Neutrophils in Health and Disease: From Molecular Mechanisms to Therapies

Dear Colleagues,

Neutrophils are the most abundant leukocytes in human circulation and serve as first responders in the innate immune system. Their roles extend far beyond microbial defense, encompassing tissue remodeling, immune regulation, and involvement in a wide spectrum of diseases. This Special Issue aims to provide a comprehensive overview of current advances in neutrophil biology, highlighting their multifaceted roles in health and disease.

We invite original research articles, reviews, and perspectives that explore the following:

• Neutrophil development, differentiation, and lifespan regulation;
• Neutrophil heterogeneity and functional plasticity;
• Mechanisms of neutrophil activation, migration, and effector functions;
• Neutrophil extracellular traps (NETs) and their implications in pathology;
• Neutrophils in infectious diseases, including bacterial, viral, and fungal infections;
• Neutrophils in chronic inflammation and autoimmune disorders;
• Neutrophil involvement in cancer progression and tumor microenvironment;
• Neutrophil dysfunction in metabolic and cardiovascular diseases;
• Technological advances in neutrophil profiling (e.g., single-cell, omics, imaging);
• Therapeutic strategies targeting neutrophils or their pathways.

This Special Issue seeks to bridge basic science and clinical research, fostering interdisciplinary dialogue and encouraging translational insights that may lead to novel diagnostics and therapies.

Dr. Xin Xu
Dr. Lawrence Rasmussen
Guest Editors

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