Advances in Ferroptosis and Metabolic Dysregulation

Dear Colleagues,

Cellular and organ metabolism is regulated by an integrated network of signaling pathways that sense nutrient availability, organellar function, and stress conditions. Redox signaling is a critical component of this network, maintaining metabolic homeostasis and enabling adaptive responses. However, sustained or dysregulated oxidative stress not only accompanies disease but, in many pathological contexts, has been shown to drive its onset and progression across multiple organ systems.

Ferroptosis is an iron‑dependent form of regulated cell death defined by iron‑driven lipid peroxidation and loss of cellular viability. It constitutes a distinct terminal outcome of dysregulated iron, lipid, and redox metabolism. Ferroptosis has been implicated in cancer, cardiovascular and metabolic disorders, neurodegeneration, inflammatory diseases, and ischaemic–reperfusion injury. Despite substantial progress in defining its core machinery, critical questions remain unanswered: how metabolic and redox pathways, including organelle‑specific processes in mitochondria, endoplasmic reticulum, peroxisomes, and the plasma membrane, interact in a context‑dependent manner to initiate, amplify, or suppress ferroptosis in physiological and pathological settings.

This Special Issue, “Advances in Ferroptosis and Metabolic Dysregulation”, aims to bring together cutting-edge research addressing the molecular mechanisms, regulatory networks, and therapeutic implications of these interconnected processes. Particular emphasis will be placed on the crosstalk between iron metabolism, lipid metabolism, mitochondrial function, cellular stress responses, and ferroptotic pathways, as well as their roles in disease development and progression.

Authors are encouraged to submit original research articles, reviews, and perspectives that focus on the following:

1. Define how ferroptosis is established, regulated, and executed under homeostatic and pathological conditions;
2. Determine how metabolic reprogramming and redox regulation modulate cellular susceptibility to oxidative stress and ferroptosis;
3. Explore how these mechanisms can be therapeutically exploited to either prevent ferroptotic cell loss in vulnerable tissues or harness ferroptosis to selectively eliminate disease‑associated cells;
4. Elucidate how these interactions may reveal novel disease mechanisms, biomarkers, and therapeutic targets.

Manuscripts should be submitted through the journal's online submission system.

Authors are encouraged to provide clear and concise explanations of their findings, including experimental details, results, and implications.

All articles will undergo peer review to ensure quality and relevance to the theme of this Special Issue.

We look forward to your contributions to this exciting and rapidly evolving field.

Dr. Udayakumar Karunakaran
Dr. Suma Elumalai
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• reactive oxygen species
• antioxidants
• glutathione
• iron
• H₂S signaling
• diabetes
• metabolic disease
• mitochondrial biology
• ferroptosis
• cell death
• inflammation
• aging
• neurodegenerative diseases

• Oxidative Stress and Ferroptosis in Health and Disease in Biomolecules (2 articles)