Editorial Board Members’ Collection Series: Advances in Redox-Tools and Therapies in Cardiovascular Disease

Dear Colleagues,

Cardiovascular diseases represent a growing global epidemic with an immense economic burden, making their prevention and the provision of care for patients suffering from them paramount challenges worldwide. Reduced endothelial function is recognized as an early, subclinical harbinger of vascular alteration, preceding and accompanying the development of various cardiovascular conditions and significantly contributing to increased vascular complications. The key drivers of this impaired endothelial integrity and increase in cardiovascular risk include diminished synthesis and enhanced oxidative breakdown of the central vasodilator and antithrombotic/atherosclerotic messenger nitric oxide, exacerbated oxidative damage to various cardiovascular structures and signalling pathways, low-grade inflammation, and aberrant lipid handling.

While numerous pharmacological interventions exist, their precise molecular mechanisms and potential long-term side effects remain areas of intense investigation. Notably, the current biological markers of cardiovascular diseases often lack the specificity to predict patient disease progression accurately.

Specific requirements for submissions:

In light of these challenges and opportunities, we invite investigators to contribute original research and comprehensive review articles that leverage cutting-edge technologies to identify novel molecular mechanisms and therapeutic strategies for combating cardiovascular diseases. We are particularly interested in studies related to antioxidant/oxidative mechanisms and redox signalling pathways that explore:

The identification of novel molecules involved in the onset and progression of cardiovascular diseases, utilizing genomics, proteomics, and metabolomics to pinpoint previously uncharacterized targets.

Novel potential therapeutic approaches to reduce vascular injury, employing nanotechnology for targeted drug delivery and gene editing techniques to modulate key pathways.

The discovery of novel pharmacological approaches to fight cardiovascular disease, including high-throughput screening and computational drug design to identify innovative compounds.

The identification of novel molecules able to contribute to a reduction in vascular dysfunction, utilizing advanced imaging techniques to monitor vascular responses to potential therapeutics in real-time.

The identification of novel natural compounds with beneficial cardiovascular properties, employing advanced extraction and characterization methods combined with rigorous pre-clinical testing.

This Special Issue aims to highlight the transformative potential of new technologies in unravelling the complexities of cardiovascular disease and in paving the way for innovative therapeutic interventions that directly address underlying mechanisms and improve patient outcomes. By focusing on upstream signalling modulation and exploring novel molecular entities, we aim to foster a new era in the fight against this global health challenge.

Prof. Dr. Andreas Daiber
Dr. Albino Carrizzo
Prof. Dr. Moo-Yeol Lee
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• cardiovascular disease
• oxidative stress
• inflammation
• reactive oxygen species
• redox signalling