetic diseases; treatments; lipid storage myopathies; glycogen storage myopathies; lysosomal storage myopathies

(This special issue belongs to the Section Molecular Biology)

Protein Structure Prediction in Drug Discovery, 3rd Edition

edited by

Alessandro Paiardini

submission deadline 28 Feb 2027 | Viewed by 483 | Submission Open

Keywords: protein structure prediction; drug design; docking; virtual screening; drug discovery; machine learning; alphafold

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Design and Applications of 3D Bioprinting

edited by

Saman Naghieh

and

Chaozong Liu

submission deadline 28 Feb 2027 | Viewed by 361 | Submission Open

Keywords: 3D bioprinting; biofabrication; tissue engineering; regenerative medicine; smart biomaterials; scaffold design; organ models; personalized therapeutics; biomedical additive manufacturing; translational bioprinting

(This special issue belongs to the Section Bio-Engineered Materials)

Novel Insights into Epithelial Mesenchymal Transition (EMT) in Cancer

edited by

Shuya Yano

submission deadline 28 Feb 2027 | 1 articles | Viewed by 303 | Submission Open

Keywords: EMT; epithelial–mesenchymal plasticity; hybrid E/M states; single-cell; spatial transcriptomics/proteomics; multiplex IHC/IF; RNA in situ; CTCs; ctDNA; radiomics; computational pathology; immune evasion; therapy resistance; metastasis; biomarkers; reporting standards; reproducibility; clinical translation

(This special issue belongs to the Section Molecular Medicine)

White Matter Injury and Neurovascular Dysfunction in Neurological Disorders

edited by

Xuemei Zong

submission deadline 28 Feb 2027 | 1 articles | Viewed by 292 | Submission Open

Keywords: white matter injury, remyelination, neurovascular dysfunction; neurovascular unit; ischemic stroke; neurodegeneration; blood–brain barrier; cellular mechanisms; molecular pathways; vascular cognitive impairment; Alzheimer's disease

(This special issue belongs to the Section Molecular Medicine)

Nanomaterials and Their Applications in Biomedicine—2nd Edition

edited by

George Pasparakis

submission deadline 28 Feb 2027 | Viewed by 255 | Submission Open

Keywords: photothermal and photodynamic therapies and tumor ablation strategies; theranostics and image-guided drug delivery; biosensors, including surface-enhanced Raman scattering and metal-enhanced fluorescence; biosensors; point-of-care diagnostics and lateral-flow tests; controlled drug delivery, including delivery of RNA/DNA and other biologics; additive manufacturing and 3D/4D printing applications; antimicrobials; cell therapeutics and tissue regeneration

(This special issue belongs to the Section Bio-Engineered Materials)

Molecular Regulation of Biomaterials and Engineering for Skeletal and Cartilage Regeneration

edited by

Young Yul Kim

submission deadline 28 Feb 2027 | Viewed by 254 | Submission Open

Keywords: biomaterials; molecular regulation; skeletal regeneration; cartilage regeneration; cell–matrix interaction; osteogenesis and chondrogenesis; mechanotransduction; immunomodulation; translational regenerative medicine

(This special issue belongs to the Section Bio-Engineered Materials)

When Molecules Meet Light: Advances in Photodynamic Therapy and Imaging

edited by

Lucinda V. Reis

Eurico Lima

and

Paulo Jorge da Silva Almeida

submission deadline 28 Feb 2027 | Viewed by 139 | Submission Open

Keywords: molecules; light; photodynamic therapy; imaging

(This special issue belongs to the Section Molecular Medicine)

Cytogenetics, Molecular Diagnostics and Biomarkers in Hematologic Malignancies

edited by Changqing Xia and

Zhenya Tang

submission deadline 28 Feb 2027 | Viewed by 108 | Submission Open

Keywords: cytogenomics; cytogenetics; molecular biomarkers; leukemia; lymphoma; multiple myeloma; diagnosis; prognosis; targeted therapies; precision medicine

(This special issue belongs to the Section Molecular Biomarkers)

NFAT Transcription Factors in Immunity and Disease : A Themed Issue in Honor of Prof. Edgar Serfling

edited by

Khalid Muhammad

submission deadline 28 Feb 2027 | Viewed by 84 | Submission Open

Keywords: NFAT transcription factors; T-cell activation; immune regulation; transcriptional control; inflammation; cancer immunology; signal transduction; immunotherapy; calcineurin signaling; transplantation; transplant immunology; immunosuppression; targeted therapy

(This special issue belongs to the Section Cellular Biochemistry)

Chronic Heart Failure: From Molecular Mechanisms to Therapies Strategies: 2nd Edition

edited by

Josep Comín-Colet

and

Marta Tajes

submission deadline 28 Feb 2027 | Viewed by 55 | Submission Open

Keywords: chronic heart failure; pathophysiology; comorbidities; new therapies; molecular pathways

(This special issue belongs to the Section Molecular Medicine)

Iron Metabolism and the Biophysical Landscape of Cells

edited by

Jenifer Gomez Pastora

submission deadline 28 Feb 2027 | Viewed by 13 | Submission Open

Keywords: Fe metabolism; Fe regulation proteins; Fe quantification; Fe dysregulation; Fe transport; Fe recycling; Fe uptake; ferroptosis

(This special issue belongs to the Section Molecular Biology)

Emerging Bioactives from Underexplored Botanical Sources and By-Products for Food Applications

edited by Suelen Pereira Ruiz Herrig, Zilda Cristiani Gazim and Beatriz Cervejeira Bolanho Barros

submission deadline 1 Mar 2027 | Viewed by 338 | Submission Open

Keywords: botanical bioactives; by-products; natural food additives; green extraction

(This special issue belongs to the Section Natural and Bio-derived Molecules)

The Impact of Obesity, Ethnicity, and Genetic Susceptibility on Beta Cell Function

edited by Joseph Proietto

submission deadline 12 Mar 2027 | Viewed by 77 | Submission Open

Keywords: obesity-induced diabetes; beta cell function; diabetes complications; susceptibility; genetics

(This special issue belongs to the Section Biological Factors)

Molecular Mechanisms and Emerging Therapies for Diabetic Cardiomyopathy

edited by

Samuel Dudley

and

Gyeoung-Jin Kang

submission deadline 15 Mar 2027 | Viewed by 101 | Submission Open

Keywords: diabetic cardiomyopathy; diabetes-related cardiac dysfunction; cardiac remodeling; molecular mechanisms; emerging therapies; cardiometabolic disease

(This special issue belongs to the Section Molecular Medicine)

Dynamic Remodeling of the 3D Genome in Development and Diseases

edited by

Chunhui Hou

submission deadline 18 Mar 2027 | Viewed by 88 | Submission Open

Keywords: 3D genome organization; cell fate specification; disease pathogenesis; topologically associating domains (TADs); enhancer–promoter interactions; gene expression regulation

(This special issue belongs to the Section Molecular Reproduction)

Biomarkers in Musculoskeletal and Orthopedic Disorders

edited by

Elena De Vecchi

submission deadline 20 Mar 2027 | 2 articles | Viewed by 1847 | Submission Open

Keywords: musculo-skeletal pathologies; orthopaedic infections; synovial fluid analysis

(This special issue belongs to the Section Molecular Biomarkers)

Effects of Microvascular Dysfunction on Neurological and Cardiovascular Diseases

edited by Adjanie Patabendige and

Ruoli Chen

submission deadline 20 Mar 2027 | Viewed by 33 | Submission Open

Keywords: microvascular dysfunction; heart-brain axis; neurovascular interface; blood–brain barrier; stroke; dementia; small vessel disease; hypertension; atrial fibrillation; heart failure

(This special issue belongs to the Section Molecular Medicine)

Signal Transduction and Pathway Regulation in Cancer

edited by

Carmen Cristina Diaconu

submission deadline 25 Mar 2027 | 5 articles | Viewed by 4517 | Submission Open

Keywords: signal transduction; pathway modulation; targeted treatment strategies; cancer treatment; drug resistance; cancer diagnosis; cancer prognosis

(This special issue belongs to the Section Molecular Biology)

Computational Analysis and Conformational Modeling for Protein Structure and Interaction: Second Edition

edited by

Clement Agoni

and

Indrani Bera

submission deadline 26 Mar 2027 | 2 articles | Viewed by 1601 | Submission Open

Keywords: protein structure prediction; drug discovery targeting proteins; structural bioinformatics; molecular dynamics simulations; protein–protein interactions; protein–ligand binding; conformational dynamics; molecular docking studies

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Endocrine Regulation of Reproductive Tissues: From Molecular Mechanisms to Therapies

edited by

Waldemar Grzegorzewski

submission deadline 26 Mar 2027 | Viewed by 530 | Submission Open

Keywords: hormone signaling; reproductive physiology; steroid receptors; infertility; endocrine disruptors; epigenetic regulation; gonadal steroids; hormone-dependent cancers; therapeutic targeting; gametogenesis

(This special issue belongs to the Section Biological Factors)

Roles of Epigenetics in Plant Defense

edited by

Niraj Lodhi

and

Rakesh Srivastava

submission deadline 28 Mar 2027 | Viewed by 76 | Submission Open

Keywords: plant defense; epigenetics; epitranscriptomics; non-coding RNAs; chromatin remodeling; RNA modifications; plant–pathogen interactions; defense priming; CRISPR epigenome editing; genome wide; multi-omics; disease-resistant crops; artificial intelligence (AI); systemic acquired resistance (SAR); induced systemic resistance (ISR); pattern-triggered immunity (PTI); effector-triggered immunity (ETI)

(This special issue belongs to the Section Molecular Genetics)

Molecular Factors Involved in Healthy and Diseased States of Skeletal Muscle: Overview and Perspectives

edited by

Virginia Tancredi

Roberto Bonanni

and

Ida Cariati

submission deadline 30 Mar 2027 | 3 articles | Viewed by 4090 | Submission Open

Keywords: skeletal muscle; ageing; muscle physiology; muscle-multiorgan crosstalk; muscle health; muscle atrophy; molecular factors; sedentariness; exercise

(This special issue belongs to the Section Biological Factors)

Pathogenesis and Targeted Therapy of Neurodegenerative Diseases

edited by

Wioletta Rozpędek-Kamińska

submission deadline 31 Mar 2027 | 4 articles | Viewed by 10543 | Submission Open

Keywords: neurodegeneration; neurodegenerative diseases; targeted therapy; molecular mechanisms; disease-modifying treatments

(This special issue belongs to the Section Molecular Medicine)

Endocrine, Immune and Molecular Biomarkers in Pain and Psychosomatic Disorders: Bridging Mechanisms and Medical Application

edited by