Studies on Antioxidants and Anti-Aging Substances Using Model Organisms and Cell Cultures
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 83
Special Issue Editor
Interests: drosophila; antioxidants; oxidative stress response; Nrf2; autophagy; hemocytes; tumors; innate immunity; cell division
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Some anti-aging substances, which extend the lifespan of organisms or delay the onset of age-related phenomena, have shown the ability to prevent oxidative damage to biomaterials within cells. Other health-promoting substances and natural products have been demonstrated to enhance the removal of damaged proteins and organelles, thereby preventing their accumulation in the cells. These substances are expected to prevent the decline of biological functions and could ultimately delay the progression of aging. Although cultured cells have primarily been used to search for compounds and natural products with such effects and to analyze their mechanisms of action, many identified substances are not digested or absorbed when administered to organisms. For this reason, screenings are also conducted using experimental animals to identify substances with antioxidant and anti-aging effects. However, it is time-consuming and expensive to use mammalian models. In contrast, utilizing nematode and Drosophila models facilitate efficient research and analysis in mechanisms of action in a shorter time frame. More recently, studies have begun to use 3D models of cultured cells and organoids, which mimic tissues. For this Special Issue, we welcome research papers that explore substances and natural products with antioxidant and anti-aging effects, as well as works that elucidate the mechanisms of these effects, using living organisms and organoids. High-quality papers dealing with the screening and analysis of action mechanisms using cultured cells are also acceptable.
Prof. Dr. Yosihhiro H. Inoue
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- antioxidants
- anti-aging substances and natural products
- experimental animals
- 3D cell culture models
- organoids
- acting mechanisms
- antioxidant genes
- autophagy
- proteasome
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