Significance of Antioxidant Mechanisms in Intestinal Inflammation—2nd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (20 December 2025) | Viewed by 1155

Special Issue Editors


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Guest Editor
1. Department of Pharmacology, Centro de Investigación Biomédica (CIBM), University of Granada, 18071 Granada, Spain
2. Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18012 Granada, Spain
Interests: antioxidant; immune response; inflammation; microbiota; polyphenols; prebiotics; probiotics
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department of Pharmacology, Centro de Investigación Biomédica (CIBM), University of Granada, 18071 Granada, Spain
2. Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18012 Granada, Spain
Interests: antioxidant; intestinal inflammation; microbiota; natural compounds; postbiotics; prebiotics; probiotics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In view of the great response to our previous Special Issue "Significance of Antioxidant Mechanisms in Intestinal Inflammation", we are excited to announce a new edition dedicated to this important and evolving topic.

Oxidative stress continues to play a pivotal role in the pathogenesis and progression of intestinal inflammation. In recent years, antioxidant therapy has emerged as a potential approach to mitigate inflammation and oxidative damage in the gut. In the context of intestinal inflammation, antioxidants such as vitamins C and E, selenium, and natural polyphenols like curcumin and resveratrol have shown promise in reducing inflammation by reducing oxidative damage to intestinal cells. Although numerous experimental and clinical studies have demonstrated that antioxidants could modulate key pathways involved in inflammation, such as NF-κB and MAPK signalling, leading to a reduced production of pro-inflammatory cytokines, many questions remain unanswered. A more comprehensive understanding of how reactive oxygen species are generated and regulated during intestinal inflammation—and how these processes interact with current and emerging therapies—will be essential in identifying novel therapeutic targets and strategies.

As Guest Editors, we invite you to contribute to this Special Issue focused on the role of oxidative stress in the initiation and progression of intestinal inflammation, as well as during therapeutic interventions.

Dr. Alba Rodríguez-Nogales
Dr. Maria Elena Rodriguez Cabezas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • antioxidant therapy
  • antioxidants
  • intestinal inflammation
  • oxidative stress
  • polyphenol
  • reactive oxygen/nitrogen species
  • redox homeostasis

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Published Papers (1 paper)

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Review

34 pages, 5371 KB  
Review
Nrf2 as a Molecular Guardian of Redox Balance and Barrier Integrity in IBD
by Bojan Stojanovic, Ivana Milivojcevic Bevc, Milica Dimitrijevic Stojanovic, Bojana S. Stojanovic, Marina Jovanovic, Snezana Lazarevic, Bojan Milosevic, Ivan Radosavljevic, Danijela Tasic-Uros, Nenad Markovic, Đorđe Todorovic, Irfan Corovic, Filip Milutinovic, Damnjan Pantic, Mladen Maksic and Snezana Lukic
Antioxidants 2025, 14(12), 1407; https://doi.org/10.3390/antiox14121407 - 26 Nov 2025
Viewed by 928
Abstract
Inflammatory bowel disease (IBD), encompassing Crohn’s disease and ulcerative colitis, represents a chronic inflammatory condition of the gastrointestinal tract characterized by immune dysregulation, oxidative stress, and impaired epithelial barrier function. Among the complex molecular networks involved, the transcription factor nuclear factor erythroid 2–related [...] Read more.
Inflammatory bowel disease (IBD), encompassing Crohn’s disease and ulcerative colitis, represents a chronic inflammatory condition of the gastrointestinal tract characterized by immune dysregulation, oxidative stress, and impaired epithelial barrier function. Among the complex molecular networks involved, the transcription factor nuclear factor erythroid 2–related factor 2 (Nrf2) has emerged as a central regulator of redox balance, anti-inflammatory signaling, and mucosal homeostasis. This review provides a comprehensive overview of the pathogenic role of oxidative stress in IBD, detailing the sources and consequences of reactive oxygen species (ROS) accumulation, and the mechanisms by which Nrf2 activation counters these effects. We discuss the dual regulation of Nrf2 through Keap1-dependent and Keap1-independent pathways, its influence on epithelial integrity, immune cell polarization, microbiota composition, and its paradoxical role in IBD-associated tumorigenesis and fibrosis. Furthermore, we highlight emerging therapeutic strategies aimed at modulating Nrf2 activity via pharmacologic agents, dietary phytochemicals, and probiotics. Taken together, these insights position Nrf2 as a pivotal therapeutic target in IBD, offering new avenues for restoring epithelial resilience, mitigating chronic inflammation, and improving clinical outcomes. Full article
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