Strangles, a major contagious disease in horses caused by Streptococcus equi subsp. equi (SEE), is difficult to control because of limitations associated with antimicrobial treatment and persistent carrier states. In this study, we characterized the...
Tropical peat swamp forests (TPSFs) are waterlogged, acidic ecosystems whose microbial communities remain poorly characterized, particularly members of the phylum Actinomycetota, which include many prolific producers of bioactive secondary metabolite...
Antimicrobial resistance (AMR) is an emerging global health concern that demands the identification of novel drug targets and bioactive molecules to combat resistant bacterial pathogens. In the present study, AmvR, a TetR family transcriptional regul...
Nitrogen (N) and phosphorus (P) are critical nutrients governing legume growth and productivity, while excessive dependence on mineral fertilizers can reduce nutrient use efficiency and environmental sustainability. This study evaluated the agronomic...
Cacao (Theobroma cacao L.) production is severely constrained by frosty pod rot, caused by Moniliophthora roreri. Beneficial bacteria such as Bacillus subtilis represent a promising biological-control strategy, but their influence on cacao transcript...
Potassium (K) deficiency and inefficient fertilizer use constrain sustainable maize production, highlighting the need for biological strategies to improve soil K availability. This study evaluated the potassium-solubilizing capacity of Bacillus albus...
Streptococcus agalactiae is a major contagious pathogen that causes bovine mastitis and substantial economic losses in the dairy industry. This study investigated the capsular genotypes, antimicrobial susceptibility, and virulence-associated phenotyp...
Bacterial biofilms are sessile microbial communities, and their inherent resistance to antimicrobials is the main cause of many persistent and chronic infections. Their complex and heterogeneous status provides conditions that may contribute to the e...
Crohn’s disease (CD) is a chronic inflammatory condition of the gastrointestinal tract. This case–control study included 20 patients with CD and 20 healthy controls at Mohammed VI University Hospital in Marrakech. The study aimed to chara...
Microbial biofilms are highly structured multicellular communities that exhibit remarkable tolerance to antimicrobial agents and host defenses, contributing to persistent infections, industrial biofouling, food contamination, and environmental challe...
Biofilm formation by uropathogenic Escherichia coli contributes to antibiotic resistance and the persistence of urinary tract infections. Whether biofilm formation is an intrinsic characteristic of UPEC or an adaptive response to antibiotic stress re...
Microbial exopolysaccharides (EPS) are structurally diverse biopolymers with ecological and biotechnological relevance due to their physicochemical and functional properties, including emulsification, metal chelation, and contributions to biofilm for...
Recent studies have focused on developing innovative therapeutic interventions in response to the increasing antibiotic resistance reported in opportunistic pathogens such as Pseudomonas aeruginosa. Sabinene is a bicyclic monoterpene found in various...
Infection with antibiotic-resistant Enterococcus faecalis is a major public health concern. Enhancing antibiotic efficacy is a key therapeutic strategy. This study investigates whether sub-inhibitory concentrations (sub-MICs) of hydrogen peroxide (H2...
Background: Urinary tract infections (UTIs) are among the most common bacterial infections worldwide and remain a major cause of antimicrobial prescribing in both community and hospital settings. Continuous epidemiological surveillance is essential t...
Probiotics, especially Bacillus species, have gained attention for their potential to improve growth and strengthen disease resistance in cultured shrimp. This study evaluated the effects of native Bacillus strains on growth performance, disease resi...
Hydroquinine, a cinchona alkaloid, has demonstrated antibacterial activity against multidrug-resistant pathogens, with previous transcriptomic data implicating the arginine deiminase (ADI) pathway. However, its potential molecular target engagement r...
Carbapenem resistance in Pseudomonas aeruginosa is frequently mediated by the mutational inactivation or complete loss of the oprD porin gene. However, extreme genetic polymorphism within oprD limits traditional PCR amplification, a bottleneck for mo...
Objectives: To determine whether stunting modifies periodontal microbial dynamics, inflammatory responses, and short-term responses to oral interventions in children. Materials and Methods: This open-label, non-randomized study included 36 children a...
Probiotic efficacy may depend on reliable intestinal exposure, yet clinical evidence linking delivery engineering to measurable microbiome responses in humans remains limited. We compared two active doses of microencapsulated Lacticaseibacillus rhamn...
Staphylococcus aureus (S. aureus) produces an array of virulence factors (VFs), which contribute to its pathogenicity. One of the VFs is the type VII secretion system (T7SS), a protein secretion apparatus present in many Gram-positive bacteria, which...
Hospital wastewater is an important matrix for monitoring clinically relevant bacteria and antimicrobial resistance genes (ARGs). We used shotgun metagenomic sequencing for an exploratory comparison of untreated wastewater and treated effluent from a...
Understanding the potential mechanisms of bacterial azo dye decolorization remains a challenge due to a limited understanding of the exact stereochemical forces guiding enzyme–substrate interactions. This study addresses these interactions by e...
Multiplex PCR assays report Ureaplasma urealyticum (UU) and Ureaplasma parvum (UP) separately, but the results are often combined as “Ureaplasma positive.” We compared Gardnerella vaginalis (GV) co-detection in UU-only and UP-only adult s...
Beef is an excellent source of protein in the human diet; however, high production levels in the livestock industry expose meat products to a greater risk of contamination by bacteria such as Escherichia coli, a pathogen of great significance in publ...
Smokeless tobacco (SLT) consumption is a significant risk factor for oral dysbiosis and oral cancer in South Asian countries, including India. However, its impact on oral microbial ecology, functional restructuring, and sex-specific microbial respons...
Antarctic soils harbor highly specialized bacterial communities that perform essential functions in the functioning of polar ecosystems; however, the composition and structure of these communities remain poorly understood in many areas of Antarctica....
Extremophilic prokaryotes survive salt, temperature, and pH extremes by coordinating stress-induced protein networks that preserve macromolecules, sustain energetics, and repair damage. This review integrates recent proteomics with functional genomic...
Gamma (γ)-aminobutyric acid (GABA) is a non-proteinogenic amino acid recognized for its primary function as the main inhibitory neurotransmitter in the mammalian central nervous system and its role as a stress-responsive metabolite in various m...
Aquaculture production of Asian seabass is increasingly threatened by recurrent bacterial diseases, while practical vaccination strategies that provide protection against bacterial challenges involving multiple pathogens during extended grow-out peri...
One of the challenges in the practical application of plant growth-promoting bacteria (PGPB) is predicting their effectiveness under field conditions. Performance can vary due to environmental factors and the recruitment of genotype-specific microbio...
Escherichia coli O157:H7 represents a major food safety concern, with cattle serving as the primary reservoir host. A better understanding of the interactions between O157 and the potential physiochemical indicators to which it is exposed to in the c...
Flacherie is a major bacterial disease compromising silkworm health and cocoon productivity; however, the diversity and genomic features of larva-associated pathogens remain poorly characterized. In the present study, we isolated and characterized a...
The origin of life is commonly framed within the RNA World hypothesis, yet increasing evidence suggests that early evolution may have involved a broader diversity of hereditary systems than those preserved in modern biology. Alternative informational...
Legume–rhizobium symbiosis is fundamental to sustainable agriculture because it supplies biologically fixed nitrogen, improves soil fertility, and reduces reliance on synthetic fertilizers. However, abiotic and chemical stresses, including drou...
Scientific journals are, at their best, reflections of the disciplines they serve [...]
Carbohydrate-active enzymes (CAZymes) encoded by the human gut microbiome are central mediators of dietary glycan metabolism and host–microbe biochemical homeostasis. Among these, β-glucuronidases represent functionally pivotal hydrolases...
Background/objectives: Foodborne diseases remain a significant global public health concern, requiring innovative and effective antimicrobial strategies to control food pathogens. Encapsulation of natural antimicrobials have attracted increasing inte...
Plague remains a globally important zoonotic disease maintained in natural foci, with ongoing epizootic activity and periodic human cases reported in several regions of the world. Continuous monitoring of antimicrobial susceptibility in Yersinia pest...
Seven indigenous strains of Bradyrhizobium japonicum subsp. saratovii isolated from soybean nodules (Glycine max (L.) Merr.) grown in the arid Lower Volga region of Russia were investigated. A complete set of the major symbiotic genes was detected in...
Pseudomonas aeruginosa, an opportunistic pathogen, is a major threat to hospital infection control and global public health due to its strong environmental adaptability, complex virulence systems, efficient biofilm formation capability, and widesprea...
Background: The rapid rise in antimicrobial resistance (AMR) represents one of the most pressing global health challenges of the 21st century, threatening antibiotic effectiveness, compromising clinical outcomes, and undermining healthcare systems. U...
L. angustifolia is a perennial shrub native to the Mediterranean region with multiple medicinal properties. In this study, we report on the chemical composition of L. angustifolia essential oil (LEO), its antibacterial, antibiofilm, and antioxidant a...
Saline ecosystems, including saline lakes, are indeed major hotbeds of microbial novelty, harboring diverse and largely unexplored microbes. The sebkha of Lake Naïla (Morocco), an ecologically protected area registered under the Ramsar Conventio...
Shiga toxin-producing Escherichia coli (STEC) is a major zoonotic foodborne pathogen associated with severe human illnesses, including hemorrhagic colitis and hemolytic uremic syndrome. While ruminants are traditionally recognized as the primary rese...
Background: Urinary tract infections (UTIs) are among the most common bacterial infections worldwide and represent a significant public health concern due to their high prevalence and increasing antimicrobial resistance. This study aimed to systemati...
This Special Issue brings together a diverse collection of contributions that highlight the soil microbiome, including bacteria, fungi, and other microorganisms, which play a crucial role in enhancing crop productivity and nutrient absorption while m...
Biosurfactant production by hydrocarbon-degrading bacteria is strongly influenced by the nature and concentration of available carbon substrates, which determine hydrocarbon bioavailability and microbial metabolic responses. In this study, five Bacil...
Background: Antibiotic misuse and prescribing errors are significant concerns in clinical practice, contributing to unnecessary antibiotic exposure, increased adverse effects, rising healthcare costs, and the escalation of antibiotic resistance. Unde...
Enterococcus lactis is increasingly recognized as an emerging mastitis pathogen, yet the functional basis of its virulence and associated health risks remain poorly defined. This study presents an integrated genomic and phenotypic characterization of...
