New Discoveries in the Field of Neuropharmacology: 2nd Edition

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 28 February 2027 | Viewed by 294

Editors


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Guest Editor
Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania
Interests: blood brain barrier; drug safety; drug arrhythmogenic effects; neuropharmacology; epileptogenesis; depression
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania
Interests: biophysical and pharmacological properties of ion channels (particularly ENaC/Deg and TRP channels); mathematical modeling of complex biological systems; applied research in cardiac electrophysiology and cardiac safety drug testing; stem cells–diagnostic and therapeutic applications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This is an inspiring time in biomedical sciences, where new, dynamic methods are being developed and used to produce groundbreaking results in fundamental and applied research, including neuroscience and related fields, such as neuropharmacology. Every year, new promising drugs (new molecular entities) are approved and launched on the market, offering hope to numerous patients affected by severe and debilitating neurologic and psychiatric disorders. This outcome is the result of the systematic application of advanced and highly effective techniques along the different stages of drug R&D pipelines, starting with in silico methods, new in vitro assays, high-throughput screening approaches, animal models of disease, wide genome sequencing and gene expression techniques, powerful transfection vectors, gene editing, stem cells, and many other marvels of modern science. To reflect this extensive progress in neuropharmacology research, we are launching a Special Issue in the prestigious and highly dynamic Biomolecules journal. Therefore, as guest editors, we warmly invite you to contribute by submitting manuscripts containing some of your recent original research results or comprehensive review studies on this topic. We aim to expedite a fair evaluation in this open-access publication of selected papers, offering good scientific visibility.

Yours sincerely,

Dr. Beatrice Mihaela Radu
Dr. Bogdan Amuzescu
Guest Editors

Manuscript Submission Information

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Keywords

  • neurologic and psychiatric diseases pharmacology
  • in silico drug screening
  • in vitro pharmacology assays
  • animal models
  • neuropharmacogenomics
  • drug safety
  • blood brain barrier
  • electrophysiology
  • patch-clamp

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Published Papers (1 paper)

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Review

20 pages, 802 KB  
Review
Lithium as a Potential Neuroprotective Strategy in Glaucoma: Mechanisms and Therapeutic Perspectives
by Martucci Alessio, Napoleoni Giulia, Adornetto Annagrazia, Aiello Francesco, Mancino Raffaele, Cesareo Massimo, Bagetta Giacinto, Nucci Carlo, Enrico Romano and Russo Rossella
Biomolecules 2026, 16(7), 1062; https://doi.org/10.3390/biom16071062 - 20 Jul 2026
Viewed by 127
Abstract
Glaucoma is a major global health concern, identified as the foremost cause of irreversible blindness, affecting nearly 95 million individuals. It is characterized by the progressive degeneration of retinal ganglion cells (RGCs), leading to significant vision-related disabilities and an extensive socio-economic impact. The [...] Read more.
Glaucoma is a major global health concern, identified as the foremost cause of irreversible blindness, affecting nearly 95 million individuals. It is characterized by the progressive degeneration of retinal ganglion cells (RGCs), leading to significant vision-related disabilities and an extensive socio-economic impact. The concept that glaucoma should be viewed not solely as an ocular condition but also as a neurodegenerative disorder, sharing pathophysiological features with diseases like Alzheimer’s and Parkinson’s, is now widely accepted. This review examines the convergence of molecular mechanisms, including the roles of amyloid precursor proteins and neuroinflammation, that contribute to RGC loss. Notably, lithium, traditionally used as a mood stabilizer, has emerged as a potential neuroprotective agent for the treatment of Alzheimer’s disease. In light of the common neurodegenerative mechanisms linking glaucoma with central neurodegenerative diseases, here, we review the current evidence supporting lithium’s therapeutic potential in glaucoma, emphasizing the need for further clinical studies to determine its effectiveness in preserving optic nerve health and improving patient outcomes. Full article
(This article belongs to the Special Issue New Discoveries in the Field of Neuropharmacology: 2nd Edition)
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