Antioxidant Therapies in Cardiovascular, Cardiorenal and Metabolic Diseases

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 481

Special Issue Editors


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Guest Editor
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center (UNMC), Omaha, NE 68198, USA
Interests: cardiology and nephrology

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Guest Editor
Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, Vermillion, SD 57069, USA
Interests: neuroscience and physiology

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Guest Editor Assistant
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center (UNMC), Omaha, NE 68198, USA
Interests: cardiovascular diseases; cardiorenal syndrome; genetic disorders; pharmacology; toxicology; molecular diagnosis

Special Issue Information

Dear Colleagues,

Oxidative stress is a condition which arises when there is an altered equilibrium between the reactive oxygen species (ROS) and the cellular defense system (antioxidant enzymes). The accumulation of ROS and the decline in the activity of antioxidant enzymes leads to increased oxidative stress. Such increased oxidative stress affects the physiological, biochemical, and molecular functions of the cell followed by the abnormal metabolism and functioning of the cell, tissue, organ, and organ system. Increased oxidative stress in cardiac and renal tissue affects the anatomy and physiology of the heart and kidney, respectively. Increased oxidative stress also induces the inflammation and triggers the malfunctioning of the autonomic nervous system. Both natural and synthetic compounds, by scavenging ROS and activating antioxidant enzymes, have shown a significant decline in oxidative stress and mitigating the life-threatening outcomes of ROS in the cardiovascular and renal system. Currently, nanotechnology-based antioxidant therapies are being examined as potential antioxidant therapies for the cardiovascular, cardiorenal, and metabolic diseases.

This Special Issue aims to collect original research articles, reviews, perspectives, and short communications related to the potential antioxidant therapeutic approaches for the treatment of cardiovascular, cardiorenal, and metabolic diseases. As Guest Editors, we invite you to submit your research or review manuscripts to this Special Issue, which will bring together all the current potential therapeutic strategies to reduce oxidative stress and prevent diseases associated with heart and kidney.

Prof. Dr. Kaushik P. Patel
Dr. Hong Zheng
Guest Editors

Dr. Tapan Patel
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidant therapies
  • oxidative stress
  • cardiovascular diseases
  • cardiorenal diseases
  • metabolic diseases

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Published Papers (1 paper)

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Review

16 pages, 4917 KiB  
Review
Sodium–Glucose Cotransporter 2 Inhibitors as Potential Antioxidant Therapeutic Agents in Cardiovascular and Renal Diseases
by Tapan A. Patel, Hong Zheng and Kaushik P. Patel
Antioxidants 2025, 14(3), 336; https://doi.org/10.3390/antiox14030336 - 13 Mar 2025
Viewed by 19
Abstract
Redox (reduction–oxidation) imbalance is a physiological feature regulated by a well-maintained equilibrium between reactive oxygen species (ROS) and oxidative stress (OS), the defense system of the body (antioxidant enzymes). The redox system comprises regulated levels of ROS in the cells, tissues and the [...] Read more.
Redox (reduction–oxidation) imbalance is a physiological feature regulated by a well-maintained equilibrium between reactive oxygen species (ROS) and oxidative stress (OS), the defense system of the body (antioxidant enzymes). The redox system comprises regulated levels of ROS in the cells, tissues and the overall organ system. The levels of ROS are synchronized by gradients of electrons that are generated due to sequential reduction and oxidation of various biomolecules by various enzymes. Such redox reactions are present in each cell, irrespective of any tissue or organ. Failure in such coordinated regulation of redox reactions leads to the production of excessive ROS and free radicals. Excessively produced free radicals and oxidative stress affect various cellular and molecular processes required for cell survival and growth, leading to pathophysiological conditions and, ultimately, organ failure. Overproduction of free radicals and oxidative stress are the key factors involved in the onset and progression of pathophysiological conditions associated with various cardiovascular and renal diseases. Sodium–glucose cotransporter 2 inhibitors (SGLT2is) are glucose-lowering drugs prescribed to diabetic patients. Interestingly, apart from their glucose-lowering effect, these drugs exhibit beneficial effects in non-diabetic patients suffering from various cardiovascular and chronic kidney diseases, perhaps due to their antioxidant properties. Recently, it has been demonstrated that SGLT2is exhibit strong antioxidant properties by reducing ROS and OS. Hence, in this review, we aim to present the novel antioxidant role of SGLT2is and their consequent beneficial effects in various cardiovascular and renal disease states. Full article
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