Identifying New Therapeutic Targets for Psychiatric Disease Using Transcriptomics and Epigenomics
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Genetics".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 552
Special Issue Editors
Interests: epigenetic regulation of gene expression; epigenetics of alcohol and alcohol use disorders; transcriptional mechanisms in psychiatric disorders; pre- and post-natal stress animal models and their effect
Special Issue Information
Dear Colleagues,
Psychiatric diseases are common and genetically complex. They involve the brain, one of the most complex organs in the body, and are often caused by the consequences of inappropriate interactions between genes and environmental factors. These diseases take a huge toll on affected patients, their families, and society at large. Since the 1950s, drugs have been available for treating many of these diseases. Such drugs were mainly discovered serendipitously, and so it comes as no surprise that they can be ineffective in many patients and exhibit adverse side effects. Hence, efforts have been made to find new and better drugs for treating these diseases over long periods of time.
Over the past few decades, a number of advances have been made in the study of the molecular aspects of psychiatric diseases. Such studies could aid the development of new and effective drugs by deciphering the molecular bases of these diseases, and they include genomic, epigenomic, and transcriptomic studies. Prior to the development of new pharmacotherapies based on results from omics studies, it is vital to identify new druggable targets that can be replicated across patient cohorts. This Special Issue of Biomolecules contains articles that discuss the possibilities of using the current data from such studies for the development of new drugs for treating psychiatric diseases, including schizophrenia, bipolar disorder, major depressive disorder, anxiety and panic disorder, post-traumatic stress disorder, Alzheimer’s disease, obsessive-compulsive disorder, and attention-deficit hyperactivity disorder. We believe that this Special Issue will spread knowledge on and increase interest in efforts to find new and better drugs for treating these diseases. Original articles and reviews dealing with these topics are welcome.
Prof. Dr. Dennis Grayson
Prof. Dr. Jacob Peedicayil
Guest Editors
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Keywords
- epigenomics
- psychiatric disease
- psychiatry
- therapeutic target
- transcriptomics
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