Hydrogen and Oxidative Stress: Implications for Health and Longevity
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "ROS, RNS and RSS".
Deadline for manuscript submissions: 25 December 2025 | Viewed by 18
Special Issue Editors
Interests: molecular hydrogen; alkaline ionized water; antioxidant; human health
Special Issues, Collections and Topics in MDPI journals
Interests: molecular hydrogen; inflammation; oxidative stress; antioxidant; alkaline ionized water
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress plays a central role in the development and progression of a wide spectrum of chronic and age-related diseases, including neurodegeneration, cardiovascular disorders, cancer, and metabolic dysfunction. Molecular hydrogen (H2) has become a novel treatment candidate with unmatched biological potential as the hunt for safe, efficient, and tailored antioxidant therapies heats up.
This Special Issue is dedicated to advancing our understanding of hydrogen’s transformative role in oxidative stress modulation and redox biology. A growing body of compelling evidence demonstrates that hydrogen is far more than a selective antioxidant—it actively neutralizes harmful reactive oxygen species (ROS), modulates critical gene expression, influences key cellular signaling cascades, and enhances mitochondrial integrity. Together, these actions position hydrogen as a powerful agent in fortifying cellular defenses, mitigating damage, and counteracting age-related physiological decline.
We invite cutting-edge original research, comprehensive reviews, and translational studies that elucidate the molecular mechanisms, delivery systems, and clinical applications of hydrogen therapy. Contributions addressing hydrogen’s impact on aging biology, disease prevention, tissue regeneration, and lifespan extension are especially encouraged.
This Special Issue aims to advance our understanding of hydrogen as a novel redox-modulating agent and its far-reaching implications for enhancing human health, delaying the onset of age-related diseases, and extending healthy longevity.
Prof. Dr. Kyu-Jae Lee
Dr. Cheol-Su Kim
Guest Editors
Manuscript Submission Information
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Keywords
- molecular hydrogen (H2)
- oxidative stress
- redox homeostasis
- selective antioxidant
- reactive oxygen species (ROS)
- aging and longevity
- mitochondrial protection
- cellular resilience
- hydrogen therapy
- inflammation and immunity
- neurodegeneration
- cardiovascular health
- metabolic disorders
- gene regulation
- translational medicine
- longevity
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