Cellular and Molecular Basis of Metabolic Alterations in Transplantation
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: 30 June 2027 | Viewed by 6
Special Issue Editors
2. OMIC Science Lab, Scientific Direction, Fondazione IRCCS Ca’ Granda, 20122 Milan, Italy
Interests: lung transplantation; chronic lung allograft dysfunction; extracellular vesicles; MicroRNA; pulmonary inflammation; tumor metabolism; glioma stem cells; prostate cancer; metabolic dysfunction; immune regulation; NF-κB signaling; chromatin remodeling
Special Issues, Collections and Topics in MDPI journals
Interests: hepatobiliary pathology; transplant immunopathology; histopathology; immune microenvironment; immunometabolic crosstalk; hepatic primary tumor
Special Issue Information
Dear Colleagues,
The cellular and molecular landscape of organ transplantation is defined by profound metabolic alterations that begin at organ procurement and surgery, continue through immunomodulation during immunosuppressive treatment and ultimately contribute to the risk of allograft failure and rejection. Indeed, the ischemia-to-reperfusion transition triggers a cascade of energetic crises: during graft procurement, oxygen deprivation forces a switch from oxidative phosphorylation to anaerobic glycolysis, resulting in ATP depletion and succinate accumulation. Upon graft implantation and reperfusion, the abrupt reintroduction of oxygen causes a mitochondrial "burst" of reactive oxygen species, damaging cellular membranes and activating innate immune pathways, such as the NLRP3 inflammasome. In the long term, allograft rejection events are closely related to a metabolically driven activation of effector T cells. Furthermore, current immunosuppressive therapies also have profound metabolic impacts: calcineurin inhibitors and mTOR inhibitors target glycolysis in immune cells and corticosteroids affect insulin sensitivity and disrupt lipid metabolism.
This Special Issue aims to highlight recent advances in the cellular and molecular basis of metabolic alterations in transplantation. We invite researchers to contribute to understanding these crucial mechanisms, such as the interplay between metabolite flux and molecular signaling and the immune-metabolic crosstalk, that are key determinants of the metabolic health of donor organs and, ultimately, of long-term graft survival.
We welcome submissions of original research and review articles addressing these topics.
Dr. Valentina Vaira
Dr. Alessandro Gambella
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mitochondria
- bioenergetics
- metabolomics
- glycolysis
- immunometabolism
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
