BioMedInformatics, Volume 2, Issue 4

In recent years, the advent of new experimental methodologies for studying the high complexity of the human genome and proteome has led to the generation of an increasing amount of digital information, hence bioinformatics, which harnesses computer s...

Behavioral factors can affect the blood glucose (BG) levels in people with type 1 diabetes (T1D), therefore, their effects need to be incorporated in blood glucose management for these individuals. Accordingly, in this work, we study the effect of tw...

Feature selection is a common step in data preprocessing that precedes machine learning to reduce data space and the computational cost of processing or obtaining the data. Filtering out uninformative variables is also important for knowledge discove...

Photorefractive keratectomy (PRK) has long been the method of choice for refractive surgery in pilots, and was FDA approved for U.S. Air Force aviators in 2000. We retrospectively reviewed the medical records of 16 male combat pilots (mean age 25.0 &...

Breast carcinoma (BCa) remains the second most common cause of cancer-related death among American women. Whereas estrogen receptor (ER) expression is typically regarded as a favorable prognostic indicator, a significant proportion of ER(+) patients...

Individualized, serial production of innovative implants is a major area of application for additive manufacturing in the field of medicine. Individualized healthcare requires faster delivery of the implant to the clinic or hospital facility. The tot...

Accurate and early detection of causes of pneumonia is important for implementing fast treatment and preventive strategies, reducing the burden of infections, and establishing more effective ways of interventions. After the outbreak of COVID-19, the...

Mitochondrial DNA (mtDNA) damage is closely associated with typical diseases of aging, such as Alzheimer’s or Parkinson’s disease, and other health conditions, such as infertility. This damage manifests in reduced mitochondrial copy numbe...

Background: High-quality oligonucleotides for molecular amplification and detection procedures of diverse target sequences depend on sequence homology. Processing input sequences and identifying homogeneous regions in alignments can be carried out by...

The retinal degenerative disease retinitis pigmentosa (RP) is a genetic disease that is the most common cause of blindness in adults. In 2016, Chow et. al. identified over 100 candidate modifier genes for RP through the genome-wide analysis of 173 in...

The adoption of “artificial intelligence (AI) in drug discovery”, where AI is used in the process of pharmaceutical research and development, is progressing. By using the ability to process large amounts of data, which is a characteristic...

Determining whether emergency catheterization is necessary for treating heart disease in older patients in rural hospitals is important. Their transportation may be affected by ageism. This retrospective cohort study investigated the relationship bet...

Immune checkpoint blockade targeting PDCD1 (PD-1) or CD274 (PD-L1) has demonstrated efficacy and interest across multiple cancers. However, the exact determinants of the response and cancer-specific molecular features remain unclear. A recent pan-can...

Bacteria that are capable of organizing themselves as biofilms are an important public health issue. Knowledge discovery focusing on the ability to swarm and conquer the surroundings to form persistent colonies is therefore very important for microbi...

Omicron is the dominant strain of COVID-19 in the United States and worldwide. Although this variant is highly transmissible and may evade natural immunity, vaccines, and therapeutic antibodies, preclinical results in animal models and clinical data...

Knowledge discovery in biomedical data using supervised methods assumes that the data contain structure relevant to the class structure if a classifier can be trained to assign a case to the correct class better than by guessing. In this setting, acc...

In this paper, a novel approach for abnormal gait and tremor detection using a smart walking cane is introduced. Periodic muscle movement associated with Parkinson’s disease, such as arm shaking, vibrating arm, trembling fingers, rhythmic wrist...