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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cellular and Molecular Mechanisms of Endometriosis: 2nd Edition

edited by

Luciana Bordin

, Alessandra Andrisani and Chiara Sabbadin

submission deadline 15 Sep 2026 | 3 articles | Viewed by 7194 | Submission Open

Keywords: endocrine disfunction in endometriosis; glycosylphosphatidylinositols (GPIs) and GPI-anchored proteins; oxidative stress markers (glutathione, carbonic anhydrase, etc.); endometriosis and deep endometriosis; endometriosis-related immune system

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Bronchiolitis Obliterans

edited by Ralf Schubert and Silvija-Pera Jerkic

submission deadline 15 Sep 2026 | 3 articles | Viewed by 4197 | Submission Open

Keywords: bronchiolitis obliterans (BO); inflammation; fibrosis; molecular mechanisms

(This special issue belongs to the Section Molecular Medicine)

Prion Biology and Disease: Molecular Mechanisms and Emerging Technologies

edited by Takashi Onodera and

Akikazu Sakudo

submission deadline 15 Sep 2026 | Viewed by 1187 | Submission Open

Keywords: prions; PrPC; PrPSc; prion strain diversity; neurodegeneration; immunodetection methods; nonthermal gas plasma; protein misfolding cyclic amplification (PMCA); real-time quaking-induced conversion (RT-QuIC)

Microbial Extracellular Vesicles: From Virulence Factors to Therapeutic Targets

edited by

Daria Nicolosi

submission deadline 15 Sep 2026 | Viewed by 611 | Submission Open

Keywords: microbial extracellular vesicles; virulence factors; host–pathogen interaction; drug delivery; biomarkers

Epigenetic and Pharmacological Insights into Cognitive Dysfunction Driven by Genetic and Environmental Factors

edited by

Pei Li

submission deadline 15 Sep 2026 | Viewed by 226 | Submission Open

Keywords: cognitive dysfunction; epigenetic regulation; genetic risk; environmental exposure

(This special issue belongs to the Section Molecular Genetics)

Extracellular Non-Coding RNAs as Key Regulators and Biomarkers in Reproductive Processes

edited by Rosalia Battaglia

submission deadline 15 Sep 2026 | Viewed by 206 | Submission Open

Keywords: extracellular non-coding RNAs; reproductive biology; extracellular vesicles; biomarkers; assisted reproductive technology

(This special issue belongs to the Section Molecular Reproduction)

Targeting Protein Misfolding: From Alzheimer's Amyloids to Therapeutic Peptides

edited by

Dariusz Stępkowski

submission deadline 16 Sep 2026 | 2 articles | Viewed by 6895 | Submission Open

Keywords: amyloidogenesis; amyloidosis; amyloid fibrils; dissolution of amyloid fibrils; beta-sheet breakers; peptide inhibitors; small molecule inhibitors

Novel Diagnostic Tools and Biomarkers in Hematology

edited by Lars Kaestner

submission deadline 17 Sep 2026 | 1 articles | Viewed by 1513 | Submission Open

Keywords: blood-based biomarkers; diagnostic innovation; omics technologies; microfluidics; photonics; machine learning; hematology; precision medicine

(This special issue belongs to the Section Molecular Biomarkers)

Biotherapeutic Analysis: Precision Characterization and Quality Control

edited by

Jared Auclair

submission deadline 20 Sep 2026 | 2 articles | Viewed by 2691 | Submission Open

Keywords: biotherapeutics; analytical characterization; quality control; mass spectrometry; cell therapy; gene therapy; biologics; process analytical technology; regulatory science

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Evolutionary Genomics of Bacterial Endosymbionts: From Mutualism to Parasitism

edited by

Amit Sinha

submission deadline 20 Sep 2026 | 1 articles | Viewed by 2343 | Submission Open

Keywords: host–symbiont coevolution; metabolic pathways; horizontal DNA transfer; phylogenetics

Angiogenin: From Molecular Mechanisms to Clinical Implications

edited by

Iogann Tolbatov

submission deadline 20 Sep 2026 | Viewed by 337 | Submission Open

Keywords: angiogenin; angiogenesis; neuroprotection; cancer; neurodegeneration; biomarker; therapeutic target

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Advances in Molecular Mechanisms of Hearing Loss

edited by

Sten Hellström

submission deadline 20 Sep 2026 | Viewed by 205 | Submission Open

Keywords: molecular signaling pathways; inflammation in hearing loss; genetic mutations; neurotransmitter dysregulation; cellular mechanotransduction

(This special issue belongs to the Section Molecular Genetics)

CD5 and CD6 Immunobiology: Multitask Immunomodulatory Molecules in Infection, Cancer and Autoimmunity

edited by Lozano Francisco and María Velasco-de Andrés

submission deadline 24 Sep 2026 | 2 articles | Viewed by 1888 | Submission Open

Keywords: CD5; CD6; T cells; B1a cells; NK cells; immunomodulation; infection; cancer; autoimmunity; immunotherapy

(This special issue belongs to the Section Biological Factors)

Functional Analysis of Genes Related to DNA Damage

edited by Ryan P. Barnes and Amy M. Whitaker

submission deadline 25 Sep 2026 | 10 articles | Viewed by 11167 | Submission Open

Keywords: DNA damage; DNA repair; genome stability; DNA replication stress

(This special issue belongs to the Section Molecular Biology)

Dietary Polyphenols and Their Impact on Inflammation and Cardiovascular Metabolic Health

edited by Sonila Alia and

Arianna Vignini

submission deadline 25 Sep 2026 | 1 articles | Viewed by 1043 | Submission Open

Keywords: dietary polyphenols; inflammation; cardiometabolic health; cardiovascular diseases; oxidative stress; antioxidant activity; molecular mechanisms; nutritional interventions

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Focus on Perineural Invasion in Pancreatic Cancer

edited by

Ingrid Garajová

submission deadline 25 Sep 2026 | Viewed by 582 | Submission Open

Keywords: pancreatic cancer; perineural invasion; pain; NGF; neutrophins

(This special issue belongs to the Section Molecular Medicine)

Advances in Plant Genetic Engineering

edited by

Bin Li

submission deadline 25 Sep 2026 | Viewed by 211 | Submission Open

Keywords: plant genetic engineering and biotechnology; CRISPR-Cas system; precise genome editing; synthetic biology; plant transformation and modification; genetically modified plants; plant improvement; biofactories

(This special issue belongs to the Section Molecular Genetics)

Advances in Drosophila Models for Amyloid and Neurodegenerative Diseases

edited by Ann Christin Brorsson

submission deadline 28 Sep 2026 | 1 articles | Viewed by 1458 | Submission Open

Keywords: neurodegeneration; protein aggregation; amyloid structures; neurotoxicity; Drosophila melanogaster; model organism

Molecular Advances in Wound Healing and Skin Regeneration

edited by

Hiroyuki Ijima

and Muhammad Shafiq

submission deadline 30 Sep 2026 | 3 articles | Viewed by 45156 | Submission Open

Keywords: artificial dressings; electrospun fiber-based wound dressings; artificial skin equivalents; wound healing; instructive biomaterials for in situ skin repair; microneedles for skin therapy; drug delivery systems for wound healing; cell-free approaches for skin repair; stem cell therapy for wound healing; scarless skin repair

(This special issue belongs to the Section Biological Factors)

Biologics and Biomaterials for Periodontal Treatment: Current and Future Challenges

edited by

Atsushi Saito

submission deadline 30 Sep 2026 | 3 articles | Viewed by 14917 | Submission Open

Keywords: periodontal disease; periodontitis; periodontal regeneration; periodontal tissue engineering; biological agents; biomaterials

(This special issue belongs to the Section Bio-Engineered Materials)

Feature Papers in Section "Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates"

edited by

Valentyn Oksenych

submission deadline 30 Sep 2026 | 10 articles | Viewed by 11212 | Submission Open

Keywords: biomacromolecules; proteins; DNA; RNA; chromatin; epigenetics; gene regulation; genomics; proteomics; metabolomics; computational approaches; molecular biotechnology; molecular therapeutics

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Alcohol-Related Organ Damage: Mechanisms, Outcomes, and Treatment Modalities

edited by

Natalia Osna

and

Kusum K. Kharbanda

submission deadline 30 Sep 2026 | 4 articles | Viewed by 9660 | Submission Open

Keywords: alcoholic liver disease (ALD); steatohepatitis; fibrosis; cirhosis; parenhymal and non-parenhymal liver cells; brain; gut; lungs; immune responses; oxidative stress; methylation; viral infections; post-translational protein modifications; treatment of ALD

(This special issue belongs to the Section Molecular Medicine)

The Biomarkers in Renal Diseases

edited by

Rosemary Wangensteen

and María Carmen Ruiz Fuentes

submission deadline 30 Sep 2026 | 4 articles | Viewed by 7011 | Submission Open

Keywords: biomarkers; acute kidney injury; chronic kidney disease; microvesicles; exosomes

(This special issue belongs to the Section Molecular Biomarkers)

Natural Products and Their Derivatives with Antiviral Activity

edited by

Zhijun Zhang

submission deadline 30 Sep 2026 | 3 articles | Viewed by 6949 | Submission Open

Keywords: natural products; synthetic antivirals; antiviral drugs; antiviral strategies; influenza; HBV; HIV; RSV; COVID-19; SARS-CoV-2

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Deciphering Disease Progression Through Multi-Omics Integration

edited by Cinzia Franchin

submission deadline 30 Sep 2026 | 2 articles | Viewed by 5245 | Submission Open

Keywords: multi-omics integration; systems biology; biomarkers; disease progression; precision medicine; computational modelling

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms Underlying Liver Diseases: 2nd Edition

edited by

Wei Zhong

submission deadline 30 Sep 2026 | 4 articles | Viewed by 4893 | Submission Open

Keywords: pathogenesis of liver diseases; molecular mechanisms; organelle damages; genetic determinants; organ–organ interactions; biomarkers; in vivo models of liver diseases; therapeutic insights

(This special issue belongs to the Section Cellular Biochemistry)

Mitochondrial ROS in Health and Disease: 2nd Edition

edited by

Frank Krause

submission deadline 30 Sep 2026 | 3 articles | Viewed by 4494 | Submission Open

Keywords: aging; apoptosis; respiratory chain; redox signaling; paclitaxel

(This special issue belongs to the Section Chemical Biology)

Ferroptosis and Cuproptosis: Mechanism and Crosstalk in Cancer, Neurodegeneration, and Metabolic Syndrome

edited by

Rosanna Squitti

submission deadline 30 Sep 2026 | 1 articles | Viewed by 4300 | Submission Open

Keywords: ferroptosis; cuproptosis; Alzheimer's disease; colorectal cancer; neurodegeneration; metabolic syndrome; regulated cell death; iron metabolism; copper metabolism; psychiatric disorders

(This special issue belongs to the Section Molecular Medicine)

Fibrinogen and Fibrin in Human Diseases

edited by

Abha Sahni

submission deadline 30 Sep 2026 | 3 articles | Viewed by 3915 | Submission Open

Keywords: fibrinogen; fibrin; inflammation; cardiovascular; neurological; endothelium; thrombosis; hemostasis; fibrosis

(This special issue belongs to the Section Molecular Biology)

Advances in the Pathology of Prostate Cancer: 2nd Edition

edited by

Piwen Wang

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3833 | Submission Open

Keywords: prostate cancer; molecular pathology; biomarker; chemoprevention; therapy

(This special issue belongs to the Section Chemical Biology)

Metallic Nanoparticles: Biosynthesis and Therapeutic Potential

edited by

Sónia Gonçalves

and

Isabelle Michaud-Soret

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3692 | Submission Open

Keywords: silver nanoparticle; antibacterial agent; green synthesis; therapeutics

(This special issue belongs to the Section Biological Factors)

Feature Papers in Section “Cellular Biochemistry”, 2nd Edition

edited by

Anna Rita Franco Migliaccio

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3346 | Submission Open

Keywords: cell signalling; cell death; intracellular trafficking (protein, lipids, cytoskeleton, etc.); host–pathogen interactions; extracellular vesicle biology; intercellular communication; autophagy; cellular metabolism; inter-organelle communication; membrane transport; mitochondrial dynamics and function; cell polarity

(This special issue belongs to the Section Cellular Biochemistry)

The Role of Extracellular Vesicles (EVs) in Cell-to-Cell Communication

edited by

Yuqian Yan

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3319 | Submission Open

Keywords: extracellular vesicles (EVs); tumorigenesis; initiation; progression; metastasis

(This special issue belongs to the Section Cellular Biochemistry)

Cancer Research: Molecular Insights and Therapeutic Strategies

edited by

Wioletta Rozpędek-Kamińska

and

Joanna Marta Sikora

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2943 | Submission Open

Keywords: cancer biology; molecular mechanisms; oncogenic signaling pathways; molecular targets; targeted therapy

(This special issue belongs to the Section Molecular Medicine)

Molecular Basis and Oxidative Stress of Thyroid Diseases

edited by

Małgorzata Karbownik-Lewińska

and

Jan Stȩpniak

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2878 | Submission Open

Keywords: thyroid diseases; oxidative stress; reactive oxygen species (ROS); thyroid hormone synthesis; molecular mechanisms; genetic mutations; epigenetic modifications; autoimmune thyroid diseases; Hashimoto thyroiditis; Graves' disease

(This special issue belongs to the Section Biological Factors)

Advanced Therapeutic Strategies for Hormone-Dependent Cancers

edited by

Athanasios A. Panagiotopoulos

submission deadline 30 Sep 2026 | 1 articles | Viewed by 2752 | Submission Open

Keywords: hormone-dependent cancers; endocrine therapy resistance; targeted therapy; combination treatment strategies; cancer biomarkers

(This special issue belongs to the Section Molecular Medicine)

Molecular Regulation of Transcription Factors in Plant Growth and Stress Responses

edited by

Mingcheng Wang

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2412 | Submission Open

Keywords: transcription factors; plant growth and development; abiotic and biotic stress; gene regulatory networks; molecular regulation

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Current Treatment Strategy of Sarcomas

edited by

Katia Scotlandi

and

Caterina Mancarella

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2326 | Submission Open

Keywords: sarcoma; therapeutic vulnerabilities; preclinical models; molecular target

(This special issue belongs to the Section Molecular Medicine)

Future Innovation and Challenges in Bioactive Compounds from Plant Foods: Towards Sustainable Health

edited by

Giacomo Fais

and

Giorgia Sarais

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1633 | Submission Open

Keywords: bioactive compounds; plant-based foods; functional phytochemicals; sustainable nutrition; nutraceuticals; eco-friendly extraction; agro-industrial byproducts; microalgae and cyanobacteria; food waste valorization; innovative food systems

From Gene to Metabolite: Decoding the Transcriptional Regulatory Networks Controlling the Biosynthesis of Bioactive Compounds

edited by

Zhenming Yu

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1596 | Submission Open

Keywords: bioactive compounds; transcriptional regulation; abiotic and biotic factor; exogenous elicitor

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Mechanisms in Stress-Related Disorders, Anxiety and Fear

edited by Veronica Begni

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1270 | Submission Open

Keywords: stress-related disorders; anxiety; fear; genetic and environmental interactions; behavioral neuroscience; biological pathways; biomarkers; therapeutic interventions

(This special issue belongs to the Section Molecular Biology)

Nutritional Immunity and Inflammation: Decoding Mechanisms for Therapeutic Advancement

edited by

Franziska Roth-Walter

and

Carolina Frizzo-Ramos

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1245 | Submission Open

Keywords: nutritional deficiencies; antioxidants; minerals; vitamins; mucosal block; cross feeding; microbes; inflammation; tolerance

New Technologies and Translational Approach for an Early Diagnosis of Bipolar Spectrum and Hyperactive and Novelty Seeking Profiles

edited by

Massimo Tusconi

, Serdar Dursun and

Germano Orru

submission deadline 30 Sep 2026 | Viewed by 902 | Submission Open

Keywords: psychiatry; mental health; bipolar disorders; mood; biomarkers; new technology; BD

Biomolecules and Material-Based Approaches in Biomedical Field—3rd Edition

edited by

Sabrina Morelli

Antonella Piscioneri

Loredana De Bartolo

and Zhaoliang Cui

submission deadline 30 Sep 2026 | Viewed by 451 | Submission Open

Keywords: biomolecules roles in biological processes and pathologies; therapeutic molecules; biomarkers; biomolecules for disease diagnostics, and pharmaceutical development; cell signaling biomolecules; biomaterials for biomedical applications; self-assembled biomaterials; biofunctionalization of materials; new fabrication technologies (e.g., 3D printing); biosensors for disease diagnostics and/or prognosis; 3D scaffolds and hydrogels; 3D material-based tissue models; membrane bioreactors; bioartificial organs; materials for cell-/drug-delivery systems; in vitro material platforms for disease modeling/drug screening; materials for fabricating microfluidic systems

(This special issue belongs to the Section Molecular Medicine)

Spatial and Single-Cell Phosphoproteomics: Emerging Methods and Applications

edited by Cinzia Franchin

submission deadline 30 Sep 2026 | Viewed by 445 | Submission Open

Keywords: phosphoproteomics; single-cell phosphoproteomics; cell signalling; spatial phosphoproteomics; phosphopeptides

(This special issue belongs to the Section Molecular Biology)

Role of Lipids in Cellular Metabolism and Communication

edited by

Leyre Brizuela

submission deadline 30 Sep 2026 | Viewed by 391 | Submission Open

Keywords: sphingolipids; phospholipids; eicosanoids; steroids; extracellular vesicles; cancer; diabetes; obesity; atherosclerosis

(This special issue belongs to the Section Lipids)

Molecular Mechanisms and Novel Targets in Peripheral Neurotoxicity

edited by

Eleonora Pozzi

Paola Alberti

and Federico Iseppon

submission deadline 30 Sep 2026 | 1 articles | Viewed by 388 | Submission Open

Keywords: peripheral neuropathies; peripheral neurotoxicity; ion channels; axonal damage; chemotherapy-induced peripheral neurotoxicity; pain; neuropathic pain

(This special issue belongs to the Section Molecular Biology)

Choline and Its Supplementation in Human Health and Disease

edited by

Francesco Amenta

and Enea Traini

submission deadline 30 Sep 2026 | Viewed by 379 | Submission Open

Keywords: choline; transporters; deficiencies; supplementations

(This special issue belongs to the Section Molecular Medicine)

Molecular Circuits of Cell Fate Reprogramming and Plasticity

edited by

Myon Hee Lee

submission deadline 30 Sep 2026 | Viewed by 366 | Submission Open

Keywords: stem cell self-renewal and differentiation; pluripotency networks; cell fate reprogramming (dedifferentiation and trans-differentiation); cellular plasticity; transcriptional, post-transcriptional, and epigenetic regulation; chemical reprogramming; regenerative medicine; technologies for cell fate reprogramming; model organisms; disease models

(This special issue belongs to the Section Cellular Biochemistry)

Advances in Targeted At-211 Alpha Therapy

edited by Hsiaoju Sharon Lee and Yawen Li

submission deadline 30 Sep 2026 | Viewed by 357 | Submission Open

Keywords: Astatine-211; astatination; targeted alpha therapy; alpha radioimmunotherapy; radiotheranostics; radiopharmaceuticals

(This special issue belongs to the Section Chemical Biology)

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