Fermentation, Volume 9, Issue 8
2023 August - 82 articles
Cover Story: Baker’s yeast stands as an extensively characterized and versatile microorganism pivotal in biomanufacturing diverse specialty molecules, including enzymes, biofuels, chemicals and pharmaceuticals. Despite its genetic tractability, the evaluation of its sustained production prowess has remained understudied. Here, we introduced a fluorescent reporter gene on select genomic loci to monitor fluorescence levels across a span of over 100 generations. A clear decline in fluorescence over time was observed, yet what the underlying causes were warrants further investigation. Alongside this pioneering testament to the evolutionary dynamics of engineered yeast strains, we propose several new and strain-specific parameters to expedite microbial cell factory construction. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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