Molecular and Cellular Mechanisms in Skin Disorders
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 October 2025 | Viewed by 910
Special Issue Editor
Interests: inflammatory skin disease; psoriasis; atopic dermatitis; cytokine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The skin is one of the largest immune organs involving innate and acquired immune systems. Thus, it can respond to exogenous stimuli by producing large amounts of proinflammatory cytokines, resulting in systemic inflammation.
In psoriasis, one of the intractable inflammatory cytokine-mediated skin disorders, the average life span is six years shorter than the population without a history of psoriasis due to cerebrovascular and cardiovascular complications. Patients with severe eczema also have an increased risk of cardiovascular disorders. Several studies have shown that severe inflammatory skin disorders are strongly associated with systemic complications such as arteriosclerosis, cardiomyopathy, abnormal lipid metabolism, nonalcoholic fatty liver disease, renal sclerosis, and systemic amyloidosis. This has led to the concept of the "inflammatory skin march", highlighting the investigation of molecular and cellular mechanisms of skin disorders and the intimate relationship between skin inflammation and systemic complications.
In this context, we welcome clinical evidence and research findings focusing on molecular and cellular mechanisms of skin diseases, as well as systemic inflammatory changes and systemic organ diseases complicated by inflammatory skin disorders.
Prof. Dr. Keiichi Yamanaka
Guest Editor
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Keywords
- inflammatory skin disease
- psoriasis
- atopic dermatitis
- cytokine
- comorbidity
- complication
- systemic inflammation
- internal organ
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