Molecular Mechanisms and Therapeutic Strategies for Metabolic Dysfunction: From Molecules to Population Health
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 31 May 2026 | Viewed by 37
Special Issue Editor
Special Issue Information
Dear Colleagues,
Metabolic dysfunction, encompassing a spectrum of highly prevalent conditions such as obesity, type 2 diabetes (T2DM), and metabolic dysfunction-associated steatotic liver disease (MASLD), represents one of the most significant challenges to global health worldwide. These disorders often co-occur with cardiovascular disease, psychiatric disorders, cancer, and other conditions, highlighting the need for integrated molecular research. Advances in genomics, genetic epidemiology, and systems biology are revealing the complex genetic and environmental factors underlying metabolic dysregulation, while novel therapeutic strategies are being developed.
This Special Issue aims to provide a comprehensive platform for advancing our understanding of the molecular underpinnings of metabolic dysfunction and its associated comorbidities. By integrating insights from basic molecular biology, multi-omics profiling, genetic association studies, and translational research, we seek to highlight how mechanistic discoveries can inform novel therapeutic interventions and preventive strategies. In doing so, this issue will bridge experimental research and population-scale data, offering a holistic perspective on disease pathogenesis, prevention, and treatment.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- Molecular and physiological mechanisms underlying metabolic dysfunction
- Identification of novel therapeutic targets and development of precision medicine strategies
- Genetic and epigenetic determinants of metabolic disorders
- Molecular interplay between metabolic dysfunction and its comorbidities
- Genetic epidemiology approaches to investigate causal relationships between risk factors and metabolic outcomes
- Biomarker discovery and molecular diagnostics for metabolic syndrome
We look forward to receiving your contributions.
Dr. Zhipeng Liu
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- metabolic dysfunction
- molecular mechanisms
- therapeutic strategies
- genomics
- genetic epidemiology
- comorbidities
- biomarkers
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