Emerging Trends in Antioxidant Nutraceuticals

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 419

Special Issue Editors


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Guest Editor
1. Laboratory of Chromatography, Institute of Advanced Horticulture Research of Transylvania, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania
2. Department of Pharmaceutical Sciences 3rd, Iuliu Hațieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania
Interests: natural antioxidants; biology of oxidative stress; endogenous antioxidants; clinical use of antioxidants; (clinical) laboratory methods for antioxidants detection; molecular bases of human nutrition; melatonin
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Guest Editor Assistant
Department of Pharmaceutical Botany, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
Interests: antioxidant activity; functional foods; nutrition; meta-analysis; systematic review; biological activity

Special Issue Information

Dear Colleagues,

The field of antioxidant nutraceuticals is rapidly advancing within the scientific community, fueling valuable discussions on their health benefits and increasing consumer interest. Research has consistently highlighted the health-promoting potential of the antioxidant compounds found in various plants, particularly phenolics such as anthocyanins, flavonols, and phenolic acids. These compounds are found in varying concentrations in a range of plants, including turmeric, green tea, rosemary, ginger, thyme, and basil, among others.

A key trend in the field focuses on eco-friendly extraction methods, including ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), and high-pressure technologies, which maximize the recovery of these beneficial compounds in an environmentally sustainable way. Extensive studies have reviewed both the in vitro and in vivo effects of phenolic-rich plant and berry extracts, confirming potent antioxidant, anti-inflammatory, anti-hypertensive, and anti-hyperglycemic activities.

These findings underscore the potential of antioxidant nutraceuticals to combat oxidative stress, highlighting both significant health benefits and growing commercial appeal. As evidence supporting their role in promoting human health continues to accumulate, antioxidant-rich plant products are emerging as valuable functional foods and nutraceuticals with robust therapeutic potential and considerable market promise.

This Special Issue invites high-quality original research articles, narrative and systematic reviews, and meta-analyses that focus on emerging trends in antioxidant nutraceuticals, with an emphasis on their innovative extraction techniques, bioactivity, and therapeutic potential. Contributions should explore the isolation, characterization, and mechanistic evaluation of antioxidant compounds, particularly phenolics, from diverse natural sources.

Submissions are encouraged on the following topics:

  • Advanced and eco-friendly extraction methods (e.g., UAE, MAE, high-pressure technologies) to maximize the yield and functionality of antioxidant compounds.
  • In vitro, in vivo, and clinical studies assessing the antioxidant, anti-inflammatory, and metabolic effects of nutraceuticals.
  • The development of functional foods or supplements enriched with antioxidant bioactives.
  • Investigations into the stability, bioavailability, and synergistic interactions of antioxidant compounds in nutraceutical formulations.
  • Novel applications of antioxidant nutraceuticals in mitigating oxidative stress-related diseases, such as cardiovascular diseases, diabetes, neurodegenerative disorders, and cancer.

Dr. Andrei Mocan
Guest Editors

Dr. Oleg Frumuzachi
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutraceuticals
  • diabetes
  • cancer
  • oxidative stress
  • inflammation
  • antioxidant

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Published Papers (1 paper)

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Research

23 pages, 1298 KB  
Article
Untargeted UHPLC-HRMS Metabolomic Profiling of Cornus mas L. Fruits: Impact of Conventional and Emerging Extraction Methods on Phenolic Composition and Bioactivity
by Oleg Frumuzachi, Alexandru Nicolescu, Mihai Babotă, Andrei Mocan, Luigi Lucini, Sascha Rohn, Gianina Crișan and Gabriele Rocchetti
Antioxidants 2025, 14(12), 1419; https://doi.org/10.3390/antiox14121419 - 27 Nov 2025
Abstract
A growing number of studies evaluated cornelian cherry (Cornus mas L.) fruits due to their rich phenolic profile. It is obvious that the efficient recovery of these compounds depends on the extraction method used. Thus, this study aimed at comparing conventional (maceration, [...] Read more.
A growing number of studies evaluated cornelian cherry (Cornus mas L.) fruits due to their rich phenolic profile. It is obvious that the efficient recovery of these compounds depends on the extraction method used. Thus, this study aimed at comparing conventional (maceration, decoction) and non-conventional (ultrasound-assisted [UAE], enzyme-assisted [EAE]) extractions. Two novel aspects were characterized: the first application of EAE for cornelian cherry fruit phenolic recovery and the use of untargeted UHPLC-HRMS metabolomics. Untargeted UHPLC-HRMS profiling in positive electrospray ionization mode annotated 342 compounds, the broadest chemical analysis of C. mas fruits reported to date, followed by a semi-quantitative assessment of main phenolic compound subclasses using representative standards and multivariate statistical approaches. UAE proved most effective for recovering total flavonoids (433.6 μg eq./g) and phenolic acids (420.2 μg eq./g), while EAE selectively enriched other phenolic category compounds, semi-quantified as oleuropein equivalents (1975.4 μg eq./g). Multivariate analysis further confirmed distinct phytochemical fingerprints across extraction methods: the UAE extract was characterized by isocoumarin 2,4-di-O-methylolivetonide, while two compounds, cardamonin and ellagic acid arabinoside, were specifically up-accumulated in the EAE extract. All extracts showed moderate antioxidant (UAE > decoction > maceration > EAE) and enzyme inhibitory activities, with UAE and maceration being the most promising for multifunctional bioactivity. However, while untargeted UHPLC-HRMS revealed unprecedented complexity, results remain tentative and highlight the need for future targeted validation. Full article
(This article belongs to the Special Issue Emerging Trends in Antioxidant Nutraceuticals)
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