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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Tissue Calcification in Normal and Pathological Environments

edited by

Fulvia Ortolani

submission deadline 31 May 2026 | 10 articles | Viewed by 39025 | Submission Open

Keywords: calcification; ectopic mineralization; bone; heterotopic ossification; calcium phosphate; calcium carbonate; calcium oxalate; procalcific cell death

(This special issue belongs to the Section Molecular Medicine)

Liver Damage and Associated Metabolic Disorders

edited by

Lin Jia

submission deadline 31 May 2026 | 5 articles | Viewed by 23593 | Submission Open

Keywords: lipid species; lipid metabolism; organelle dynamics; hepatokines; metabolic risk; immune responses

(This special issue belongs to the Section Molecular Medicine)

The Structure and Function of Neurotransmitter Receptors and Transporters: From Molecular Biology to Translational Research

edited by

Riccardo Fesce

submission deadline 31 May 2026 | 3 articles | Viewed by 20369 | Submission Open

Keywords: neurotransmitters; receptors; neurotransporters; structure– function relationship; neuropharmacology

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Nonalcoholic Fatty Liver Disease: From Molecular Mechanisms to Therapeutic Approaches

edited by

Yumin Dai

and

Martina Beretta

submission deadline 31 May 2026 | 4 articles | Viewed by 17972 | Submission Open

Keywords: nonalcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH); reactive oxygen species; mitochondria; lipotoxicity

(This special issue belongs to the Section Molecular Medicine)

Oxidative Stress and Inflammation in Aging and Cancer: Biological Bases, Therapeutic Strategies and Opportunities

edited by

Antonio Garrido

submission deadline 31 May 2026 | 3 articles | Viewed by 10840 | Submission Open

Keywords: ROS; inflammatory compounds; oxidative stress; chronic inflammation; aging; cancer; immunomodulation; antioxidant strategies; exercise; nutrition

(This special issue belongs to the Section Biological Factors)

Advances in Metabolomics in Health and Disease

edited by

Carmen Socaciu

submission deadline 31 May 2026 | 5 articles | Viewed by 9720 | Submission Open

Keywords: metabolomics; disease biomarkers; metabolic phenotyping; metabolic pathways; mass spectrometry; NMR spectroscopy; metabolic databases; bioinformatics

(This special issue belongs to the Section Molecular Medicine)

Calcium Signaling and Transport in Health and Disease: Recent Developments and New Insights

edited by

Mykola Mamenko

and Brandi M. Wynne

submission deadline 31 May 2026 | 3 articles | Viewed by 9506 | Submission Open

Keywords: calcium signaling; calcium transport; calcium channel; calbindin; calcium pump; calcium stores; mitochondrial calcium; store-operated calcium entry; calcium release

(This special issue belongs to the Section Cellular Biochemistry)

Advancing Innovations in Biomedical Research for Translational Applications

edited by Jianjie Ma,

Ki Ho Park

and

Zui Pan

submission deadline 31 May 2026 | 6 articles | Viewed by 9387 | Submission Open

Keywords: nanoparticle drug delivery; precision medicine; stem cell; proteomic and lipidomic profiling; novel therapeutic strategies; regenerative medicine; biologic drug development; IND submission

(This special issue belongs to the Section Molecular Medicine)

Bioactive Molecules in the Control of Oxidative Stress and Oxidative Stress-Related Diseases

edited by

Jian Yao

submission deadline 31 May 2026 | 4 articles | Viewed by 9383 | Submission Open

Keywords: antioxidants; bioactive molecules; ROS; redox signaling; oxidative stress-related diseases

(This special issue belongs to the Section Molecular Medicine)

Redox Balance and Proteostasis Surveillance in Neurodegenerative Disorders

edited by

Fabio Di Domenico

and

Antonella Tramutola

submission deadline 31 May 2026 | 1 articles | Viewed by 8848 | Submission Open

Keywords: redox homeostasis; oxidative stress; antioxidant response; proteostasis; protein folding; protein oxidation; unfolded protein response; ubiquitin proteosome system; autophagy; neurodegeneration

(This special issue belongs to the Section Molecular Medicine)

Biomarkers of Cardiovascular and Cerebrovascular Diseases, 2nd Edition

edited by

Ana Catarina Fonseca

submission deadline 31 May 2026 | 5 articles | Viewed by 8262 | Submission Open

Keywords: biomarkers; cardiovascular disease; cerebrovascular disease; cardiovascular therapy; diagnosis

(This special issue belongs to the Section Molecular Biomarkers)

Recent Advances in RNA Editing and Modification

edited by

Toshifumi Tsukahara

submission deadline 31 May 2026 | 2 articles | Viewed by 6298 | Submission Open

Keywords: RNA editing; RNA modification; deamination; transamination; pseudouridylation

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular and Cellular Mechanisms in Skin Disorders

edited by

Keiichi Yamanaka

submission deadline 31 May 2026 | 3 articles | Viewed by 5883 | Submission Open

Keywords: inflammatory skin disease; psoriasis; atopic dermatitis; cytokine; comorbidity; complication; systemic inflammation; internal organ

(This special issue belongs to the Section Molecular Biology)

Acute Kidney Injury and Mitochondrial Involvement

edited by

Iva Suman

and

Alenka Višnić

submission deadline 31 May 2026 | 4 articles | Viewed by 5693 | Submission Open

Keywords: acute kidney injury; mitochondrial dysfunction; mitochondrial dynamics; mitophagy; biomarkers

(This special issue belongs to the Section Chemical Biology)

Cutting-Edge Perspectives on Protein and Enzyme Engineering

edited by Haishan Qi and Haoran Yu

submission deadline 31 May 2026 | 2 articles | Viewed by 3992 | Submission Open

Keywords: protein engineering; protein material; enzyme evolution; therapy protein; protein expression; machine learning; unnatural amino acids

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Mechanisms and Therapeutic Strategies for Metabolic Dysfunction: From Molecules to Population Health

edited by

Zhipeng Liu

submission deadline 31 May 2026 | 2 articles | Viewed by 3310 | Submission Open

Keywords: metabolic dysfunction; molecular mechanisms; therapeutic strategies; genomics; genetic epidemiology; comorbidities; biomarkers

Advances in Microbial CRISPR Editing

edited by

Dongdong Yang

and Rongming Liu

submission deadline 31 May 2026 | 2 articles | Viewed by 3104 | Submission Open

Keywords: CRISPR-Cas; microbial genome editing; synthetic biology; base and prime editing; multiplexed CRISPR engineering; microbiome manipulation; phage and plasmid control; evolutionary stability of CRISPR edits; CRISPR-driven biocontainment; novel CRISPR systems

(This special issue belongs to the Section Molecular Biology)

Dysregulated Cytokine Signals in Human Disease

edited by

Alister C. Ward

submission deadline 31 May 2026 | 2 articles | Viewed by 2806 | Submission Open

Keywords: cytokine; signaling; dysregulation; immunity; development; disease

(This special issue belongs to the Section Molecular Medicine)

Obesity, Hormones and Reproductive Health

edited by

Srinivas Nammi

submission deadline 31 May 2026 | 1 articles | Viewed by 2781 | Submission Open

Keywords: obesity; leptin; insulin; estrogens; androgens; growth hormone; sexual dysfunction; reproductive health

(This special issue belongs to the Section Biological Factors)

Nitric Oxide and Reactive Species in Plant Physiology and Pathology

edited by

Bong-Gyu Mun

submission deadline 31 May 2026 | 2 articles | Viewed by 2554 | Submission Open

Keywords: nitric oxide; reactive oxygen species; reactive sulfur species; redox signaling; S-nitrosylation; plant stress tolerance; antioxidant systems; phytohormones; metabolic regulation

(This special issue belongs to the Section Biological Factors)

Identifying New Therapeutic Targets for Psychiatric Disease Using Transcriptomics and Epigenomics

edited by

Dennis R. Grayson

and

Jacob Peedicayil

submission deadline 31 May 2026 | 1 articles | Viewed by 2211 | Submission Open

Keywords: epigenomics; psychiatric disease; psychiatry; therapeutic target; transcriptomics

(This special issue belongs to the Section Molecular Genetics)

Genomic Instability: Insights into Molecular Mechanisms, Human Diseases, and Therapies

edited by

Dong Zhang

submission deadline 31 May 2026 | 2 articles | Viewed by 2055 | Submission Open

Keywords: genome instability; DNA damage response; cancer; therapy; diagnosis

(This special issue belongs to the Section Molecular Genetics)

Botanic Metabolites: From Extraction to Application

edited by

Carmen Formisano

submission deadline 31 May 2026 | 1 articles | Viewed by 1573 | Submission Open

Keywords: medicinal plants; phytochemistry; antimicrobial activity; plant extracts; essential oils; synergism

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Bench and Bedside: Molecular Insights and Neuroprotective Strategies for Stroke

edited by

Yuchuan Ding

submission deadline 31 May 2026 | 1 articles | Viewed by 1378 | Submission Open

Keywords: neuroprotection; neurorehabilitation; conditioning medicine; ischemia and reperfusion injury; cerebral hemor-rhages; stress; vascular diseases

(This special issue belongs to the Section Molecular Medicine)

Pediatric Epilepsy: Insights from Genetics to Mechanisms

edited by Denise Drongitis and

Maria Giuseppina Miano

submission deadline 31 May 2026 | Viewed by 589 | Submission Open

Keywords: integrative omics; organoid models; brain development; PE-related pathways; innovative therapeutic approaches

(This special issue belongs to the Section Molecular Genetics)

Metabolic and Signal Transduction Pathways Controlling Platelet and Megakaryocyte Activity

edited by Ana Kasirer-Friede and Deepa Gautam

submission deadline 31 May 2026 | Viewed by 483 | Submission Open

Keywords: platelet; megakaryocyte; signaling; omics; immune

(This special issue belongs to the Section Molecular Biology)

Assembly of RNA and DNA

edited by

Roman Marks

and

Jürg Bähler

submission deadline 31 May 2026 | Viewed by 454 | Submission Open

Keywords: polymerization of RNA and DNA; electrical functioning of RNA/DNA; rotational– electric principles of replication; interactions between RNA/DNA and physical/chemical field; chirality in biomolecules

(This special issue belongs to the Section Molecular Genetics)

Molecular Basis and Translational Research in Metabolic Myopathies: A Themed Issue in Honor of Professor Corrado Angelini, 2nd Edition

edited by

Marija Meznaric

Daniela Tavian

and

Sara Missaglia

submission deadline 31 May 2026 | Viewed by 434 | Submission Open

Keywords: metabolic myopathies; lipid metabolism; glycogen metabolism; genetic diseases; treatments; lipid storage myopathies; glycogen storage myopathies; lysosomal storage myopathies

(This special issue belongs to the Section Molecular Biology)

Artificial Intelligence in Structural Biology and Drug Discovery

edited by Kyle Biggar

submission deadline 31 May 2026 | Viewed by 374 | Submission Open

Keywords: protein structure prediction; drug discovery; molecular docking; experimental validation

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Molecular Mechanisms of Viral Infections—2nd Edition

edited by

Ioannis Karakasiliotis

Christine Kottaridi

and

Konstantinos Konstantinidis

submission deadline 31 May 2026 | Viewed by 318 | Submission Open

Keywords: viral replication; virus evolution; immune response; antiviral strategies virus; infection; pathogenesis; virulence

(This special issue belongs to the Section Molecular Biology)

Molecular Diagnostics and Targeted Therapies for Breast and Prostate Cancers

edited by

Anna Orlova

, Ekaterina Bezverkhniaia and Panagiotis Kanellopoulos

submission deadline 31 May 2026 | Viewed by 282 | Submission Open

Keywords: molecular imaging; targeted therapy; prostate cancer; breast cancer; theranostics

(This special issue belongs to the Section Biological Factors)

Molecular Mechanisms of Oocyte and Early Embryo Development: RNA Regulation and Epigenetic Modifications

edited by

Heng-Yu Fan

and

Xing‐Xing Dai

submission deadline 31 May 2026 | Viewed by 263 | Submission Open

Keywords: oocyte; embryo development; follicular development; RNA regulation; epigenetic modifications

(This special issue belongs to the Section Molecular Reproduction)

Immune Microenvironment in Cancer: Myeloid Cells and Therapeutic Insights

edited by

Daniëlle Krijgsman

submission deadline 31 May 2026 | Viewed by 262 | Submission Open

Keywords: cancer; immunotherapy; myeloid cells; macrophages; neutrophils; tumor microenvironment; therapy resistance

(This special issue belongs to the Section Molecular Medicine)

Genetic Variations and Gene Expression in Diseases

edited by

Éva Kereszturi

submission deadline 31 May 2026 | Viewed by 243 | Submission Open

Keywords: omics; gene expression; genetic variation; SNPs; polymorphisms; complex traits; monogenic disorders; gene-environment interactions; transcriptomics; functional analysis

(This special issue belongs to the Section Molecular Biology)

Advances in Cardiometabolic Health, 2nd Edition

edited by Pamela Senesi and

Anna Ferrulli

submission deadline 31 May 2026 | Viewed by 236 | Submission Open

Keywords: obesity; cardiovascular diseases; biomarkers; lifestyle interventions; personalized medicine

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Research on Autoimmune Diseases: From Diagnosis to Therapy

edited by

Serena Guiducci

submission deadline 31 May 2026 | Viewed by 236 | Submission Open

Keywords: systemic sclerosis; autoimmune diseases; rheumatic diseases; chronic inflammation; mechanisms

(This special issue belongs to the Section Biological Factors)

Metagenomics and Genomics of Marine Organisms

edited by

Padmanabhan Mahadevan

submission deadline 31 May 2026 | Viewed by 234 | Submission Open

Keywords: metagenomics genomics viruses bacteria symbiosis microbiome

Molecular Pathogenesis and Emerging Therapeutic Targets and Strategies in Huntington’s Disease

edited by

Laszlo Bodai

and

Nora Zsindely

submission deadline 31 May 2026 | Viewed by 200 | Submission Open

Keywords: Huntington’ s disease; huntingtin; polyglutamine; neurodegeneration; pathogenesis; therapeutic targets; proteopathy; autophagy dysfunction; transcriptional dysregulation; mitochondrial dysfunction

(This special issue belongs to the Section Molecular Medicine)

Advances in Nano-Based Drug Delivery Systems

edited by

Amalendu P. Ranjan

Nirupama A. Sabnis

and

Zacharias Suntres

submission deadline 1 Jun 2026 | 6 articles | Viewed by 12384 | Submission Open

Keywords: drug delivery system; nanotechnology; nanomedicine; nanocarriers; nanoparticles; nanoformulation; biomolecules

(This special issue belongs to the Section Molecular Medicine)

Aldehyde Metabolism and Innate Immune Signaling in Cardiovascular Disease: From Pathogenesis to Regeneration

edited by Suresh S. Palaniyandi

submission deadline 1 Jun 2026 | Viewed by 220 | Submission Open

Keywords: reactive aldehydes (4-HNE; acrolein; and malondialdehyde); lipid peroxidation and oxidative stress; aldehyde detoxification enzymes (ALDH2; ALDHs; AKRs; and GSTs); glutathione and antioxidant defense systems; mitochondrial dysfunction and redox imbalance; protein adducts and cellular signaling; endothelial dysfunction and vascular injury; inflammation; innate immunity; and inflammasomes; cardiac remodeling; heart failure; and atherosclerosis; biomarkers and therapeutic strategies (enzyme activators; scavengers; and regeneration)

(This special issue belongs to the Section Molecular Medicine)

Defects in the Transport Mechanism of Membrane Proteins and Related Diseases, 2nd Edition

edited by Daniela Valeria Miniero

submission deadline 10 Jun 2026 | 3 articles | Viewed by 5916 | Submission Open

Keywords: function; structure and folding of membrane transport proteins; pathological mutations; mechanism of transport; neurological and metabolic disease; transport of nanoparticles; organelle membranes; cellular function and signaling; bioenergetics; neuroinflammation; nanoformulations for drug targets

(This special issue belongs to the Section Cellular Biochemistry)

Computational Intelligence in Structure and Function Prediction and Modeling of Proteins—2nd Edition

edited by

Jian Zhang

Bi Zhao

and Haiting Chai

submission deadline 15 Jun 2026 | 4 articles | Viewed by 10429 | Submission Open

Keywords: protein tertiary structure; protein folding; protein functions; intrinsic disorder; drug discovery; protein– drug interaction; computational intelligent algorithms; artificial intelligence for proteomics; high-throughput proteomics

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

State-of-the-Art Molecular Structure and Dynamics and Biophysics in Asia

edited by

Xuanyu Meng

and

Ruhong Zhou

submission deadline 15 Jun 2026 | 3 articles | Viewed by 4138 | Submission Open

Keywords: molecular modeling; molecular dynamics simulation; protein– protein interaction; protein folding; bioinformatics; molecular docking; drug design; machine learning

(This special issue belongs to the Section Chemical Biology)

Functional Structures in RNA Viruses

edited by Riccardo Delli Ponti,

Gian Gaetano Tartaglia

Andrea Vandelli

and Laura Broglia

submission deadline 15 Jun 2026 | Viewed by 277 | Submission Open

Keywords: RNA secondary structure; RNA viruses; machine learning; SHAPE; protein– RNA interactions

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Epigenetic Drivers of Cancer Metastasis: From Methylation to Non-Coding RNAs

edited by

Toshifumi Hara

submission deadline 19 Jun 2026 | 2 articles | Viewed by 3205 | Submission Open

Keywords: epigenetics; metastasis; DNA methylation; RNA methylation; non-coding RNAs

Cellular Stress Responses in Oncogenesis and Metabolic Reprogramming

edited by

Kuo Hui Su

submission deadline 19 Jun 2026 | Viewed by 265 | Submission Open

Keywords: cellular stress response; metabolic reprogramming; oncogenesis; lipid metabolism; tumor adaptation; mitochondrial metabolism

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Biomarkers of Epileptogenesis

edited by

Pedro J. Serrano-Castro

submission deadline 20 Jun 2026 | 6 articles | Viewed by 19312 | Submission Open

Keywords: epileptogenesis; neuroinflammation; biomarkers; drug-resistant epilepsy; personalized neurology

(This special issue belongs to the Section Molecular Biomarkers)

Advances in p53 Research

edited by

Gabriella D’Orazi

submission deadline 20 Jun 2026 | 3 articles | Viewed by 18194 | Submission Open

Keywords: p53; small molecules; tumor suppressor; apoptosis; tumor– host interaction; targeted therapies; tumor microenvironment (TME)

(This special issue belongs to the Section Molecular Biology)

Biochemistry and Molecular Biology of Vitamin D and Its Analog, 3rd Edition

edited by

Toshiyuki Sakaki

and Naoko Tsugawa

submission deadline 20 Jun 2026 | 3 articles | Viewed by 3488 | Submission Open

Keywords: vitamin D; vitamin D receptor; vitamin D analog; genomic action; non-genomic action; bone formation; immune response; cancer; rickets; osteoporosis; psoriasis; drug discovery; disease prevention; nutrition improvement metabolism of vitamin D or its analogs cytochrome P450

(This special issue belongs to the Section Chemical Biology)

Molecular Mechanisms and Therapeutic Potential of Extracellular Vesicles in Neurovascular Diseases

edited by

Ji Chen Bihl

submission deadline 20 Jun 2026 | 3 articles | Viewed by 2449 | Submission Open

Keywords: extracellular vesicles; neurovascular diseases; cellular communications; biomarkers; therapeutic targets

(This special issue belongs to the Section Cellular Biochemistry)

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