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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Biology of Age-Related Macular Degeneration: From Pathogenesis to Therapeutic Strategies

edited by

Serena Fragiotta

, Pier Luigi Grenga and Chiara Ciancimino

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2203 | Submission Open

Keywords: age-related macular degeneration; vascular endothelial growth factor (VEGF); inflammation; neurodegeneration; single-nucleotide polymorphisms (SNP)

(This special issue belongs to the Section Molecular Biology)

Advances in the Pathology of Prostate Cancer: 2nd Edition

edited by

Piwen Wang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1712 | Submission Open

Keywords: prostate cancer; molecular pathology; biomarker; chemoprevention; therapy

(This special issue belongs to the Section Chemical Biology)

Molecular and Cellular Mechanisms of Aortic Diseases

edited by Maria Giovanna Scioli

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1569 | Submission Open

Keywords: aortic aneurysms; acute aortic syndromes; aortic dissection; intramural haematoma; penetrating atherosclerotic ulcer; traumatic aortic injury; pseudoaneurysm; aortic rupture; atherosclerotic; inflammatory affections; Marfan syndrome; congenital abnormalities; aortic diseases

(This special issue belongs to the Section Molecular Biology)

Exploring Thermophilic Enzymes: From Structural Foundations to Functional Enhancement

edited by

Renjun Gao

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1428 | Submission Open

Keywords: thermostable enzymes; structural biology; protein engineering; functional enhancement; industrial applications; thermal stability mechanisms; biotechnology

(This special issue belongs to the Section Enzymology)

Cellular and Molecular Mechanisms in Cardiorenal Syndrome

edited by

Rosemary Wangensteen

, María Carmen Ruiz Fuentes and Maria José Espigares Huete

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1189 | Submission Open

Keywords: cardiorenal syndrome; renal failure; heart; kidney; heart failure

(This special issue belongs to the Section Molecular Biology)

The Planarian Model in Pharmacology, Toxicology, and Neuroscience

edited by Oné R. Pagán

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1016 | Submission Open

Keywords: planarians; pharmacology; toxicology; neuroscience; neurotransmission; regeneration

(This special issue belongs to the Section Molecular Biology)

Oxidative Stress and Ferroptosis in Health and Disease

edited by Udayakumar Karunakaran and Suma Elumalai

submission deadline 28 Feb 2026 | 1 articles | Viewed by 939 | Submission Open

Keywords: reactive oxygen species; antioxidants; glutathione; iron; H2S signaling; diabetes; metabolic disease; mitochondrial biology; ferroptosis; cell death; inflammation; aging; neurodegenerative diseases

(This special issue belongs to the Section Chemical Biology)

Insights into Mitochondria in Psychiatric Disorders

edited by Ji Geng

submission deadline 28 Feb 2026 | 1 articles | Viewed by 930 | Submission Open

Keywords: mitochondria; depression; schizophrenia; autism; neurodevelopmental disorders

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Mechanisms and Drug Research in Alzheimer’s Disease

edited by

Xudong Huang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 602 | Submission Open

Keywords: Alzheimer's disease; molecular mechanisms; drug discovery; Aβ amyloid; tau protein; neuroinflammation; oxidative stress; metal homeostasis; blood– brain barrier; dysbiosis

(This special issue belongs to the Section Molecular Medicine)

Biomarkers and Therapeutic Approaches in Melanoma: New Omics-Strategies

edited by

Italia Falcone

Fabio Valenti

and

Stefano Giuliani

submission deadline 28 Feb 2026 | 1 articles | Viewed by 590 | Submission Open

Keywords: melanoma; biomarkers; omics; precision oncology; drug resistance

(This special issue belongs to the Section Molecular Biomarkers)

Functional Analysis of Genes Related to DNA Damage

edited by Ryan P. Barnes and Amy M. Whitaker

submission deadline 28 Feb 2026 | 1 articles | Viewed by 395 | Submission Open

Keywords: DNA damage; DNA repair; genome stability; DNA replication stress

(This special issue belongs to the Section Molecular Biology)

Exploring Novel Molecular Pathways and Emerging Treatments for Neuromuscular Disorders

edited by

Arturo Lopez-Castel

submission deadline 28 Feb 2026 | Viewed by 381 | Submission Open

Keywords: gene therapy; repurposing; therapeutic oligonucleotides; personalized medicine; biomarkers

(This special issue belongs to the Section Molecular Medicine)

Virus-Host Protein Interactions

edited by

Benoit Coulombe

submission deadline 28 Feb 2026 | Viewed by 280 | Submission Open

Keywords: protein– protein interactions; antiviral drug discovery; protein target inhibitors

Novel Drug Targets and RNA Epigenetics in Cancer Therapy

edited by Manjeet K. Rao

submission deadline 28 Feb 2026 | Viewed by 269 | Submission Open

Keywords: RNA modifications; cancer epigenetics; novel drug targets; RNA therapeutics; tumorigenesis

(This special issue belongs to the Section Molecular Biology)

Cellular Signaling and Cardiovascular Diseases: From NF-κB to Golgi Dynamics

edited by

Tong-You Wei

submission deadline 28 Feb 2026 | Viewed by 235 | Submission Open

Keywords: cardiovascular diseases; NF-κ B signaling; vascular cells; epigenetic regulation; vascular inflammation; intercellular crosstalk; Golgi dynamics

(This special issue belongs to the Section Cellular Biochemistry)

Studies of Protein Dynamics, Interactions, and Concentration by Fluorescence Fluctuation Correlation Spectroscopy (FFCS)

edited by Jieqiong Lou and Elvis Pandžić

submission deadline 28 Feb 2026 | Viewed by 202 | Submission Open

Keywords: fluorescence fluctuation correlation spectroscopy (FFCS); fluorescence correlation spectroscopy (FCS); image correlation spectroscopy (ICS); pair correlation function (pCF) analysis; line-scan correlation; protein dynamics; molecular diffusion; molecular flow; confinement dynamics; protein– protein interactions; membrane organization; intracellular transport; molecular crowding; spatiotemporal fluctuations; concentration heterogeneity; live-cell imaging; single-molecule analysis; quantitative fluorescence microscopy; biophysics; super-resolution fluctuation analysis

Unveiling Protein Functions, Dynamics and Interactions in Health and Disease Using Experimental and Theoretical Approaches, 2nd Edition

edited by Alice Romagnoli,

Stefano Motta

and

Jesmina Rexha

submission deadline 28 Feb 2026 | Viewed by 185 | Submission Open

Keywords: protein structure and dynamics; protein– protein interactions; point mutations; molecular biology; molecular modeling; molecular dynamics; biochemistry; bioinformatics; protein– ligand interaction; protein– nucleic acid interaction; protein conformational changes

(This special issue belongs to the Section Chemical Biology)

Exploring the Pathophysiology of Epilepsy: Metabolic Mechanisms and Therapeutic Potential

edited by

Halina Baran

and Christoph Baumgartner

submission deadline 28 Feb 2026 | Viewed by 181 | Submission Open

Keywords: epilepsy; metabolic regulation; signaling pathways; kynurenic acid; seizure detection; antiseizure drugs; innovative therapies

(This special issue belongs to the Section Molecular Medicine)

Novel Insights and Applications of Pluripotent Stem Cells

edited by

Huseyin Sumer

and Ben Rollo

submission deadline 28 Feb 2026 | Viewed by 170 | Submission Open

Keywords: pluripotent stem cells; pluripotency; differentiation; stem cell transplant; regenerative medicine; disease modeling; organoids; therapeutic screening; cell therapies; drug discovery

(This special issue belongs to the Section Cellular Biochemistry)

VDAC1 as a Hub Protein–Modulation of VDAC1-Mediated Prograde Cell Death, Metabolism, Inflammation and Immunity via Interacting Proteins, Metabolites and Small Molecules

edited by Jay H. Chung and

Vito De Pinto

submission deadline 28 Feb 2026 | Viewed by 164 | Submission Open

Keywords: apoptosis; binding sites; ferroptosis; inflammation; metabolism; mitochondria; oxidative strass; pyroptosis; small molecules; VDAC

(This special issue belongs to the Section Cellular Biochemistry)

The N-Methyl-D-Aspartate (NMDA) Receptor: From Pathophysiology to Clinical Significance

edited by

Motohiro Okada

submission deadline 28 Feb 2026 | Viewed by 153 | Submission Open

Keywords: L-glutamate; D-serine; ionotropic glutamate receptors; psychiatric disorders; neurodegeneration; synaptic plasticity; epilepsy; pathophysiology; signaling

Zebrafish: A Gateway to Understanding Human Disease

edited by

Gregory Kelly

and

Marc Ekker

submission deadline 28 Feb 2026 | Viewed by 149 | Submission Open

Keywords: zebrafish development; genetic pathways in zebrafish and humans; a better understanding of human disease conditions related to zebrafish

Membrane Clusters in Health and Neurodegenerative Disease

edited by Tayuan Chang and Catherine C. Y. Chang

submission deadline 28 Feb 2026 | Viewed by 147 | Submission Open

Keywords: membrane cluster; membrane lipids; membrane proteins; caveolin; lipid rafts; phospholipid; cholesterol; sphingolipids; cholesteryl esters

Advances in Drosophila Models for Amyloid and Neurodegenerative Diseases

edited by Ann Christin Brorsson

submission deadline 28 Feb 2026 | Viewed by 137 | Submission Open

Keywords: neurodegeneration; protein aggregation; amyloid structures; neurotoxicity; Drosophila melanogaster; model organism

Modern Studies of Nucleic Acid Dynamics

edited by

Gary A. Meints

submission deadline 28 Feb 2026 | Viewed by 128 | Submission Open

Keywords: nucleic acid dynamics; DNA; RNA; nucleic acid energetics; dynamics of biomolecular recognition; timescales and magnitudes of dynamics

Molecular Genetics of Parasitic Protozoa

edited by

Paştiu Anamaria Ioana

submission deadline 28 Feb 2026 | Viewed by 111 | Submission Open

Keywords: molecular genetics; parasitic protozoa; zoonosis; One Health

(This special issue belongs to the Section Molecular Genetics)

Photosynthetic Adaptation and Photoprotection in Plants

edited by

Roland Valcke

submission deadline 28 Feb 2026 | Viewed by 72 | Submission Open

Keywords: pigment– protein complexes; excess energy; quenching; photoprotection; electron transport; reactive oxygen species

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Alcohol-Related Nervous System Damage and Disease: From Mechanisms to Therapies

edited by

Suzanne M. De La Monte

submission deadline 14 Mar 2026 | 1 articles | Viewed by 345 | Submission Open

Keywords: alcohol; brain; neurodegeneration; diagnostics; treatment; disease mechanisms; prevention; pathology; imaging; molecular and cellular studies; co-factor effects

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Treatment and Prognosis of Autoimmune Bullous Diseases

edited by Kristina Seiffert-Sinha and Animesh A. Sinha

submission deadline 15 Mar 2026 | 1 articles | Viewed by 1100 | Submission Open

Keywords: autoimmunity; blistering; gene expression; immunome; keratinocyte; pathomechanism; proteome; skin

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Bronchiolitis Obliterans

edited by Ralf Schubert and Silvija-Pera Jerkic

submission deadline 15 Mar 2026 | Viewed by 93 | Submission Open

Keywords: bronchiolitis obliterans (BO); inflammation; fibrosis; molecular mechanisms

(This special issue belongs to the Section Molecular Medicine)

Molecular Effects of Environmental Pollutants on Health of Human, Animals and Plants, 2nd Edition

edited by

Marina Piscopo

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1686 | Submission Open

Keywords: health damage; reproductive health; environmental pollution; epigenetics; human; animals and plants

(This special issue belongs to the Section Natural and Bio-derived Molecules)

DNA Damage Response for Targeted Cancer Therapy: Molecular Basis and Mechanisms Pathways

edited by

Renata Krupa

submission deadline 20 Mar 2026 | Viewed by 193 | Submission Open

Keywords: DNA repair; targeted cancer therapy; DNA damage response; predictive factors; gene editing; personalized cancer therapy

(This special issue belongs to the Section Molecular Biology)

Future Innovation and Challenges in Bioactive Compounds from Plant Foods: Towards Sustainable Health

edited by

Giacomo Fais

and

Giorgia Sarais

submission deadline 20 Mar 2026 | Viewed by 159 | Submission Open

Keywords: bioactive compounds; plant-based foods; functional phytochemicals; sustainable nutrition; nutraceuticals; eco-friendly extraction; agro-industrial byproducts; microalgae and cyanobacteria; food waste valorization; innovative food systems

The Kynurenine Pathway in Mood Disorders: From Mechanisms to Therapeutics

edited by Gregory F. Oxenkrug

submission deadline 27 Mar 2026 | Viewed by 102 | Submission Open

Keywords: kynurenine; tryptophan; mood disorders; stress; inflammation

(This special issue belongs to the Section Biological Factors)

Research Progress on Anti-Aging with Natural Products

edited by

Sang-Han Lee

submission deadline 29 Mar 2026 | 1 articles | Viewed by 2116 | Submission Open

Keywords: natural products; anti-aging signaling; autophagy; antioxidants; skin aging; bioactive compounds; molecular mechanisms; translational applications

(This special issue belongs to the Section Biological Factors)

Advances in Lysosomal Disorders: From Molecular Mechanisms to Diagnosis

edited by

Gianandrea Pasquinelli

and Irene Capelli

submission deadline 29 Mar 2026 | Viewed by 71 | Submission Open

Keywords: Fabry disease; lysosomal disorders; globotriaosylceramide (GB3); inherited disease; GLA-gene; nephropathy; hypertrophic cardiomyopathy; small fiber neuropathy

(This special issue belongs to the Section Molecular Medicine)

Biogenic Amines, Their Receptors and Transporters in Health and Disease: Commemorative Issue in Honor of Professor Marc G. Caron (1946–2022)

edited by

Raul Gainetdinov

Bruno Giros

, Jean Martin Beaulieu and Stephen S.G. Ferguson

submission deadline 31 Mar 2026 | 16 articles | Viewed by 62361 | Submission Open

Keywords: dopamine; serotonin; norepinephrine; epinephrine; histamine; trace amines; beta-phenylethylamine; GPCR; TAAR

(This special issue belongs to the Section Biological Factors)

Esophageal Diseases: Molecular Basis and Therapeutic Approaches

edited by

Hiroshi Nakagawa

and Amanda B. Muir

submission deadline 31 Mar 2026 | 6 articles | Viewed by 16942 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

The Role of Astrocytes in Neurodegenerative Diseases

edited by

Nima Sanadgol

submission deadline 31 Mar 2026 | 4 articles | Viewed by 12794 | Submission Open

Keywords: astrocytes; neurodegeneration; neuroinflammation; neuroprotection; neuroregeneration

(This special issue belongs to the Section Cellular Biochemistry)

Molecular Mechanisms and Novel Therapeutic Approaches of Neurodegenerative Diseases

edited by

Zhidong Zhou

submission deadline 31 Mar 2026 | 5 articles | Viewed by 9725 | Submission Open

Keywords: neurodegenerative disease; therapeutic approaches; molecular mechanisms; RNA-based therapies; gene therapy; small-molecule inhibitors; immunotherapy

(This special issue belongs to the Section Biological Factors)

State of the Art and Perspectives in Retinal Pigment Epithelium

edited by

Paola Secchiero

and

Elisabetta Melloni

submission deadline 31 Mar 2026 | 3 articles | Viewed by 7937 | Submission Open

Keywords: retinal pigment epithelium; innovative treatments/therapeutic approaches; retinal diseases; bioactive molecules; eye delivery strategy

(This special issue belongs to the Section Cellular Biochemistry)

Novel Antimicrobial Strategies for Animal Health

edited by

Anna Aris

and

Elena Garcia-Fruitos

submission deadline 31 Mar 2026 | 2 articles | Viewed by 7124 | Submission Open

Keywords: antimicrobial alternatives; antimicrobial resistance; animal health; infectious disease

(This special issue belongs to the Section Molecular Medicine)

Metabolic Pathways, COVID-19 and Other Viral Acute Respiratory Infections: Mechanisms and Clinical Implications: 2nd Edition

edited by

Simona Iftimie

and

Jordi Camps

submission deadline 31 Mar 2026 | 3 articles | Viewed by 6945 | Submission Open

Keywords: COVID-19; respiratory syncytial virus; influenza; SARS-CoV-2; viral acute respiratory infections; metabolic pathways; herpes virus

(This special issue belongs to the Section Molecular Medicine)

Molecular Advances in Drug Resistance and Novel Therapies for Cancer

edited by

Agnieszka Wolnicka-Glubisz

and

Konrad Kleszczyński

submission deadline 31 Mar 2026 | 4 articles | Viewed by 6889 | Submission Open

Keywords: cell signalling; cancer treatment; cancer metastasis; target validation; cancer and new molecules; cancer and cellular organelles

(This special issue belongs to the Section Biological Factors)

Advances in Nano-Based Drug Delivery: Unveiling the Next Frontier

edited by

Yuping Bao

and

Jessica M. Larsen

submission deadline 31 Mar 2026 | 2 articles | Viewed by 6667 | Submission Open

Keywords: targeted drug delivery; smart nanoformulation; controlled drug release; biocompatible nanocarriers; extracellular vesicles; immunotherapy

(This special issue belongs to the Section Bio-Engineered Materials)

Stem Cells in Musculoskeletal Tissue Engineering

edited by

Chenshuang Li

and

Zhong Zheng

submission deadline 31 Mar 2026 | 2 articles | Viewed by 4360 | Submission Open

Keywords: tissue regeneration; stem cell; cell reporgramming; iPSCs

(This special issue belongs to the Section Bio-Engineered Materials)

The Role of Glycosaminoglycans and Proteoglycans in Human Disease

edited by

Umesh Desai

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3609 | Submission Open

Keywords: glycosaminoglycans (GAGs); proteoglycans (PGs); diseases; mechanisms; molecules

(This special issue belongs to the Section Molecular Biology)

New Discoveries in the Field of Neuropharmacology

edited by

Beatrice Mihaela Radu

and Bogdan Amuzescu

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3090 | Submission Open

Keywords: neurologic and psychiatric diseases pharmacology; in silico drug screening; in vitro pharmacology assays; animal models; neuropharmacogenomics; drug safety; blood brain barrier; electrophysiology; patch-clamp

(This special issue belongs to the Section Molecular Medicine)

Advances in Glycosaminoglycans (GAGs) and Mimetics

edited by

Daniel Afosah

and

Rami A. Al-Horani

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2449 | Submission Open

Keywords: glycosaminoglycans (GAGs); hyaluronan; heparin; chondroitin sulfate; keratan sulfate; dermatan sulfate; sulfation; GAG mimetics; GAG-binding proteins

(This special issue belongs to the Section Chemical Biology)

Unraveling the Complexity of Autoimmune and Autoinflammatory Skin Diseases: From Molecular Pathways to Targeted Therapies

edited by