Redox Biology and Genomic Integrity

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 30 June 2025 | Viewed by 643

Special Issue Editor


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Guest Editor
NASA Ames Research Center, Space BioSciences, Moffett Field, CA 94035, USA
Interests: redox-sensitive signaling pathways and gene expression; oxidative stress-induced DNA damage and repair; antioxidant defense mechanisms and genomic stability; impact of redox imbalances on DNA replication and transcription; role of redox modifications in epigenetic regulation; mitochondrial redox signaling and genome maintenance; redox regulation of telomere length and function; effects of environmental stressors (radiation, microgravity, toxins) on redox status and genome integrity; nutritional modulation of redox balance for genome protection; therapeutic targeting of redox pathways to prevent genomic instability
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Special Issue Information

Dear Colleagues,

The journal Antioxidants is pleased to announce a Special Issue titled "Redox Biology and Genomic Integrity". This Issue will delve into the complex interplay between redox biology and the maintenance of genomic stability. We aim to explore the biochemical mechanisms underlying the cellular responses to reactive oxygen species (ROS) and oxidative stress, and how these processes influence genomic integrity across diverse organisms.

Specifically, we invite contributions that investigate the following topics:

  • The impact of redox imbalances on the following processes:
    • Mutation rates;
    • DNA damage and repair pathways;
    • Genomic stability;
    • Mitochondrial function and dysfunction;
    • Telomere maintenance;
    • Epigenetic modifications;
  • The role of antioxidant defense mechanisms in the following processes:
    • Protecting against oxidative DNA damage;
    • Maintaining genome integrity;
    • Modulating DNA repair processes;
  • The significance of redox signaling in the following processes:
    • Regulating cellular responses to oxidative stress;
    • Adapting to redox stress conditions;
  • Model organisms and their relevance to human health, including the following:
    • Yeast (Saccharomyces cerevisiae);
    • Mammalian systems;
    • Other relevant model organisms.

We encourage submissions of original research articles, reviews, and short communications that address these topics and advance our understanding of how redox biology affects genome integrity. Studies employing cutting-edge methodologies, such as high-throughput sequencing, proteomics, and live-cell imaging are particularly welcome.

Dr. Viktor Stolc
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • redox biology
  • reactive oxygen species (ROS)
  • oxidative stress
  • oxidative DNA damage
  • genome stability
  • DNA repair
  • hypermutation
  • antioxidant defense mechanisms
  • mitochondrial dysfunction
  • Saccharomyces cerevisiae
  • cellular adaptation
  • epigenetics
  • telomeres

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Published Papers (1 paper)

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Review

31 pages, 4276 KiB  
Review
RNA–DNA Differences: Mechanisms, Oxidative Stress, Transcriptional Fidelity, and Health Implications
by Viktor Stolc, Ondrej Preto, Miloslav Karhanek, Friedemann Freund, Yuri Griko, David J. Loftus and Maurice M. Ohayon
Antioxidants 2025, 14(5), 544; https://doi.org/10.3390/antiox14050544 - 30 Apr 2025
Viewed by 144
Abstract
RNA–DNA differences (RDDs) challenge the traditional view of RNA as a faithful copy of DNA, arising through RNA editing, transcriptional errors, and oxidative damage. Reactive oxygen species (ROS) play a central role, inducing lesions like 8-oxo-guanine that compromise transcription and translation, leading to [...] Read more.
RNA–DNA differences (RDDs) challenge the traditional view of RNA as a faithful copy of DNA, arising through RNA editing, transcriptional errors, and oxidative damage. Reactive oxygen species (ROS) play a central role, inducing lesions like 8-oxo-guanine that compromise transcription and translation, leading to dysfunctional proteins. This review explores the biochemical basis of RDDs, their exacerbation under oxidative stress, and their dual roles in cellular adaptation and disease. RDDs contribute to genomic instability and are implicated in cancers, neurodegenerative disorders, and autoimmune diseases, while also driving phenotypic diversity. Drawing on terrestrial and spaceflight studies, we highlight the intersection of oxidative stress, RDD formation, and cellular dysfunction, proposing innovative mitigation approaches. Advancements in RDD detection and quantification, along with ROS management therapies, offer new avenues to restore cellular homeostasis and promote resilience. By positioning RDDs as a hallmark of genomic entropy, this review underscores the limits of biological adaptation. Furthermore, the prevalence of guanine-rich codons in antioxidant genes increases their susceptibility to ROS-induced oxidative lesions, linking redox stress, genomic instability, and constrained adaptation. These insights have profound implications for understanding aging, disease progression, and adaptive mechanisms in both terrestrial and space environments. Full article
(This article belongs to the Special Issue Redox Biology and Genomic Integrity)
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