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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Advances in Drug Resistance and Novel Therapies for Cancer

edited by

Agnieszka Wolnicka-Glubisz

and

Konrad Kleszczyński

submission deadline 31 Mar 2026 | 4 articles | Viewed by 5904 | Submission Open

Keywords: cell signalling; cancer treatment; cancer metastasis; target validation; cancer and new molecules; cancer and cellular organelles

(This special issue belongs to the Section Biological Factors)

Metabolic Pathways, COVID-19 and Other Viral Acute Respiratory Infections: Mechanisms and Clinical Implications: 2nd Edition

edited by

Simona Iftimie

and

Jordi Camps

submission deadline 31 Mar 2026 | 3 articles | Viewed by 5790 | Submission Open

Keywords: COVID-19; respiratory syncytial virus; influenza; SARS-CoV-2; viral acute respiratory infections; metabolic pathways; herpes virus

(This special issue belongs to the Section Molecular Medicine)

Advances in Nano-Based Drug Delivery: Unveiling the Next Frontier

edited by

Yuping Bao

and

Jessica M. Larsen

submission deadline 31 Mar 2026 | 2 articles | Viewed by 5642 | Submission Open

Keywords: targeted drug delivery; smart nanoformulation; controlled drug release; biocompatible nanocarriers; extracellular vesicles; immunotherapy

(This special issue belongs to the Section Bio-Engineered Materials)

State of the Art and Perspectives in Retinal Pigment Epithelium

edited by

Paola Secchiero

and

Elisabetta Melloni

submission deadline 31 Mar 2026 | 3 articles | Viewed by 5538 | Submission Open

Keywords: retinal pigment epithelium; innovative treatments/therapeutic approaches; retinal diseases; bioactive molecules; eye delivery strategy

(This special issue belongs to the Section Cellular Biochemistry)

Stem Cells in Musculoskeletal Tissue Engineering

edited by

Chenshuang Li

and

Zhong Zheng

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3892 | Submission Open

Keywords: tissue regeneration; stem cell; cell reporgramming; iPSCs

(This special issue belongs to the Section Bio-Engineered Materials)

New Discoveries in the Field of Neuropharmacology

edited by

Beatrice Mihaela Radu

and Bogdan Amuzescu

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2564 | Submission Open

Keywords: neurologic and psychiatric diseases pharmacology; in silico drug screening; in vitro pharmacology assays; animal models; neuropharmacogenomics; drug safety; blood brain barrier; electrophysiology; patch-clamp

(This special issue belongs to the Section Molecular Medicine)

The Role of Glycosaminoglycans and Proteoglycans in Human Disease

edited by

Umesh Desai

submission deadline 31 Mar 2026 | 2 articles | Viewed by 2055 | Submission Open

Keywords: glycosaminoglycans (GAGs); proteoglycans (PGs); diseases; mechanisms; molecules

(This special issue belongs to the Section Molecular Biology)

Advances in Glycosaminoglycans (GAGs) and Mimetics

edited by

Daniel Afosah

and

Rami A. Al-Horani

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1926 | Submission Open

Keywords: glycosaminoglycans (GAGs); hyaluronan; heparin; chondroitin sulfate; keratan sulfate; dermatan sulfate; sulfation; GAG mimetics; GAG-binding proteins

(This special issue belongs to the Section Chemical Biology)

Light as a Tool to Manipulate the Structure and Function of Membranes and Membrane Proteins

edited by

Peter Pohl

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1247 | Submission Open

Keywords: photopharmacology; optogenetics; membrane transport; light-gated channels; photoswitchable lipids

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Advanced Therapeutic Strategies for Hormone-Dependent Cancers

edited by

Athanasios A. Panagiotopoulos

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1195 | Submission Open

Keywords: hormone-dependent cancers; endocrine therapy resistance; targeted therapy; combination treatment strategies; cancer biomarkers

(This special issue belongs to the Section Molecular Medicine)

Unraveling the Complexity of Autoimmune and Autoinflammatory Skin Diseases: From Molecular Pathways to Targeted Therapies

edited by

Chiara Moltrasio

Angelo Valerio Marzano

and

Sergio Crovella

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1154 | Submission Open

Keywords: autoimmune/autoinflammatory skin diseases; omics; bioinformatics; pathogenesis; tailored medicine

(This special issue belongs to the Section Molecular Genetics)

Extracellular Vesicles and Their Roles in Cancer Progression

edited by

Federica Calore

and

Giovanni Nigita

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1067 | Submission Open

Keywords: extracellular vesicles; tumor microenvironment; biomolecule profiling; multi-omics; cancer biomarkers

(This special issue belongs to the Section Molecular Biology)

Breast Cancer: Molecular Pathology, Drug Resistance and Novel Treatment Strategies

edited by

Yesim Gökmen-Polar

submission deadline 31 Mar 2026 | 1 articles | Viewed by 979 | Submission Open

Keywords: breast cancer; mechanism of resistance; targeted therapy resistance; ER+; HER2; TNBC; tumor microenvironment; recurrence; metastasis; tumor evasion

(This special issue belongs to the Section Molecular Medicine)

Updates on Molecular Mechanisms of Lysosomal Storage Disease

edited by

Anna Tylki-Szymanska

and

Patryk Lipiński

submission deadline 31 Mar 2026 | 1 articles | Viewed by 945 | Submission Open

Keywords: lysosomal storage disease (LSD); molecular mechanisms of LSD; genetic analyses; genotype– phenotype correlation in LSD; molecular biomarkers in LSD; gene therapy in LSD

(This special issue belongs to the Section Biological Factors)

Bioinspired and Biomimicking Materials for Biomedical Applications: Second Edition

edited by

Bahman Anvari

submission deadline 31 Mar 2026 | Viewed by 563 | Submission Open

Keywords: biomedical and biological imaging; biophotonics; biosensors; cell-based therapy; delivery systems; theranostics

From Gene to Metabolite: Decoding the Transcriptional Regulatory Networks Controlling the Biosynthesis of Bioactive Compounds

edited by

Zhenming Yu

submission deadline 31 Mar 2026 | 1 articles | Viewed by 417 | Submission Open

Keywords: bioactive compounds; transcriptional regulation; abiotic and biotic factor; exogenous elicitor

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Tissue-Specific Organelle Dynamics

edited by

Agnese De Mario

and

Marta Giacomello

submission deadline 31 Mar 2026 | Viewed by 314 | Submission Open

Keywords: organelles crosstalk; organelles contact sites; organelle dynamics

(This special issue belongs to the Section Cellular Biochemistry)

Fibrinogen and Fibrin in Human Diseases

edited by

Abha Sahni

submission deadline 31 Mar 2026 | Viewed by 220 | Submission Open

Keywords: fibrinogen; fibrin; inflammation; cardiovascular; neurological; endothelium; thrombosis; hemostasis; fibrosis

(This special issue belongs to the Section Molecular Biology)

Nutritional Immunity and Inflammation: Decoding Mechanisms for Therapeutic Advancement

edited by

Franziska Roth-Walter

and

Carolina Frizzo-Ramos

submission deadline 31 Mar 2026 | Viewed by 189 | Submission Open

Keywords: nutritional deficiencies; antioxidants; minerals; vitamins; mucosal block; cross feeding; microbes; inflammation; tolerance

Protein Arginine Methylation: Functions, Mechanisms, and Therapeutic Implications

edited by Yanzhong Yang

submission deadline 31 Mar 2026 | Viewed by 172 | Submission Open

Keywords: protein arginine methyltransferases; transcription; RNA splicing; signaling transduction; DNA repair; cancer; development; small molecule inhibitor

(This special issue belongs to the Section Molecular Genetics)

Molecular Chaperones in Neurodegenerative Diseases: Mechanistic Role and Therapeutic Potential

edited by Umesh Kumar Jinwal

submission deadline 31 Mar 2026 | Viewed by 147 | Submission Open

Keywords: molecular chaperones; neurodegenerative diseases; Hsp90; Hsp70; Alzheimer's Disease; Parkinson’ s Disease; Huntington's disease; amyotrophic lateral sclerosis

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Genetics and Molecular Mechanisms of Parkinson's Disease

edited by

Hugo Fernandes

submission deadline 31 Mar 2026 | Viewed by 140 | Submission Open

Keywords: Parkinson’ s disease; genetics; molecular mechanisms; neurodegeneration

(This special issue belongs to the Section Molecular Genetics)

Targeted Protein Degradation and Beyond: Integrated Biological, Chemical and Computational Approaches to Proximity-Based Modulation

edited by

Gabriele La Monica

and

Antonino Lauria

submission deadline 31 Mar 2026 | Viewed by 125 | Submission Open

Keywords: PROTACs; protein degradation; drug discovery; chemical biology; ternary complex; undruggable targets

Molecular Advances in Stress Response, Growth, Development, and Breeding of Horticultural Crops

edited by

Bo Sun

Xin Li

and Jian Lyu

submission deadline 31 Mar 2026 | Viewed by 110 | Submission Open

Keywords: horticultural crops; multi-omics integration; genome editing; molecular plant breeding; abiotic and biotic stress; quality; metabolic pathways; plant hormones; transcriptional and epigenetic regulation; protein interaction networks

(This special issue belongs to the Section Biological Factors)

Zebrafish: A Powerful Model in Neuroscience to Investigate Genes, Brain Mechanisms, and Behavior

edited by

Marco Dal Maschio

Nicola Facchinello

and

Maria Elena Miletto Petrazzini

submission deadline 31 Mar 2026 | Viewed by 102 | Submission Open

Keywords: zebrafish; behavioural neuroscience; neurodevelopment; neurodegeneration

(This special issue belongs to the Section Chemical Biology)

Obesity-Related Diseases: Molecular Basis and Therapeutic Approaches

edited by

Dénes Molnár

and

Szilvia Bokor

submission deadline 31 Mar 2026 | Viewed by 100 | Submission Open

Keywords: obesity; causes; therapy; epigenetics; biomolecules

Structure, Molecular Dynamics, Assembly, and Evolution of Protein Systems with AI-Enhanced Modeling in Pharmacology and Structural Biology

edited by

Michal Blazej Ponczek

and

Mohamed Ragab AbdelGawwad

submission deadline 31 Mar 2026 | Viewed by 100 | Submission Open

Keywords: machine learning in structural biology; molecular dynamics simulations; protein– ligand interactions; computational pharmacology; structure-based drug design

(This special issue belongs to the Section Molecular Biology)

Post-Translational Modifications in Disease: From Computational Prediction to Functional Mechanisms

edited by

Mengsha Tong

submission deadline 31 Mar 2026 | Viewed by 95 | Submission Open

Keywords: post-translational modifications; PTMs; disease

The Role of Heparin in Blood

edited by

Viktoria Weber

and

Stephan Harm

submission deadline 31 Mar 2026 | Viewed by 94 | Submission Open

Keywords: heparin; glycocalyx; anti-inflammatory properties; immunothrombosis; sepsis; inflammation; hemocompatibility; extracorporeal therapies; antiviral activity; heparin-induced thrombocytopenia (HIT)

(This special issue belongs to the Section Molecular Medicine)

SAM Domains in Health and Diseases: Structural and Functional Insights

edited by

Flavia Anna Mercurio

and

Marilisa Leone

submission deadline 31 Mar 2026 | Viewed by 90 | Submission Open

Keywords: SAM domains; oligomer- and polymer-forming SAM; mid-loop/end-helix architecture of binding; SAM physiological and pathological signaling pathways; SAM domains as drug targets

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Amino Acids and Their Metabolism in Disease

edited by

Toshiyuki Kitoh

submission deadline 31 Mar 2026 | Viewed by 90 | Submission Open

Keywords: amino acid metabolism; disease pathophysiology; cancer metabolism; immunometabolism; metabolic reprogramming; amino acid transporters; therapeutic targeting; biomarkers; nutrient sensing; systems biology

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Exploring the Molecular and Cellular Mechanisms of Pulmonary Arterial Hypertension

edited by

Fabrice Antigny

and Grégoire Ruffenach

submission deadline 31 Mar 2026 | Viewed by 87 | Submission Open

Keywords: pulmonary arterial hypertension; PAH predisposing genes; ion channels; transcription factors; RNA-binding protein; omics approaches

(This special issue belongs to the Section Molecular Medicine)

Fibronectin, Integrins and Related Molecules in Health and Diseases

edited by

Yoshikazu Takada

submission deadline 31 Mar 2026 | Viewed by 71 | Submission Open

Keywords: integrin; fibronectin; cytokines

(This special issue belongs to the Section Chemical Biology)

Choline and Its Supplementation in Human Health and Disease

edited by

Francesco Amenta

and Enea Traini

submission deadline 31 Mar 2026 | Viewed by 68 | Submission Open

Keywords: choline; transporters; deficiencies; supplementations

(This special issue belongs to the Section Molecular Medicine)

From Molecular Mechanisms to Therapies: Advances in Retinal Disease Research

edited by

Marco Feligioni

and

Maccarone Rita

submission deadline 31 Mar 2026 | Viewed by 65 | Submission Open

Keywords: retinal diseases; retinal pathologies; preclinical studies

(This special issue belongs to the Section Molecular Biology)

Molecular and Cellular Mechanisms of Therapy Resistance in Acute Myeloid Leukemia

edited by

Yong-Mi Kim

submission deadline 31 Mar 2026 | Viewed by 58 | Submission Open

Keywords: acute myeloid leukemia; molecular mechanism; cellular mechanism; therapy resistance; microenvironment

(This special issue belongs to the Section Cellular Biochemistry)

Advances in Genetic and Epigenetic Gene Therapy for Diabetic Wound Healing

edited by

Kanhaiya Singh

submission deadline 31 Mar 2026 | Viewed by 55 | Submission Open

Keywords: chronic wounds; DFU; wound healing; diet; diabetes; obesity; nutrition; genomics; epigenetics; DNA methylation; histone modifications

(This special issue belongs to the Section Molecular Genetics)

Citrin Deficiency: Molecular Pathogenesis and Novel Targets for Therapy

edited by

Takeyori Saheki

submission deadline 31 Mar 2026 | Viewed by 53 | Submission Open

Keywords: citrin deficiency; pathogenesis; therapeutic procedures

(This special issue belongs to the Section Molecular Medicine)

Synthetic Biology's Potential to Address Undruggable Targets and Difficult-to-Treat Diseases

edited by

Dario Mizrachi

submission deadline 31 Mar 2026 | Viewed by 52 | Submission Open

Keywords: synthetic biology; protein engineering; drug development; biologics; undruggable targets

(This special issue belongs to the Section Molecular Medicine)

Mitochondrial Calcium Signaling in Cardiac Health and Disease

edited by Enrique Balderas

submission deadline 2 Apr 2026 | Viewed by 48 | Submission Open

Keywords: mitochondrial Ca2+; OXPHOS; H+ gradient; ATP-synthesis; NAD(H) balance; Ca2+-overload; mitochondrial permeability; apoptosis; mtDNA; ROS production-clearance

(This special issue belongs to the Section Cellular Biochemistry)

The Urokinase System in Cancer: From Stress Responses to Therapeutic Targeting

edited by

Maja Matulić

and

Petra Korać

submission deadline 3 Apr 2026 | 1 articles | Viewed by 1164 | Submission Open

Keywords: urokinase plasminogen activator; PAI1; urokinase plasminogen activator receptor; transcription; regulation; cancer; migration; invasion; stress

DNA Damage and Repair in Cancer Treatment

edited by

Alexandros Georgakilas

and

Lorenzo Manti

submission deadline 15 Apr 2026 | 1 articles | Viewed by 4100 | Submission Open

Keywords: ionizing radiation; DNA damage; DNA repair; genomic instability; patient radioprotection; tumour radiosensitization; radiation-induced carcinogenesis

(This special issue belongs to the Section Molecular Biology)

Molecular Aspects of Diseases Origin and Development

edited by

Natalia Kurhaluk

submission deadline 20 Apr 2026 | 6 articles | Viewed by 22284 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

Novel Approaches to Harness Neuropathic Pain: Modulation of Glial Cells as a Therapeutic Strategy

edited by

Célia Duarte Cruz

and

José Tiago Costa-Pereira

submission deadline 20 Apr 2026 | Viewed by 97 | Submission Open

Keywords: neuropathic pain; neuroinflammation; descending pain modulation; glial cells; pharmacological therapies; non-pharmacological therapies; microglia; astrocytes

Recent Advances in the Role of Translation Machinery and Translational Control in the Cardiovascular System, 2nd Edition

edited by Peng Yao and

Wei Guo

submission deadline 20 Apr 2026 | Viewed by 29 | Submission Open

Keywords: translational control; translation machinery; RNA-binding protein; non-coding RNA

(This special issue belongs to the Section Molecular Genetics)

Synthetic Chemistry in Drug Discovery: Novel Compounds for Antimicrobial and Antioxidant Applications

edited by

Hawraz Ibrahim M. Amin

submission deadline 25 Apr 2026 | 1 articles | Viewed by 1904 | Submission Open

Keywords: synthetic chemistry; drug discovery; essential oils; antimicrobial activity; antiproliferative agents; antioxidant properties; bioactive molecules; structure– activity relationship; natural product derivatives; medicinal chemistry; chemical synthesis; pharmacological evaluation

(This special issue belongs to the Section Chemical Biology)

Mitochondria and Central Nervous System Disorders: 3rd Edition

edited by

Marta Zaninello

and

Camilla Bean

submission deadline 30 Apr 2026 | 5 articles | Viewed by 10908 | Submission Open

Keywords: mitochondria; metabolism; neurodegeneration; neuroinflammation; ageing; central nervous system

(This special issue belongs to the Section Molecular Biology)

Nanoparticles for Cancer Therapy: Challenges and Opportunities

edited by

Nagavendra Kommineni

and

Venkatesh Pooladanda

submission deadline 30 Apr 2026 | 2 articles | Viewed by 5735 | Submission Open

Keywords: nanoparticles; cancer; nanotheranostics; drug delivery; gene delivery

(This special issue belongs to the Section Bio-Engineered Materials)

Genetics and Epigenetics of Breast Cancer

edited by

Ashakumary Lakshmikuttyamma

submission deadline 30 Apr 2026 | 2 articles | Viewed by 4750 | Submission Open

Keywords: breast cancer; genetic landscape; epigenetics; diagnostic/prognostic/predictive biomarkers

(This special issue belongs to the Section Molecular Genetics)

Biomarkers in Neurodegenerative Diseases: Shaping the Future of Diagnosis and Treatment

edited by

Martine Tétreault

and

Laura Hamilton

submission deadline 30 Apr 2026 | 5 articles | Viewed by 4348 | Submission Open

Keywords: molecular diagnostics; lipidomics; genomics; proteomics; transcriptomics

(This special issue belongs to the Section Molecular Biomarkers)

Displaying special issue 301-350 on page 7 of 11.

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