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Antioxidants publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Phytochemical Analysis and Evaluation of Antioxidant Properties in Medicinal Plants

edited by

Magdalena Jeszka-Skowron

Agnieszka Zgoła-Grześkowiak

Tomasz Grześkowiak

and

Robert Frankowski

submission deadline 20 Dec 2025 | 7 articles | Viewed by 22613 | Submission Open

Keywords: antioxidant activity; phytochemicals in plants; medicinal plants; extraction; in vivo analysis; in vitro analysis

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Interplay of Microbiome and Oxidative Stress

edited by

Julio Plaza-Díaz

Lourdes Herrera-Quintana

and

Héctor Vázquez Lorente

submission deadline 20 Dec 2025 | 3 articles | Viewed by 12930 | Submission Open

Keywords: microbiome; oxidative stress; antioxidants; gut microbiota; free radicals; reactive oxygen species; gut– brain axis; dysbiosis; microbial metabolites; mitochondrial function; probiotics; microbe– host interactions

Antioxidant and Anti-Inflammatory Properties of Mushrooms: From Structure to Functionality

edited by

Michał Swieca

submission deadline 20 Dec 2025 | 3 articles | Viewed by 12704 | Submission Open

Keywords: mushroom; antioxidants; metabolic syndrome; functional food; nutraceuticals; polysaccharides; phenolics; terpenoids

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

The Use of Antioxidant-Rich Foods and Supplements in Disease Prevention

edited by

Abraham Wall Medrano

Escobar-Puentes Alberto A.

and

Gustavo Adolfo González-Águilar

submission deadline 20 Dec 2025 | 3 articles | Viewed by 10114 | Submission Open

Keywords: dietary antioxidants; bioactivity; metabolomics; human diet; xenobiotics; polyphenols; vitamins; health promotion

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Significance of Antioxidant Mechanisms in Intestinal Inflammation—2nd Edition

edited by

Alba Rodríguez-Nogales

and

María Elena Rodríguez Cabezas

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1085 | Submission Open

Keywords: antioxidant therapy; antioxidants; intestinal inflammation; oxidative stress; polyphenol; reactive oxygen/nitrogen species; redox homeostasis

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Advances in Plant Redox Biology Research

edited by Yurong Xie and Ming Chang

submission deadline 20 Dec 2025 | Viewed by 259 | Submission Open

Keywords: plant redox biology; reactive oxygen species; reactive nitrogen species; plant development; environmental stress; abiotic/biotic stresses; host– microbe interactions

(This special issue belongs to the Section ROS, RNS and RSS)

Antioxidants as Adjuvants for Inflammatory Bowel Disease Treatment

edited by

Marcello Chieppa

and

Angelo Santino

submission deadline 22 Dec 2025 | 4 articles | Viewed by 9881 | Submission Open

Keywords: IBD; antioxidant; gut barrier; inflammation; natural compounds; microbiome; colon cancer; adjuvant; nutritional bioactive products; polyphenols

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Hydrogen and Oxidative Stress: Implications for Health and Longevity

edited by

Kyu-Jae Lee

and

Cheol-Su Kim

submission deadline 25 Dec 2025 | 2 articles | Viewed by 2171 | Submission Open

Keywords: molecular hydrogen (H2); oxidative stress; redox homeostasis; selective antioxidant; reactive oxygen species (ROS); aging and longevity; mitochondrial protection; cellular resilience; hydrogen therapy; inflammation and immunity; neurodegeneration; cardiovascular health; metabolic disorders; gene regulation; translational medicine; longevity

(This special issue belongs to the Section ROS, RNS and RSS)

Antioxidant Response in Aquatic Animals

edited by Martha Gabriela Gaxiola-Cortes

submission deadline 30 Dec 2025 | 9 articles | Viewed by 15115 | Submission Open

Keywords: antioxidant system; respiration; nutrition; culture; fish; aquatic animals; reactive oxygen species (ROS); superoxide dismutase (SOD)

Nitric Oxide and Redox Mechanisms

edited by

Massimiliano Coletta

, Paolo Ascenzi and

Giovanna De Simone

submission deadline 30 Dec 2025 | 6 articles | Viewed by 14593 | Submission Open

Keywords: nitric oxide; ROS and RNS; nitrosative stress; NO signaling; redox mechanisms

(This special issue belongs to the Section ROS, RNS and RSS)

Antioxidant and Anti-Inflammatory Potential of Plants in Cancer Treatment

edited by

Brigitte Deguin

Lorenza Trabalzini

and

Rosa Tundis

submission deadline 30 Dec 2025 | 3 articles | Viewed by 7829 | Submission Open

Keywords: phytochemical characterization; antioxidant and anti-inflammatory natural compounds and extracts; natural waste resources; horticultural or wild plants; medicinal plants; and edible plants; green selective extraction processes

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Male Reproductive Health

edited by

and

submission deadline 31 Dec 2025 | 10 articles | Viewed by 33334 | Submission Open

Keywords: oxidative stress; antioxidant therapy; male reproductive health; male fertility; erectile dysfunction; prostatic disease; male ageing

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Therapies in Cardiovascular, Cardiorenal and Metabolic Diseases

edited by Kaushik P. Patel, Hong Zheng and

Tapan Patel

submission deadline 31 Dec 2025 | 5 articles | Viewed by 20510 | Submission Open

Keywords: antioxidant therapies; oxidative stress; cardiovascular diseases; cardiorenal diseases; metabolic diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Carotenoids in Health and Disease

edited by Kazutoshi Shindo

submission deadline 31 Dec 2025 | 3 articles | Viewed by 12878 | Submission Open

Keywords: antioxidant activities of carotenoids; analytical chemistry on carotenoids; reactive oxygen species (ROS) and disease; production of carotenoids

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Multi-Target Profile of Antioxidant Compounds, Including Repurposing and Combination Strategies—2nd Edition

edited by

Roberta Rocca

submission deadline 31 Dec 2025 | 5 articles | Viewed by 10926 | Submission Open

Keywords: polypharmacology; multi-target ligands; rational drug; design repurposing; off-target effects; computational techniques

Agri-Food Wastes as Natural Source of Bioactive Antioxidants: Fourth Edition

edited by

Silvana Hrelia

Cristina Angeloni

and

Maria Cristina Barbalace

submission deadline 31 Dec 2025 | 4 articles | Viewed by 10350 | Submission Open

Keywords: agri-food by-products; agri-food waste; nutraceuticals; functional foods; cosmeceutical products; sustainable practices; bioactive compounds; health effects

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Redox Regulation in Cardiovascular Diseases

edited by

Yiliang Chen

and

Jacek Zielonka

submission deadline 31 Dec 2025 | 3 articles | Viewed by 9155 | Submission Open

Keywords: oxidative stress; mitochondria; metabolism; chronic inflammation; atherosclerosis; CVD; ROS

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Selected Papers from the 2nd International Electronic Conference on Antioxidants (IECAN2025)

edited by

Alessandra Napolitano

and

Mario Allegra

submission deadline 31 Dec 2025 | 2 articles | Viewed by 8983 | Submission Open

Keywords: obesity; cardiovascular diseases; chronic disease; dietary prevention; antioxidants intake; gut microbiome; natural and synthetic antioxidants; antioxidant enzyme systems; antioxidant extraction

Oxidative Stress, Antioxidants, and Mechanisms in FLASH Radiotherapy

edited by

Jean Paul Jay-Gerin

submission deadline 31 Dec 2025 | 4 articles | Viewed by 7795 | Submission Open

Keywords: radiobiology and radiotherapy; ultra-high dose rate irradiation and the FLASH effect; molecular and cellular mechanisms; radiation-induced oxidative stress; reactive oxygen and nitrogen species; inflammatory processes; antioxidants and radioprotectors; pulse radiolysis; kinetics; physicochemical and biological processes; DNA damage; role of oxygen and the oxygen depletion hypothesis; modeling and experimental; FLASH particle therapy

Role of Reactive Oxygen Species (ROS) in Tumor Microenvironment Modulation

edited by

Antonis Giakountis

and

Dimitrios Kouretas

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7127 | Submission Open

Keywords: reactive oxygen species; tumor microenvironment; stroma cells; functional genomics; spatial transcriptomics; single-cell sequencing; RNA-seq; cancer; diagnosis and prognosis; biomarkers

Antioxidant Activity of Polyphenolic Extracts

edited by

Dimitrios Stagos

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6959 | Submission Open

Keywords: antioxidant activity; polyphenols; plant extracts; oxidative stress

Oxidative Stress in Rare Diseases: Mechanisms, Implications, and Therapeutic Opportunities

edited by

Christophe Desterke

and

Jorge Mata-Garrido

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5815 | Submission Open

Keywords: rare diseases; oxidative stress; free radicals; biomedicine; redox biomarkers; redox epigenetics; redox metabolism; redox control of protein function; ferroptosis

Redox Biology and Genomic Integrity

edited by

Viktor Stolc

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5540 | Submission Open

Keywords: redox biology; reactive oxygen species (ROS); oxidative stress; oxidative DNA damage; genome stability; DNA repair; hypermutation; antioxidant defense mechanisms; mitochondrial dysfunction; Saccharomyces cerevisiae; cellular adaptation; epigenetics; telomeres

Natural Antioxidants in Animal Nutrition

edited by

Lili Zhang

Xiang Zhong

, Chao Wang, Hao Zhang and Jingfei Zhang

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5234 | Submission Open

Keywords: antioxidants; animal; growth; metabolism; nutrition; oxidative stress; plant extracts

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Editorial Board Members’ Collection Series: Advances in Redox-Tools and Therapies in Cardiovascular Disease

edited by

Andreas Daiber

Albino Carrizzo

and

Moo-Yeol Lee

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3500 | Submission Open

Keywords: cardiovascular disease; oxidative stress; inflammation; reactive oxygen species; redox signalling

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Novel Strategies for Oxidative Stress Management: Dietary Interventions for Liver and Gut Health

edited by

Antonio Cilla

and

Mussa Makran

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3196 | Submission Open

Keywords: antioxidant compounds; phytochemicals; dietary interventions; hepatic disease; intestinal disease; redox homeostasis

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Metabolic Dysfunction and Oxidative Stress

edited by

Vinood B. Patel

and

Mohammed Gulrez Zariwala

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2939 | Submission Open

Keywords: iron; mitochondria; oxidative stress; inflammation; metabolism; free radicals

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Respiratory Disorders

edited by

Daniela Mokra

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2865 | Submission Open

Keywords: oxidative stress; lung; reactive oxygen species; reactive nitrogen species; acute lung injury; asthma; COPD; lung fibrosis; pulmonary silicosis; premature neonate

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Radiation Exposure and Health: The Role of Oxidative Stress and Inflammatory Response

edited by

Siamak Haghdoost

and

Benjamin Frey

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2131 | Submission Open

Keywords: radiation; inflammatory response; oxidative stress

Super Oxide Dismutase (SOD) Isoenzymes and Reactive Oxygen Species (ROS) in Immuno-Pathophysiology

edited by Giuseppina Ruggiero and

Paolo Mondola

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1844 | Submission Open

Keywords: superoxide dismutase (SOD) isoenzymes; superoxide dismutase (SOD)1; cell signalling; cell metabolism; cell functions; cellular stress; disease pathogenesis

Natural Antioxidants in Functional Foods

edited by

Angela Cardinali

, Palmira De Bellis and

Anna Rita Bavaro

submission deadline 31 Dec 2025 | 3 articles | Viewed by 1652 | Submission Open

Keywords: polyphenols; functional foods; fermentation; antioxidant activity; anti-inflammatory activity

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Modulation of Biochemical, Cellular and Physiological Mechanisms in Response to Oxidative Stress in Animals

edited by

Konstantinos Feidantsis

and

Vasiliki Sapanidou

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1644 | Submission Open

Keywords: animals; cell signaling; metabolism; cell death responses; oxidative damage

Phenolic Antioxidants in Functional Foods and Nutraceuticals

edited by

Diana Andreia Tavares Pinto

and

Francisca Rodrigues

submission deadline 31 Dec 2025 | 1 articles | Viewed by 969 | Submission Open

Keywords: bioactive compounds; agri-food byproducts; in vitro assays; in vivo studies; green extraction; biological activities; safety assessment; industrial application

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Algal Antioxidants: Physiology, Metabolism, and Evolution

edited by

Shan Lu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 880 | Submission Open

Keywords: algae; antioxidant; oxidative stresses; algal physiology

Emerging Trends in Antioxidant Nutraceuticals

edited by

Andrei Mocan

and

Oleg Frumuzachi

submission deadline 31 Dec 2025 | 1 articles | Viewed by 746 | Submission Open

Keywords: nutraceuticals; diabetes; cancer; oxidative stress; inflammation; antioxidant

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Mitochondrial Dysfunction in Metabolic Disorders

edited by

Pablo M. García-Rovés

Steen Larsen

and Hugo J Alves-Figueiredo

submission deadline 31 Dec 2025 | 1 articles | Viewed by 716 | Submission Open

Keywords: metabolic diseases; oxidative stress; mitochondrial dysfunction; antioxidant therapies; lifestyle interventions; gene therapies; mitochondrial transfer therapies

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants and Dietary Nutrition: Emerging Trends, and Clinical Applications

edited by

Sofia Lotti

and

Raúl Zamora-Ros

submission deadline 31 Dec 2025 | Viewed by 460 | Submission Open

Keywords: antioxidants; oxidative stress; chronic disease prevention; dietary strategies; bioavailability

Antioxidant Properties of Functional Foods

edited by Konstantinos G. Adamopoulos and

Patroklos Vareltzis

submission deadline 31 Dec 2025 | Viewed by 437 | Submission Open

Keywords: antioxidant; extraction; bioavailability; processing; optimization; functional food; phytochemicals

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Metabolism and Epigenetics: A Potential Dual Interaction in the Microenvironment of Solid Tumors

edited by

Federico Pio Fabrizio

Lucia Anna Muscarella

Filippo Torrisi

and Sebastiano Giallongo

submission deadline 31 Dec 2025 | Viewed by 330 | Submission Open

Keywords: metabolomics; tumor cell metabolism; tumor microenvironment; cell communication; cell signaling; epigenetics; post-translational modifications; cancer therapy

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

The Role of Dietary Antioxidants in Alleviating Oxidative Stress and Inflammation for Enhanced Immunity in Animals

edited by Yanka D. Karamalakova and

Jie Yin

submission deadline 31 Dec 2025 | Viewed by 326 | Submission Open

Keywords: antioxidants; antioxidant feeding; insect meal; growth performance; digestible energy; nutrient digestibility; blood biochemistry; oxidative stress (OS); lipid peroxidation (MDA); ROS/RNS; superoxide dismutase (SOD); catalase (CAT); glutathione (GSH); glutathione peroxidase (GPx); inflammation markers; total antioxidant capacity (TAC); meat; milk; eggs quality

Development and Application of Detection Methods for Reactive Oxygen Species and Antioxidants

edited by

Naoya Kishikawa

and

Mahmoud El-Maghrabey

submission deadline 31 Dec 2025 | Viewed by 303 | Submission Open

Keywords: antioxidant extraction; antioxidant assay; sensors for reactive oxygen species (ROS); ROS scavenger assays; biological samples; oxidative stress status; nutritional value; food analysis; bioassays; enzymatic assays; redox cycle; cell imaging

(This special issue belongs to the Section Methods for Antioxidants Evaluation/Measurement)

Antioxidant Natural Products and Peptides in Cosmetics

edited by

Fotini Lamari

Vassiliki Magafa

and

Sophia Hatziantoniou

submission deadline 31 Dec 2025 | Viewed by 272 | Submission Open

Keywords: cosmetics; herbal extracts; natural products; peptides; synthesis; isolation; oxidative stress; emulsions; nanoparticles; fibroblasts; ageing

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Bioavailability of Antioxidants: From Omics Insights to Health Outcomes

edited by

Pascual García-Pérez

submission deadline 31 Dec 2025 | Viewed by 241 | Submission Open

Keywords: bioavailability; nutrigenomics; metabolomics; gut microbiota; dietary polyphenols; functional foods; biotransformation; systems biology; antioxidants; bioactivity

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Studies on Antioxidants and Anti-Aging Substances Using Model Organisms and Cell Cultures

edited by

Yoshihiro H. Inoue

submission deadline 31 Dec 2025 | Viewed by 218 | Submission Open

Keywords: antioxidants; anti-aging substances and natural products; experimental animals; 3D cell culture models; organoids; acting mechanisms; antioxidant genes; autophagy; proteasome

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Redox Regulation of Plant Growth and Development

edited by Judit Dobránszki and

Judit Remenyik

submission deadline 31 Dec 2025 | Viewed by 162 | Submission Open

Keywords: plant biology; ascorbate; free-radical scavenging; glutathione; heat shock proteins; melatonin; oxidative stress; plant growth and development; redox homeostasis; RNP; ROS; plant stress mitigation; plant stress adaptation; transcription factors

(This special issue belongs to the Section ROS, RNS and RSS)

Hydrogen Sulfide and Its Role in Inflammatory and Degenerative Joint Diseases

edited by Guenter Steiner and Burkhard Klösch

submission deadline 31 Dec 2025 | Viewed by 158 | Submission Open

Keywords: hydrogen sulfide; inflammation; antioxidant; osteoarthritis; rheumatoid arthritis; degeneration; chondrocyte; monocyte; fibroblast; drug development

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Biomarkers of Oxidative Stress in Lung Disease

edited by

Rafał Pawliczak

submission deadline 31 Dec 2025 | Viewed by 127 | Submission Open

Keywords: oxidative stress; reactive oxygen species; reactive nitrogen species; antioxidants; lung inflammation; bronchial inflammation; COPD; asthma; lung fibrosis; mitochondria

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Adaptive Responses in Space Medicine and Physiology

edited by

Dawon Kang

submission deadline 31 Dec 2025 | Viewed by 123 | Submission Open

Keywords: antioxidant defense ; microgravity ; oxidative stress ; radiation ; space medicine ; space physiology

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Phytochemicals for Promoting Human Health and Well-Being

edited by

Teresa Mencherini

Francesca Sansone

and

Tiziana Esposito

submission deadline 10 Jan 2026 | 6 articles | Viewed by 9837 | Submission Open

Keywords: antioxidant phytochemicals; oxidative stress; health promotion; chronic disease; functional foods; nutraceuticals

Antioxidant Effects of Natural Compounds on Cell Metabolism

edited by Ester Tellone and Annamaria Russo

submission deadline 12 Jan 2026 | 3 articles | Viewed by 6351 | Submission Open

Keywords: antioxidants; metabolic pathways; dietary intake; blood cells; bioactive compounds

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

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