Nonalcoholic Fatty Liver Disease: From Molecular Mechanisms to Therapeutic Approaches

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 2604

Special Issue Editors

Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA
Interests: peptides; secondary metabolites; nutraceuticals; interactions between small molecules; enzymes; obesity; cytotoxicity; anti-HIV; analytical methods; LC-MS; NMR
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Guest Editor
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
Interests: non-alcoholic fatty liver disease; diabetes; mitochondrial uncouplers; mouse models of metabolic disease; obesity; energy metabolism

Special Issue Information

Dear Colleagues,

Nonalcoholic fatty liver disease, or NAFLD, refers to a liver problem that affects human beings who drink little to no alcohol, and it is becoming more common, especially in Middle Eastern and Western countries, with increasing rates of obesity. In recent years, great efforts have been made to investigate the pathogenesis of NAFLD; accordingly, a large quantity of biomolecules (small synthetic molecules, natural products, active peptides, oligonucleotide, etc.) with decent activities have been discovered as promising therapeutics through a variety of mechanisms, such as mitochondrial uncouplers, fibroblast growth factor activators, etc. Therefore, this Special Issue aims to publish submissions covering either the identification of biomolecules with promising therapeutic effects or mechanistic studies of biomolecules targeting NAFLD.

Dr. Yumin Dai
Dr. Martina Beretta
Guest Editors

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Keywords

  • nonalcoholic fatty liver disease (NAFLD)
  • non-alcoholic steatohepatitis (NASH)
  • reactive oxygen species
  • mitochondria
  • lipotoxicity

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Published Papers (1 paper)

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Review

40 pages, 1249 KiB  
Review
Drug Advances in NAFLD: Individual and Combination Treatment Strategies of Natural Products and Small-Synthetic-Molecule Drugs
by Xing Wan, Jingyuan Ma, He Bai, Xuyang Hu, Yanna Ma, Mingjian Zhao, Jifeng Liu and Zhijun Duan
Biomolecules 2025, 15(1), 140; https://doi.org/10.3390/biom15010140 - 17 Jan 2025
Cited by 2 | Viewed by 2148
Abstract
Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease and is closely associated with metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome. However, effective treatment strategies for NAFLD are still lacking. In recent years, [...] Read more.
Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease and is closely associated with metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome. However, effective treatment strategies for NAFLD are still lacking. In recent years, progress has been made in understanding the pathogenesis of NAFLD, identifying multiple therapeutic targets and providing new directions for drug development. This review summarizes the recent advances in the treatment of NAFLD, focusing on the mechanisms of action of natural products, small-synthetic-molecule drugs, and combination therapy strategies. This review aims to provide new insights and strategies in treating NAFLD. Full article
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