Calcium Signaling and Transport in Health and Disease: Recent Developments and New Insights

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1653

Special Issue Editors


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Guest Editor
Department of Physiology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA
Interests: collecting duct; hypertension; nephrogenic diabetes insipidus; calcium signaling; aldosterone
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Internal Medicine, Division of Nephrology & Hypertension, University of Utah, Salt Lake City, UT 84112, USA
Interests: hypertension; aldosterone; vascular function; calcium signaling; sodium transport; inflammation

Special Issue Information

Dear Colleagues,

Calcium signaling and transport play critical roles in various physiological processes. Calcium ions are pivotal in mediating cellular functions such as muscle contraction, neurotransmitter release, cell proliferation and controlled death during organ development or responses to injury. Mechanotransducing calcium signals triggered by shear stress or stretch are crucial to maintaining cellular integrity and function in the bone, cartilage, vascular, and epithelial cells. Mitochondrial calcium uptake is essential for energy production and apoptosis regulation. The dysregulation of calcium homeostasis can result in a range of pathologies, including hypertension, cardiovascular and renal diseases, neurodegenerative disorders, inflammation, osteoporosis, and obesity. Calcium also plays a paramount role in cancer biology, where alterations in calcium signaling pathways can influence cell proliferation and migration. This Special Issue will highlight recent research advances in the field of calcium signaling and transport through original research, review, and communication articles, as well as brief reports.

Dr. Mykola Mamenko
Dr. Brandi M. Wynne
Guest Editors

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Keywords

  • calcium signaling
  • calcium transport
  • calcium channel
  • calbindin
  • calcium pump
  • calcium stores
  • mitochondrial calcium
  • store-operated calcium entry
  • calcium release

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Published Papers (1 paper)

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Review

15 pages, 1300 KiB  
Review
Endoplasmic Reticulum Calcium Signaling in Hippocampal Neurons
by Vyacheslav M. Shkryl
Biomolecules 2024, 14(12), 1617; https://doi.org/10.3390/biom14121617 - 18 Dec 2024
Viewed by 1326
Abstract
The endoplasmic reticulum (ER) is a key organelle in cellular homeostasis, regulating calcium levels and coordinating protein synthesis and folding. In neurons, the ER forms interconnected sheets and tubules that facilitate the propagation of calcium-based signals. Calcium plays a central role in the [...] Read more.
The endoplasmic reticulum (ER) is a key organelle in cellular homeostasis, regulating calcium levels and coordinating protein synthesis and folding. In neurons, the ER forms interconnected sheets and tubules that facilitate the propagation of calcium-based signals. Calcium plays a central role in the modulation and regulation of numerous functions in excitable cells. It is a versatile signaling molecule that influences neurotransmitter release, muscle contraction, gene expression, and cell survival. This review focuses on the intricate dynamics of calcium signaling in hippocampal neurons, with particular emphasis on the activation of voltage-gated and ionotropic glutamate receptors in the plasma membrane and ryanodine and inositol 1,4,5-trisphosphate receptors in the ER. These channels and receptors are involved in the generation and transmission of electrical signals and the modulation of calcium concentrations within the neuronal network. By analyzing calcium fluctuations in neurons and the associated calcium handling mechanisms at the ER, mitochondria, endo-lysosome and cytosol, we can gain a deeper understanding of the mechanistic pathways underlying neuronal interactions and information transfer. Full article
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