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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Nitrogen Signaling, Transport, and Function in Plants, 2nd Edition

edited by

Takushi Hachiya

submission deadline 20 Apr 2027 | Viewed by 289 | Submission Open

Keywords: nitrogen assimilation; nitrogen sensing; nitrogen transport; nitrogen signaling; primary nitrate response; systemic nitrogen signaling

(This special issue belongs to the Section Biological Factors)

Biomolecular Insights into Exercise-Induced Modulation of Immunometabolism

edited by

Katsuhiko Suzuki

and

Kayvan Khoramipour

submission deadline 30 Apr 2027 | 2 articles | Viewed by 6778 | Submission Open

Keywords: biomolecular signaling in exercise adaptation; exercise and immune cell metabolism; inflammatory pathways and exercise; mitochondrial bioenergetics and exercise; exercise and adaptive immunity; neuroimmunometabolism and brain health; exercise and cancer immunometabolism; metabolic biomarkers of exercise-induced immunomodulation

(This special issue belongs to the Section Molecular Biology)

Insights into G-Quadruplexes and I-Motifs: Structure, Dynamics and Function

edited by

Keiko Kawauchi

and Tamaki Endoh

submission deadline 30 Apr 2027 | 4 articles | Viewed by 5203 | Submission Open

Keywords: non-B DNA structures; G-quadruplex; i-motif; nucleic acid structural dynamics; gene regulation; bioinformatics; ligand development; therapeutic applications

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Heterocyclic Compounds: Synthesis, Characterization, and Validation

edited by

Monika Pitucha

submission deadline 30 Apr 2027 | 3 articles | Viewed by 3343 | Submission Open

Keywords: heterocyclic compounds; synthesis; spectroscopy; molecular modeling; biological activity; radiopharmaceuticals

(This special issue belongs to the Section Chemical Biology)

Molecular Mechanisms and Drug Research in Alzheimer’s Disease

edited by

Xudong Huang

submission deadline 30 Apr 2027 | 2 articles | Viewed by 2851 | Submission Open

Keywords: Alzheimer's disease; molecular mechanisms; drug discovery; Aβ amyloid; tau protein; neuroinflammation; oxidative stress; metal homeostasis; blood–brain barrier; dysbiosis

(This special issue belongs to the Section Molecular Medicine)

CRISPR-Directed Gene Editing: Molecular Approaches to Cancer Therapeutics

edited by

Eric B. Kmiec

and

Kelly Banas

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1411 | Submission Open

Keywords: CRISPR; gene editing; genome engineering; cancer therapy; solid tumors; precision medicine; translational research; functional genomics; tumor-specific targeting; CRISPR diagnostics; off-target effects

(This special issue belongs to the Section Molecular Medicine)

Mechanistic Insights of Retinal Diseases and Directions for New Therapeutics

edited by

Jing Chen

and Neetu Kushwah

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1403 | Submission Open

Keywords: retinopathy; AMD; retinal degeneration; ocular pharmacology; translational therapeutics

(This special issue belongs to the Section Molecular Medicine)

Mesenchymal Stromal Cells in Regenerative Medicine and Immune Modulation: Mechanisms, Engineering, and Therapeutic Applications

edited by

Makram Merimi

submission deadline 30 Apr 2027 | 1 articles | Viewed by 919 | Submission Open

Keywords: mesenchymal stromal cells; immunomodulation; regenerative medicine; tumor microenvironment; cancer immunotherapy; extracellular vesicles; non‑coding RNAs; engineered MSCs; cell–cell communication

(This special issue belongs to the Section Cellular Biochemistry)

Nanotechnology in Agriculture and the Environment: From Molecular Mechanisms to Sustainable Applications

edited by

Nubia Zuverza-Mena

and Luis Hernandez-Adame

submission deadline 30 Apr 2027 | Viewed by 450 | Submission Open

Keywords: nanotechnology; molecular mechanisms; biomolecules; environment; sustainable agriculture

(This special issue belongs to the Section Bio-Engineered Materials)

Protein Spreading in Neurodegenerative Diseases: From Mechanisms to Therapeutics

edited by

Xiaobo Mao

and

Enrico Moro

submission deadline 30 Apr 2027 | Viewed by 336 | Submission Open

Keywords: neurodegeneration; protein aggregation; Alzheimer disease; Lewy bodies; frontotemporal dementia

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms of Immunometabolism in Inflammation and Insulin Resistance: Potential Interventional Therapies

edited by

Sandro Massao Hirabara

Gabriel Nasri Marzuca Nassr

, Renata Gorjao and Rui Curi

submission deadline 30 Apr 2027 | Viewed by 115 | Submission Open

Keywords: obesity and diabetes; metabolism; insulin signaling; physical exercise; nutritional intervention; anti-inflammatory compounds

(This special issue belongs to the Section Molecular Medicine)

Immunohistochemical and Molecular Approaches to Gastrointestinal Disease Characterization

edited by

Bogdan Silviu Ungureanu

and

Andrei Biță

submission deadline 30 Apr 2027 | Viewed by 95 | Submission Open

Keywords: gastrointestinal diseases; biomarkers; artificial intelligence; multimodal therapy; immunohistochemistry

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights Into Antibody-Drug Conjugates for Application in Oncology and Beyond

edited by

Nicolas Joubert

and

Caroline Denevault-Sabourin

submission deadline 30 Apr 2027 | Viewed by 72 | Submission Open

Keywords: antibody–drug conjugates; protein-drug conjugates; small molecule–drug conjugates; targeted delivery; controlled release; cancer research; inflammation; proteases; infectiology

(This special issue belongs to the Section Molecular Medicine)

Emerging Biomarkers for Precision Oncology: Integrating Liquid Biopsy, Multi-Omics, and Molecular Imaging

edited by

Filippos Koinis

Anastasia Xagara

and Maria-Smaragdi Vlachou

submission deadline 30 Apr 2027 | Viewed by 61 | Submission Open

Keywords: precision oncology; liquid biopsy; molecular biomarkers; circulating tumor cells; circulating tumor DNA; multi-omics; molecular imaging; exosomes; artificial intelligence; translational oncology

(This special issue belongs to the Section Molecular Biomarkers)

The Genomics in Biodiversity Conservation (Vertebrates and Invertebrates)

edited by

Shantanu Kundu

submission deadline 30 Apr 2027 | Viewed by 59 | Submission Open

Keywords: aquatic genomics; biodiversity monitoring; comparative genomics; conservation genetics; DNA metabarcoding; environmental DNA; evolutionary genomics; genome-wide study; landscape genetics; metagenomics; mitogenomics; molecular ecology; molecular systematics; museum genomics; phylogenetics; phylogenomics; population genetics; precision conservation; threatened and endemic species; transcriptomics; whole-genome sequencing; wildlife genomics

(This special issue belongs to the Section Molecular Genetics)

Conditional Cell Models and Biomaterials for Regenerative Medicine and Disease Modeling

edited by

Parmjit S. Jat

Melissa Rayner

and

Poppy Smith

submission deadline 30 Apr 2027 | Viewed by 59 | Submission Open

Keywords: regenerative medicine; disease modelling; cell models; biomaterials; advanced therapies

(This special issue belongs to the Section Bio-Engineered Materials)

Advances in Ferroptosis and Metabolic Dysregulation

edited by Udayakumar Karunakaran and Suma Elumalai

submission deadline 30 Apr 2027 | Viewed by 33 | Submission Open

Keywords: reactive oxygen species; antioxidants; glutathione; iron; H2S signaling; diabetes; metabolic disease; mitochondrial biology; ferroptosis; cell death; inflammation; aging; neurodegenerative diseases

(This special issue belongs to the Section Cellular Biochemistry)

Apolipoproteins L in Membrane Remodeling and Human Disorders—Honorary Special Issue Commemorating the Work of Dr. Etienne Pays

edited by Benoit Vanhollebeke

submission deadline 30 Apr 2027 | Viewed by 29 | Submission Open

Keywords: African trypanosomes; antigen cross-presentation; Apolipoproteins L; APOL1 trypanolytic activity; APOL1-mediated kidney disease; APOLs-associated proteins (PI4KB, NCS1, NM2A, PHB2, GBP1); apoptosis; infection; inflammation; membrane fusion/fission/traffic; membrane megapores; mitophagy; parasitophorous vacuole; pathogen-containing membrane; phagosomal membrane; pore-forming activity

(This special issue belongs to the Section Molecular Medicine)

The Role of Heparin in Blood

edited by

Viktoria Weber

Stephan Harm

and Denisa Cont

submission deadline 15 May 2027 | 1 articles | Viewed by 3942 | Submission Open

Keywords: heparin; glycocalyx; anti-inflammatory properties; immunothrombosis; sepsis; inflammation; hemocompatibility; extracorporeal therapies; antiviral activity; heparin-induced thrombocytopenia (HIT)

(This special issue belongs to the Section Molecular Medicine)

Microbial Metabolites, Host Responses and Gastrointestinal Diseases

edited by

Xiaolun Sun

Ayidh Almansour

and Tahrir Alenezi

submission deadline 20 May 2027 | Viewed by 115 | Submission Open

Keywords: gut homeostasis and disease; inflammation; microbiota; metabolites; microbial factors

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Platelet Disease, Thrombosis and Hemostasis

edited by

José Rivera

submission deadline 31 May 2027 | 3 articles | Viewed by 11154 | Submission Open

Keywords: platelets; hemostasis and thrombosis; inherited platelet disorders; coagulation; immunothrombosis; miRNA; GPVI; Runx1; antiplatelet therapy

(This special issue belongs to the Section Molecular Biology)

Protein Biophysics

edited by

Vladimir N. Uversky

and

Orkid Coskuner-Weber

submission deadline 31 May 2027 | 6 articles | Viewed by 10853 | Submission Open

Keywords: protein function; protein folding; protein misfolding; protein structure; protein dynamics; protein stability; protein and peptide aggregation; posttranslational modifications; intrinsically disordered proteins; protein–ligand interactions; protein–protein interactions; protein–nucleic acid interactions; membrane proteins; liquid–liquid phase separation

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Biomolecular Approaches and Drugs for Neurodegeneration—2nd Edition

edited by

Caterina Vicidomini

and

Giovanni N. Roviello

submission deadline 31 May 2027 | 4 articles | Viewed by 8726 | Submission Open

Keywords: proteins; peptides; amyloid; Alzheimer disease; Parkinson’s disease; neurodrugs; G-quadruplex nucleic acids; biotechnology; biomolecular targets; peptide aggregation; natural products; synthetic drugs; anti-amyloid therapeutics; machine learning

(This special issue belongs to the Section Chemical Biology)

The Role of Non-Coding RNAs in Health and Disease: 2nd Edition

edited by

Narasimman Gurusamy

submission deadline 31 May 2027 | 2 articles | Viewed by 2746 | Submission Open

Keywords: non-coding RNA,; microRNA (miRNA); long noncoding RNA (lncRNA); circular RNA (circRNA); gene expression regulation; epigenetic modifications

(This special issue belongs to the Section Molecular Genetics)

Molecular Mechanisms of Antimicrobial Activity and Resistance in Pathogens

edited by

Lia Mara Diţu

submission deadline 31 May 2027 | 1 articles | Viewed by 2097 | Submission Open

Keywords: MDR profile in fungi; anti-fungal strategies; drug–target interactions; nanotechnology in antimicrobials; quorum-sensing molecular interactions; biofilm

(This special issue belongs to the Section Molecular Biology)

Molecular Engineering and Applications of Protein Cages and Cavities

edited by

John F. Honek

submission deadline 31 May 2027 | Viewed by 374 | Submission Open

Keywords: host-guest encapsulation; drug targeting; virus-like nanoparticles; ferritins; cavity-containing biomolecules; vault proteins; encapsulins; nanocompartments; medicinal, materials science, and analytical applications

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

The Molecular and Cellular Mechanisms in Multiple Sclerosis

edited by

Magdalena Zoledziewska

and Maria laura Idda

submission deadline 31 May 2027 | Viewed by 335 | Submission Open

Keywords: multiple sclerosis; gene expression; immunophenotyping; molecular-, expression- and protein-quantitative loci QTLs; non-coding RNAs; precision medicine

(This special issue belongs to the Section Molecular Medicine)

Decoding Cellular Pathogenesis of Hypertension: Emerging Mechanisms and Therapeutic Targets

edited by Satoru Eguchi and Yuka Terada

submission deadline 31 May 2027 | Viewed by 305 | Submission Open

Keywords: omics; microbiota; signal transduction; epigenetics; cellular mechanisms

(This special issue belongs to the Section Molecular Medicine)

Molecular Biomarkers, Immune Mechanisms, and Next-Generation Immunodiagnostics in Autoimmune Diseases

edited by

Yahya F. Jamous

submission deadline 31 May 2027 | Viewed by 126 | Submission Open

Keywords: autoimmune diseases; molecular biomarkers; immune mechanisms; multi-omics; next-generation immunodiagnostics

(This special issue belongs to the Section Biological Factors)

Biomolecules in Colorectal Cancer: From Bench to Bedside

edited by

Justas Žilinskas

submission deadline 31 May 2027 | Viewed by 100 | Submission Open

Keywords: colorectal cancer; biomarkers; precision oncology; perioperative biology; translational medicine

(This special issue belongs to the Section Molecular Medicine)

Deciphering Molecular Landscape and Biomarkers of Tumor Progression for Precision Oncology

edited by Claudia Sabato and

Zein Mersini Besharat

submission deadline 31 May 2027 | Viewed by 83 | Submission Open

Keywords: intratumor heterogeneity dynamics; oncogenic signaling networks; EMT-mediated matrix remodeling; metabolic reprogramming pathway; metastatic dissemination; cancer biomarkers; immune evasion signaling; therapeutic resistance; multi-omics profiling; tumor microenvironment

(This special issue belongs to the Section Molecular Medicine)

Molecular Modeling and Computational Toxicology: Bridging Food and Drug Safety, Environmental Health, and Drug–Target Interactions

edited by

Luca Dellafiora

and

Lorenzo Pedroni

submission deadline 31 May 2027 | Viewed by 24 | Submission Open

Keywords: food safety; environmental health; one-health; computational toxicology; protein-ligand interaction; drug discovery; pharmacological safety; emerging biomolecular hazards; artificial intelligence; novel biomolecular systems

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Molecular and Cellular Mechanism of Gynecologic Malignancies

edited by

Mikołaj Piotr Zaborowski

and Cezary Miedziarek

submission deadline 10 Jun 2027 | Viewed by 67 | Submission Open

Keywords: gynecological neoplasms; ovarian cancer; endometrial cancer; cervical cancer; vulvar cancer; gestational neoplastic disease; tumor microenvironment; genomics; transcriptome; metabolomics

(This special issue belongs to the Section Molecular Medicine)

Preclinical: Drug, Model and Imaging Development

edited by

Mohamed El-Tanani

and

Mohammad Isreb

submission deadline 15 Jun 2027 | 1 articles | Viewed by 585 | Submission Open

Keywords: preclinical drug development; disease models; molecular imaging; patient-derived organoids; cancer pharmacology; drug resistance; translational biomarkers; high-content screening; AI-assisted drug discovery; theranostics

(This special issue belongs to the Section Biological Factors)

The Brain–Heart Axis: Neurohumoral and Neuroimmune Pathways in Cardiovascular Pathology

edited by Xiao-Dong Zhang

submission deadline 22 Jun 2027 | Viewed by 55 | Submission Open

Keywords: brain–heart axis; cardiovascular disease; neurohormones; neuroimmune; stress; hypothalamic–pituitary–adrenal axis; sympathetic-adreno-medulla axis; cortisol; inflammation; sympathetic nervous system; parasympathetic nervous system

(This special issue belongs to the Section Biological Factors)

New Insights into Mechanisms and Therapeutics for Cardiovascular Disorders: 2nd Edition

edited by

Carola Yvette Förster

Mohsin Saleet Jafri

and Tarun W. Dasari

submission deadline 30 Jun 2027 | 3 articles | Viewed by 9354 | Submission Open

Keywords: brain–heart axis; heart and stroke; stress-induced cardiomyopathy; cardiovascular disease

(This special issue belongs to the Section Molecular Medicine)

The Heme Oxygenase/Biliverdin Reductase System in Human Health and Disease: New Molecular Insights and Therapeutic Targets

edited by Cesare Mancuso

submission deadline 30 Jun 2027 | 7 articles | Viewed by 8612 | Submission Open

Keywords: Alzheimer’s disease; bilirubin; cancer; carbon monoxide; cardiovascular diseases; cerebral malaria; diabetes mellitus; drug research and development; inflammation; Parkinson’s disease

(This special issue belongs to the Section Molecular Medicine)

Molecular Pathology, Diagnostics and Therapeutics of Lung Disease: 2nd Edition

edited by

Toshimitsu Yamaoka

submission deadline 30 Jun 2027 | 1 articles | Viewed by 749 | Submission Open

Keywords: pulmonary diseases; diagnostics; therapeutics

(This special issue belongs to the Section Molecular Medicine)

Dendrimers, Dendrons, and the Dendritic State: A Themed Issue in Honor of Prof. Donald Tomalia

edited by

Jørn Bolstad Christensen

submission deadline 30 Jun 2027 | Viewed by 711 | Submission Open

Keywords: dendrimers; dendrons; physical properties; biomedical applications; material applications

(This special issue belongs to the Section Molecular Biology)

Physiological Responses and Biomolecular Adaptations to Environmental and Biotic Stress in Aquatic Species

edited by

Eleni Golomazou

submission deadline 30 Jun 2027 | 1 articles | Viewed by 617 | Submission Open

Keywords: aquaculture; fish pathogens; fish welfare; health protection

(This special issue belongs to the Section Molecular Biology)

Cellular and Molecular Basis of Metabolic Alterations in Transplantation

edited by

Valentina Vaira

and

Alessandro Gambella

submission deadline 30 Jun 2027 | Viewed by 175 | Submission Open

Keywords: mitochondria; bioenergetics; metabolomics; glycolysis; immunometabolism

(This special issue belongs to the Section Chemical Biology)

Advances in Islet Biology: A Themed Issue in Honor of Prof. Claes B. Wollheim

edited by

Romano Regazzi

submission deadline 30 Jun 2027 | Viewed by 70 | Submission Open

Keywords: diabetes; beta cell; insulin secretion; mitochondria; calcium signaling; cell death; circadian rhythms; metabolism–secretion coupling; proinsulin biosynthesis; inflammation

(This special issue belongs to the Section Molecular Biology)

Functions and Mechanisms of Protective Biomolecules in Metabolic Diseases

edited by Mirela Baus Lončar,

Anita Horvatić

and

Mirela Sedić

submission deadline 20 Jul 2027 | 3 articles | Viewed by 4516 | Submission Open

Keywords: protective biomolecules; metabolic homeostasis; insulin resistance; cancer metabolism

(This special issue belongs to the Section Molecular Medicine)

Multi-Scale Integrative Radiobiology

edited by

Nicolas Foray

submission deadline 20 Jul 2027 | 1 articles | Viewed by 618 | Submission Open

Keywords: integrative radiobiology; radiosensitivity; radiosusceptibility; radiodegeneration; radiation-induced energy microdepositions; radiation-induced radical oxygen species; radiation-induced DNA damage; DNA damage recognition and repair; radiation-induced tissue injuries; radiation-induced risks

(This special issue belongs to the Section Molecular Biology)

Human ABC Transporters in Drug Disposition and Resistance: 50 Years of Progress and Future Perspectives

edited by

Hiroshi Nakagawa

submission deadline 31 Jul 2027 | Viewed by 318 | Submission Open

Keywords: ABC transporters; drug disposition; drug resistance; pharmacokinetics; pharmacodynamics; pharmacogenetics; single nucleotide polymorphisms (SNPs)

(This special issue belongs to the Section Chemical Biology)

Natural Small Molecules and Biologics for Targeting Aging and Aging-Associated Diseases

edited by

Haiteng Deng

submission deadline 31 Jul 2027 | Viewed by 102 | Submission Open

Keywords: natural small molecules; biologics; aging; chronic diseases; mitochondrial dysfunction; inflammation; oxidative stress; cellular senescence; metabolic dysregulation

(This special issue belongs to the Section Molecular Medicine)

From Target Antigens to Companion Diagnostics: Antibody-Based Therapies in Women’s Cancers

edited by

Salvatore Cortellino

and

Canio Martinelli

submission deadline 15 Aug 2027 | 1 articles | Viewed by 1310 | Submission Open

Keywords: antibody–drug conjugate (ADC); antibody therapy; bispecific antibody; companion diagnostics; biomarker thresholds; immunohistochemistry; FRα; HER2; tissue factor; spatial heterogeneity; tumor penetration; endocytosis/trafficking; bystander effect; resistance mechanisms

(This special issue belongs to the Section Molecular Reproduction)

Digital Twins in Biomedical and Pharmaceutical Research

edited by Shuxing Zhang and Yinan Sun

submission deadline 30 Aug 2027 | Viewed by 278 | Submission Open

Keywords: digital twins; artificial intelligence (AI); big data; drug discovery and development; clinical trials; personalized medicine

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Molecular Mechanisms and Therapeutic Strategies in Pediatric Immune Dysregulation

edited by Rita Consolini and

Giorgio Costagliola

submission deadline 31 Aug 2027 | Viewed by 297 | Submission Open

Keywords: immune dysregulation; autoimmunity; inborn errors of immunity; targeted therapies; immunomodulatory treatments; genetics; gene therapy; hematopoietic stem cell transplantation

(This special issue belongs to the Section Molecular Medicine)

Copper Signaling and Redox Biology in Vascular Function and Disease

edited by Archita Das

submission deadline 31 Aug 2027 | Viewed by 213 | Submission Open

Keywords: redox signaling; endothelial cell; vascular biology; angiogenesis; atherosclerosis; diabetes; copper transporter proteins

(This special issue belongs to the Section Molecular Medicine)

Displaying special issue 401-450 on page 9 of 10.

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