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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Research Progress in Pediatric Oncology

edited by Emmanouel Hatzipantelis and

Maria Kourti

submission deadline 31 Dec 2026 | Viewed by 180 | Submission Open

Keywords: pediatric oncology; childhood cancer; targeted therapy; immunotherapy; precision medicine; supportive care; infection; survivorship; global health

(This special issue belongs to the Section Molecular Medicine)

Amyloid-Beta and Alzheimer’s Disease, 2nd Edition

edited by

Fumiaki Ito

submission deadline 31 Dec 2026 | Viewed by 171 | Submission Open

Keywords: Alzheimer's disease (AD) ; amyloid-beta (Aβ) ; neurotoxicity of Aβ ; Aβ phagocytosis ; Aβ clearance ; neuroinflammation in AD ; glial cells in AD ; tau protein ; anti-Aβ monoclonal antibodies; CAR-A therapy

(This special issue belongs to the Section Cellular Biochemistry)

Spinal Muscular Atrophy: From Genetics to Therapeutics

edited by Eduardo F. Tizzano and

Lucia Tabares

submission deadline 31 Dec 2026 | Viewed by 125 | Submission Open

Keywords: spinal muscular atrophy; motor neuron; survival motor neuron genes; genetic modifiers; disease-modifying therapies; multisystemic disease; synapsis; later-onset phenotypes

(This special issue belongs to the Section Molecular Medicine)

Advances in GPCRs: Structure, Dynamics, and Drug Discovery

edited by Jun Xu

submission deadline 31 Dec 2026 | Viewed by 74 | Submission Open

Keywords: GPCRs; conformational dynamics; biased signaling; allostery; chemical biology and nanobodies; computational chemistry; deorphanization; drug discovery

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Innovative Therapeutic Strategies for Chronic Diseases: From Small Molecule Inhibitors to Natural Products

edited by

Maria Teresa Borello

and David Hill

submission deadline 31 Dec 2026 | Viewed by 55 | Submission Open

Keywords: chronic diseases; natural products; bioactive compounds; small molecule inhibitors; drug discovery; medicinal chemistry; pharmacology; mechanism of action; target identification; preclinical evaluation; drug development; therapeutic strategies

(This special issue belongs to the Section Molecular Medicine)

Signaling Networks and Novel Biomarkers for Precision Cancer Medicine

edited by

Dirk Geerts

submission deadline 8 Jan 2027 | 1 articles | Viewed by 718 | Submission Open

Keywords: biomarkers; cancer signaling networks; ctDNA; ctRNA; extracellular vesicles; liquid biopsy; multi-omics; precision oncology; proteomics; TME; therapy resistance

(This special issue belongs to the Section Molecular Medicine)

Inflammasome and Inflammasome Inhibitors

edited by

Zhonghua Liu

submission deadline 8 Jan 2027 | Viewed by 215 | Submission Open

Keywords: inflammasomes; pyroptosis; innate immunity; inflammasome modulators; inhibitors; inflammatory diseases; drug discovery; translational research

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Mesenchymal Stem Cell-Derived Exosomes in Tissue Repair and Regeneration

edited by

Carl Randall Harrell

and

Crissy Fellabaum

submission deadline 10 Jan 2027 | 3 articles | Viewed by 4277 | Submission Open

Keywords: MSC; vesicles; exosomes; tissue repair and regeneration

Bench and Bedside: Molecular Insights and Neuroprotective Strategies for Stroke

edited by

Yuchuan Ding

submission deadline 15 Jan 2027 | 2 articles | Viewed by 3068 | Submission Open

Keywords: neuroprotection; neurorehabilitation; conditioning medicine; ischemia and reperfusion injury; cerebral hemor-rhages; stress; vascular diseases

(This special issue belongs to the Section Molecular Medicine)

Discovery of Therapeutic Target Genes in Oral and Craniofacial Cancers: From Molecular Signatures to Precision Dentistry

edited by

Valentina Belli

submission deadline 15 Jan 2027 | Viewed by 266 | Submission Open

Keywords: oral squamous cell carcinoma; head and neck cancer; therapeutic targets; target genes; biomarkers; saliva diagnostics; oral potentially malignant disorders; epigenetics; transcriptomics; single-cell; microbiome; precision dentistry

(This special issue belongs to the Section Molecular Genetics)

Molecular Mechanisms of the Epidermal Microenvironment in Pigmentation Disorders

edited by

Lingli Yang

submission deadline 15 Jan 2027 | Viewed by 230 | Submission Open

Keywords: epidermal microenvironment; melanocyte homeostasis; intercellular signaling networks; epidermal cell–cell crosstalk; pigmentation disorders

(This special issue belongs to the Section Molecular Medicine)

Albumin in Health and Disease: Physiological Roles, Pathogenic Mechanisms, and Biomedical Applications

edited by

Jian Yao

submission deadline 15 Jan 2027 | Viewed by 191 | Submission Open

Keywords: albumin; antioxidant; biomarker; drug delivery system; biomaterials

(This special issue belongs to the Section Molecular Medicine)

Epigenetic Drivers of Cancer Metastasis: From Methylation to Non-Coding RNAs

edited by

Toshifumi Hara

submission deadline 18 Jan 2027 | 2 articles | Viewed by 3888 | Submission Open

Keywords: epigenetics; metastasis; DNA methylation; RNA methylation; non-coding RNAs

Amino Acids and Their Metabolism in Disease

edited by

Toshiyuki Kitoh

submission deadline 20 Jan 2027 | 2 articles | Viewed by 3374 | Submission Open

Keywords: amino acid metabolism; disease pathophysiology; cancer metabolism; immunometabolism; metabolic reprogramming; amino acid transporters; therapeutic targeting; biomarkers; nutrient sensing; systems biology

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Role of Oxidative Stress in Vascular Diseases

edited by

Vittoria Cammisotto

and

Valentina Castellani

submission deadline 20 Jan 2027 | 1 articles | Viewed by 1247 | Submission Open

Keywords: oxidative stress; vascular disease; endothelial dysfunction; NADPH oxidase/NOX2; platelet activation; autophagy; gut microbiota; inflammation; reactive oxygen species (ROS); cardiovascular risk

Cellular and Molecular Mechanisms of Spermatogenesis, 2nd Edition

edited by YanHe Lue

submission deadline 20 Jan 2027 | 2 articles | Viewed by 1224 | Submission Open

Keywords: spermatogenesis; regulation; biomolecules

(This special issue belongs to the Section Molecular Reproduction)

Role of Oxidative Stress and Redox Signaling in Inner Ear Dysfunction

edited by

and

submission deadline 20 Jan 2027 | Viewed by 396 | Submission Open

Keywords: inner ear; cochlea; stria vascularis; auditory pathways; ion channels; ion transporters; molecular targets; oxidative stress; antioxidants; hearing loss; vestibular dysfunction; tinnitus

(This special issue belongs to the Section Molecular Biology)

Protein Structure–Function and Proteomics in Health and Environment

edited by

Khawar Sohail Siddiqui

and Tharusha Jayasena

submission deadline 20 Jan 2027 | Viewed by 282 | Submission Open

Keywords: proteins; proteomics; mass spectrometry; enzymes; health and disease; environment; bioinformatics; computational; evolution; artificial intelligence, ai

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Polyamine Metabolism and Targets: Glial Cell Function in Neural Health, Aging, and Disease

edited by

Serguei Skatchkov

, Rüdiger W. Veh and Christian J. Malpica-Nieves

submission deadline 20 Jan 2027 | Viewed by 254 | Submission Open

Keywords: neuroglia; polyamines; neurophysiology; ion channels; gap junctions; transporters; neurogliovascular ensembles; gliotransmission; diseases; syndromes

Neutrophils in Health and Disease: From Molecular Mechanisms to Therapies

edited by

Xin Xu

and

Lawrence Rasmussen

submission deadline 22 Jan 2027 | Viewed by 458 | Submission Open

Keywords: neutrophils; immune regulation; inflammation; infectious diseases; autoimmune disease; tumor

(This special issue belongs to the Section Biological Factors)

The Role of Amyloid in Neurological Disorders: 2nd Edition

edited by

Marny Fedrigo

and Tamara Berno

submission deadline 25 Jan 2027 | 1 articles | Viewed by 1722 | Submission Open

Keywords: amyloid-beta; neurodegenerative disorders; aducanumab; oligomers; cross-amyloid interaction

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Second Messenger Systems in Cellular Communication and Disease

edited by

Vijay Parashar

submission deadline 29 Jan 2027 | 1 articles | Viewed by 1088 | Submission Open

Keywords: second messengers; cyclic di-AMP (c-di-AMP); cyclic di-GMP (c-di-GMP); CBASS antiphage immunity; cGAS-STING signaling; cyclic oligonucleotides; signal transduction; structural biology; phosphodiesterases; biofilm formation; thoeris defense system; antimicrobial targets

(This special issue belongs to the Section Molecular Biology)

Developmental-Related Brain Disorders

edited by

Ricardo Rodrigues

submission deadline 29 Jan 2027 | Viewed by 313 | Submission Open

Keywords: neurogenesis; neuronal migration; cell differentiation; axon pathfinding; synaptogenesis; neurodevelopmental disorders

(This special issue belongs to the Section Molecular Medicine)

Cellular and Molecular Mechanisms Underlying Neuromuscular System Disorders

edited by Laura Cristina Ceafalan and

Bogdan Ovidiu Popescu

submission deadline 29 Jan 2027 | Viewed by 196 | Submission Open

Keywords: neuromuscular disorders; skeletal muscle; motor neurons; neuromuscular junction; neurodegeneration; muscle atrophy; sarcopenia; cachexia; α-synuclein; mitochondrial dysfunction; oxidative stress; inflammation; proteostasis; ubiquitin–proteasome system; autophagy; mitophagy; calcium homeostasis; epigenetics; myokines; extracellular vesicles; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms of Brain Injury and Repair in the Developing Neonate

edited by

Lauren L. Jantzie

and Robin K. Ohls

submission deadline 30 Jan 2027 | Viewed by 182 | Submission Open

Keywords: neonatal brain injury; microglial polarization; neuroinflammation; hypoxic-ischemic encephalopathy (HIE); translational research

(This special issue belongs to the Section Molecular Medicine)

Ovarian Cancer and Breast Cancer: Molecular Mechanisms, and Therapeutic Targets

edited by

Emily Golden

and

Priya Gopal Krishnan

submission deadline 31 Jan 2027 | 2 articles | Viewed by 7456 | Submission Open

Keywords: breast neoplasms; ovarian neoplasms; cancers; molecular subtyping; genomic instability; tumour heterogeneity; precision medicine; targeted therapy; PARP inhibitors; immunotherapy; chemotherapy resistance; triple negative breast neoplasms; HER2-positive breast cancer; high-grade serous ovarian cancer; low-grade serous ovarian cancer; rare cancer subtypes; next-generation sequencing

Functional Peptides and Their Interactions (3rd Edition)

edited by

Mikhail Soloviev

and

Simon M. Cutting

submission deadline 31 Jan 2027 | 3 articles | Viewed by 5946 | Submission Open

Keywords: peptides; antimicrobial peptides; immunomodulatory peptides; neuropeptides; signaling peptides; regulatory peptides; cyclic peptides; peptidomics; peptide profiling; peptoids; peptide engineering; peptide docking; peptide therapeutics; peptide self-assembly; biomaterials; biocatalysts; small proteins

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Molecular Mechanisms and Pathophysiology of Gliomas

edited by Fengchao Lang

submission deadline 31 Jan 2027 | 2 articles | Viewed by 5358 | Submission Open

Keywords: gliomas; cell cycle; epigenetic modifications; metabolic reprogramming; tumor microenvironment; targeted therapies

(This special issue belongs to the Section Molecular Biology)

The Role of Extracellular Non-Coding RNAs in Health and Disease

edited by

Arijit Mukhopadhyay

submission deadline 31 Jan 2027 | 3 articles | Viewed by 4501 | Submission Open

Keywords: extracellular vesicles; exosomes; non-coding RNA; microRNA; biomarker

(This special issue belongs to the Section Molecular Biomarkers)

Plant Secondary Metabolism Engineering and Bioactive Compounds

edited by

Barbara Tokarz

and

Wojciech Makowski

submission deadline 31 Jan 2027 | 5 articles | Viewed by 4161 | Submission Open

Keywords: bioactive compounds; elicitation; plant metabolism; fenetic transformation

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Advances in Microbial CRISPR Editing

edited by

Dongdong Yang

and Rongming Liu

submission deadline 31 Jan 2027 | 2 articles | Viewed by 4033 | Submission Open

Keywords: CRISPR-Cas; microbial genome editing; synthetic biology; base and prime editing; multiplexed CRISPR engineering; microbiome manipulation; phage and plasmid control; evolutionary stability of CRISPR edits; CRISPR-driven biocontainment; novel CRISPR systems

(This special issue belongs to the Section Molecular Biology)

Emerging Insights into the Role of Polyamines in Cellular Metabolism and Function

edited by

Cassandra E. Holbert

and

Tracy Murray Stewart

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3516 | Submission Open

Keywords: polyamine metabolism; putrescine; spermidine; spermine; polyamines in development; polyamines in health and disease; polyamines in cancer; polyamines in plant physiology

(This special issue belongs to the Section Cellular Biochemistry)

Redox Dysregulation and Mitochondrial Adaptation in Kidney Disease

edited by

Liang-Jun Yan

submission deadline 31 Jan 2027 | 4 articles | Viewed by 3228 | Submission Open

Keywords: acute kidney injury; chronic kidney disease; diabetic nephropathy; diabetic kidney disease; redox imbalance; reductive stress; reactive oxygen species; oxidative stress; mitochondrial stress response and adaptation; mitochondrial abnormalities; mitochondrial homeostasis; mitophagy; unfolded protein response

Role of Mesenchymal Stem/Stromal Cells and Their Extracellular Vesicles in the Regenerative Medicine of Musculoskeletal System

edited by

Dimitrios Kouroupis

and

Enrico Ragni

submission deadline 31 Jan 2027 | 1 articles | Viewed by 2026 | Submission Open

Keywords: mesenchymal stem/stromal cells; extracellular vesicles ; musculoskeletal regeneration ; immunomodulation ; anabolism ; cell therapy ; cell-free therapy ; secretome

VDAC1 as a Hub Protein–Modulation of VDAC1-Mediated Prograde Cell Death, Metabolism, Inflammation and Immunity via Interacting Proteins, Metabolites and Small Molecules

edited by Jay H. Chung and

Vito De Pinto

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1697 | Submission Open

Keywords: apoptosis; binding sites; ferroptosis; inflammation; metabolism; mitochondria; oxidative strass; pyroptosis; small molecules; VDAC

(This special issue belongs to the Section Cellular Biochemistry)

Genetic Insights into Cardiomyopathy: From Mechanisms to Medicine

edited by Xiao Fan and Youngil Lee

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1502 | Submission Open

Keywords: cardiomyopathy; genetics; epigenetics; genomics; genotype–phenotype correlation; genetic penetrance; precision medicine; mitochondria; personalized treatment; gene therapy

(This special issue belongs to the Section Molecular Genetics)

Roles of Alpha-1 Antitrypsin in Human Health and Disease Models: 2nd Edition

edited by

Sihong Song

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1208 | Submission Open

Keywords: alpha-1 antitrypsin; serine proteinase inhibitor (SERPIN); autoimmunity; inflammation; aging; cancer

(This special issue belongs to the Section Molecular Medicine)

Immunometabolism and Signaling Networks in Autoimmune Rheumatic Diseases

edited by Ryu Watanabe and

Yushiro Endo

submission deadline 31 Jan 2027 | Viewed by 696 | Submission Open

Keywords: immunometabolism; intracellular signaling pathways; T-cell and B-cell metabolism; metabolic–signaling crosstalk; innate immune cell signaling

Therapeutics Targeting Pathogenic Mechanisms of Leishmaniasis

edited by

Kwang Poo Chang

submission deadline 31 Jan 2027 | Viewed by 665 | Submission Open

Keywords: leishmaniasis; host–parasite interactions; pathogenicity; precision medicine; AI-assisted development of therapeutics

Pain and Therapy: Molecular Perspectives and Future Directions

edited by

Francesco Scaglione

submission deadline 31 Jan 2027 | Viewed by 496 | Submission Open

Keywords: pain; nociceptive pain; neuropathic pain; neoplastic pain; pain physiology; pain treatment

(This special issue belongs to the Section Molecular Biology)

Cellular Stress Responses in Oncogenesis and Metabolic Reprogramming

edited by

Kuo Hui Su

submission deadline 31 Jan 2027 | Viewed by 408 | Submission Open

Keywords: cellular stress response; metabolic reprogramming; oncogenesis; lipid metabolism; tumor adaptation; mitochondrial metabolism

(This special issue belongs to the Section Cellular Biochemistry)

Molecular and Physiological Regulation of Biomechanical Signalling

edited by

Lars Kaestner

submission deadline 31 Jan 2027 | Viewed by 395 | Submission Open

Keywords: biomechanics; molecular signalling; mechanosensitive ion channels; Piezo1&2; microfluidics

Adipose-Derived Stem Cells: 3D Culture Systems and Biological Insights

edited by Anna Barbara Di Stefano

submission deadline 31 Jan 2027 | Viewed by 377 | Submission Open

Keywords: stem cell biology; cancer stem cells; mesenchymal stem cells; induced pluripotent stem cells; 3D cultures; cell-based therapies

(This special issue belongs to the Section Cellular Biochemistry)

Design and Synthesis of Bioactive Compounds for Therapeutic Applications—2nd Edition

edited by

Saïd El Kazzouli

and

Gerald Guillaumet

submission deadline 31 Jan 2027 | 1 articles | Viewed by 326 | Submission Open

Keywords: drug design and discovery; synthesis of bioactive molecules; biological evaluations and applications; diagnostics; drug delivery

(This special issue belongs to the Section Natural and Bio-derived Molecules)

WDFY1 in Immune Regulation and Disease: From Molecular Mechanisms to Therapeutic Applications

edited by Wenhai Shao

submission deadline 31 Jan 2027 | Viewed by 308 | Submission Open

Keywords: WDFY1; membrane tracking; TLR3; TLR4; autophagy; ubiquitination; lupus

(This special issue belongs to the Section Molecular Medicine)

Molecular Research on Autoimmune Diseases: From Diagnosis to Therapy

edited by

Serena Guiducci

submission deadline 31 Jan 2027 | Viewed by 305 | Submission Open

Keywords: systemic sclerosis; autoimmune diseases; rheumatic diseases; chronic inflammation; mechanisms

(This special issue belongs to the Section Biological Factors)

Melatonin Functions and Stress Adaptation in Plants

edited by

Kyoungwhan Back

submission deadline 31 Jan 2027 | Viewed by 288 | Submission Open

Keywords: melatonin biosynthesis; melatonin metabolites; biotic stresses; abiotic stresses; plant growth and development

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Significance of KEAP1 and NRF2 Protein-Protein Interactions in Cancer

edited by

Mihaela Matovina

submission deadline 31 Jan 2027 | Viewed by 270 | Submission Open

Keywords: cancer; protein–protein interactions (PPIs); KEAP1; NRF2

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

The Roles of Glycosylation in Disease

edited by

Rudolf Tauber

and Véronique Blanchard

submission deadline 31 Jan 2027 | Viewed by 240 | Submission Open

Keywords: Glycomics; Glycosylation; Oligosaccharides; rare diseases; cancer; immunology; infection; structural analysis; therapeutic glycoproteins

(This special issue belongs to the Section Cellular Biochemistry)

The Role of Astrocytes in Neurodegenerative Diseases: 2nd Edition

edited by

Nima Sanadgol

submission deadline 31 Jan 2027 | Viewed by 203 | Submission Open

Keywords: astrocytes; neurodegeneration; neuroinflammation; neuroprotection; neuroregeneration

(This special issue belongs to the Section Cellular Biochemistry)

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